Impact of polyunsaturated fatty acids on cytoskeletal linkage of L-selectin.

Abstract:

:Polyunsaturated fatty acid [omega-3 polyunsaturated fatty acids (omega-3PUFAs)] incorporation into cell membranes has been shown to have potent anti-inflammatory activity, though the mechanisms involved are only partially characterized. Here, we show that PUFA enrichment of T cell membranes decreased the overall expression of L-selectin as well as a highly conserved epitope on L-selectin that may serve as a marker for optimal protein function. Additionally, PUFA enrichment inhibited L-selectin cytoskeletal association, which is thought to be important for optimal functional activity. In support of this, PUFA enrichment of gammadelta T cell membranes reduced L-selectin-dependent rolling interactions under conditions mimicking physiological flow. Taken together, these data suggest that the anti-inflammatory activity of omega-3 polyunsaturated fatty acids may be due, in part, to a novel effect on L-selectin, namely PUFA reduction or prevention of cytoskeletal association of L-selectin.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Leid JG,Jutila MA

doi

10.1016/j.cellimm.2004.04.004

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

91-8

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008874904000589

journal_volume

228

pub_type

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