当前位置： SCI文献检索 > CELLULAR IMMUNOLOGY期刊下所有文献 > Respiratory macrophages regulate CD4 T memory responses to mucosal immunization with recombinant adenovirus-based vaccines.

Respiratory macrophages regulate CD4 T memory responses to mucosal immunization with recombinant adenovirus-based vaccines.

Abstract：

:Respiratory immunization is an attractive way to generate systemic and mucosal protective memory responses that are required for preventing mucosally transmitted infections. However, the molecular and cellular mechanisms for controlling memory T cell responses remain incompletely understood. In this study, we investigated the role of respiratory macrophage (MΦ) in regulating CD4 T cell responses to recombinant adenovirus-based (rAd) vaccines. We demonstrated that rAd intranasal (i.n.) vaccination induced migration and accumulation of respiratory MΦ and circulatory monocytes in the mediastinal lymph nodes and lung parenchyma. Under the influence of respiratory MΦ CD4 T cells exhibited slow proliferation kinetics and an increased tendency of generating central memory, as opposed to effector memory, CD4 T cell responses in vitro and in vivo. Correspondingly, depletion of MΦ using clodronate-containing liposome prior to i.n. immunization significantly enhanced CD4 T cell proliferation and increased the frequency of CD4 memory T cells in the airway lumen, demonstrating that MΦ initially serve as a negative regulator in limiting generation of mucosal tissue-resident memory CD4 T cells. However, clodronate-containing liposome delivery following i.n. immunization markedly reduced the frequencies of memory CD4 T cells in the airway lumen and spleen, indicating that respiratory MΦ and potentially circulating monocytes are critically required for maintaining long-term memory CD4 T cells. Collectively, our data demonstrate that rAd-induced mucosal CD4 T memory responses are regulated by respiratory MΦ and/or monocytes at multiple stages.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Acosta-Ramirez E,Tram C,Kampen RM,Tillman MR,Schwendener RA,Xing Z,Halperin SA,Wang J

doi

10.1016/j.cellimm.2016.07.006

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

53-62

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(16)30055-7

journal_volume

310

pub_type

杂志文章

相关文献

CELLULAR IMMUNOLOGY文献大全
  • Strain variation of lymphokine production and specific antibody secretion in mice infected with Mycobacterium lepraemurium.

    abstract：:Mice from strains showing either phenotypical expression of Bcg gene (C57BL/6, BALB/c, DBA/1, and (C57BL/6 X DBA/2)/F1, CBA, A/J, DBA/2) were infected intravenously with 10(7) Mycobacterium lepraemurium (MLM). The number of acid-fast bacilli (AFB) within the spleens, the ability of spleen cells to produce in vitro int...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90026-7

    authors： Hoffenbach A,Lagrange PH,Bach MA

    更新日期：1985-03-01 00:00:00

  • Testosterone treatment of aged male mice improves some but not all aspects of age-associated increases in influenza severity.

    abstract：:The severity of influenza increases with age, with worse disease in aged males than females. Testosterone concentrations decline with age in males, which may impact influenza pathogenesis. Aged male mice were treated with testosterone or placebo and outcomes during influenza A virus (IAV) infection were compared with ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2019.103988

    authors： Vom Steeg LG,Attreed SE,Zirkin B,Klein SL

    更新日期：2019-11-01 00:00:00

  • Intrathymic T cell repertoire after prenatal trinitrobenzene-sulfonic acid-treatment.

    abstract：:It is still a matter of debate, whether tolerance toward self-non-MHC antigens is due to intrathymic deletion or to regulatory processes in the periphery. To further pursue this question, responsiveness toward TNP and an anti-TNP monoclonal antibody (Sp6) carrying a recurrent idiotype was evaluated in prenatally trini...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90298-6

    authors： Zöller M

    更新日期：1990-03-01 00:00:00

  • HIV-1 Tat protein induces TNF-alpha and IL-10 production by human macrophages: differential implication of PKC-betaII and -delta isozymes and MAP kinases ERK1/2 and p38.

    abstract：:In this study, we demonstrate that HIV-1 Tat protein is able to induce IL-10 and TNF-alpha in human macrophages. We show that N-terminal Tat 1-45 fragment initiates the PKC pathway by acting at the membrane. Inhibition of PKC pathway, by chemical inhibitors or after PMA treatment, abolishes both IL-10 and TNF-alpha pr...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2008.06.011

    authors： Leghmari K,Contreras X,Moureau C,Bahraoui E

    更新日期：2008-01-01 00:00:00

  • Role of heme oxygenase-1 in potentiation of phagocytic activity of macrophages by taurine chloramine: Implications for the resolution of zymosan A-induced murine peritonitis.

    abstract：:Phagocytosis of pathogens by macrophages is crucial for the successful resolution of inflammation induced by microbial infection. Taurine chloramine (TauCl), an endogenous anti-inflammatory and antioxidative substance, is produced by reaction between taurine and hypochlorous acid by myeloperoxidase activity in neutrop...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2018.02.003

    authors： Kim W,Kim SH,Jang JH,Kim C,Kim K,Suh YG,Joe Y,Chung HT,Cha YN,Surh YJ

    更新日期：2018-05-01 00:00:00

  • Properties of anti-Lyb-2-mediated B-cell activation and the relationship between Lyb-2 molecules and receptors for B-cell stimulatory factor-1 on murine B lymphocytes.

    abstract：:The murine B-cell differentiation antigen Lyb-2 has been shown to be involved in B-lymphocyte activation and has been postulated by some to be related to a receptor for B-cell stimulatory factor I (BSF-1) (H. Yakura et al., J. Immunol. 137, 1475, 1986). Here we have demonstrated that monoclonal antibody (mAB) to Lyb-2...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90302-4

    authors： Subbarao B,Morris J,Baluyut AR

    更新日期：1988-04-01 00:00:00

  • Simultaneous production of T helper-1-like cytokines and cytolytic activity by tumor-specific T cells in ovarian and breast cancer.

    abstract：:Cytotoxic T-cell (CTL) cultures were generated from five ovarian cancer patients (OvCTL) and from three breast cancer patients (BrCTL). All CTL lines were T-cell receptor (TcR) alphabeta+ and predominantly CD8+ (73 +/- 13%). These CTL lines preferentially recognized autologous tumor cells in an HLA class I-restricted,...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1996.1055

    authors： Goedegebuure PS,Douville CC,Doherty JM,Linehan DC,Lee KY,Ganguly EK,Eberlein TJ

    更新日期：1997-02-01 00:00:00

  • The TLR7/8 ligand resiquimod targets monocyte-derived dendritic cell differentiation via TLR8 and augments functional dendritic cell generation.

    abstract：:Imidazoquinolone compounds, such as resiquimod are Toll-like receptor (TLR) 7/8 ligands representing novel immune response modifiers undergoing clinical testing. Resiquimod has been reported to modulate conventional human monocyte-derived DC (moDC) differentiation, but the role of TLR7 and TLR8 is unclear. We directly...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2011.08.008

    authors： Hackstein H,Knoche A,Nockher A,Poeling J,Kubin T,Jurk M,Vollmer J,Bein G

    更新日期：2011-01-01 00:00:00

  • Staphylococcal enterotoxins direct and trigger CTL killing of autologous HLA-DR+ mononuclear leukocytes and freshly prepared leukemia cells.

    abstract：:Attempts have been made to induce cytolytic T cells to kill target cells that do not express the appropriate target molecules by crosslinking the T cells and the target cells in various ways. One successful strategy has been to use heteroconjugates or bispecific monoclonal antibodies reacting with T cell molecules wit...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90218-g

    authors： Hedlund G,Dohlsten M,Lando PA,Kalland T

    更新日期：1990-09-01 00:00:00

  • Comparison of the capacity of murine and human class I MHC molecules to stimulate T cell activation.

    abstract：:The mechanism underlying the apparent differences in the capacity of murine and human class I MHC molecules to function as signal transducing structures in T cells was examined. Cross-linking murine class I MHC molecules on splenic T cells did not stimulate an increase in intracellular calcium ([Ca2+]i) and failed to ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90254-m

    authors： Gur H,Wacholtz MC,Lie WR,Lipsky PE,Geppert TD

    更新日期：1992-10-15 00:00:00

  • How many signals are enough?

    abstract：:The many signals that control the progress of various immune responses to both foreign and self antigens can be divided into no less than three major groups. The first group is the initial positive stimulus, associated with activation events through antigen receptors and their associated proteins. These signals launch...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/0008-8749(90)90174-p

    authors： Sinclair NR

    更新日期：1990-10-01 00:00:00

  • A cycle involving HMGB1, IFN-γ and dendritic cells plays a putative role in anti-tumor immunity.

    abstract：:An important subset in regulating antitumor immunity is the maturation and accumulation of intratumor dendritic cells (DCs), inducing potent T cell cytotoxicity. In this study, we explored how the soluble abundant high-mobility group box 1 protein (HMGB1) affected DC activation and retention within lung cancers, and i...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2018.08.011

    authors： Gao Q,Li F,Wang S,Shen Z,Cheng S,Ping Y,Qin G,Chen X,Yang L,Cao L,Liu S,Zhang B,Wang L,Sun Y,Zhang Y

    更新日期：2019-09-01 00:00:00

  • Tumor necrosis factor (TNF alpha) regulates intestinal mucus production during salmonellosis.

    abstract：:Mucus production by goblet cells in the gastrointestinal tract following Salmonella typhimurium infection using a ligated ileal loop model in mice was investigated. Assessment of the morphology of the loop tissue after Salmonella challenge revealed generalized tissue inflammation, characterized by edema and an inflamm...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1243

    authors： Arnold JW,Klimpel GR,Niesel DW

    更新日期：1993-10-15 00:00:00

  • Effect of LTB4 on the inhibition of natural cytotoxic activity by PGE2.

    abstract：:NK activity is regulated by arachidonic acid metabolites. More precisely PGE2 and LTB4 decreases and increases respectively non-MHC-restricted cytotoxicity in humans. We have observed similar data in mice since NK activity was inhibited by PGE2 (10(-6) to 10(-8) M) and enhanced by LTB4 (10(-8) to 10(-12) M). On the ot...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90117-8

    authors： Vaillier D,Daculsi R,Gualde N,Bezian JH

    更新日期：1992-01-01 00:00:00

  • Norepinephrine and serotonin content of the murine spleen: its relationship to lymphocyte beta-adrenergic receptor density and the humoral immune response in vivo and in vitro.

    abstract：:Numerous reports in the literature describe the effects of beta-adrenergic agonists and/or their second messenger cyclic AMP on in vitro and in vivo immune responses. The fact that the murine spleen receives rich adrenergic innervation and that the pharmacologic disruption of this innervation leads to altered immune r...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90123-2

    authors： Fuchs BA,Campbell KS,Munson AE

    更新日期：1988-12-01 00:00:00

  • Cytokine production by NZB, C58, and NZB X C58 recombinant inbred mice.

    abstract：:Humans with autoimmune disease and autoimmune mouse strains such as NZB have been shown to produce reduced levels of the cytokines interleukin 1 and interleukin 2. The NZB X C58 recombinant inbred (N X 8 RI) strains exhibit certain of the autoimmune characteristics of the NZB strain. Their abilities to produce interle...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90177-1

    authors： Bocchieri MH,Knittweis L,Seaton DS

    更新日期：1984-10-15 00:00:00

  • IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression.

    abstract：:TE44, an H-2b-restricted, self-reactive T-cell line, did not produce autocrine-acting growth factors, neither after antigenic nor after mitogenic activation; they remained for their proliferation completely dependent on exogenously added IL-2. Administration of IL-4, which poorly promotes growth by itself, resulted in...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90163-l

    authors： Vandenabeele P,Grooten J,Fiers W

    更新日期：1990-10-01 00:00:00

  • Psychological stress is associated with altered levels of myeloid-derived suppressor cells in breast cancer patients.

    abstract：:Our group has shown in a randomized clinical trial that psychological intervention to reduce stress in patients with stages II and III breast cancer led to enhanced immune function, fewer recurrences and improved overall survival. We hypothesized that patients with high levels of stress would have alterations in myelo...

    journal_title：Cellular immunology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cellimm.2011.04.003

    authors： Mundy-Bosse BL,Thornton LM,Yang HC,Andersen BL,Carson WE

    更新日期：2011-01-01 00:00:00

  • Monocyte-derived macrophage and alveolar macrophage fibronectin production and cathepsin D activity.

    abstract：:Alveolar macrophages are thought to play an important role in ongoing tissue breakdown and repair processes in the normal lung. The secretion and regulation of cathepsin D (important for the final breakdown of collagen) and fibronectin (involved in the healing process) in human peripheral blood monocytes (PBM) and pul...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90320-q

    authors： Rossman MD,Maida BT,Douglas SD

    更新日期：1990-04-01 00:00:00

  • A murine thymic stromal cell line which may support the differentiation of CD4-8- thymocytes into CD4+8- alpha beta T cell receptor positive T cells.

    abstract：:A fibroblastoid cell line TSt-4 was established from fetal thymus tissue of C57BL/6 mice. When fetal thymus (FT) cells or CD4-8- (DN) cells of adult thymuses were cultured on the monolayer of TSt-4, a considerable proportion of lymphocytes expressed CD4 or both CD4 and CD8 within 1 day, and the CD4+CD8- cells were mai...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90299-5

    authors： Watanabe Y,Mazda O,Aiba Y,Iwai K,Gyotoku J,Ideyama S,Miyazaki J,Katsura Y

    更新日期：1992-07-01 00:00:00

  • Triggering HLA-DR molecules on human peripheral monocytes induces their death.

    abstract：:Although engagement of MHC class II molecules on human monocytes triggers various cellular events, their possible role in monocyte death is yet unknown. We demonstrate that ligation of MHC class II on primary monocytes induces a rapid cell death that has all the characteristics of monocyte apoptosis, does not require ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1998.1428

    authors： Thibeault A,Zekki H,Mourad W,Charron D,Al-Daccak R

    更新日期：1999-02-25 00:00:00

  • Differential cytokine regulation by eicosanoids in T cells primed by contact sensitisation with TNP.

    abstract：:Eicosanoids are important mediators of inflammation, but also play a role in regulation of lymphocyte function. In this study we have examined the function of both prostaglandins (PGs) and leukotrienes in regulating the release of a set of cytokines produced by T cells from mice primed with the contact-sensitising age...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1157

    authors： Marcinkiewicz J,Chain BM

    更新日期：1993-07-01 00:00:00

  • Interleukin-10 production by B cells is regulated by cytokines, but independently of GATA-3 or FoxP3 expression.

    abstract：:The knowledge of mechanisms of regulation of IL-10 production by B cells remains still very limited. We show here that highly purified mouse B cells stimulated with LPS produce significant levels of IL-10, but Bregs in our model do not express detectable level of either Foxp3 or GATA-3. Nevertheless, IL-10 production ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2019.103987

    authors： Bohacova P,Kossl J,Hajkova M,Hermankova B,Javorkova E,Zajicova A,Krulova M,Holan V

    更新日期：2020-01-01 00:00:00

  • Role of macrophages as modulators but not as stimulators in primary mixed leukocyte reaction.

    abstract：:The role of macrophages (M phi) and that of splenic dendritic cells (DC) in the allogeneic mixed leukocyte reaction (MLR) in the mouse have been investigated. In contrast with the high stimulatory capacity of DC, we obtained no evidence in favor of the competence of M phi, whether Ia + or Ia-, as an autonomous stimula...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90169-2

    authors： Naito K,Komatsubara S,Kawai J,Mori K,Muramatsu S

    更新日期：1984-10-15 00:00:00

  • The regulation of resistance to Schistosoma mansoni by a soluble alpha/beta TCR analog, produced by a cloned T cell hybridoma.

    abstract：:Immunity to Schistosoma mansoni is regulated by an auto-anti-idiotypic network. The T cells in this network interact through soluble regulatory factors. These studies describe a soluble suppressor-inducer factor (TsiF) derived from TCR+ suppressor-inducer clone Q37. Q37 is the fusion product of CD4+ T cells derived fr...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1144

    authors： Perrin PJ,Phillips SM

    更新日期：1993-06-01 00:00:00

  • Human natural cytotoxic lymphocytes: definition by a monoclonal antibody of a subset which kills an anchorage-dependent target cell line but not the K-562 cell line.

    abstract：:A monoclonal mouse antibody (HNC-1A3) which defines a subset of human lymphocytes with natural cytotoxic activity was produced and studied. HNC-1A3+ cells represent 12 +/- 3% of peripheral blood mononuclear leukocytes. When sorted out using a fluorescence-activated cell sorter, they consist of 60% small lymphocytes, 3...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(83)90166-1

    authors： Rola-Pleszczynski M,Lieu H

    更新日期：1983-12-01 00:00:00

  • The role of B cells in the establishment of T cell response in mice infected with an intracellular bacteria, Listeria monocytogenes.

    abstract：:To clarify the role of B cells in the establishment of T cell response against intracellular bacteria, B-cell-deficient (muMT-/-) mice were infected with an intracellular bacteria, Listeria monocytogenes, and T cell response against the bacteria was analyzed. On day 6 of primary Listeria infection, spleen T cells of t...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1999.1503

    authors： Matsuzaki G,Vordermeier HM,Hashimoto A,Nomoto K,Ivanyi J

    更新日期：1999-06-15 00:00:00

  • Surface immunoglobulins as targets for anti-immunoglobulin-dependent cell-mediated lysis of B cells.

    abstract：:Human K cells are able to lyse human lymphoblastoid B cells in the presence of specific anti-human immunoglobulin isotype antibodies. The human lymphoblastoid B-cell line DAUDI (surface mu- and kappa-chains positive) was lysed in the presence of anti-mu and anti-kappa antisera, or IgG fraction of these antisera, and B...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(83)90380-5

    authors： Caraux J,Weigle WO

    更新日期：1983-03-01 00:00:00

  • Severe and prolonged inflammatory response to localized cowpox virus infection in footpads of C5-deficient mice: investigation of the role of host complement in poxvirus pathogenesis.

    abstract：:Poxviruses are a large, complex group of highly successful pathogens that cause disease in humans and other animals. They encode several proteins postulated to be involved in the evasion of host immunity and therefore serve as excellent models for understanding virus-host interaction during the early stages of viral i...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1995.1086

    authors： Miller CG,Justus DE,Jayaraman S,Kotwal GJ

    更新日期：1995-05-01 00:00:00

  • Ontogeny and expression of non-MHC-restricted T cell antigen-binding molecules by thymocytes and peripheral T cell subsets.

    abstract：:The ontogeny of T cells which express major histocompatibility complex (MHC)-unrestricted T cell antigen-binding molecules (TABM) on the cell membrane was investigated. We used a rabbit anti-mouse TABM antiserum to investigate the expression of TABM by subsets of adult thymocytes, peripheral T cells, and thymocytes du...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90171-m

    authors： Rellahan BL,Cone RE

    更新日期：1990-10-01 00:00:00