Abstract:
:Humans with autoimmune disease and autoimmune mouse strains such as NZB have been shown to produce reduced levels of the cytokines interleukin 1 and interleukin 2. The NZB X C58 recombinant inbred (N X 8 RI) strains exhibit certain of the autoimmune characteristics of the NZB strain. Their abilities to produce interleukin 1 and interleukin 2 have been tested. Deficiencies in the production of one or both of these cytokines were observed in the N X 8 RI strains. Decreased interleukin 2 production was not due to inability to respond to concanavalin A or allogeneic stimulation, nor to altered kinetics of the response. No correlation was observed between cytokine deficiencies and the inherited autoimmune characteristics previously studied in these strains. One especially interesting strain was N X 8 RI 16, which made high amounts of interleukin 2 but no detectable interleukin 1.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Bocchieri MH,Knittweis L,Seaton DSdoi
10.1016/0008-8749(84)90177-1subject
Has Abstractpub_date
1984-10-15 00:00:00pages
453-63issue
2eissn
0008-8749issn
1090-2163pii
0008-8749(84)90177-1journal_volume
88pub_type
杂志文章abstract::Human melanoma tumor cells were genetically modified in vitro by transferring the interleukin-2 (IL-2) gene via a retroviral vector into established or fresh tumor cells. In addition, human melanoma cells were transduced in vivo by the direct injection of the IL-2/retroviral vector into melanoma xenografts in nude mic...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1292
更新日期:1994-11-01 00:00:00
abstract::Antigen-nonspecific CD8+ T suppressor cells, which suppressed delayed-type hypersensitivity (DTH) against sheep red blood cells in BALB/c mice, were induced by incubating spleen cells from mice treated with 7,12-dimethylbenz[a]anthracene (DMBA), a tumor initiator, with 12-O-tetradecanoylphorbol 13-acetate (TPA), a tum...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(91)90167-a
更新日期:1991-12-01 00:00:00
abstract::In this study we assessed the viability of cultured human umbilical vein endothelial cells (HUVE) treated with bacterial lipopolysaccharide (LPS), recombinant human interleukin-1 (rhIL-1), or recombinant human tumor necrosis factor-alpha (rhTNF-alpha) during inhibition of RNA or protein synthesis. Cytotoxicity was det...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(89)90222-0
更新日期:1989-03-01 00:00:00
abstract::Previous work has shown ICOS can function independently of CD28, but whether either molecule can compensate for the other in vivo is not known. Since ICOS is a potent inducer of Th2 cytokines and linked to allergy and elevated serum IgE in humans, we hypothesized that augmenting ICOS costimulation in murine allergic a...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2009.06.013
更新日期:2009-01-01 00:00:00
abstract::The effects of progesterone on murine suppressor cell function generated in allogeneic MLCs were investigated. BALB/c splenic lymphocytes stimulated in vitro with C3H/He cells significantly suppressed the proliferative response of BALB/c lymphocytes in a secondary MLC. This suppression was highly specific for the sens...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(83)90377-5
更新日期:1983-03-01 00:00:00
abstract::We have previously shown that whole cell preparations of Candida albicans are capable of inducing immunosuppressive B-cell activity both in vivo and in vitro. In an effort to characterize the components of the yeast which manifest this immunomodulatory activity, we have successfully generated a soluble extract with di...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(89)90149-4
更新日期:1989-08-01 00:00:00
abstract::Senescence is characterized by several alterations in the immune system. Such modifications can be found in lymphoid organs as well as in the cellular components of the immune system. Several reports have suggested that immune dysfunction can affect both T and B cells, but T cells have been shown to be more susceptibl...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2009.01.010
更新日期:2009-01-01 00:00:00
abstract::T cells from genetically susceptible mice developing experimental autoimmune thyroiditis (EAT) proliferate in response to restimulation with mouse thyroglobulin (MTg) in vitro. The in vitro-activated cells adoptively transfer EAT as well as differentiate into cells cytotoxic for syngeneic thyroid monolayers. To examin...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90078-6
更新日期:1990-01-01 00:00:00
abstract::A radioautographic immunolabeling technique has been developed to detect pre-B cells bearing cytoplasmic mu chains among populations of bone marrow lymphoid cells identified by conventional hematologic stains. 125I-Anti-mu antibody was applied either to fixed marrow smears, labeling total mu chains both in the cytopla...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90007-8
更新日期:1984-09-01 00:00:00
abstract::Permanent graft acceptance was induced with cyclosporine A in a low responder rat strain combination PVG (RT1(c)) to DA (RT1(av1)) of cardiac transplants. Challenge (alloimmunization) with donor and third-party WF (RT1(u)) cells was performed and followed by the analysis of alloreactive cytotoxicity. The cytotoxic T l...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1998.1353
更新日期:1998-10-10 00:00:00
abstract::The concentration of cytosolic-free calcium (Ca2+i) was determined with aequorin in RAW-264 macrophage-like cells activated in vitro for tumor cell killing with lymphokine (LK) and lipopolysaccharide (LPS). Treatments of these cells with optimal doses of stimulants, which evoked the development of cytolytic activity, ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(86)90040-7
更新日期:1986-07-01 00:00:00
abstract::Large suppressive macrophages (LSM) were induced by restimulating spleen cells from rats with experimental autoimmune myasthenia gravis (EAMG) in vitro, with the autoantigen acetylcholine receptor (AChR) in the presence of cyclosporine A. LSM, purified from these cultures, are extremely potent suppressors of AChR-stim...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1998.1445
更新日期:1999-04-10 00:00:00
abstract::Attempts have been made to induce cytolytic T cells to kill target cells that do not express the appropriate target molecules by crosslinking the T cells and the target cells in various ways. One successful strategy has been to use heteroconjugates or bispecific monoclonal antibodies reacting with T cell molecules wit...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90218-g
更新日期:1990-09-01 00:00:00
abstract::Extracellular adenine nucleotides are inhibitors of the human natural killer cell line NK3.3 natural cytotoxicity activity. Natural cytotoxicity was inhibited approximately 26% by 1 mM ATP and 21% by 1 mM ADP. 5'-Adenylyl imidodiphosphate, a nonhydrolyzable ATP analog, inhibited natural cytotoxicity by 41% at a concen...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(95)80028-h
更新日期:1995-02-01 00:00:00
abstract::Vitamin D regulates homeostasis, anti-microbial response, and inflammation. The vitamin D receptors are expressed in the macrophages and other immune cells, regulating the transcription of many different genes, including those coding the anti-microbial peptides. One of the most severe complications of the SARS-CoV-2 i...
journal_title:Cellular immunology
pub_type: 杂志文章,评审
doi:10.1016/j.cellimm.2020.104259
更新日期:2021-02-01 00:00:00
abstract::Ca(2+) and Sr(2+) entry pathways activated by pro-inflammatory agonists FMLP, LTB(4) and PAF have been compared to thapsigargin in human neutrophils. 2-APB (10microM) increased Ca(2+) influx and to a greater extent in agonist than in thapsigargin stimulated neutrophils. This action of 2-APB was specific to Ca(2+) beca...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2010.07.009
更新日期:2010-01-01 00:00:00
abstract::Natural killer (NK) cells play an important role in innate and adaptive immune responses to obligate intracellular pathogens. Nevertheless, the regulation of NK cell trafficking and migration to inflammatory sites is poorly understood. Exodus-1/MIP-3alpha/LARC, Exodus-2/6Ckine/SLC, and Exodus-3/MIP-3beta/ELC/CKbeta-11...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1999.1601
更新日期:2000-01-10 00:00:00
abstract::Despite significant improvements in the overall survival of patients with multiple myeloma (MM) over the past 15 years, the disease remains incurable. Treatment options are limited for patients who have relapsed or are refractory to immunomodulatory drugs (IMiDs), proteasome inhibitors, and monoclonal antibodies. In t...
journal_title:Cellular immunology
pub_type: 杂志文章,评审
doi:10.1016/j.cellimm.2018.10.003
更新日期:2018-12-01 00:00:00
abstract::The clinical outcome of Leishmania pathogenesis ranges from active skin lesions to fatal visceral dissemination and severely impaired T cell immunity. It is well established that a strong Th1 immune response is protective against cutaneous forms of the disease, however a mixed Th1/Th2 response is most commonly observe...
journal_title:Cellular immunology
pub_type: 杂志文章,评审
doi:10.1016/j.cellimm.2016.07.004
更新日期:2016-11-01 00:00:00
abstract::Hen egg white lysozyme (HEL)-specific T cell lines and clones were generated from B6 and BDF1 mice. A variety of clonotypes were found among clones generated at an early stage (1 month) whereas fewer clonotypes were detected after several weeks of culture. Furthermore, a bulk line switched from its initial fine peptid...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1088
更新日期:1994-04-01 00:00:00
abstract::That M1/70, a monoclonal anti-murine macrophage antibody, recognizes murine natural killer cells (NK) and that there is an increase in NK following intraperitoneal infection with live Listeria monocytogenes (LM) was previously reported. Here, LM-induced NK cells were further characterized with respect to tumor target ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90206-5
更新日期:1984-11-01 00:00:00
abstract::A recombinant form of human soluble CD23 (sCD23), the low affinity receptor for IgE (FcepsilonRII), was produced by PCR cloning the lectin-binding domain sequence into a bacterial expression vector. After renaturation and purification, the sCD23 bound IgE and divalent metal ions, indicating its activity. The recombina...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2005.06.006
更新日期:2005-04-01 00:00:00
abstract::Observational studies in multiple sclerosis (MS) demonstrated altered expression of chemokine receptors (CkRs) on comparable populations of mononuclear cells (e.g. CD4(+)/CD45RO(+) T-cells) in brain sections compared with blood. These findings raised questions about the regulation of CkRs on trafficking cells. Regulat...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2006.12.001
更新日期:2006-09-01 00:00:00
abstract::We describe here a culture system for studying the development, in vitro, of antigen-specific CD4 T cells from unprimed mice. T cells from young mice are initially exposed to antigen, such as pigeon cytochrome C or keyhole limpet hemocyanin, in the presence of adherent accessory cells and then allowed to proliferate i...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1997.1134
更新日期:1997-06-15 00:00:00
abstract::Within the lymphoid compartment, CD8 is expressed either as an alphaalpha homodimer or as an alphabeta heterodimer. Prior functional characterization of CD8alpha transfectants has demonstrated that CD8alphaalpha homodimers can reconstitute T cell responses in the absence of the CD8beta subunit. In order to now examine...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1998.1412
更新日期:1999-02-01 00:00:00
abstract::Anti-CD3 mAb can activate T cells to help in B cell activation as detected by late events, such as maturation of B cells into Ig-secreting cells (IgSC), or by early events, such as B cell surface expression of the activation marker CD23. Two different anti-CD2 mAb each inhibited anti-CD3-induced T cell-dependent B cel...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90269-w
更新日期:1990-10-15 00:00:00
abstract::Treatment with bacterial lipopolysaccharide elicits the appearance of greater numbers of background antigen-specific plaque-forming cells (PFC) in the spleens of mice previously exposed or primed to subimmunogenic amounts of various non-cross-reacting antigens so as to generate detectable immunological memory. These f...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(87)90235-8
更新日期:1987-07-01 00:00:00
abstract::The expression and function of surface immunoglobulin (sIg) receptors was analyzed using antigen-specific monoclonal B cells and T cells. When B cells were incubated with antigen (hapten carrier), hapten-specific sIg receptor expression was greatly reduced. The specific antigen-presentation activity of the B cells was...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(88)90291-2
更新日期:1988-03-01 00:00:00
abstract::A low-virulence, agerminative strain of Candida albicans (PCA-2) is able to confer a high degree of nonspecific protection against subsequent challenge with highly virulent microorganisms in mice. In an attempt to better define the effect of PCA-2 vaccination on the immune system and the nature of the mechanisms invol...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(89)90135-4
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:Piper nigrum L. (Piperaceae) is commonly used as a spice and traditional medicine in many countries. It has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. However, the protective role of P. nigrum on epithelial function of uppe...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2019.104035
更新日期:2020-05-01 00:00:00