Surface immunoglobulins as targets for anti-immunoglobulin-dependent cell-mediated lysis of B cells.

Abstract:

:Human K cells are able to lyse human lymphoblastoid B cells in the presence of specific anti-human immunoglobulin isotype antibodies. The human lymphoblastoid B-cell line DAUDI (surface mu- and kappa-chains positive) was lysed in the presence of anti-mu and anti-kappa antisera, or IgG fraction of these antisera, and B-cell-depleted human lymphocytes. Lysis was not induced by anti-isotypic antisera alone or human lymphocytes alone. Lysis was not induced by antisera directed at isotypes which were not expressed on the DAUDI cells. The human lymphoblastoid B-cell line RAJI, which does not express surface membrane isotypes, could not be lysed by the anti-isotype-dependent cell-mediated mechanism. Lysis of DAUDI cells by this mechanism was mediated by Fc gamma receptor-bearing human non-B lymphocytes and required an intact Fc piece in the inducing anti-isotypic antibody. These observations are discussed as a possible role for K cells in the regulation of immune responses by interaction between anti-idiotypic antibodies and idiotype-bearing cells.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Caraux J,Weigle WO

doi

10.1016/0008-8749(83)90380-5

subject

Has Abstract

pub_date

1983-03-01 00:00:00

pages

372-8

issue

2

eissn

0008-8749

issn

1090-2163

pii

0008-8749(83)90380-5

journal_volume

76

pub_type

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