High dose antigen treatment with a peptide epitope of myelin basic protein modulates T cells in multiple sclerosis patients.

abstract：:The primary objective of this study was to determine whether the n-3 PUFA-mediated changes in host response to a Listeria monocytogenes infection (e.g., cytokine production and bacterial clearance) were dependent upon neutrophils. Balb/c mice were fed one of two semi-purified diets that contained either 0 or 41 g of n...

journal_title：Cellular immunology

authors： Fritsche K,Irons R,Pompos L,Janes J,Zheng Z,Brown C

更新日期：2005-05-01 00:00:00

abstract：:We have previously shown that interleukin-2 (IL-2) is able to induce the generation of natural killer (NK) activity in bone marrow (BM) cells from mice pretreated with 5-fluorouracil. IL-2 alone could dose-dependently induce NK activity in marrow cells and interleukin-4 (IL-4) has dual effect on the NK activity in tha...

journal_title：Cellular immunology

authors： Migliorati G,Cardinali L,Riccardi C

更新日期：1991-08-01 00:00:00

abstract：:Human mononuclear cells stimulated with soluble IgG aggregates generated chemiluminescence, a response attributable to monocytes. Some requirements of this reaction were examined by preincubation of the cells with a variety of inhibitors. The protease antagonists TPCK and TLCK, the phospholipase inhibitors quinacrine ...

journal_title：Cellular immunology

authors： Rush DN,Keown PA

更新日期：1984-08-01 00:00:00

abstract：:It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cel...

journal_title：Cellular immunology

authors： Takeuchi T,Schlossman SF,Morimoto C

更新日期：1987-06-01 00:00:00

abstract：:The lymphokine IL-4 is a potent enhancer of anti-IgM-induced B cell proliferation. Although the mechanism of this enhancement is not known, a commonly held view suggests that IL-4 acts together with anti-IgM as a costimulating factor for the activation of a subpopulation of B cells. To evaluate this hypothesis we exam...

journal_title：Cellular immunology

authors： Hodgkin PD,Go NF,Cupp JE,Howard M

更新日期：1991-04-15 00:00:00

abstract：:The programmed death (PD)-1/PD-1 ligands (PD-Ls) pathway, is a new member of the B7/CD28 family, and consists of the PD-1 receptor and its ligands PD-L1 (B7-H1, CD274) and PD-L2 (B7-DC, CD273). Recently, it is reported that PD-1, PD-L1 and PD-L2 also have soluble forms aside from their membrane bound forms. The solubl...

journal_title：Cellular immunology

authors： Dai S,Jia R,Zhang X,Fang Q,Huang L

更新日期：2014-07-01 00:00:00

abstract：:The relay hypothesis [R. Nayak, S. Mitra-Kaushik, M.S. Shaila, Perpetuation of immunological memory: a relay hypothesis, Immunology 102 (2001) 387-395] was earlier proposed to explain perpetuation of immunological memory without requiring long lived memory cells or persisting antigen. This hypothesis envisaged cycles ...

journal_title：Cellular immunology

authors： Vani J,Nayak R,Shaila MS

更新日期：2007-03-01 00:00:00

abstract：:A monoclonal mouse antibody (HNC-1A3) which defines a subset of human lymphocytes with natural cytotoxic activity was produced and studied. HNC-1A3+ cells represent 12 +/- 3% of peripheral blood mononuclear leukocytes. When sorted out using a fluorescence-activated cell sorter, they consist of 60% small lymphocytes, 3...

journal_title：Cellular immunology

authors： Rola-Pleszczynski M,Lieu H

更新日期：1983-12-01 00:00:00

abstract：:Intravenous injection of spleen cells (SC) coated with an antitrinitrophenyl (anti-TNP) IgM monoclonal antibody, Sp6 (Sp6-SC), which carries a recurrent idiotype, resulted in activation of a Lyt-2-positive population which did adhere to Sp6-coated plates. No effect of Sp6-SC injection could be observed in vivo on an a...

journal_title：Cellular immunology

authors： Zöller M,Lopatta D,Andrighetto G

更新日期：1986-04-01 00:00:00

abstract：:BST2 is a type II transmembrane protein that had been initially identified as a surface molecule expressed on terminally differentiated B cells. Here, we characterize the expression of BST2 in human endothelial cells, HUVECs. IFN-γ, among various inflammatory stimuli, dramatically upregulates BST2 expression in HUVECs...

journal_title：Cellular immunology

authors： Yoo H,Park SH,Ye SK,Kim M

更新日期：2011-01-01 00:00:00

abstract：:Micromolar amounts of SV-IV, one of the major proteins secreted from the rat seminal vesicle epithelium, induce in vitro a marked release of a variety of cytokines (interferon-gamma, tumor necrosis factor-alpha, interleukin 6, and granulocyte-monocyte colony-stimulating factor) from human resting peripheral blood mono...

journal_title：Cellular immunology

authors： Tufano MA,Porta R,Farzati B,Di Pierro P,Rossano F,Catalanotti P,Baroni A,Metafora S

更新日期：1996-03-15 00:00:00

abstract：:Although most intraepithelial lymphocytes (IEL) in mouse small intestine bear surface markers classically associated with T lymphocytes, the T-cell nature of these cells remains controversial. In the present study IEL from normal mice, or from mice infected with the gut nematode Trichinella spiralis, were therefore te...

journal_title：Cellular immunology

authors： Dillon SB,Dalton BJ,MacDonald TT

更新日期：1986-12-01 00:00:00

abstract：:In this study we investigated whether T cells expressing high or low levels of CD62L were differentially susceptible to the T cell chemokine lymphotactin. We found that lymphotactin induced preferential migration of antigen-specific (CD62L(lo)) T cells over the nonspecific (CD62L(hi)) T cells in vitro and in vivo. The...

journal_title：Cellular immunology

authors： Kurt RA,Bauck M,Harma S,McCulloch K,Baher A,Urba WJ

更新日期：2001-05-01 00:00:00

abstract：:Respiratory immunization is an attractive way to generate systemic and mucosal protective memory responses that are required for preventing mucosally transmitted infections. However, the molecular and cellular mechanisms for controlling memory T cell responses remain incompletely understood. In this study, we investig...

journal_title：Cellular immunology

authors： Acosta-Ramirez E,Tram C,Kampen RM,Tillman MR,Schwendener RA,Xing Z,Halperin SA,Wang J

更新日期：2016-12-01 00:00:00

abstract：:Mammals and microorganisms have evolved a complex and tightly controlled mutual relationship. This interaction grants protection and energy source for the microorganisms, and on the other hand, provides several immunologic, metabolic and physiological advantages for the host. The gastrointestinal tract (GI) harbors th...

journal_title：Cellular immunology

authors： Nakagaki BN,Vieira AT,Rezende RM,David BA,Menezes GB

更新日期：2018-08-01 00:00:00

abstract：:TNF-alpha plays an important role in the development of secondary lymphoid tissues. Earlier studies showed that fibroblastic reticular cells express TNF-alpha receptor, suggesting that TNF-alpha may affect the development of FRCs. To test this, we analyzed the development and function of FRCs in wild-type or TNF-alpha...

journal_title：Cellular immunology

authors： Zhao L,Chen J,Liu L,Gao J,Guo B,Zhu B

更新日期：2015-02-01 00:00:00

abstract：:Antigen-nonspecific CD8+ T suppressor cells, which suppressed delayed-type hypersensitivity (DTH) against sheep red blood cells in BALB/c mice, were induced by incubating spleen cells from mice treated with 7,12-dimethylbenz[a]anthracene (DMBA), a tumor initiator, with 12-O-tetradecanoylphorbol 13-acetate (TPA), a tum...

journal_title：Cellular immunology

authors： Negoro T,Iinuma F,Watanabe M

更新日期：1991-12-01 00:00:00

abstract：:Accessory cell (A-cell) function in a Con A response was analyzed. Irradiated P388D1 cells efficiently induced a proliferative response to Con A of T cells purified from spleen cells, whereas paraformaldehyde-fixed P388D1 cells failed to serve as A cells. Although IL-1 containing culture supernatant (SN) of a macropha...

journal_title：Cellular immunology

authors： Kohno K,Kakiuchi T,Takeuchi M,Taira S,Nariuchi H

更新日期：1987-05-01 00:00:00

abstract：:Delta opioid receptors (DORs) are known to modulate multiple T-cell responses. However, little is known about the expression of these receptors. These studies evaluated the expression of DOR mRNA and protein after a single in vivo exposure to staphylococcal enterotoxin B (SEB). SEB (20 microg, ip) significantly enhanc...

journal_title：Cellular immunology

authors： Shahabi NA,McAllen K,Matta SG,Sharp BM

更新日期：2000-11-01 00:00:00

abstract：:We have compared the interaction of Mycobacterium tuberculosis with the human macrophage-like cell line THP-1 and with human monocyte-derived macrophages (MDM). The association of M. tuberculosis with THP-1 and MDM was comparable in both the presence and the absence of serum. For both cells, serum-mediated binding was...

journal_title：Cellular immunology

authors： Stokes RW,Doxsee D

更新日期：1999-10-10 00:00:00

abstract：:Previous studies established that low in vitro temperatures (27 degrees C, termed nonpermissive) suppressed murine primary thymus-dependent (TD), but not primary thymus-independent (TI) or secondary TD, antibody responses. Suppression was rescued by the addition of oleic acid (18:1), recombinant interleukin (rIL)-2 an...

journal_title：Cellular immunology

authors： Wooten RM,Clem LW,Bly JE

更新日期：1993-11-01 00:00:00

abstract：:Cytotoxic T-cell (CTL) cultures were generated from five ovarian cancer patients (OvCTL) and from three breast cancer patients (BrCTL). All CTL lines were T-cell receptor (TcR) alphabeta+ and predominantly CD8+ (73 +/- 13%). These CTL lines preferentially recognized autologous tumor cells in an HLA class I-restricted,...

journal_title：Cellular immunology

authors： Goedegebuure PS,Douville CC,Doherty JM,Linehan DC,Lee KY,Ganguly EK,Eberlein TJ

更新日期：1997-02-01 00:00:00

abstract：AIMS:Non-enzymatic reaction of biomolecules leads to the formation of advanced glycation end products (AGEs). AGEs plays significant role in the pathophysiology of type 2 diabetes mellitus. Methylglyoxal (MG) is a highly reactive carbonyl compound which causes formation of early (ketoamines), intermediate (dicarbonyls)...

journal_title：Cellular immunology

authors： Khan MY,Alouffi S,Khan MS,Husain FM,Akhter F,Ahmad S

更新日期：2020-05-01 00:00:00

abstract：:Possible causes were examined for the inability of heat-inactivated lymphocytes to induce proliferative responses in mixed-lymphocyte cultures (MLC). Cells heated at 45 degrees C for 60 min lost greater than 90% of their capacity to stimulate in primary (1 degree) or secondary (2 degrees) MLC. This was not due to acce...

journal_title：Cellular immunology

authors： Boyer CM,Kostyu DD,Brissette CS,Amos DB

更新日期：1986-09-01 00:00:00

abstract：:That M1/70, a monoclonal anti-murine macrophage antibody, recognizes murine natural killer cells (NK) and that there is an increase in NK following intraperitoneal infection with live Listeria monocytogenes (LM) was previously reported. Here, LM-induced NK cells were further characterized with respect to tumor target ...

journal_title：Cellular immunology

authors： Holmberg LA,Ault KA

更新日期：1984-11-01 00:00:00

abstract：:Transformed murine fetal thymocyte cell lines were derived by incubating fetal thymic organ cultures with a v-myc/v-raf-containing retroviral construct in order to model developmental stages within the early triple negative (CD3-CD4-CD8-) thymocyte population. The resulting 10 cell lines had a lymphoid morphology, wer...

journal_title：Cellular immunology

authors： Taubenberger JK,Reid AH,Izon D,Boehme SA

更新日期：1996-07-10 00:00:00

abstract：:The role of macrophages (M phi) in the in vitro primary antibody response of murine lymphocytes to sheep erythrocytes was investigated. Peritoneal M phi were activated to express Ia antigens either in vitro or in vivo. Nonactivated Ia- M phi were also examined. We observed that only Ia- M phi but also Ia+ M phi failed...

journal_title：Cellular immunology

authors： Komatsubara S,Hirayama Y,Inaba K,Naito K,Yoshida K,Kawai J,Muramatsu S

更新日期：1985-10-15 00:00:00

abstract：:In this study, cellular requirements for rejection are examined by the use of adoptive transfer assays in the ACI to Lewis cardiac allograft model. The findings show that adoptive transfer of 1 x 10(8) spleen cells (SpL), 5 x 10(7) T-cells, and 2 x 10(7) helper T-cells (W3/25+) obtained from normal, nonsensitized dono...

journal_title：Cellular immunology

authors： Oluwole SF,Engelstad K,Hardy MA

更新日期：1989-11-01 00:00:00

abstract：:Positive selection of T lymphocytes expressing self. MHC-restricted T cell receptors is mediated by MHC molecules expressed on thymic stroma. Among the more controversial aspects of this process is the relative role of MHC molecules on epithelial versus bone marrow-derived stromal elements (BM-APC). For CD4+ T cells, ...

journal_title：Cellular immunology

authors： Fort MM,Pardoll DM

更新日期：1996-07-10 00:00:00

abstract：:Veto cells suppress generation of CD8(+) T cell immune responses in an antigen-specific manner, with specificity dictated by antigens on the veto cell surface. Activated bone marrow (ABM) veto cells belong to the NK cell type lineage and veto by clonally deleting antigen-specific precursor cytotoxic T cell lymphocyte ...

journal_title：Cellular immunology

authors： Chrobak P,Gress RE

更新日期：2001-03-15 00:00:00