Characterization of a novel H2A(-)E+ transgenic model susceptible to heterologous but not self thyroglobulin in autoimmune thyroiditis: thyroiditis transfer with Vbeta8+ T cells.

abstract：:The mechanism by which purinergic agonists modulate murine T-lymphocyte activation and proliferation was investigated. Adenosine and other compounds such as ATP and 2-chloroadenosine (ClAdo) were found to block T-cell mitogenesis induced by concanavalin A (Con A) in a dose-dependent fashion. The nonmetabolizable adeno...

journal_title：Cellular immunology

authors： DosReis GA,Nóbrega AF,de Carvalho RP

更新日期：1986-08-01 00:00:00

abstract：:In the mouse, activation of T cells by T cell receptor (TCR) crosslinking with anti-CD3 antibodies in the absence of a costimulatory signal induces Th1 but not Th2 cell anergy. Furthermore, anti-CD3 induces anergy of Th1- but not Th2-type lymphokine secretion in Th0 cells. This study was designed to determine whether ...

journal_title：Cellular immunology

authors： Nguyen DD,Beck L,Spiegelberg HL

更新日期：1995-10-01 00:00:00

abstract：:Human mononuclear cells stimulated with soluble IgG aggregates generated chemiluminescence, a response attributable to monocytes. Some requirements of this reaction were examined by preincubation of the cells with a variety of inhibitors. The protease antagonists TPCK and TLCK, the phospholipase inhibitors quinacrine ...

journal_title：Cellular immunology

authors： Rush DN,Keown PA

更新日期：1984-08-01 00:00:00

abstract：:When guinea pigs were treated by complete Freund's adjuvant (CFA), eosinophil-directed chemotactic inhibitory factor (ECIF) appeared in the serum of the treated animals. The inhibition of the response of eosinophils by ECIF was selective for the T cell-derived chemotactic factor, which has been isolated from DNP-ascar...

journal_title：Cellular immunology

authors： Hirashima M,Tashiro K,Hayashi H

更新日期：1984-11-01 00:00:00

abstract：:G proteins are membrane-bound molecules involved in coupling of surface receptors with signal transduction effector systems in multiple cell types including T lymphocytes. Given that mature T cells which lack antigen receptors (CDl-Ti) are refractory to stimulation through CD2 or other accessory molecules, T cell rece...

journal_title：Cellular immunology

authors： Moingeon P,Jin YJ,Stebbins CC,Lopez PA,Alcover A,Reinherz EL

更新日期：1990-07-01 00:00:00

abstract：:Chitin oligosaccharides (NA-COS) of two different molecular weight ranges (below 1 and 1-3 kDa) were examined for their capabilities against lipopolysaccharide-induced inflammatory responses in BV-2 murine microglia. It was found that NA-COS reduced the level of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) produc...

journal_title：Cellular immunology

authors： Vo TS,Ngo DH,Ta QV,Wijesekara I,Kong CS,Kim SK

更新日期：2012-05-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS), and is induced by immunization with disease-causative self-antigens such as myelin oligodendrocyte glycoprotein (MOG). We have previously reported that transplantation of MOG expressing thymic epithelial progenitors (TEPs) ...

journal_title：Cellular immunology

authors： Su M,Lin Y,Cui C,Tian X,Lu X,He Z,Lai L

更新日期：2017-12-01 00:00:00

abstract：:Staphylococcus enterotoxins bind class II MHC molecules on antigen-presenting cells (APC) and stimulate T cells expressing appropriate V beta gene products. Although the role of non-TcR-associated costimulatory receptors during antigen-specific T cell stimulation has been clearly established, the involvement of costim...

journal_title：Cellular immunology

authors： Muraille E,De Smedt T,Thielemans K,Urbain J,Moser M,Leo O

更新日期：1995-05-01 00:00:00

abstract：:Sequential immunization with a carrier molecule and a new epitope (hapten) conjugated to the carrier (carrier/hapten-carrier immunization) induces specific suppression for IgG antibody production to the new epitope (hapten) on the carrier. Once induced, this "epitope-specific" suppression persists and specifically sup...

journal_title：Cellular immunology

authors： Tagawa M,Tokuhisa T,Ono K,Taniguchi M,Herzenberg LA,Herzenberg LA

更新日期：1984-07-01 00:00:00

abstract：:We tested the effect of different inhibitors of cytochrome P450 on tumor necrosis factor (TNF) production. Metyrapone and SKF525A (100 and 50 mg/kg, ip, respectively) suppressed serum TNF induced by cotreatment with endotoxin (LPS), (2.5 micrograms/mouse). Inhibition was independent of endogenous corticosteroids since...

journal_title：Cellular immunology

authors： Fantuzzi G,Cantoni L,Sironi M,Ghezzi P

更新日期：1993-09-01 00:00:00

abstract：:Recently, we reported that the CD5 protein can bind to the B cell antigen CD72. So far, no functional evidence has been given for this interaction. We used soluble native CD5 and two anti-CD72 monoclonal antibodies, JT3 and WL225, produced and characterized in our laboratory in order to investigate the role of CD5 in ...

journal_title：Cellular immunology

authors： Van de Velde H,Thielemans K

更新日期：1996-08-25 00:00:00

abstract：:Imidazoquinolone compounds, such as resiquimod are Toll-like receptor (TLR) 7/8 ligands representing novel immune response modifiers undergoing clinical testing. Resiquimod has been reported to modulate conventional human monocyte-derived DC (moDC) differentiation, but the role of TLR7 and TLR8 is unclear. We directly...

journal_title：Cellular immunology

authors： Hackstein H,Knoche A,Nockher A,Poeling J,Kubin T,Jurk M,Vollmer J,Bein G

更新日期：2011-01-01 00:00:00

abstract：:The interaction between Newcastle disease virus (NDV) and the suppressor cell circuit which regulates the induction phase of contact sensitivity reaction to picryl chloride (Pcl) was investigated. NDV infection impairs the activity of the T suppressor afferent cells (Ts-aff) which inhibit DNA synthesis in the draining...

journal_title：Cellular immunology

authors： Dieli F,Colonna Romano G,Abrignani S,Colizzi V,Salerno A

更新日期：1985-08-01 00:00:00

abstract：:IL-2 was previously shown to induce cytotoxic effectors with a broad spectrum of target specificities in thymus and spleen cell cultures. This study was designed to show whether T cells activated by H-2 allogeneic cells in MLC or by syngeneic tumor cells in MLTC are also potential targets for these cytotoxic effectors...

journal_title：Cellular immunology

authors： Biasi G,Mazzocchi M,Zanovello P,Collavo D,Festenstein H

更新日期：1989-12-01 00:00:00

abstract：:The aim of this study was to clarify the role of IL-4, IL-10, IL-13 and interferon (IFN) -γ levels in atopic asthma patients by studying the relation between their serum levels and severity of the disease. The effect of IL-10 -1082G/A and IFN-γ +874T/A SNPs was also studied. The study included 200 atopic children with...

journal_title：Cellular immunology

authors： Hussein YM,Alzahrani SS,Alharthi AA,Ghonaim MM,Alhazmi AS,Eed EM,Shalaby SM

更新日期：2014-05-01 00:00:00

abstract：:Soluble suppressor factors in the sera of cancer patients inhibit lectin-stimulated lymphocyte proliferation. These factors, derived from human material, preclude easy corroboration by other investigators. To gain a general understanding of soluble suppressor factors and to avoid the necessary restrictions of human ex...

journal_title：Cellular immunology

authors： Wile AG,Hensen D,Nahabedian M,Ibsen KH,Granger GA

更新日期：1984-07-01 00:00:00

abstract：:NK and extrathymic T cells are abundant in the decidua of the pregnant uterus. To determine how this unique pattern is induced, overall populations of leukocytes were examined in the blood and other tissues in pregnant women. Time-kinetic studies showed that a basal change of leukocytes during pregnancy was granulocyt...

journal_title：Cellular immunology

authors： Minagawa M,Narita J,Tada T,Maruyama S,Shimizu T,Bannai M,Oya H,Hatakeyama K,Abo T

更新日期：1999-08-25 00:00:00

abstract：:An important subset in regulating antitumor immunity is the maturation and accumulation of intratumor dendritic cells (DCs), inducing potent T cell cytotoxicity. In this study, we explored how the soluble abundant high-mobility group box 1 protein (HMGB1) affected DC activation and retention within lung cancers, and i...

journal_title：Cellular immunology

authors： Gao Q,Li F,Wang S,Shen Z,Cheng S,Ping Y,Qin G,Chen X,Yang L,Cao L,Liu S,Zhang B,Wang L,Sun Y,Zhang Y

更新日期：2019-09-01 00:00:00

abstract：:In view of the critical role played by bacillus Calmette-Guérin (BCG) in the development and functional activation of protective T cells against tuberculosis, it has become important to understand the mechanisms by which cytokines regulate BCG-mediated immune responses. There is evidence that cytokine-mediated suppres...

journal_title：Cellular immunology

authors： Méndez-Samperio P,Hernández-Garay M,García-Martínez E

更新日期：2000-06-15 00:00:00

abstract：:Cultures of gradient-purified human peripheral blood mononuclear cells (PBMC) have been employed to examine the effects of three bacteria-derived human leukocyte interferon subtypes on certain aspects of in vitro immune responses. The addition of highly purified IFN-alpha 1, -alpha 2, -alpha 2/alpha 1 to PMBC cultures...

journal_title：Cellular immunology

authors： Shalaby MR,Weck PK

更新日期：1983-12-01 00:00:00

abstract：:Thirty-two cord blood samples taken after caesarean section or vaginal delivery and concurrent venous blood samples obtained from normal adult controls were evaluated using monoclonal antibodies. The percentage of circulating pan-T-cell+ lymphocytes was significantly lower in cord blood (46%) compared with adult contr...

journal_title：Cellular immunology

authors： Solinger AM

更新日期：1985-04-15 00:00:00

abstract：:The activities of the enzymes involved in purine nucleoside metabolism, adenosine deaminase (ADA), adenosine kinase (AK), purine nucleoside phosphorylase (PNP) and deoxycytidine kinase (deoxyCRK), were determined in mouse thymocytes at various stages of differentiation and maturation, and compared with those in other ...

journal_title：Cellular immunology

authors： Kizaki H,Habu S,Ohsaka F,Sakurada T

更新日期：1983-12-01 00:00:00

abstract：AIMS:Non-enzymatic reaction of biomolecules leads to the formation of advanced glycation end products (AGEs). AGEs plays significant role in the pathophysiology of type 2 diabetes mellitus. Methylglyoxal (MG) is a highly reactive carbonyl compound which causes formation of early (ketoamines), intermediate (dicarbonyls)...

journal_title：Cellular immunology

authors： Khan MY,Alouffi S,Khan MS,Husain FM,Akhter F,Ahmad S

更新日期：2020-05-01 00:00:00

abstract：:Spleen cells from normal, nonautoimmune mice (C3H/HeN) spontaneously produce hemolytic plaques against autologous bromelain-treated red blood cells (BrMRBC). The number of anti-BrMRBC plaques detectable can be increased by including either a 3 M KCl extracted antigen from BrMRBCs or the hapten phosphorylcholine chlori...

journal_title：Cellular immunology

authors： Wieties KM,Moticka EJ

更新日期：1986-03-01 00:00:00

abstract：:The frequency of obesity is enormously growing worldwide. Obesity results when energy intake exceeds, energy expenditure. Excess adiposity is a major risk factor in the progress of various metabolic disorders accounting insulin resistance, hypertension, Type 2 diabetes, nonalcoholic fatty liver disease, polycystic ova...

journal_title：Cellular immunology

authors： Asghar A,Sheikh N

更新日期：2017-05-01 00:00:00

abstract：:We tested the impact of interleukin-12 (IL-12) and of cytotoxic leukocytes (particularly natural killer (NK) cells) from normal and HIV-1-infected subjects on lysis of human monocytes infected with Mycobacterium tuberculosis. Nylon wool nonadherent cells stimulated with interleukin-2 (IL-2) or with IL-12 developed sig...

journal_title：Cellular immunology

authors： Denis M

更新日期：1994-07-01 00:00:00

abstract：:Peripheral CD4+CD8+ T cells have been identified as a T cell subset existing in animals and humans. However, the characterization of CD4+CD8+ T cells, their relationship with T memory (T(M)), T effector (T(E)), Th1/Th2, Treg and Th-17, remain unclear. This study was to characterize the CD4+CD8+ T cells. The results fr...

journal_title：Cellular immunology

authors： Xie D,Hai B,Xie X,Liu L,Ayello J,Ma X,Zhang J

更新日期：2009-01-01 00:00:00

abstract：:Mice infected with murine acquired immunodeficiency syndrome (MAIDS) virus developed lymphoadenopathy and profound immunodeficiency. Concomitantly the expression of endogenous mammary tumor virus (MTV) mRNA increased significantly, especially for the 1.7-kb 3' open reading frame (ORF) mRNA encoding MTV superantigen. B...

journal_title：Cellular immunology

authors： Gayama S,Doyon L,Vaupel B,Sekaly RP,Kanagawa O

更新日期：1998-08-01 00:00:00

abstract：:Pentraxin 3 (PTX3) is a prototype protein of long pentraxin. PTX3 is produced by various cells, such as monocytes/macrophages (Mphis) in response to lipopolysaccharide (LPS) and proinflammatory signals. We performed immunoblotting, immunohistochemical staining, reverse transcriptase-polymerase chain reaction (RT-PCR),...

journal_title：Cellular immunology

authors： Imamura M,Kawasaki T,Savchenko AS,Ohashi R,Jiang S,Miyamoto K,Ito Y,Iwanari H,Sagara M,Tanaka T,Hamakubo T,Kodama T,Uchiyama M,Naito M

更新日期：2007-08-01 00:00:00

abstract：:Monocytes and macrophages link the innate and adaptive immune systems and protect the host from the outside world. In inflammatory disorders their activation leads to tissue damage. Galectins have emerged as central regulators of the immune system. However, if they regulate monocyte/macrophage physiology is still unkn...

journal_title：Cellular immunology

authors： Paclik D,Werner L,Guckelberger O,Wiedenmann B,Sturm A

更新日期：2011-01-01 00:00:00