当前位置： SCI文献检索 > CELLULAR IMMUNOLOGY期刊下所有文献 > Differential expression of the proteome of myeloid dendritic cells in severe aplastic anemia.

Differential expression of the proteome of myeloid dendritic cells in severe aplastic anemia.

Abstract：

:Severe aplastic anemia (SAA) is a syndrome of severe bone marrow failure with high mortality. Our previous studies have demonstrated that both immature and activated DC1 increased in the bone marrow of SAA patients, and the balance of DC1 subsets shifted the stable form to active one, which might promote Th0 cells to polarize to Th1 cells and cause the over-function of T lymphocytes and hematopoiesis failure in SAA. So we assumed myeloid dendritic cells (mDCs) may be the key immune cells that cause destruction of hematopoietic cells in SAA, but the mechanism of activation of mDCs is unclear. Here, we investigated the proteome of mDCs in SAA patients to further explore the pathogenesis of SAA and the possible antigen that leads to immune activation in SAA. mDCs from 12 SAA patients, 12 remission patients and 12 controls were sorted by flow cytometry and examined by two-dimensional gel electrophoresis and mass spectrometry. Intensity changes of 41 spots were detected with statistical significance. Nine of the 41 spots were identified by MALDI-TOF/TOF tandem mass spectrometry. Changes in protein expression levels were found in the SAA group. These changes reveal that abnormal expression of cofilin, glucose-6-phosphate dehydrogenase and pyruvate kinase enzyme M2 in mDCs from SAA patients may be the reason for mDC hyperfunction.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Liu C,Sheng W,Fu R,Wang H,Li L,Liu H,Shao Z

doi

10.1016/j.cellimm.2013.09.007

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

141-8

issue

1-2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(13)00165-2

journal_volume

285

pub_type

杂志文章

相关文献

CELLULAR IMMUNOLOGY文献大全
  • Experimental food allergy leads to adipose tissue inflammation, systemic metabolic alterations and weight loss in mice.

    abstract：:To investigate the consequences of food allergy in adipose tissue and metabolism, we used a murine model in which mice have been sensitized subcutaneously with ovalbumin and further received antigen-containing diet. Allergic mice presented a significant weight loss 7 days after oral challenge with a concomitant decrea...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2011.05.008

    authors： Dourado LP,Noviello Mde L,Alvarenga DM,Menezes Z,Perez DA,Batista NV,Menezes GB,Ferreira AV,de Souza Dda G,Cara DC

    更新日期：2011-01-01 00:00:00

  • Activation of macrophages for ADCC in vitro: effects of IL-4, TNF, interferons-alpha/beta, interferon-gamma, and GM-CSF.

    abstract：:Macrophages in varying states of activation differ in their ability to perform antibody-dependent cellular cytotoxicity (ADCC) and antibody-independent macrophage-mediated tumor cytotoxicity (MTC). To define further the activation requirements for macrophages to perform various cytolytic functions, we stimulated pepto...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90255-a

    authors： Fan S,Fehr HG,Adams D

    更新日期：1991-06-01 00:00:00

  • Inhibition of T cell activation and adhesion functions by soluble CD2 protein.

    abstract：:The CD2 (T11) molecule belongs to a family of cell-surface glycoproteins that function as adhesion molecules in the immune system. Human CD2 is found exclusively on cells of the T lineage: peripheral T lymphocytes, NK cells, and thymocytes. CD2 binds specifically to the surface glycoprotein LFA-3. CD2/LFA-3 adhesion i...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1133

    authors： Rabin EM,Gordon K,Knoppers MH,Luther MA,Neidhardt EA,Flynn JF,Sardonini CA,Sampo TM,Concino MF,Recny MA

    更新日期：1993-06-01 00:00:00

  • Suppressive effects of soluble histocompatibility antigens on the in vitro generation of cytotoxic T cells to D-end alloantigens.

    abstract：:Murine histocompatibility antigens were solubilized from the spleens and lungs of C57BL/6 (H-2b) animals with hypertonic salt (3 M KC1). Aggregate-free soluble antigens were incubated with nonadherent lymph node cells from BALB/c (H-2d) mice for 18 hr prior to their use as responder cells in the mixed-lymphocyte react...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(83)90281-2

    authors： Long PM,Sommer CV,Kong YM

    更新日期：1983-06-01 00:00:00

  • Cyclophosphamide-induced tolerance in fully allogeneic heart transplantation in mice.

    abstract：:We have established a long-lasting heart allograft tolerance in H-2-incompatible combinations by intravenous injection of 10(8) allogeneic spleen cells followed by the administration of 200 mg/kg of cyclophosphamide (CP). When C57BL/10 mice (B10, H-2b) were primed iv with 1 x 10(8) viable spleen cells from naive BALB/...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1994.1142

    authors： Matsuura A,Katsuno M,Suzuki Y,Ito T,Yasuura K,Abe T,Yoshikai Y

    更新日期：1994-05-01 00:00:00

  • Promoter anchored interaction landscape of THP-1 macrophages captures early immune response processes.

    abstract：:Macrophages are highly plastic immune cells with temporally distinct transcriptome changes upon lipopolysaccride (LPS) activation. However, to what extent transcriptome reprogramming is mediated via spatial chromatin looping is not well studied. We generated high resolution chromatin interaction maps for LPS-stimulate...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2020.104148

    authors： Pradhananga S,Spalinskas R,Poujade FA,Eriksson P,Sahlén P

    更新日期：2020-09-01 00:00:00

  • Estrogen induces suppression of natural killer cell cytotoxicity and augmentation of polyclonal B cell activation.

    abstract：:Estrogen displays potent immunoregulatory properties. In the present study we investigated the in vivo effect of estrogen on natural killer (NK) cell cytotoxic activity in several mouse strains. After castration, 17 beta-estradiol was administered in low or high doses. After 3-6 weeks of hormone administration an in v...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1994.1262

    authors： Nilsson N,Carlsten H

    更新日期：1994-10-01 00:00:00

  • Overexpressing autoimmune regulator regulates the expression of toll-like receptors by interacting with their promoters in RAW264.7 cells.

    abstract：:Autoimmune regulator (Aire) is a transcriptional activator that regulates the ectopic expression of many tissue-restricted antigens in medullary thymic epithelial cells, and that has an important role in the negative selection of autoreactive T cells. However, the roles of Aire expression in peripheral lymphoid tissue...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2011.05.002

    authors： Zhu W,Yang W,He Z,Liao X,Wu J,Sun J,Yang Y,Li Y

    更新日期：2011-01-01 00:00:00

  • Testosterone treatment of aged male mice improves some but not all aspects of age-associated increases in influenza severity.

    abstract：:The severity of influenza increases with age, with worse disease in aged males than females. Testosterone concentrations decline with age in males, which may impact influenza pathogenesis. Aged male mice were treated with testosterone or placebo and outcomes during influenza A virus (IAV) infection were compared with ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2019.103988

    authors： Vom Steeg LG,Attreed SE,Zirkin B,Klein SL

    更新日期：2019-11-01 00:00:00

  • Vibrio vulnificus-induced death of Jurkat T-cells requires activation of p38 mitogen-activated protein kinase by NADPH oxidase-derived reactive oxygen species.

    abstract：:Vibrio vulnificus, a pathogenic bacterium causing primary septicemia, exhibited cytotoxicity towards Jurkat cells of T-lymphocytes through intracellular reactive oxygen species (ROS) production. Pretreatment of Jurkat T-cells with diphenyleneiodonium chloride (DPI) abolished V. vulnificus-induced ROS generation and ba...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2008.05.003

    authors： Kim WH,Goo SY,Shin MH,Chun SJ,Lee H,Lee KH,Park SJ

    更新日期：2008-05-01 00:00:00

  • An evaluation of the maternal natural killer cell population during the course of murine pregnancy.

    abstract：:Earlier work from this laboratory revealed an increase in the level of null (Thy-1-, IgM-) lymphocytes in the maternal lymphoid organs during the first pregnancy in the mouse that was more pronounced during allogeneic pregnancy than during syngeneic pregnancy. In view of the suggestive evidence for the bone marrow ori...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90098-4

    authors： Chatterjee-Hasrouni S,Parhar R,Lala PK

    更新日期：1984-04-01 00:00:00

  • Subpopulations of colony-forming B lymphocytes exhibit distinct in vitro growth characteristics.

    abstract：:Human peripheral blood cells enriched for B lymphocytes were stimulated to focal proliferation in semisolid cultures with lymphocyte-conditioned media, Protein A (Prot A), lipopolysaccharide (LPS) and 2-mercaptoethanol (2-ME). After 6-8 days of incubation, two morphologically distinct colony types were observed. Type ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90059-5

    authors： Peschel C,Gattringer C,Konwalinka G,Geissler D,Boyd J,Huber H,Braunsteiner H

    更新日期：1984-10-01 00:00:00

  • Altered immune response patterns in murine syngeneic pregnancy: presence of natural null suppressor cells in maternal spleen identifiable by monoclonal antibodies.

    abstract：:Expression of certain autologous lymphocyte-activating antigenic determinants on the developing embryo is known to provide a stimulus for maternal anti-fetal autoproliferative responses. If left unregulated these responses could exert negative influences on the reproductive process by converting to autoaggressive form...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90173-1

    authors： Hoskin DW,Gronvik KO,Hooper DC,Reilly BD,Murgita RA

    更新日期：1989-04-15 00:00:00

  • Filament-associated TSGA10 protein is expressed in professional antigen presenting cells and interacts with vimentin.

    abstract：:Testis-specific gene antigen 10 (TSGA10) encodes an 82-kDa protein expressed during development, and in testis and brain tissues. We report its expression in human monocyte-derived dendritic cells (DC) and macrophages in vitro and in murine spleen CD11c(+) cells ex vivo. An interaction between DC/macrophage-derived TS...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2010.07.012

    authors： Roghanian A,Jones DC,Pattisapu JV,Wolfe J,Young NT,Behnam B

    更新日期：2010-01-01 00:00:00

  • Lymphokine regulation of surface Ia expression on rat B cells.

    abstract：:Class II major histocompatibility antigens (Ia) play a major role in regulating T-B cell interactions; therefore, regulation of the amount of Ia on B cells may be an important point of control in the immune response. Mitogens in human and murine systems have been reported to increase Ia expression on B cells, and in t...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90108-6

    authors： Leitenberg D,Feldbush TL

    更新日期：1988-02-01 00:00:00

  • gld and lpr hematopoietic cell transfers: common and different serological features of the C57BL/6 chimeras.

    abstract：:Homozygosity for either the lpr (lymphoproliferation) or the gld (generalized lymphoproliferative disease) mutation in mice causes the development of strikingly similar hyperglobulinemia and lymphoproliferative syndromes. Nevertheless, previous studies of various C57BL/6 chimeras obtained by reconstitution of irradiat...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1116

    authors： Velin D,Goettelfinger P,Froidevaux S,Loor F

    更新日期：1993-05-01 00:00:00

  • Natural cytotoxic T cells (NCTC) that differ from natural killer (NK) and natural cytotoxic (NC) cells are present in Peyer's patches of mice.

    abstract：:We have examined noninduced cytotoxicity of mouse gut associated and peripheral lymphoid tissues for a wide variety of syngeneic as well as allogeneic cell lines and lymphoblasts. Lymphoid cells from Peyer's patches were found to lyse these targets in a 3-hr chromium release assay whereas lymphoid cells from intestina...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(86)90158-9

    authors： Gautam SC,Beckman K,Battisto JR

    更新日期：1986-09-01 00:00:00

  • B cell differentiation factor-induced B cell maturation: regulation via reduction in cAMP.

    abstract：:We have previously described a novel human B cell differentiation factor (BCDF), 446-BCDF, that is distinct biochemically and functionally from other cytokines. Since signal transduction pathways involved in human B cell differentiation have been incompletely studied and are poorly understood, we assessed the effects ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1995.1050

    authors： Huang R,Cioffi J,Berg K,London R,Cidon M,Maayani S,Mayer L

    更新日期：1995-04-15 00:00:00

  • Rabbit bone marrow suppressor cells block the production or release of a soluble bone marrow growth factor.

    abstract：:Fc gamma-receptor (Fc gamma R)-bearing cells from normal rabbit bone marrow suppressed the constitutive proliferation rates of the remaining, Fc gamma R-, cells. In the absence of the suppressive influences of Fc gamma R+ cells, cells in the Fc gamma R- population spontaneously elaborated a soluble growth factor (GF) ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90012-7

    authors： Soderberg LS

    更新日期：1985-05-01 00:00:00

  • The effects of temperature and oleic acid on murine memory and virgin T cell activation: interleukin-2 secretion and interleukin-2 receptor expression.

    abstract：:Previous studies established that low in vitro temperatures (27 degrees C, termed nonpermissive) suppressed murine primary thymus-dependent (TD), but not primary thymus-independent (TI) or secondary TD, antibody responses. Suppression was rescued by the addition of oleic acid (18:1), recombinant interleukin (rIL)-2 an...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1265

    authors： Wooten RM,Clem LW,Bly JE

    更新日期：1993-11-01 00:00:00

  • Inhibitors of cytochrome P450 suppress tumor necrosis factor production.

    abstract：:We tested the effect of different inhibitors of cytochrome P450 on tumor necrosis factor (TNF) production. Metyrapone and SKF525A (100 and 50 mg/kg, ip, respectively) suppressed serum TNF induced by cotreatment with endotoxin (LPS), (2.5 micrograms/mouse). Inhibition was independent of endogenous corticosteroids since...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1209

    authors： Fantuzzi G,Cantoni L,Sironi M,Ghezzi P

    更新日期：1993-09-01 00:00:00

  • Interleukin-3 and Flt3-ligand induce adhesion of Baf3/Flt3 precursor B-lymphoid cells to fibronectin via activation of VLA-4 and VLA-5.

    abstract：:Adhesion of hematopoietic cells to extracellular matrix components is important for blood cell development. However, little is known regarding the potential influence of IL-3 on this process for precursor B cells and Flt3-ligand has not yet been implicated in induction of adhesion of any blood cell types to extracellu...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1998.1318

    authors： Shibayama H,Anzai N,Ritchie A,Zhang S,Mantel C,Broxmeyer HE

    更新日期：1998-07-10 00:00:00

  • Role of immune cells in obesity induced low grade inflammation and insulin resistance.

    abstract：:The frequency of obesity is enormously growing worldwide. Obesity results when energy intake exceeds, energy expenditure. Excess adiposity is a major risk factor in the progress of various metabolic disorders accounting insulin resistance, hypertension, Type 2 diabetes, nonalcoholic fatty liver disease, polycystic ova...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2017.03.001

    authors： Asghar A,Sheikh N

    更新日期：2017-05-01 00:00:00

  • Preferential recognition of peroxynitrite modified human DNA by circulating autoantibodies in cancer patients.

    abstract：:Peroxynitrite (ONOO(-)) has been vastly implicated in mutagenesis and cancer development. Present study probes the antigenicity of peroxynitrite damaged DNA (ONOO(-)-DNA) in cancer patients. Purified human placental DNA was damaged by the synergistic action of sodium nitroprusside (SNP) and Pyrogallol for 3h at 37 deg...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2008.08.002

    authors： Habib S,Moinuddin,Ali A,Ali R

    更新日期：2009-01-01 00:00:00

  • Cytokine production by NZB, C58, and NZB X C58 recombinant inbred mice.

    abstract：:Humans with autoimmune disease and autoimmune mouse strains such as NZB have been shown to produce reduced levels of the cytokines interleukin 1 and interleukin 2. The NZB X C58 recombinant inbred (N X 8 RI) strains exhibit certain of the autoimmune characteristics of the NZB strain. Their abilities to produce interle...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90177-1

    authors： Bocchieri MH,Knittweis L,Seaton DS

    更新日期：1984-10-15 00:00:00

  • Activation of CD3/TCR negative human thymocytes via CD28 molecule.

    abstract：:We have observed that the CD28 molecule was present on the cell surface of a large fraction of resting CD3- thymocytes (40 to 100%). Interestingly, the majority (greater than 90%) of surface CD3-CD28-cells reacted in the cytoplasm with anti-CD28 (CK248, 9.3) and anti-CD3 epsilon chain mAbs (Leu4, OKT3). Along this lin...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90385-o

    authors： Zocchi MR,Poggi A

    更新日期：1991-08-01 00:00:00

  • The induction of T-suppressor cells with a soluble extract of Candida albicans.

    abstract：:We have previously shown that whole cell preparations of Candida albicans are capable of inducing immunosuppressive B-cell activity both in vivo and in vitro. In an effort to characterize the components of the yeast which manifest this immunomodulatory activity, we have successfully generated a soluble extract with di...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90149-4

    authors： Cuff CF,Taub DD,Rogers TJ

    更新日期：1989-08-01 00:00:00

  • IFN-γ-induced BST2 mediates monocyte adhesion to human endothelial cells.

    abstract：:BST2 is a type II transmembrane protein that had been initially identified as a surface molecule expressed on terminally differentiated B cells. Here, we characterize the expression of BST2 in human endothelial cells, HUVECs. IFN-γ, among various inflammatory stimuli, dramatically upregulates BST2 expression in HUVECs...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2010.10.011

    authors： Yoo H,Park SH,Ye SK,Kim M

    更新日期：2011-01-01 00:00:00

  • Effector and precursor phenotypes of lymphokine-activated killer cells in mice with severe combined immunodeficiency (scid) and athymic (nude) mice.

    abstract：:The lineage of lymphokine-activated killer (LAK) cells is poorly understood. To examine the relationship between LAK and natural killer (NK) cells we utilized two congenitally immunodeficient mice, namely severe combined immunodeficient (scid) and athymic (nude) mice that lack T cells but have normal NK cells. LAK act...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90190-1

    authors： Hasui M,Saikawa Y,Miura M,Takano N,Ueno Y,Yachie A,Miyawaki T,Taniguchi N

    更新日期：1989-04-15 00:00:00

  • γδ T cell activation by bispecific antibodies.

    abstract：:Bispecific antibodies have been successfully introduced into clinical application. γδ T cells are of special interest for tumor immunotherapy, due to their recognition of pyrophosphates that are overproduced by many tumor cells resulting in HLA-nonrestricted tumor cell killing. Here we describe in detail a [(Her2)2 × ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2015.04.009

    authors： Oberg HH,Kellner C,Gonnermann D,Peipp M,Peters C,Sebens S,Kabelitz D,Wesch D

    更新日期：2015-07-01 00:00:00