Abstract:
:Sequential immunization with a carrier molecule and a new epitope (hapten) conjugated to the carrier (carrier/hapten-carrier immunization) induces specific suppression for IgG antibody production to the new epitope (hapten) on the carrier. Once induced, this "epitope-specific" suppression persists and specifically suppresses subsequent in vivo IgG antibody responses to the hapten presented on the same or on an unrelated carrier molecule. In vitro studies presented here characterize the surface markers and specificity of suppressor T cells generated in carrier/hapten-carrier-immunized animals. Thus we show (1) that spleen cells from these donors suppress in vitro IgG anti-hapten antibody production by cocultured hapten-primed spleen cells; (2) that some but not all of the suppressor cells carry surface Lyt-2; (3) that at least some of the suppressor cells have receptors for the inducing hapten (DNP); and (4) that, unlike the suppression obtained in vivo, the in vitro suppression extends to IgG responses to unrelated carrier protein epitopes presented in association with the inducing hapten.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Tagawa M,Tokuhisa T,Ono K,Taniguchi M,Herzenberg LA,Herzenberg LAdoi
10.1016/0008-8749(84)90387-3subject
Has Abstractpub_date
1984-07-01 00:00:00pages
327-36issue
2eissn
0008-8749issn
1090-2163pii
0008-8749(84)90387-3journal_volume
86pub_type
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