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Prostaglandin E2 and IL-4 provide naive CD4+ T cells with distinct inhibitory signals for the priming of IFN-gamma production.

Abstract：

:We investigated the effects of prostaglandin E2 and IL-4 on the acquisition of cytokine-producing ability by naive CD4(+) T cells in human umbilical cord blood. The presence of PGE2 or IL-4 at primary stimulation inhibited the production of IFN-gamma at secondary stimulation, and the combination of these stimuli resulted in cooperative effects. During primary stimulation with anti-CD3, the intracellular cAMP level was elevated in PGE2-treated cells but not in IL-4-treated or control cells. The signal provided by PGE2, but not by IL-4, was inhibited with RpcAMP, indicating that it was mediated by cAMP. After differentiation into Th2-like cells, cAMP levels in PGE2- and IL-4-treated cells were not different. Our results suggest that both PGE2 and IL-4 play important roles with distinct mechanisms in inhibiting the priming of IFN-gamma production of naive CD4(+) T cells.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Abe N,Katamura K,Shintaku N,Fukui T,Kiyomasu T,Iio J,Ueno H,Tai G,Mayumi M,Furusho K

doi

10.1006/cimm.1997.1180

subject

Has Abstract

pub_date

1997-10-10 00:00:00

pages

86-92

issue

1

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(97)91180-1

journal_volume

181

pub_type

杂志文章

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