Preferential recognition of peroxynitrite modified human DNA by circulating autoantibodies in cancer patients.

abstract：:Heterotrimeric G-proteins control diverse biological processes by conveying signals from seven-transmembrane receptors to intracellular effectors. Although their signaling roles were originally ascribed to their GTP-bound alpha-subunits, more recent evidence points to the equally active roles played by their betagamma...

journal_title：Cellular immunology

authors： Dubeykovskiy A,McWhinney C,Robishaw JD

更新日期：2006-04-01 00:00:00

abstract：:We examined the effects of the inhibitors of C1q or collagen biosynthesis, 2,2'-dipyridyl (DP), and 3,4-dehydro-DL-proline (DHP) on murine macrophage (M phi) FcR subclass-mediated antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis of sheep erythrocyte targets. Oil-elicited peritoneal M phi from C3HeB/FeJ...

journal_title：Cellular immunology

authors： Mocharla R,Mocharla H,Leu RW

更新日期：1987-03-01 00:00:00

abstract：:Within the lymphoid compartment, CD8 is expressed either as an alphaalpha homodimer or as an alphabeta heterodimer. Prior functional characterization of CD8alpha transfectants has demonstrated that CD8alphaalpha homodimers can reconstitute T cell responses in the absence of the CD8beta subunit. In order to now examine...

journal_title：Cellular immunology

authors： Witte T,Spoerl R,Chang HC

更新日期：1999-02-01 00:00:00

abstract：:Hen egg white lysozyme (HEL)-specific T cell lines and clones were generated from B6 and BDF1 mice. A variety of clonotypes were found among clones generated at an early stage (1 month) whereas fewer clonotypes were detected after several weeks of culture. Furthermore, a bulk line switched from its initial fine peptid...

journal_title：Cellular immunology

authors： Manca F,Dessí V,Shastri N,Oki A,Kaplan M,Clarke J,Miller A,Sercarz EE

更新日期：1994-04-01 00:00:00

abstract：:We studied the effect of vasoactive intestinal peptide (VIP), somatostatin (SOM), and substance P (SP) on IL-4-stimulated human IgE and IgG subclass production. VIP and SOM, but not SP, inhibited IgE production without affecting IgM or IgA production by mononuclear cells (MNC) from nonatopic donors from 10 pM to 10 nM...

journal_title：Cellular immunology

authors： Kimata H,Yoshida A,Ishioka C,Mikawa H

更新日期：1992-10-15 00:00:00

abstract：:A low culture temperature of 27 degrees C inhibited mouse primary in vitro anti-hapten plaque-forming cell responses to a thymus-dependent (TD) antigen (Ag) (trinitrophenyl-keyhole limpet hemocyanin, TNP-KLH). In contrast, the magnitudes of secondary responses to TNP-KLH or primary responses to a thymus-independent (T...

journal_title：Cellular immunology

authors： Wang-Yang MC,Buttke TM,Miller NW,Clem LW

更新日期：1990-04-01 00:00:00

abstract：:This report compares the ability of cyclosporin A and FK-506 to inhibit human T cell activation triggered via cell surface molecules that utilize different intracellular processes. We stimulated highly purified peripheral blood T lymphocytes with mitogens (Con A and PHA), ionomycin + PMA, or monoclonal antibodies spec...

journal_title：Cellular immunology

authors： Lin CS,Boltz RC,Siekierka JJ,Sigal NH

更新日期：1991-04-01 00:00:00

abstract：:Conditioned medium (CM) from 24-hr culture of guinea pig L2C B lymphoblastic leukemia cells contained an inhibitor(s) of mitogen- and antigen-stimulated proliferation of syngeneic (strain 2 guinea pigs), allogeneic (Hartley guinea pigs), and xenogeneic (Balb/c mouse, NZW rabbit) lymphocytes. The proliferation of sever...

journal_title：Cellular immunology

authors： Collins DP,Cook DJ,Ricardo MJ Jr

更新日期：1987-04-01 00:00:00

abstract：:Germ-free (GF) mice have increased bone mass that is normalized by colonization with gut microbiota (GM) from conventionally raised (CONV-R) mice. To determine if innate immune signaling pathways mediated the effect of the GM, we studied the skeleton of GF and CONV-R mice with targeted inactivation of MYD88, NOD1 or N...

journal_title：Cellular immunology

authors： Ohlsson C,Nigro G,Boneca IG,Bäckhed F,Sansonetti P,Sjögren K

更新日期：2017-07-01 00:00:00

abstract：:Eighty-seven murine monoclonal antibodies (MAb) produced against human tumors of various origins and representing six different immunoglobulin classes were tested for antitumor reactivity in antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) assays. Mouse splenocytes, thio...

journal_title：Cellular immunology

authors： Herlyn D,Herlyn M,Steplewski Z,Koprowski H

更新日期：1985-04-15 00:00:00

abstract：:Transforming growth factor beta1 (TGFbeta1) is a potent negative immunoregulatory molecule. We have previously shown that the autoimmune-mediated weaning-age lethality of Tgfb1-/- mice is reversed upon genetic combination with Scid or Rag null alleles. Here, we show that elimination of T but not B cells is sufficient ...

journal_title：Cellular immunology

authors： Bommireddy R,Engle SJ,Ormsby I,Boivin GP,Babcock GF,Doetschman T

更新日期：2004-11-01 00:00:00

abstract：:Conalbumin (CA)-specific type 2 helper T cell (Th2) clone, D10G4.1 (D10) produces IL4 when stimulated with varying doses of TNP-CA in the presence of mitomycin C-treated C3H spleen cells or purified B cells as antigen-presenting cells (APC). The production of IL4 was assessed by bioassay and by expression of IL4 mRNA....

journal_title：Cellular immunology

authors： Ohmori H,Hase N,Hikida M,Takai T,Endo N

更新日期：1992-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are aberrant in many human tumors which can be transferred to immune cells by tumor-derived exosomes. Dendritic cells (DCs) play an important role in activation of immune response. However, the effect of tumor-derived exosomes on toll-like receptor (TLR) in DCs remains unclear. We investigated the i...

journal_title：Cellular immunology

authors： Zhou M,Chen J,Zhou L,Chen W,Ding G,Cao L

更新日期：2014-11-01 00:00:00

abstract：:Interleukin-1 is a potent stimulator of arachidonic acid (AA) metabolism and this activity could be attributed to the activation of the prostaglandin-forming enzyme cyclooxygenase or of the arachidonic-releasing enzyme phospholipase A2 or both. Prostaglandin E2 (PGE2), a cyclooxygenase product, and LTB4 (5-(S),12-(R)-...

journal_title：Cellular immunology

authors： Conti P,Panara MR,Barbacane RC,Placido FC,Bongrazio M,Reale M,Dempsey RA,Fiore S

更新日期：1992-11-01 00:00:00

abstract：:Normal chondrocytes display susceptibility to lysis by natural killer (NK) cells and this phenomenon may play a role in some inflammatory cartilage disorders. The mechanisms of chondrocyte recognition and killing by NK cells remain unclear. Using flow cytometry and immunohistochemical staining we found that normal hum...

journal_title：Cellular immunology

authors： Białoszewska A,Baychelier F,Niderla-Bielińska J,Czop A,Debré P,Vieillard V,Kieda C,Malejczyk J

更新日期：2013-09-01 00:00:00

abstract：:Recently we have shown that the generation of IFN-gamma-producing cells (IFN-gamma pc) were severely suppressed in cultures of Con A-stimulated splenocytes obtained from HgCl2-exposed BN but not Lewis rats. Since BN rats develop a TH2-biased polyclonal autoimmune syndrome upon exposure to HgCl2, whereas Lewis rats exh...

journal_title：Cellular immunology

authors： van der Meide PH,de Labie MC,Botman CA,Aten J,Weening JJ

更新日期：1995-04-01 00:00:00

abstract：:Latex microspheres-based artificial antigen-presenting cell constructs (aAPCs) are proved to be valuable tools to expand T cells ex vivo for adoptive cell therapy, but little is known about their potential for active immunization. In this report, HLA-A2/peptide tetramers were generated and co-coated with anti-mouse CD...

journal_title：Cellular immunology

authors： Shen C,Zhang J,Xia L,Meng F,Xie W

更新日期：2007-05-01 00:00:00

abstract：:Murine 4-1BB is an approximately 30-kDa glycoprotein expressed on activated T cells and plays a role in T-cell-mediated proliferative response. To date the majority of work on 4-1BB has been conducted in the mouse. To assess the role of 4-1BB in humans, mAbs were made against the recombinant human (rh) 4-1BB protein. ...

journal_title：Cellular immunology

authors： Garni-Wagner BA,Lee ZH,Kim YJ,Wilde C,Kang CY,Kwon BS

更新日期：1996-04-10 00:00:00

abstract：:Adoptive immunotherapy is a promising cancer treatment that entails infusion of immune cells manipulated to have antitumor specificity, in vitro. Antigen-specific cytotoxic T lymphocytes are the main executors of transformed cells during cancer immunotherapy. To induce antigen-specific cytotoxic T lymphocytes, we deve...

journal_title：Cellular immunology

authors： Shao J,Xu Q,Su S,Wei J,Meng F,Chen F,Zhao Y,Du J,Zou Z,Qian X,Liu B

更新日期：2018-12-01 00:00:00

abstract：:Expression of certain autologous lymphocyte-activating antigenic determinants on the developing embryo is known to provide a stimulus for maternal anti-fetal autoproliferative responses. If left unregulated these responses could exert negative influences on the reproductive process by converting to autoaggressive form...

journal_title：Cellular immunology

authors： Hoskin DW,Gronvik KO,Hooper DC,Reilly BD,Murgita RA

更新日期：1989-04-15 00:00:00

abstract：:We and other investigators have previously demonstrated that mycoplasmas induce macrophage-mediated lysis of tumor cells, but the mechanism responsible for this process had, thus far, not been clarified. We now report that addition of either viable or heat-killed Mycoplasma orale to murine macrophages induces a cytoly...

journal_title：Cellular immunology

authors： Gallily R,Sher T,Ben-Av P,Loewenstein J

更新日期：1989-06-01 00:00:00

abstract：:We analyzed the effect of adherent cells on the induction of lymphokine-activated killer (LAK) cell activity by depleting adherent cells from peripheral blood lymphocytes (PBL) or by adding adherent cells to PBL before culture with interleukin-2. We found that adherent cells clearly down-regulate LAK cell induction. T...

journal_title：Cellular immunology

authors： Ibayashi Y,Hoon DS,Golub SH

更新日期：1987-12-01 00:00:00

abstract：:The complement receptor 2 (CR2; CD21), a 145,000 MW glycoprotein, has been useful as a marker of B lymphocyte maturation. It is expressed on the 1:13 monoclonal, EBV-transformed, B cell line which produces TNP-specific IgM-kappa and displays an in vitro capacity for differentiation. The line expresses the CD20+CD21+ p...

journal_title：Cellular immunology

authors： Pillemer SR,Tsokos GC,Barbieri SA,Balow JE,Golding B

更新日期：1990-02-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis in the skin and internal organs. The pathogenesis of SSc is not completely understood until now. Recently, many studies have focused on the role of E3 ubiquitin ligases in organ fibrosis. However, the possible regulatory mechanisms of E3 ubiqu...

journal_title：Cellular immunology

authors： Huang XL,Zhang L,Duan Y,Wang YJ,Zhao JH,Wang J

更新日期：2016-08-01 00:00:00

abstract：:Aging diminishes the amount of phosphotyrosine in the CD3zeta chains of resting and activated mouse CD4 T cells by about threefold and might therefore be expected to a corresponding decline in Zap-70 association with CD3zeta and in Zap-70 kinase function in CD3zeta complexes. We show here that aging leads, unexpectedl...

journal_title：Cellular immunology

authors： Garcia GG,Miller RA

更新日期：1998-12-15 00:00:00

abstract：:Previous work has shown ICOS can function independently of CD28, but whether either molecule can compensate for the other in vivo is not known. Since ICOS is a potent inducer of Th2 cytokines and linked to allergy and elevated serum IgE in humans, we hypothesized that augmenting ICOS costimulation in murine allergic a...

journal_title：Cellular immunology

authors： Shilling RA,Clay BS,Tesciuba AG,Berry EL,Lu T,Moore TV,Bandukwala HS,Tong J,Weinstock JV,Flavell RA,Horan T,Yoshinaga SK,Welcher AA,Cannon JL,Sperling AI

更新日期：2009-01-01 00:00:00

abstract：:This study aimed to describe the vascular and cellular histopathological changes that occurred in post-mastectomy seroma in an animal model. Unilateral mastectomies were conducted on 45 female albino rabbits. On day seven, the skin flap and the underlying tissues of the mastectomy regions were dissected and processed ...

journal_title：Cellular immunology

authors： Al-Gaithy ZK,Ayuob NN

更新日期：2012-01-01 00:00:00

abstract：:The effect of prior maternal immunization on the murine offspring response to subsequent immunization with hen egg-white lysozyme was examined. Adult female A/J mice were immunized with 100 micrograms HEL-CFA intraperitoneally 10-27 weeks before conception. The offspring of these experimental female mice were then imm...

journal_title：Cellular immunology

authors： Jelonek MT,Brust JL,Song CH,Calandra GB,Miller A,Sercarz EE,Keller MA

更新日期：1993-05-01 00:00:00

abstract：:Peripheral blood leukocytes (PBL), nonadherent lymphocytes, and adherent monocytes separated from freshly isolated blood of 15 dogs were analyzed for their ability to mediate antibody-dependent cell-mediated cytotoxicity (ADCC) in combination with murine anti-tumor monoclonal antibodies (MAbs). Canine monocytes isolat...

journal_title：Cellular immunology

authors： Rosales C,Jeglum KA,Obrocka M,Steplewski Z

更新日期：1988-09-01 00:00:00

abstract：:We previously demonstrated that injection of a high dose (4 X 10(9] of sheep erythrocytes (SRBC) into C57BL/6 mice results in the generation of splenic B cells (plastic nonadherent, Thy-1- and Ig+) which, when transferred to normal syngeneic recipients, subsequently induce antigen-specific suppressor T cells to suppre...

journal_title：Cellular immunology

authors： Shimamura T,Habu S,Hashimoto K,Sasaki S

更新日期：1984-01-01 00:00:00