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Alternative splice variants of the human PD-1 gene.

Abstract：

:PD-1 is an immunoregulatory receptor expressed on the surface of activated T cells, B cells, and monocytes. We describe four alternatively spliced PD-1 mRNA transcripts (PD-1Deltaex2, PD-1Deltaex3, PD-1Deltaex2,3, and PD-1Deltaex2,3,4) in addition to the full length isoform. PD-1Deltaex2 and PD-1Deltaex3 are generated by alternative splicing where exon 2 (extracellular IgV-like domain) and exon 3 (transmembrane domain) respectively are spliced out. PD-1Deltaex3 is therefore likely to encode a soluble form of PD-1. PD-1Deltaex2,3 lacks exon 2 and 3. These three variants have unaffected open reading frames. PD-1Deltaex2,3,4 lacks exon 2, 3, and 4 (intracellular domain) and contains a premature stop codon in exon 5. Activation of human PBMCs with anti-CD3+anti-CD28 monoclonal antibodies induces an increased level of each PD-1 transcript. A parallel increase in the expression of PD-1Deltaex3 and flPD-1 upon activation suggests an important interplay between the putative soluble PD-1 and flPD-1 possibly involved in maintenance of peripheral self-tolerance and prevention of autoimmunity.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Nielsen C,Ohm-Laursen L,Barington T,Husby S,Lillevang ST

doi

10.1016/j.cellimm.2005.07.007

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

109-16

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(05)00174-7

journal_volume

235

pub_type

杂志文章

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