Accessory cell function in a Con A response: role of Ia and interleukin 1.

abstract：:The role of surface aminopeptidases (APs), enzymes that cleave amino-terminal residues from polypeptide chains, in the development of fetal thymocytes was studied using a murine fetal thymic organ culture (FTOC) model. FTOC AP activity was demonstrable for various amino acid-p-nitroanilide substrates, and specific inh...

journal_title：Cellular immunology

authors： Appasamy PM,Kenniston TW Jr,Amoscato AA

更新日期：1997-04-10 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS), and is induced by immunization with disease-causative self-antigens such as myelin oligodendrocyte glycoprotein (MOG). We have previously reported that transplantation of MOG expressing thymic epithelial progenitors (TEPs) ...

journal_title：Cellular immunology

authors： Su M,Lin Y,Cui C,Tian X,Lu X,He Z,Lai L

更新日期：2017-12-01 00:00:00

abstract：:The utility of multiple antigenic peptides (MAPs) for the induction of antibody and cellular immune responses in animal models has been demonstrated for a variety of peptide epitopes involved in human disease. However, little is known about immune responses to MAPs constructed with antigenic tumor epitopes, nor has pe...

journal_title：Cellular immunology

authors： Schott ME,Wells DT,Schlom J,Abrams SI

更新日期：1996-12-15 00:00:00

abstract：:Immunity to Schistosoma mansoni is regulated by an auto-anti-idiotypic network. The T cells in this network interact through soluble regulatory factors. These studies describe a soluble suppressor-inducer factor (TsiF) derived from TCR+ suppressor-inducer clone Q37. Q37 is the fusion product of CD4+ T cells derived fr...

journal_title：Cellular immunology

authors： Perrin PJ,Phillips SM

更新日期：1993-06-01 00:00:00

abstract：:The primary function of the thymus is to develop immature T-cells into cells that further in the periphery will be able to carry out immune functions. The Literature has shown that thymus can be a target for many pathogens and severe structural alterations take place in this organ during infectious diseases. Here, we ...

journal_title：Cellular immunology

authors： Andrade CF,Gameiro J,Nagib PR,Carvalho BO,Talaisys RL,Costa FT,Verinaud L

更新日期：2008-05-01 00:00:00

abstract：:The mechanism of how superantigens function to activate cells has been linked to their ability to bind and cross-link the major histocompatibility complex class II (MHCII) molecule. Cells that lack the MHCII molecule also respond to superantigens, however, with much less efficiency. Therefore, the purpose of this stud...

journal_title：Cellular immunology

authors： Wright AD,Chapes SK

更新日期：1999-11-01 00:00:00

abstract：:CD8+ T cell differentiation is controlled by the transcription factors T-bet and Eomesodermin, in concert with the cytokines IL-2, IL-10 and IL-12. Among these pathways, the mechanisms by which T-box proteins and IL-10 interact to promote a memory T cell fate remain poorly understood. Here, we show that Eomes and IL-1...

journal_title：Cellular immunology

authors： Reiser J,Sadashivaiah K,Furusawa A,Banerjee A,Singh N

更新日期：2019-01-01 00:00:00

abstract：:The aim of the study was to investigate the interaction between manLAM and DC-SIGN influencing DCs maturation and downstream immune response using small interfering RNA-expressing lentiviral vectors to specifically knockdown DC-SIGN. Our data indicated that DC-SIGN knockdown alone in DCs did not affect the maturation ...

journal_title：Cellular immunology

authors： Wu T,Guo S,Wang J,Li L,Xu L,Liu P,Ma S,Zhang J,Xu L,Luo Y

更新日期：2011-01-01 00:00:00

abstract：:T helper cells reactive to myelin basic protein are clearly implicated in the pathogenesis of murine EAE. We have developed a T cell line, BML-1 that (1) is reactive to the encephalitogenic amino terminal nonapeptide (1-9NAC) of MBP, (2) is I-Au restricted, and (3) induces relapsing EAE in B10.PL (H-2u) mice. Measurem...

journal_title：Cellular immunology

authors： Ando DG,Clayton J,Kono D,Urban JL,Sercarz EE

更新日期：1989-11-01 00:00:00

abstract：:Previous studies have shown that supernatants from concanavalin A-stimulated human peripheral blood mononuclear cells and isolated Leu-2 suppressor/cytotoxic T cells are chemotactic for Leu-3 helper/inducer T cells. The current study shows that lymphocyte chemotactic factor (LCF) is also produced following antigen (te...

journal_title：Cellular immunology

authors： Potter JW,Van Epps DE

更新日期：1986-01-01 00:00:00

abstract：:Avirulent clones of Leishmania braziliensis were produced by treatment of parental parasite stock with the mutagen N-methyl-N'-methyl-N'-nitro-N-nitrosoguanidine and selection for growth at 19 degrees C. These clones have a clear preference for infection and growth in vitro at 19 degrees C rather than the normal 28 de...

journal_title：Cellular immunology

authors： Gorczynski RM

更新日期：1985-08-01 00:00:00

abstract：:Mouse thyroglobulin (MTg)-sensitized spleen cells activated in vitro with MTg induced experimental autoimmune thyroiditis (EAT) in which the thyroid infiltrate consists primarily of mononuclear cells (MNC) (lymphocytic EAT). MTg-sensitized spleen cells cultured with MTg together with anti-IL2R antibody induce a granul...

journal_title：Cellular immunology

authors： McMurray RW,Hoffman RW,Tang H,Braley-Mullen H

更新日期：1996-08-25 00:00:00

abstract：:The nuclear receptor Small Heterodimer Partner (SHP) is a transcriptional target and inhibitor of Liver Receptor Homolog 1 (LRH-1), the transcriptional regulator of intestinal glucocorticoid (GC) synthesis. The role of SHP in the regulation of intestinal GC synthesis and its impact on T cell-mediated anti-viral immune...

journal_title：Cellular immunology

authors： Huang J,Jia R,Brunner T

更新日期：2018-12-01 00:00:00

abstract：:Severe aplastic anemia (SAA) is a syndrome of severe bone marrow failure with high mortality. Our previous studies have demonstrated that both immature and activated DC1 increased in the bone marrow of SAA patients, and the balance of DC1 subsets shifted the stable form to active one, which might promote Th0 cells to ...

journal_title：Cellular immunology

authors： Liu C,Sheng W,Fu R,Wang H,Li L,Liu H,Shao Z

更新日期：2013-09-01 00:00:00

abstract：:G proteins are membrane-bound molecules involved in coupling of surface receptors with signal transduction effector systems in multiple cell types including T lymphocytes. Given that mature T cells which lack antigen receptors (CDl-Ti) are refractory to stimulation through CD2 or other accessory molecules, T cell rece...

journal_title：Cellular immunology

authors： Moingeon P,Jin YJ,Stebbins CC,Lopez PA,Alcover A,Reinherz EL

更新日期：1990-07-01 00:00:00

abstract：:Previous studies have shown that the anti-CD4 mAb W3/25 strongly enhances T cell APC (T-APC) activity. In this study, single positive CD4+ and double negative (DN) (CD4-CD8-) T-helper cells specific for the 55-69 or 72-86 sequence of guinea pig (GP) myelin basic protein (GPMBP) were used to study CD4 regulation of T-A...

journal_title：Cellular immunology

authors： Mannie MD,White GA,Nardella JP,Davidian DK,Arnold PY

更新日期：1998-06-15 00:00:00

abstract：:The induction of ornithine decarboxylase (ODC) activity in lymphocytes is associated with activation and the initiation of cellular proliferation. ODC is also an essential component in tumor promotion. Phorbol myristic acetate (PMA) is a mitogen for lymphocytes, but can also promote tumor formation. Tumor promotion is...

journal_title：Cellular immunology

authors： Fidelus RK

更新日期：1988-04-15 00:00:00

abstract：:PICOT (PKC-interacting cousin of thioredoxin) consists of one thioredoxin homology domain in the N-terminal and two tandem PICOT homology domains in the C-terminal. PICOT specifically interacts with protein kinase C theta (PKC-theta) via its thioredoxin homology domain and acts as an important modulator of T cell rece...

journal_title：Cellular immunology

authors： Kato N,Motohashi S,Okada T,Ozawa T,Mashima K

更新日期：2008-01-01 00:00:00

abstract：:Although it is well known that the CD3/T-cell receptor (TCR) complex modulates from the surface of T cells upon exposure to monoclonal antibodies (mAb) directed against it, the fate of bound mAb has not been yet elucidated. We therefore perform direct binding experiments of 125I-labeled mAb against CD3 or TCR to inves...

journal_title：Cellular immunology

authors： Schaffar L,Dallanegra A,Breittmayer JP,Carrel S,Fehlmann M

更新日期：1988-10-01 00:00:00

abstract：:We have previously described a novel human B cell differentiation factor (BCDF), 446-BCDF, that is distinct biochemically and functionally from other cytokines. Since signal transduction pathways involved in human B cell differentiation have been incompletely studied and are poorly understood, we assessed the effects ...

journal_title：Cellular immunology

authors： Huang R,Cioffi J,Berg K,London R,Cidon M,Maayani S,Mayer L

更新日期：1995-04-15 00:00:00

abstract：:Caused mainly by Candida albicans, oropharyngeal candidiasis is the most common oral complication associated with HIV disease worldwide. Host defenses against C. albicans essentially fall into two categories: specific immune mechanisms and local oral mucosal epithelial cell defenses. Since oral mucosa is the first lin...

journal_title：Cellular immunology

authors： Rouabhia M,Semlali A,Audoy J,Chmielewski W

更新日期：2012-11-01 00:00:00

abstract：:Chemotactic migration of T lymphocytes and neutrophil granulocytes within a three-dimensional collagen matrix is distinct from spontaneous, matrix-induced migration concerning dynamic parameters and regulatory intracellular signaling. Both spontaneous T lymphocyte locomotion and stromal-cell-derived factor-1 (SDF-1)-i...

journal_title：Cellular immunology

authors： Entschladen F,Gunzer M,Scheuffele CM,Niggemann B,Zänker KS

更新日期：2000-02-01 00:00:00

abstract：:Cells from the draining lymph nodes of DBA/2 mice bearing syngeneic intradermal P-815 tumors represent an excellent responding cell population for secondary stimulation in vitro, despite the virtual absence of response by spleen cells of the same animals. Cytotoxicity is a result of stimulation with intact mitomycin-t...

journal_title：Cellular immunology

authors： Bertschmann M,Lüscher EF

更新日期：1983-05-01 00:00:00

abstract：:Five thiol compounds including 2-mercaptoethanol (2-ME) were examined for their augmenting effects on in vitro antibody response to sheep erythrocytes. Three compounds were effective with the following order of activity; 2-ME greater than dithiothreitol greater than cysteamine. Glutathione and thioglycollate failed to...

journal_title：Cellular immunology

authors： Ohmori H,Yamamoto I

更新日期：1983-07-01 00:00:00

abstract：:The murine Ly-6A cell surface antigen is normally present on a minor subset of mature T cells. This marker has been shown to become highly expressed on mitogen-activated T cells. We found that expression of Ly-6A is also markedly increased in resting T cells by incubation with IFN-alpha/beta or IFN-gamma. Here, we com...

journal_title：Cellular immunology

authors： Dumont FJ

更新日期：1987-04-01 00:00:00

abstract：:Spleen cells from neonatal mice belonging to strains with the I-J-b or I-J-k genotype, were treated with anti-I-Jb or anti-I-Jk antibody and complement. This reduces their suppressor cell activity as demonstrated by a decrease in the ability to suppress the mixed-lymphocyte reactivity of adult spleen cells. Injection ...

journal_title：Cellular immunology

authors： Argyris BF,Waltenbaugh C

更新日期：1983-09-01 00:00:00

abstract：:Our earlier studies revealed that a rapid and progressive loss of splenic NK activity in mice during the development of a number of transplanted tumors as well as of spontaneous tumors was due to an inactivation of natural killer (NK) lineage cells rather than to their disappearance. The mechanism of this inactivation...

journal_title：Cellular immunology

authors： Parhar RS,Lala PK

更新日期：1985-07-01 00:00:00

abstract：:Dendritic cells (DCs) link the sensing of the environment by the innate immune system to the initiation of adaptive immune responses. Accordingly, DCs are considered to be a major target in the development of immunomodulating compounds. In this study, the effect of niclosamide, a Food and Drug Administration-approved ...

journal_title：Cellular immunology

authors： Wu CS,Li YR,Chen JJ,Chen YC,Chu CL,Pan IH,Wu YS,Lin CC

更新日期：2014-03-01 00:00:00

abstract：:The "NK-triggering-antigen regulator" (Nktar) gene is a locus identified in the C57BL/6 genome which regulates the ability of unlabeled activated Con A blasts to compete for recognition of labeled syngeneic Con A blasts by BALB/c NK cells. Linkage analysis on Con A blasts from (BALB/c x CByB6F1) N2 backcross progeny f...

journal_title：Cellular immunology

authors： Chou SR,Brownell A,Ko MS,Kaplan J

更新日期：2000-03-15 00:00:00

abstract：:Endogenous retroviral superantigens such as vSAG-7 are highly stimulatory for T cells through interaction with the T cell receptor on the basis of V beta usage. Priming of adult MMTV 7-negative mice with vSAG-7-expressing cells has been shown to result in peripheral V beta 6/CD4+ T cell activation followed by toleranc...

journal_title：Cellular immunology

authors： Modlin CS,Todd GT,Cohen TD,Fairchild RL

更新日期：1995-09-01 00:00:00