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Comparison of the capacity of murine and human class I MHC molecules to stimulate T cell activation.

Abstract：

:The mechanism underlying the apparent differences in the capacity of murine and human class I MHC molecules to function as signal transducing structures in T cells was examined. Cross-linking murine class I MHC molecules on splenic T cells did not stimulate an increase in intracellular calcium ([Ca2+]i) and failed to induce proliferation in the presence of IL-2 or PMA. In contrast, modest proliferation was induced by cross-linking class I MHC molecules on murine peripheral blood T cells or human class I MHC molecules on murine transgenic spleen cells, but only when costimulated with PMA. Moreover, cross-linking murine class I MHC molecules or the human HLA-B27 molecule on T cell lines generated from transgenic murine splenic T cells stimulated only modest proliferation in the presence of PMA, but not IL-2. On the other hand, cross-linking murine class I MHC molecules expressed by the human T cell leukemic line, Jurkat, transfected with genes for these molecules, generated a prompt increase in [Ca2+]i, and stimulated IL-2 production in the presence of PMA. The results demonstrate that both murine and human class I MHC molecules have the capacity to function as signal transducing structures, but that murine T cells are much less responsive to this signal.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Gur H,Wacholtz MC,Lie WR,Lipsky PE,Geppert TD

doi

10.1016/0008-8749(92)90254-m

subject

Has Abstract

pub_date

1992-10-15 00:00:00

pages

392-406

issue

2

eissn

0008-8749

issn

1090-2163

pii

0008-8749(92)90254-M

journal_volume

144

pub_type

杂志文章

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