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L3T4+ T-cell-independent reactivity of Lyt2+ T cells in vivo.

Abstract：

:The aim of this study was to analyze in vivo the L3T4+ T-cell-subset-independent reactivity of Lyt2+ T cells toward transplantation alloantigens. To this end, we depleted normal mice of L3T4+ T cells by injection of monoclonal antibodies to the L3T4 antigen. This procedure not only led phenotypically to a disappearance of L3T4+ T cells, but also effectively abolished reactivity toward class II MHC antigens in vitro and in vivo. However, L3T4+ T-cell-depleted mice still reacted to class I MHC alloantigens in vivo: after immunization with class I MHC alloantigens Il-2 receptor-bearing T cells appeared in the draining lymph nodes, and developed antigen-specific cytolytic activity. Moreover, upon in vivo priming the frequencies of class I MHC-specific precursors of Il-2-producing and cytolytic Lyt2+ T lymphocytes increased up to 20-fold. L3T4+ T-cell-depleted mice rejected class I MHC-bearing skin grafts promptly. We conclude that not only in vitro but also in vivo Lyt2+ T cells remain reactive toward class I MHC antigens in the absence of L3T4+ T helper cells.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Heeg K,Steeg C,Wagner H

doi

10.1016/0008-8749(88)90059-7

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

148-57

issue

1

eissn

0008-8749

issn

1090-2163

pii

0008-8749(88)90059-7

journal_volume

111

pub_type

杂志文章

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