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The spider acylpolyamine Mygalin is a potent modulator of innate immune responses.

Abstract：

:Mygalin is an antibacterial molecule isolated from the hemocytes of the spider Acanthoscurria gomesiana. It was identified as bis-acylpolyamine spermidine. We evaluated the modulator effects of synthetic Mygalin in the innate immune response. We demonstrate that Mygalin induces IFN-γ synthesis by splenocytes increasing the nitrite secretion by splenocytes and macrophages. A specific inhibitor of iNOS abrogated Mygalin-induced nitrite production in macrophages independent of IFN-γ activation. In addition, Mygalin-activated macrophages produced TNF-α but not IL-1β, demonstrating that Mygalin does not act directly on the inflammasome. Furthermore, this compound did not affect spontaneous or Concanavalin A-induced proliferative responses by murine splenocytes and did not induce IL-5 or apoptosis of splenocytes or bone marrow-derived macrophages. These data provide evidence that Mygalin modulates the innate immune response by inducing IFN-γ and NO synthesis. The combined immune regulatory and antibacterial qualities of Mygalin should be explored as a strategy to enhance immune responses in infection.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Mafra DG,da Silva PI Jr,Galhardo CS,Nassar R,Daffre S,Sato MN,Borges MM

doi

10.1016/j.cellimm.2012.04.003

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

5-11

issue

1-2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(12)00062-7

journal_volume

275

pub_type

杂志文章

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