Testosterone treatment of aged male mice improves some but not all aspects of age-associated increases in influenza severity.

abstract：:We have investigated the ability of interleukin-10 (IL-10) to modulate murine intrathymic T cell differentiation using a fetal thymic organ culture (FTOC) model. Addition of as little as 11 ng of recombinant murine IL-10 (mIL-10) per day produced a significant increase in the proportion and number of gamma delta-TCR+ ...

journal_title：Cellular immunology

authors： Fine JS,Macosko HD,Grace MJ,Narula SK

更新日期：1994-04-15 00:00:00

abstract：:Humans with autoimmune disease and autoimmune mouse strains such as NZB have been shown to produce reduced levels of the cytokines interleukin 1 and interleukin 2. The NZB X C58 recombinant inbred (N X 8 RI) strains exhibit certain of the autoimmune characteristics of the NZB strain. Their abilities to produce interle...

journal_title：Cellular immunology

authors： Bocchieri MH,Knittweis L,Seaton DS

更新日期：1984-10-15 00:00:00

abstract：:Arriving at an understanding of the role of suppressor T-cells (regulatory T-cells, CD4(+)CD25+) depends on whether their functional repertoire is somatically selected to be anti-Self or anti-Nonself. Immunologists are ambivalent; often publications espousing opposite views share an author. Here the arguments are deta...

journal_title：Cellular immunology

authors： Cohn M

更新日期：2004-02-01 00:00:00

abstract：:The proliferative responses of natural killer (NK) cells to 12-O-tetradecanoylphorbol-13-acetate (TPA), which directly activates protein kinase c(PKC), and to the Ca2+ ionophores A23817 and ionomycin, known to enhance the intracellular calcium, have been investigated. Highly purified large granular lymphocytes (LGL) w...

journal_title：Cellular immunology

authors： Procopio A,Gismondi A,Paolini R,Morrone S,Testi R,Piccoli M,Frati L,Herberman RB,Santoni A

更新日期：1988-04-15 00:00:00

abstract：:Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) are major proinflammatory cytokines inducing the synthesis and release of many inflammatory mediators. They are involved in immune regulation, autoimmune diseases, and inflammation. Acanthoic acid, (-)-pimara-9(11),15-dien-19-oic acid, is a pimaradiene d...

journal_title：Cellular immunology

authors： Kang HS,Kim YH,Lee CS,Lee JJ,Choi I,Pyun KH

更新日期：1996-06-15 00:00:00

abstract：:Although pulmonary inflammation is a serious, sometimes life-threatening, consequence of respiratory syncytial virus (RSV) infection, the mechanisms involved are not well understood. Since the process of inflammation is initiated by a complex series of events including the activation of specific adhesion molecules on ...

journal_title：Cellular immunology

authors： Chang CH,Huang Y,Anderson R

更新日期：2003-01-01 00:00:00

abstract：:Upregulation of immunoglobulin D-specific receptors (IgD-R) on CD4+ T cells may facilitate their interaction with specific carbohydrate moieties uniquely associated with membrane IgD on B cells. Previous studies have shown that upregulation of IgD-R facilitates cognate T-B cell interactions by mediating bidirectional ...

journal_title：Cellular immunology

authors： Lakshmi Tamma SM,Wu Y,Toporovsky I,Lima V,Coico RF

更新日期：2001-02-01 00:00:00

abstract：:Patients treated with monoclonal antibodies and cytokines for cancer receive often co-medication, which may influence treatment efficacy. Therefore, we investigated with a flowcytometric cytotoxicity assay the effect of several immunomodulatory drugs on antibody dependent cellular cytotoxicity (ADCC), interleukin-2 (I...

journal_title：Cellular immunology

authors： Flieger D,Varvenne M,Kleinschmidt R,Schmidt-Wolf IG

更新日期：2007-03-01 00:00:00

abstract：:One of the auto-antigens aberrantly targeted in Multiple sclerosis is myelin basic protein (MBP). In this study, chronic progressive multiple sclerosis (CPMS) patients receiving the experimental drug MBP8298, on a compassionate care trial, were examined before and after high dose peptide treatment for their circulatin...

journal_title：Cellular immunology

authors： Loo EW,Krantz MJ,Agrawal B

更新日期：2012-11-01 00:00:00

abstract：:The adoptive transfer of tumor-reactive T lymphocytes has recently been demonstrated to be an effective means for mediating the regression of experimental intracranial fibrosarcomas. In this study, mice bearing syngeneic intracranial GL261 gliomas were cured by the combination of sublethal whole body irradiation follo...

journal_title：Cellular immunology

authors： Plautz GE,Touhalisky JE,Shu S

更新日期：1997-06-15 00:00:00

abstract：:Two signals are required for the in vitro activation of Lyt2+ T suppressor cells (Ts) from mice tolerized with 2,4-dinitrobenzene sulfonate (DNBS) to produce soluble suppressor factors (SSF) which suppress the transfer of contact sensitivity to dinitrofluorobenzene (DNFB). Recognition of DNP/class I MHC (signal one) s...

journal_title：Cellular immunology

authors： Fairchild RL,Moorhead JW

更新日期：1991-03-01 00:00:00

abstract：:To improve the engraftment of human peripheral blood lymphocytes (PBL) to severe combined immunodeficient (SCID) mice, and to elucidate the factors which prevent the PBL's survival, we treated SCID mice with mAb, which neutralizes murine IFN-gamma's ability to activate cell-mediated immunity. Compared with untreated m...

journal_title：Cellular immunology

authors： Shibata S,Asano T,Noguchi A,Kimura H,Ogura A,Naiki M,Doi K

更新日期：1998-01-10 00:00:00

abstract：:Inflammatory leukocytes of DA-to-WF rat renal allografts displayed significant cytolytic activity to natural killer (NK) target cells on Day 2 after transplantation. The NK activity, which was associated with large granular lymphocytes in discontinuous Percoll gradients, peaked on Day 4 and disappeared rapidly thereaf...

journal_title：Cellular immunology

authors： Nemlander A,Soots A,Häyry P

更新日期：1984-12-01 00:00:00

abstract：:Mice that differ at Igh loci and the reagents that permit resolution of such distinctions are powerful genetic tools for studying B cell heterogeneity. In this report, IgM-allotype-specific ELISA revealed that two of three sources of mice designated as BALB.nude express the Igh-6b (IgMb) allotype characteristic of C57...

journal_title：Cellular immunology

authors： Riggs JE

更新日期：1993-05-01 00:00:00

abstract：:Natural killer (NK) cells play an important role in innate and adaptive immune responses to obligate intracellular pathogens. Nevertheless, the regulation of NK cell trafficking and migration to inflammatory sites is poorly understood. Exodus-1/MIP-3alpha/LARC, Exodus-2/6Ckine/SLC, and Exodus-3/MIP-3beta/ELC/CKbeta-11...

journal_title：Cellular immunology

authors： Robertson MJ,Williams BT,Christopherson K 2nd,Brahmi Z,Hromas R

更新日期：2000-01-10 00:00:00

abstract：:Previous studies have demonstrated that murine thymocytes proliferate in the presence of submitogenic concentrations of phytohemagglutinin-P (PHA-P) and various cytokines such as interleukin-1 (IL-1), interleukin-4 (IL-4), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). We report that C3H/HeJ thymoc...

journal_title：Cellular immunology

authors： Kim KJ,Abrams J,Alphonso M,Pearce M,Thorbecke GJ,Palladino MA

更新日期：1990-12-01 00:00:00

abstract：:Medicinal plants are considered immunomodulatory as they display various biological activities. There is no report addressing the anti-inflammatory effects of Daphne gnidium. In this study, we investigated the effects of D. gnidium ethyl acetate (EA) leaf extract on mice immune cell function in vitro. Production of pr...

journal_title：Cellular immunology

authors： Harizi H,Chaabane F,Ghedira K,Chekir-Ghedira L

更新日期：2011-01-01 00:00:00

abstract：:In this study the influence of a non-mitogenic anti-CD3 antibody on accessory cell-dependent antigen and mitogen-induced T-lymphocyte proliferation has been investigated. The antibody was found to completely inhibit PHA, Con A, PWM, and tetanus toxoid stimulation, with no effect on the proliferation induced by the cal...

journal_title：Cellular immunology

authors： Holter W,Majdic O,Stockinger H,Liszka K,Fischer G,Knapp W

更新日期：1986-06-01 00:00:00

abstract：:Infection of certain strains of mice, such as C57BL/6 and C57BL/10 [B10], with LP-BM5 murine leukemia virus (MuLV) rapidly causes a profound and lethal immune suppression. The H2d congenic strain of B10, B10.D2, is resistant to disease, but B10 x B10.D2 F1 mice are susceptible, indicating that disease sensitivity is d...

journal_title：Cellular immunology

authors： Gilmore GL

更新日期：1996-04-10 00:00:00

abstract：:In the present study, we characterized in monocytes the rise in [Ca(2+)](i) evoked by monoclonal antibodies (mAbs) to aminopeptidase N (APN)/CD13, showing a two-phase calcium increase with a small-belled [Ca(2+)](i) rise due to the release of calcium from intracellular stores and a more sustained plateau due to the in...

journal_title：Cellular immunology

authors： Santos AN,Langner J,Herrmann M,Riemann D

更新日期：2000-04-10 00:00:00

abstract：:The nonspecific B-cell response induced by infecting mice with two nonlethal malaria parasites, Plasmodium chabaudi adami and Plasmodium yoelii, was analyzed in an isotype-specific reverse plaque assay. Our results showed different isotypic patterns in the two infections, although cells secreting immunoglobulin of all...

journal_title：Cellular immunology

authors： Langhorne J,Kim KJ,Asofsky R

更新日期：1985-01-01 00:00:00

abstract：:The role of macrophages (M phi) in the in vitro primary antibody response of murine lymphocytes to sheep erythrocytes was investigated. Peritoneal M phi were activated to express Ia antigens either in vitro or in vivo. Nonactivated Ia- M phi were also examined. We observed that only Ia- M phi but also Ia+ M phi failed...

journal_title：Cellular immunology

authors： Komatsubara S,Hirayama Y,Inaba K,Naito K,Yoshida K,Kawai J,Muramatsu S

更新日期：1985-10-15 00:00:00

abstract：:PD-1 is an immunoregulatory receptor expressed on the surface of activated T cells, B cells, and monocytes. We describe four alternatively spliced PD-1 mRNA transcripts (PD-1Deltaex2, PD-1Deltaex3, PD-1Deltaex2,3, and PD-1Deltaex2,3,4) in addition to the full length isoform. PD-1Deltaex2 and PD-1Deltaex3 are generated...

journal_title：Cellular immunology

authors： Nielsen C,Ohm-Laursen L,Barington T,Husby S,Lillevang ST

更新日期：2005-06-01 00:00:00

abstract：:Whole sporozoite vaccine (WSV) is shown to induce sterile protection that targets Plasmodium liver-stage infection. There are many underlying issues associated with induction of effective sterile protracted protection. In this study, we have addressed how the alterations in successive vaccine regimen could possibly af...

journal_title：Cellular immunology

authors： Patel H,Yadav N,Parmar R,Patel S,Singh AP,Shrivastava N,Dalai SK

更新日期：2017-07-01 00:00:00

abstract：:The immediate effects and mechanisms of desensitization of contact sensitivity to 2,4-dinitro-1-fluorobenzene (DNFB) were investigated. Mice were sensitized with DNFB, desensitized with antigen 2 weeks later, and challenged 1 day after desensitization. Significant inhibition (approximately 50%) of contact sensitivity ...

journal_title：Cellular immunology

authors： Mekori YA,Claman HN

更新日期：1984-11-01 00:00:00

abstract：:Mice carrying a rearranged TCR Vbeta 8.2 transgene express the Vbeta protein on the vast majority of peripheral T-cells. The bone marrow and peripheral blood, as well as other lymphoid organs of both untreated animals and animals depleted of T-cells by neonatal thymectomy and/or injection from birth of monoclonal anti...

journal_title：Cellular immunology

authors： Lincoln GC,Sheng B,Odebralski J,Lucchetta R,Smith RT

更新日期：1997-10-10 00:00:00

abstract：:Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide induced diabetic r...

journal_title：Cellular immunology

authors： Mojani MS,Sarmadi VH,Vellasamy S,Sandrasaigaran P,Rahmat A,Peng LS,Ramasamy R

更新日期：2014-05-01 00:00:00

abstract：:pp125FAK is a novel protein tyrosine kinase associated with focal adhesions. It has been shown that ligation of VLA beta 1 integrins on a number of cell types enhanced tyrosine phosphorylation and kinase activity of pp125FAK. Cellular transformation by retroviral oncogene products or mitogenic neuropeptides also resul...

journal_title：Cellular immunology

authors： Nojima Y,Tachibana K,Sato T,Schlossman SF,Morimoto C

更新日期：1995-03-01 00:00:00

abstract：:The aly, alymphoplasia, is an autosomal recessive mutation in mice of an unknown etiology, which induces total aplasia of lymph nodes and Peyer's patches. We hypothesized that the lack of lymphoid tissue may be due to abnormalities of lymphocyte traffic into these tissues. Therefore, we analyzed the expression of vari...

journal_title：Cellular immunology

authors： Koike R,Watanabe T,Satoh H,Hee CS,Kitada K,Kuramoto T,Serikawa T,Miyawaki S,Miyasaka M

更新日期：1997-08-25 00:00:00

abstract：:Purine nucleoside phosphorylase (PNP) is a purine salvage pathway enzyme which we have found to be 8-10 times more active (per cell) in human peripheral blood null lymphocytes than in T lymphocytes. To test the hypothesis that null cells are, in part, pre-T lymphocytes we have defined an in vitro system for null cell ...

journal_title：Cellular immunology

authors： Cowan MJ,Fraga M,Ammann AJ

更新日期：1983-06-01 00:00:00