Abstract:
:We have previously shown that interleukin-2 (IL-2) is able to induce the generation of natural killer (NK) activity in bone marrow (BM) cells from mice pretreated with 5-fluorouracil. IL-2 alone could dose-dependently induce NK activity in marrow cells and interleukin-4 (IL-4) has dual effect on the NK activity in that, depending on the concentration of IL-2, IL-4 inhibits or stimulates development of NK cells. The inhibitory effect was in part antagonized by interleukin-1 alpha. These effects were not obtained when NK-reactive spleen cells were cultured with the same concentrations of IL-2 or IL-2 plus IL-4 with or without irradiated BM cells as feeders. The effects of IL-4 were also obtained by preincubation for 6-24 hr before culturing with IL-2 alone and correlated with the expression of interleukin-2 receptor (IL-2/r), suggesting that IL-4 might play a regulatory role in the IL-2-dependent generation of NK cells in BM.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Migliorati G,Cardinali L,Riccardi Cdoi
10.1016/0008-8749(91)90394-qsubject
Has Abstractpub_date
1991-08-01 00:00:00pages
194-207issue
1eissn
0008-8749issn
1090-2163pii
0008-8749(91)90394-Qjournal_volume
136pub_type
杂志文章abstract::The proliferation of Molt-4 lymphoblasts and phytohemagglutinin-stimulated human T lymphocytes in vitro was inhibited significantly by 10(-12) to 10(-10) M to 10(-13) to 10(-9) M somatostatin, as assessed by the uptake of [3H]thymidine and [3H]leucine, respectively. The inhibitory effect of somatostatin was not attrib...
journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
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journal_title:Cellular immunology
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1988-06-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1086
更新日期:1994-04-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1998-08-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1985-10-15 00:00:00
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journal_title:Cellular immunology
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90305-8
更新日期:1984-02-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1996.0289
更新日期:1996-11-25 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(88)90320-6
更新日期:1988-07-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2013.03.006
更新日期:2013-02-01 00:00:00
abstract::The complement receptor 2 (CR2; CD21), a 145,000 MW glycoprotein, has been useful as a marker of B lymphocyte maturation. It is expressed on the 1:13 monoclonal, EBV-transformed, B cell line which produces TNP-specific IgM-kappa and displays an in vitro capacity for differentiation. The line expresses the CD20+CD21+ p...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90093-7
更新日期:1990-02-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1992-10-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1994-04-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1993-11-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2006.01.001
更新日期:2005-11-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.0012
更新日期:1995-11-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1993.1038
更新日期:1993-02-01 00:00:00
abstract::B-cell clonal expansions (BCE) in young mice are transient, detectable for less than 4 weeks. In contrast, BCE in old mice persist more than 2 months. The greater persistence of BCE in old mice does not appear to be due to the age of the host as the survival of phenyloxazolone chicken serum albumin-induced BCE in most...
journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1992-08-01 00:00:00
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journal_title:Cellular immunology
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更新日期:2010-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章,评审
doi:10.1016/j.cellimm.2004.02.004
更新日期:2004-02-01 00:00:00
abstract::We investigated the role of HLA-DR molecules in T cell stimulation by staphylococcal enterotoxin A (SEA). Previous results with immobilized purified HLA-DR preincubated with peptide showed that peptide-specific T cell clones were able to bind to and proliferate in response to purified HLA-DR/peptide complexes in the a...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1993.1255
更新日期:1993-10-15 00:00:00
abstract::Double immunofluorescence studies for terminal deoxynucleotidyl transferase (TdT) and leucocyte surface membrane antigens have been used to characterize the small subpopulation of TdT-positive cells in human peripheral blood. The predominant antigens demonstrated were those coded for by the major histocompatibility co...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90223-0
更新日期:1985-02-01 00:00:00