Abstract:
:Within lymphopenic recipients, naïve T cells undergo proliferation that is induced by homeostatic mechanisms. Earlier studies have demonstrated that commensal antigens play a key role in inducing the proliferation. However, a relative contribution of endogenous self antigens in this process has not been formally investigated. In this study, we utilized a pharmacologic inhibitor that blocks T cell egress from the lymphoid tissues, antibiotics, and germ-free animals to examine the role of commensal and self antigens. The results suggest that T cell proliferation under lymphopenic conditions is a heterogeneous process triggered by both exogenous commensal and endogenous self antigens.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Do JS,Foucras G,Kamada N,Schenk AF,Shaw M,Nuñez G,Paul WE,Min Bdoi
10.1016/j.cellimm.2011.11.002subject
Has Abstractpub_date
2012-01-01 00:00:00pages
117-23issue
2eissn
0008-8749issn
1090-2163pii
S0008-8749(11)00296-6journal_volume
272pub_type
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journal_title:Cellular immunology
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journal_title:Cellular immunology
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journal_title:Cellular immunology
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