Effects of inhibitors of C1q biosynthesis on macrophage Fc receptor subclass-mediated antibody-dependent cellular cytotoxicity and phagocytosis.

abstract：:The CD2 (T11) molecule belongs to a family of cell-surface glycoproteins that function as adhesion molecules in the immune system. Human CD2 is found exclusively on cells of the T lineage: peripheral T lymphocytes, NK cells, and thymocytes. CD2 binds specifically to the surface glycoprotein LFA-3. CD2/LFA-3 adhesion i...

journal_title：Cellular immunology

authors： Rabin EM,Gordon K,Knoppers MH,Luther MA,Neidhardt EA,Flynn JF,Sardonini CA,Sampo TM,Concino MF,Recny MA

更新日期：1993-06-01 00:00:00

abstract：:We studied the effect of vasoactive intestinal peptide (VIP), somatostatin (SOM), and substance P (SP) on IL-4-stimulated human IgE and IgG subclass production. VIP and SOM, but not SP, inhibited IgE production without affecting IgM or IgA production by mononuclear cells (MNC) from nonatopic donors from 10 pM to 10 nM...

journal_title：Cellular immunology

authors： Kimata H,Yoshida A,Ishioka C,Mikawa H

更新日期：1992-10-15 00:00:00

abstract：:There are still questions about whether macrophage differentiation is predetermined or is induced in response to tissue microenvironments. C2D macrophage cells reside early in the macrophage lineage in vitro, but differentiate to a more mature phenotype after adoptive transfer to the peritoneal cavity (PEC-C2D). Since...

journal_title：Cellular immunology

authors： Ortega MT,Xie L,Mora S,Chapes SK

更新日期：2011-01-01 00:00:00

abstract：:Aging induces a number of changes in the immune system, including the involution of the thymus which results in the loss of thymic hormone production and alteration in T cell function. One age-dependent change in immune response is the increasing risk of developing acute or chronic form of graft-versus-host disease (G...

journal_title：Cellular immunology

authors： Fast LD,Kouttab NM,Badamchian M,Goldstein AL

更新日期：1990-11-01 00:00:00

abstract：:Estrogen displays potent immunoregulatory properties. In the present study we investigated the in vivo effect of estrogen on natural killer (NK) cell cytotoxic activity in several mouse strains. After castration, 17 beta-estradiol was administered in low or high doses. After 3-6 weeks of hormone administration an in v...

journal_title：Cellular immunology

authors： Nilsson N,Carlsten H

更新日期：1994-10-01 00:00:00

abstract：:Cytotoxic T-cell (CTL) cultures were generated from five ovarian cancer patients (OvCTL) and from three breast cancer patients (BrCTL). All CTL lines were T-cell receptor (TcR) alphabeta+ and predominantly CD8+ (73 +/- 13%). These CTL lines preferentially recognized autologous tumor cells in an HLA class I-restricted,...

journal_title：Cellular immunology

authors： Goedegebuure PS,Douville CC,Doherty JM,Linehan DC,Lee KY,Ganguly EK,Eberlein TJ

更新日期：1997-02-01 00:00:00

abstract：:Macrophages are highly plastic immune cells with temporally distinct transcriptome changes upon lipopolysaccride (LPS) activation. However, to what extent transcriptome reprogramming is mediated via spatial chromatin looping is not well studied. We generated high resolution chromatin interaction maps for LPS-stimulate...

journal_title：Cellular immunology

authors： Pradhananga S,Spalinskas R,Poujade FA,Eriksson P,Sahlén P

更新日期：2020-09-01 00:00:00

abstract：:This study was conducted on human K562 lymphocytes to investigate the mechanisms implicated in the regulation of the serotonin transport process. The uptake of serotonin in these cells was saturable (Km, 3.37 microM; Vmax, 2.03 nmol/10(6) cells) and Na+ dependent; isoosmotic replacement of Na+ with choline chloride in...

journal_title：Cellular immunology

authors： Khan NA,Meyneil JP,Deschaux P

更新日期：1996-09-15 00:00:00

abstract：:We have studied the antibody-induced effect of cross-linking the major histocompatibility complex class I (MHC-I) in human T leukemic cells (Jurkat) and human B lymphoma cells (Solubo, Burkitts lymphoma) on intracellular [Ca2+]i levels. The increase in [Ca2+]i after MHC-I cross-linking in Jurkat cells and Solubo cells...

journal_title：Cellular immunology

authors： Pedersen AE,Jacoby BF,Skov S,Claesson MH

更新日期：1996-11-01 00:00:00

abstract：:Adhesion of hematopoietic cells to extracellular matrix components is important for blood cell development. However, little is known regarding the potential influence of IL-3 on this process for precursor B cells and Flt3-ligand has not yet been implicated in induction of adhesion of any blood cell types to extracellu...

journal_title：Cellular immunology

authors： Shibayama H,Anzai N,Ritchie A,Zhang S,Mantel C,Broxmeyer HE

更新日期：1998-07-10 00:00:00

abstract：:The aim of this study was to analyze in vivo the L3T4+ T-cell-subset-independent reactivity of Lyt2+ T cells toward transplantation alloantigens. To this end, we depleted normal mice of L3T4+ T cells by injection of monoclonal antibodies to the L3T4 antigen. This procedure not only led phenotypically to a disappearanc...

journal_title：Cellular immunology

authors： Heeg K,Steeg C,Wagner H

更新日期：1988-01-01 00:00:00

abstract：:Exogenous nonreplicating antigens (Ag) incorporated into immunostimulating complexes (iscoms) induce CTL responses under MHC class I restriction. A requirement for inducing CTL responses is that the Ag is delivered to the cytosol of antigen-presenting cells (APC), a route restricted to endogenously produced Ag. To inv...

journal_title：Cellular immunology

authors： Villacres MC,Behboudi S,Nikkila T,Lovgren-Bengtsson K,Morein B

更新日期：1998-04-10 00:00:00

abstract：:Osteopontin (OPN) expression in tumors is associated with more aggressive tumor growth; however, several studies have suggested that OPN as a host protein can regulate tumor growth as well. OPN is produced by macrophages and T cells, and reportedly modifies macrophage function. Here, we have investigated the effect of...

journal_title：Cellular immunology

authors： Bourassa B,Monaghan S,Rittling SR

更新日期：2004-01-01 00:00:00

abstract：:The majority of autoimmune diseases have a strong gender bias, affecting mostly females. Gender-specific factors like sex-hormones, the presence or absence of a second X chromosome, and gender-specific gut microbiota may contribute to this bias. In this review we will discuss the role of the X chromosome encoded toll-...

journal_title：Cellular immunology

authors： Rubtsova K,Marrack P,Rubtsov AV

更新日期：2015-04-01 00:00:00

abstract：:The internalization of surface immunoglobulin (Ig) by B lymphocytes is the first step in the antigen-presenting function performed by these cells. Mature B cells coexpress on their surface IgM and IgD. At this time, there is controversy over whether these two isotypes serve different functions in the antigen-presentin...

journal_title：Cellular immunology

authors： Guarini L,Weber DA,Pernis B

更新日期：1989-10-15 00:00:00

abstract：:Sequential immunization with a carrier molecule and a new epitope (hapten) conjugated to the carrier (carrier/hapten-carrier immunization) induces specific suppression for IgG antibody production to the new epitope (hapten) on the carrier. Once induced, this "epitope-specific" suppression persists and specifically sup...

journal_title：Cellular immunology

authors： Tagawa M,Tokuhisa T,Ono K,Taniguchi M,Herzenberg LA,Herzenberg LA

更新日期：1984-07-01 00:00:00

abstract：:Within lymphopenic recipients, naïve T cells undergo proliferation that is induced by homeostatic mechanisms. Earlier studies have demonstrated that commensal antigens play a key role in inducing the proliferation. However, a relative contribution of endogenous self antigens in this process has not been formally inves...

journal_title：Cellular immunology

authors： Do JS,Foucras G,Kamada N,Schenk AF,Shaw M,Nuñez G,Paul WE,Min B

更新日期：2012-01-01 00:00:00

abstract：:Psoriasis is a common dermatosis mediated by T cells. This study investigated the correlation of Th22 cells and Tc22 cells with psoriasis. A total of 30 psoriasis patients and 11 age- and sex-matched healthy controls were recruited for this study. The proportions of circulating Th22 and Tc22 cells, expression of aryl ...

journal_title：Cellular immunology

authors： Luan L,Ding Y,Han S,Zhang Z,Liu X

更新日期：2014-08-01 00:00:00

abstract：:Activation of lck-fyn kinases during T cell receptor signaling leads to Vav phosphorylation, activation of downstream targets including Rac1, and a transient decline in ezrin and moesin phosphorylation. We have shown that age increases Rac1 activity and lowers ezrin and moesin phosphorylation in resting mouse CD4 cell...

journal_title：Cellular immunology

authors： Garcia GG,Miller RA

更新日期：2009-01-01 00:00:00

abstract：:There are fewer bone marrow Pre-B cells in old compared to young mice. We have demonstrated both decreased rearrangement of the V to DJ IgH gene segments and low levels of VH germline transcripts in Pro-B cells, the precursors of Pre-B cells, from old compared to young mice. However, there was no difference in the lev...

journal_title：Cellular immunology

authors： Szabo P,Shen S,Telford W,Weksler ME

更新日期：2003-03-01 00:00:00

abstract：:Tiazofurin treatment of K562 leukemia cells in vitro depletes the metabolites of the guanylate biosynthetic pathway, inducing erythroid differentiation, that, in turn, alters the phenotypic profile. As a consequence, K562 cells possibly modify their interaction with immune cells. Here we describe the binding and killi...

journal_title：Cellular immunology

authors： Zamai L,Zauli G,Bavelloni A,Marmiroli S,Cataldi A,Weber G,Vitale M

更新日期：1995-08-01 00:00:00

abstract：:Inflammatory leukocytes of DA-to-WF rat renal allografts displayed significant cytolytic activity to natural killer (NK) target cells on Day 2 after transplantation. The NK activity, which was associated with large granular lymphocytes in discontinuous Percoll gradients, peaked on Day 4 and disappeared rapidly thereaf...

journal_title：Cellular immunology

authors： Nemlander A,Soots A,Häyry P

更新日期：1984-12-01 00:00:00

abstract：:The nonspecific suppression of immunological responses that is generated within host popliteal lymph nodes upon exposure to syngeneic normal spleen cells has been examined. The suppression, which had previously been described as being capable of preventing initiation of cytotoxic T lymphocytes (CTLs) to hapten-altered...

journal_title：Cellular immunology

authors： Emara M,Battisto JR

更新日期：1987-03-01 00:00:00

abstract：:We evaluated the effects of the immunosuppressants cyclosporin A (CsA) and FK506 on the synthesis of nitric oxide (NO) induced by bacterial lipopolysaccharide (LPS) in J774 macrophages. CsA and FK506 each inhibited NO production by LPS in a concentration-dependent fashion, but the cytotoxicity was also evident at high...

journal_title：Cellular immunology

authors： Hattori Y,Nakanishi N

更新日期：1995-10-01 00:00:00

abstract：:Immunosuppression is a well-established risk factor for Visceral Leishmaniasis. Post-immunosuppression leishmaniasis is characterized by an increase of parasite burden, hematopoietic disorders and unusual clinical manifestations. Although there are many reports on bone marrow findings in VL, less is known about the re...

journal_title：Cellular immunology

authors： Carvalho-Gontijo R,Moreira DR,Resende M,Costa-Silva MF,Peruhype-Magalhães V,Ribeiro CMF,Ribeiro DD,Silvestre R,Cordeiro-da-Silva A,Martins-Filho OA,Teixeira-Carvalho A

更新日期：2018-04-01 00:00:00

abstract：:IgA nephropathy (IgAN) is a tonsil-related disease. We previously showed that oligodeoxynucleotides with CpG (CpG-ODN) and B-cell activation factor (BAFF) are involved in hyperproduction of IgA from tonsillar mononuclear cells of patients with IgAN (IgAN-TMCs). In this study, we focused on a proliferation-inducing lig...

journal_title：Cellular immunology

authors： Takahara M,Nagato T,Nozaki Y,Kumai T,Katada A,Hayashi T,Harabuchi Y

更新日期：2019-07-01 00:00:00

abstract：:PHA stimulation of both freshly isolated and IL-2-dependent cultured T cells induced a rapid rise in intracytoplasmic calcium concentration. Chelation of extracellular calcium with EGTA resulted in a failure of PHA to induce a rise in intracytoplasmic calcium, resulting in the fresh T cells in an inhibition of IL-2 pr...

journal_title：Cellular immunology

authors： Watman NP,Crespo L,Davis B,Poiesz BJ,Zamkoff KW

更新日期：1988-01-01 00:00:00

abstract：:Aging leads to an increase in the proportion of cells that have the surface phenotype (CD45RBlo, CD44hi) characteristic of memory T lymphocytes and also to a decline in both the production of IL-2 and the response to this lymphokine. Several groups have reported an increase, with age, in the secretion of IL-4 in short...

journal_title：Cellular immunology

authors： Li SP,Miller RA

更新日期：1993-10-01 00:00:00

abstract：:Serum of an autoimmune MRL/Mp-lpr/lpr (MRL/l) mouse supported the proliferation of interleukin 3 (IL-3)-dependent cell line, FDC-P2. This IL-3-like activity initially appeared at 1 month of age and increased with age. Females showed higher titers than did males. MRL/Mp-+/+ mouse sera also exhibited such activity, thou...

journal_title：Cellular immunology

authors： Tasaka K,Sakihama T,Shirakura-Shibata Y,Matsuda S,Nakajima Y

更新日期：1989-07-01 00:00:00

abstract：:Because of the massive cytokine response elicited by superantigen exposure, it has been suggested that superantigens may act as adjuvants to boost conventional antigen responses. However, most previous studies have shown that in vivo exposure to superantigen suppressed subsequent T cell responses. Here we analyzed the...

journal_title：Cellular immunology

authors： Wen R,Surman S,Blackman MA,Woodland DL

更新日期：1997-03-15 00:00:00