Interferon-gamma stimulates lipid metabolism in human monocytes.

abstract：:The murine B-cell differentiation antigen Lyb-2 has been shown to be involved in B-lymphocyte activation and has been postulated by some to be related to a receptor for B-cell stimulatory factor I (BSF-1) (H. Yakura et al., J. Immunol. 137, 1475, 1986). Here we have demonstrated that monoclonal antibody (mAB) to Lyb-2...

journal_title：Cellular immunology

authors： Subbarao B,Morris J,Baluyut AR

更新日期：1988-04-01 00:00:00

abstract：:Toll-like receptor (TLR) 2/1 signalling is linked to autophagy through transcriptional actions of the 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-vitamin D receptor (VDR) complex. Population-specific effects have been reported for TLR2/1-VDR signalling. We hypothesized that population effects extend to autophagy and are in...

journal_title：Cellular immunology

authors： Abhimanyu,Meyer V,Jones BR,Bornman L

更新日期：2020-06-01 00:00:00

abstract：:The regulation of the migratory capacity of Percoll-purified large granular lymphocytes (LGL) into nitrocellulose filters was studied in a 2-hr assay with the use of modified Boyden chambers. Compounds that stimulate the natural killer cytotoxic function of LGL, such as interferons (natural beta, recombinant alpha A, ...

journal_title：Cellular immunology

authors： Polentarutti N,Bottazzi B,Balotta C,Erroi A,Mantovani A

更新日期：1986-08-01 00:00:00

abstract：:C3H/HeJ mice are homozygous for the Lpsd allele and, as a consequence, are hyporesponsive to all of the biological effects of bacterial lipopolysaccharide (LPS) that have been studied. These mice die in the early phase of infection when inoculated with virulent Salmonella. This susceptibility is also regulated by the ...

journal_title：Cellular immunology

authors： Weinstein DL,Lissner CR,Swanson RN,O'Brien AD

更新日期：1986-10-01 00:00:00

abstract：:The oral administration of myelin basic protein (MBP) to Lewis rats prior to an encephalitogenic challenge resulted in total inhibition or a significant delay in the onset of experimental autoimmune encephalomyelitis (EAE). In vitro lymphocyte proliferative responses to MBP were significantly decreased in MBP-fed rats...

journal_title：Cellular immunology

authors： Bitar DM,Whitacre CC

更新日期：1988-04-01 00:00:00

abstract：:Recently we have shown that the generation of IFN-gamma-producing cells (IFN-gamma pc) were severely suppressed in cultures of Con A-stimulated splenocytes obtained from HgCl2-exposed BN but not Lewis rats. Since BN rats develop a TH2-biased polyclonal autoimmune syndrome upon exposure to HgCl2, whereas Lewis rats exh...

journal_title：Cellular immunology

authors： van der Meide PH,de Labie MC,Botman CA,Aten J,Weening JJ

更新日期：1995-04-01 00:00:00

abstract：:Injection of the 708-amino-acid (aa) viral protein "large tumor antigen" (T-Ag) of simian virus 40 (SV40) or its N-terminal 272-aa fragment into C57BL/6 (B6) mice (H-2b) primed CD8+ cytotoxic T lymphocytes (CTL) in vivo. Surprisingly, injection of this nonstructural viral protein (or its N-terminal fragment) in solubl...

journal_title：Cellular immunology

authors： Schirmbeck R,Deppert W,Kury E,Reimann J

更新日期：1993-07-01 00:00:00

abstract：:The proliferative response of peripheral blood mononuclear cells (PBMC) in synthetic serum-free media depends on the presence of sufficient amounts of transferrin (Tf). In the present communication we show that the reduction of Tf concentration in culture media results in a decreased proliferation, whereas lymphokine ...

journal_title：Cellular immunology

authors： Keyna U,Nüsslein I,Rohwer P,Kalden JR,Manger B

更新日期：1991-02-01 00:00:00

abstract：:Coxsackievirus group B type 3 (CVB3) induces myocarditis in male Balb/c mice but produces little cardiac injury in females. Males develop cytolytic T lymphocytes (CTL) reactive to heart antigens which primarily cause the inflammation and cardiac injury observed in the disease. Infected female mice lack this CTL respon...

journal_title：Cellular immunology

authors： Job LP,Lyden DC,Huber SA

更新日期：1986-03-01 00:00:00

abstract：:Human peripheral blood T cells lysed autologous or allogeneic monocytes, but not polymorphonuclear cells (PMN) or lymphocytes, in the presence of anti-CD3 (OKT3 (IgG2a) or anti-Leu 4 (IgG1)) monoclonal antibody (mAb). Other mAbs such as OKT4 (IgG2b), OKT8 (IgG2a), OKT11 (IgG2a), and OKM1 (IgG2a) did not mediate lysis ...

journal_title：Cellular immunology

authors： Itoh K,Balch CM,Trial J,Platsoucas CD

更新日期：1988-07-01 00:00:00

abstract：:The antifungal activity of nonactivated resident murine peritoneal macrophages for Cryptococcus neoformans was studied. Macrophages from five of six mouse strains tested had significant (40 to 80%) fungistatic activity, depending on the inoculum size, in a 24-hr coculture system. Macrophages from two outbred (SW and I...

journal_title：Cellular immunology

authors： Brummer E,Stevens DA

更新日期：1994-08-01 00:00:00

abstract：:Lenalidomide, a daughter molecule of Thalidomide, and IMIDs are immunomodulatory drugs that have been described as having immunomodulatory properties and anti-tumor activity. The effect of Lenalidomide towards Peripheral Blood Mononuclear Cells (PBMC) has been studied and direct effects towards T cells have been descr...

journal_title：Cellular immunology

authors： Dauguet N,Fournié JJ,Poupot R,Poupot M

更新日期：2010-01-01 00:00:00

abstract：:Human skin contains epidermal Langerhans cells (LCs) and dermal dendritic cells (DCs) that are key players in induction of adaptive immunity upon infection. After major burn injury, suppressed adaptive immunity has been observed in patients. Here we demonstrate that burn injury affects adaptive immunity by altering bo...

journal_title：Cellular immunology

authors： van den Berg LM,de Jong MA,Witte Ld,Ulrich MM,Geijtenbeek TB

更新日期：2011-01-01 00:00:00

abstract：:The fine specificity of anti-Glu60Ala30Tyr10 (GAT) and anti-Glu60Ala40 (GA) proliferating cells was studied. T cells primed with GAT proliferate both to GAT and GA and GA-primed T cells proliferate also to GA and GAT. This cross-reactivity was unexpected given the results previously reported on the fine specificity of...

journal_title：Cellular immunology

authors： Gougeon ML,Bismuth G,Leclercq L,Somme G,Thèze J

更新日期：1983-01-01 00:00:00

abstract：:Peripheral CD4+CD8+ T cells have been identified as a T cell subset existing in animals and humans. However, the characterization of CD4+CD8+ T cells, their relationship with T memory (T(M)), T effector (T(E)), Th1/Th2, Treg and Th-17, remain unclear. This study was to characterize the CD4+CD8+ T cells. The results fr...

journal_title：Cellular immunology

authors： Xie D,Hai B,Xie X,Liu L,Ayello J,Ma X,Zhang J

更新日期：2009-01-01 00:00:00

abstract：:Germ-free (GF) mice have increased bone mass that is normalized by colonization with gut microbiota (GM) from conventionally raised (CONV-R) mice. To determine if innate immune signaling pathways mediated the effect of the GM, we studied the skeleton of GF and CONV-R mice with targeted inactivation of MYD88, NOD1 or N...

journal_title：Cellular immunology

authors： Ohlsson C,Nigro G,Boneca IG,Bäckhed F,Sansonetti P,Sjögren K

更新日期：2017-07-01 00:00:00

abstract：:Activated macrophages synthesize and release numerous tumoricidal soluble factors that can be divided into receptor- or nonreceptor-dependent agents. Tumor necrosis factor (TNF) would be an example of the former. In our experimental model the killing of EL4 thymoma cells by syngeneic activated macrophages involves, bu...

journal_title：Cellular immunology

authors： Fishman M,Essani N,Costlow M

更新日期：1990-04-15 00:00:00

abstract：:The cellular requirements for the in vitro induction of antigen-specific suppressor T cells were examined. Previous reports indicated that Ia-bearing macrophages and anti-idiotypic B cells are required as accessory cells to facilitate the generation of suppressor effector (TS3) cells which regulate the response to the...

journal_title：Cellular immunology

authors： O'Hara RM Jr,Hausman PB,Sherr DH,Abromson-Leeman SR,Dorf ME

更新日期：1988-10-15 00:00:00

abstract：:Veto cells suppress generation of CD8(+) T cell immune responses in an antigen-specific manner, with specificity dictated by antigens on the veto cell surface. Activated bone marrow (ABM) veto cells belong to the NK cell type lineage and veto by clonally deleting antigen-specific precursor cytotoxic T cell lymphocyte ...

journal_title：Cellular immunology

authors： Chrobak P,Gress RE

更新日期：2001-03-15 00:00:00

abstract：:The effect of low-dose irradiation on the immune system was investigated in mice. When a 0.2 Gy dose of X-ray irradiation was administered every other day for a total of four times, the number of lymphocytes yielded by the liver, spleen and thymus decreased at the initial stage (around day 10). At this stage, NK cells...

journal_title：Cellular immunology

authors： Ren H,Shen J,Tomiyama-Miyaji C,Watanabe M,Kainuma E,Inoue M,Kuwano Y,Abo T

更新日期：2006-11-01 00:00:00

abstract：:In the present study, we characterized in monocytes the rise in [Ca(2+)](i) evoked by monoclonal antibodies (mAbs) to aminopeptidase N (APN)/CD13, showing a two-phase calcium increase with a small-belled [Ca(2+)](i) rise due to the release of calcium from intracellular stores and a more sustained plateau due to the in...

journal_title：Cellular immunology

authors： Santos AN,Langner J,Herrmann M,Riemann D

更新日期：2000-04-10 00:00:00

abstract：:The relay hypothesis [R. Nayak, S. Mitra-Kaushik, M.S. Shaila, Perpetuation of immunological memory: a relay hypothesis, Immunology 102 (2001) 387-395] was earlier proposed to explain perpetuation of immunological memory without requiring long lived memory cells or persisting antigen. This hypothesis envisaged cycles ...

journal_title：Cellular immunology

authors： Vani J,Nayak R,Shaila MS

更新日期：2007-03-01 00:00:00

abstract：:The hematopoietically restricted member of the NF-kappaB/Rel family, c-Rel, is essential for B cell survival and proliferation. Here we demonstrate that the production of the interleukins 6, 10, and 15 (IL-6, IL-10, and IL-15) are diminished in c-Rel(-/-) B lymphocytes. In a manner similar to that seen in IL-6(-/-) B ...

journal_title：Cellular immunology

authors： Tumang JR,Hsia CY,Tian W,Bromberg JF,Liou HC

更新日期：2002-05-01 00:00:00

abstract：:T cell hybridomas that are deathless upon TCR crosslinking were generated from lpr mice. The deathless hybridomas (1.4 and 5D5) expressed extremely low Fas even after anti-CD3 activation, whereas activation-induced cell death (AICD) was observed for Fas-expressing hybridomas. The deathless hybridomas were activated to...

journal_title：Cellular immunology

authors： Cui H,el-Khatib M,Sherr DH,Ettinger R,Sy MS,Marshak-Rothstein A,Ju ST

更新日期：1996-02-01 00:00:00

abstract：:Recently we reported on a novel H2E transgenic, IA-negative model of experimental autoimmune thyroiditis (EAT) that excludes reactivity to self in its susceptibility pattern to heterologous thyroglobulin (Tg). In conventional, susceptible mouse strains, EAT is inducible with both homologous and heterologous Tg; e.g., ...

journal_title：Cellular immunology

authors： Yan Y,Panos JC,McCormick DJ,Wan Q,Giraldo AA,Brusic V,David CS,Kong YC

更新日期：2001-08-25 00:00:00

abstract：:Previous investigations have demonstrated a strain-associated differential susceptibility to herpes simplex virus-1 (HSV-1) infection in mice; C57BL/6 mice are more resistant to infection than BALB/c mice. Despite considerable research dealing with the immune response to HSV-1, relatively little attention has been pai...

journal_title：Cellular immunology

authors： Brenner GJ,Cohen N,Moynihan JA

更新日期：1994-09-01 00:00:00

abstract：:Facilitating cells (FC) are bone marrow-derived cells that facilitate allogeneic hematopoietic stem cell (SC) engraftment and induce transplantation tolerance without causing graft vs. host disease. Although there is evidence for FC directing the development of FoxP3+CD4+CD25+ regulatory T cells, the specific FC subse...

journal_title：Cellular immunology

authors： Taylor KN,Laszkowska M,Cohick E,Colson YL

更新日期：2008-01-01 00:00:00

abstract：:We tested the effect of different inhibitors of cytochrome P450 on tumor necrosis factor (TNF) production. Metyrapone and SKF525A (100 and 50 mg/kg, ip, respectively) suppressed serum TNF induced by cotreatment with endotoxin (LPS), (2.5 micrograms/mouse). Inhibition was independent of endogenous corticosteroids since...

journal_title：Cellular immunology

authors： Fantuzzi G,Cantoni L,Sironi M,Ghezzi P

更新日期：1993-09-01 00:00:00

abstract：:Mice carrying a rearranged TCR Vbeta 8.2 transgene express the Vbeta protein on the vast majority of peripheral T-cells. The bone marrow and peripheral blood, as well as other lymphoid organs of both untreated animals and animals depleted of T-cells by neonatal thymectomy and/or injection from birth of monoclonal anti...

journal_title：Cellular immunology

authors： Lincoln GC,Sheng B,Odebralski J,Lucchetta R,Smith RT

更新日期：1997-10-10 00:00:00

abstract：:The poor immunogenicity of many tumors can be partly explained by the inefficiency of the MHC class I peptide presentation pathway. MHC-I-based single-chain trimers (SCT) represent a new class of molecules with the potential to overcome this limitation. We here evaluated the ability of SCT presenting a melanoma antige...

journal_title：Cellular immunology

authors： Ordaz ML,Larmonier N,Lybarger L

更新日期：2010-01-01 00:00:00