Differential endocytosis of IgM and IgD in murine B cell lines.

abstract：:Supplementation of the diet with fish oil (FO) decreases growth of the Walker 256 tumor and decreases the cachexia associated with tumor-bearing. The mechanisms by which FO inhibits tumor growth and cachexia are unknown. Macrophages are very important in host defence against tumors since they produce several anti-tumo...

journal_title：Cellular immunology

authors： Bonatto SJ,Folador A,Aikawa J,Yamazaki RK,Pizatto N,Oliveira HH,Vecchi R,Curi R,Calder PC,Fernandes LC

更新日期：2004-09-01 00:00:00

abstract：:Apolipoprotein E (apoE), a lipid transport protein important in cholesterol homeostasis, inhibits the proliferation of interleukin-dependent lymphocytes. Growth factor-responsive cells are blocked in the G1A phase of the cell cycle. Suppression by apoE is independent of growth factor, as evidenced by the fact that int...

journal_title：Cellular immunology

authors： Mistry MJ,Clay MA,Kelly ME,Steiner MA,Harmony JA

更新日期：1995-01-01 00:00:00

abstract：:Several lines of evidence suggest that nitric oxide (NO), generated through nitric oxide synthase (NOS) by cleavage of terminal guanidino nitrogen from L-arginine, mediates tumor cell killing by mononuclear phagocytes. Natural killer (NK) cells are cytotoxic effector cells that lyse a variety of tumor and virus-infect...

journal_title：Cellular immunology

authors： Cifone MG,Festuccia C,Cironi L,Cavallo G,Chessa MA,Pensa V,Tubaro E,Santoni A

更新日期：1994-08-01 00:00:00

abstract：:Study of primary immune responses in leprosy has been limited, since disease becomes manifest long after infection or is not detectable. To study primary immune responses, we immunized in vitro human peripheral blood mononuclear cells from unexposed individuals using phenolic glycolipid 1 (PGL-1), an important water-i...

journal_title：Cellular immunology

authors： Schauf V,Holobaugh P,Miller P,Mittal K

更新日期：1991-10-01 00:00:00

abstract：:In the search for its role in inflammatory joint diseases, soluble HLA-DR (sHLA-DR) was quantitated in 72 synovial fluids (SF) by a newly established immunoenzyme assay. Unlike other soluble receptors which accumulated only moderately (sCD25, sCD4) or negligibly (sHLA class I, sCD8) in the SF, SF sHLA-DR levels exceed...

journal_title：Cellular immunology

authors： Claus R,Bittorf T,Walzel H,Brock J,Uhde R,Meiske D,Schulz U,Hobusch D,Schumacher K,Witt M,Bartel F,Hausmann S

更新日期：2000-12-15 00:00:00

abstract：:The immediate effects and mechanisms of desensitization of contact sensitivity to 2,4-dinitro-1-fluorobenzene (DNFB) were investigated. Mice were sensitized with DNFB, desensitized with antigen 2 weeks later, and challenged 1 day after desensitization. Significant inhibition (approximately 50%) of contact sensitivity ...

journal_title：Cellular immunology

authors： Mekori YA,Claman HN

更新日期：1984-11-01 00:00:00

abstract：:Mice repeatedly immunized with the methanol extraction residue fraction of tubercle bacilli (MER) in incomplete Freund's adjuvant produced high titers of circulating antibodies against MER, as assessed by the enzyme-linked immunosorbent assay (ELISA) method. Spleen cells derived from these animals failed to respond to...

journal_title：Cellular immunology

authors： Halperin D,Reuben C,Ben-Efraim S,Grover N,Weiss DW

更新日期：1985-05-01 00:00:00

abstract：:Latex microspheres-based artificial antigen-presenting cell constructs (aAPCs) are proved to be valuable tools to expand T cells ex vivo for adoptive cell therapy, but little is known about their potential for active immunization. In this report, HLA-A2/peptide tetramers were generated and co-coated with anti-mouse CD...

journal_title：Cellular immunology

authors： Shen C,Zhang J,Xia L,Meng F,Xie W

更新日期：2007-05-01 00:00:00

abstract：:The purpose of this project was to characterize changes in murine T lymphocyte subpopulations during thymic atrophy induced by protein malnutrition and to determine the role of elevated serum corticosterone in this process. A suitable animal model was generated by placing mice on protein-sufficient (PS) and protein-de...

journal_title：Cellular immunology

authors： Barone KS,O'Brien PC,Stevenson JR

更新日期：1993-04-15 00:00:00

abstract：:Polyunsaturated fatty acid [omega-3 polyunsaturated fatty acids (omega-3PUFAs)] incorporation into cell membranes has been shown to have potent anti-inflammatory activity, though the mechanisms involved are only partially characterized. Here, we show that PUFA enrichment of T cell membranes decreased the overall expre...

journal_title：Cellular immunology

authors： Leid JG,Jutila MA

更新日期：2004-04-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis in the skin and internal organs. The pathogenesis of SSc is not completely understood until now. Recently, many studies have focused on the role of E3 ubiquitin ligases in organ fibrosis. However, the possible regulatory mechanisms of E3 ubiqu...

journal_title：Cellular immunology

authors： Huang XL,Zhang L,Duan Y,Wang YJ,Zhao JH,Wang J

更新日期：2016-08-01 00:00:00

abstract：:Hybrid human-murine major histocompatibility antigens have been constructed and expressed on the surface of both human RD and murine L cell lines after DNA mediated gene transfer. These antigens linked the polymorphic domains (alpha 1 and alpha 2) of H-2Kb and the carboxy-terminal domains (alpha 3, transmembrane, and ...

journal_title：Cellular immunology

authors： Maziarz RT,Burakoff SJ,Reiss CS

更新日期：1986-04-15 00:00:00

abstract：:We have studied the effects of prostaglandin E2 (PGE2) and cholera toxin, two modulators of adenylyl cyclase, and 8-bromo cAMP (8-BrcAMP) on various parameters of lymphocyte activation using the human T cell line Jurkat. Our results show that PGE2 and cholera toxin inhibit, in a dose-related manner, the phytohemagglut...

journal_title：Cellular immunology

authors： Bastin B,Payet MD,Dupuis G

更新日期：1990-07-01 00:00:00

abstract：:Mucus production by goblet cells in the gastrointestinal tract following Salmonella typhimurium infection using a ligated ileal loop model in mice was investigated. Assessment of the morphology of the loop tissue after Salmonella challenge revealed generalized tissue inflammation, characterized by edema and an inflamm...

journal_title：Cellular immunology

authors： Arnold JW,Klimpel GR,Niesel DW

更新日期：1993-10-15 00:00:00

abstract：:With DNA vaccines, it is important to monitor the movement of transfectants and to overcome immune deviations. We used a pCMV-LacZ plasmid (expressing β-galactosidase) and a pcDNA-hNIS plasmid (expressing the human sodium/iodide symporter [hNIS] gene) as non-secreted visual-imaging markers. Transfectants carrying the ...

journal_title：Cellular immunology

authors： Son HY,Apostolopoulos V,Chung JK,Kim CW,Park JU

更新日期：2018-07-01 00:00:00

abstract：:Previous investigations have demonstrated a strain-associated differential susceptibility to herpes simplex virus-1 (HSV-1) infection in mice; C57BL/6 mice are more resistant to infection than BALB/c mice. Despite considerable research dealing with the immune response to HSV-1, relatively little attention has been pai...

journal_title：Cellular immunology

authors： Brenner GJ,Cohen N,Moynihan JA

更新日期：1994-09-01 00:00:00

abstract：:We evaluated the role of molecules of the major histocompatibility complex (MHC) involved in the cellular interactions of two T-cell clones by testing the effect of monoclonal antibodies on the responses of the clones in vitro. The two T-cell clones used in the study are specific for minor histocompatibility antigens ...

journal_title：Cellular immunology

authors： Brückner T,Di Pauli R

更新日期：1986-04-15 00:00:00

abstract：:Upregulation of immunoglobulin D-specific receptors (IgD-R) on CD4+ T cells may facilitate their interaction with specific carbohydrate moieties uniquely associated with membrane IgD on B cells. Previous studies have shown that upregulation of IgD-R facilitates cognate T-B cell interactions by mediating bidirectional ...

journal_title：Cellular immunology

authors： Lakshmi Tamma SM,Wu Y,Toporovsky I,Lima V,Coico RF

更新日期：2001-02-01 00:00:00

abstract：:FOXP3+ regulatory T cells (Tregs) constitute a critical barrier that enforces tolerance to both the self-peptidome and the extended-self peptidome to ensure tissue-specific resistance to autoimmune, allergic, and other inflammatory disorders. Here, we review intuitive models regarding how T cell antigen receptor (TCR)...

journal_title：Cellular immunology

authors： Mannie MD,DeOca KB,Bastian AG,Moorman CD

更新日期：2020-09-01 00:00:00

abstract：:The systemic adoptive transfer of activated T cells, derived from tumor-draining lymph nodes (LNs), mediates the regression of established tumors. In this study, the requirement of cell adhesion molecules, CD11a/CD18 (LFA-1), CD54 (ICAM-1), CD49d/CD29 (VLA-4), and CD106 (VCAM-1), for T cell infiltration into tumors an...

journal_title：Cellular immunology

authors： Mukai S,Kagamu H,Shu S,Plautz GE

更新日期：1999-03-15 00:00:00

abstract：:Spleen cells from normal, nonautoimmune mice (C3H/HeN) spontaneously produce hemolytic plaques against autologous bromelain-treated red blood cells (BrMRBC). The number of anti-BrMRBC plaques detectable can be increased by including either a 3 M KCl extracted antigen from BrMRBCs or the hapten phosphorylcholine chlori...

journal_title：Cellular immunology

authors： Wieties KM,Moticka EJ

更新日期：1986-03-01 00:00:00

abstract：:We have recently established a new animal model for primary Sjögren's syndrome in NFS/sld mutant mice thymectomized 3 days after birth (3dTX) bearing an autosomal recessive gene with sublingual gland differentiation arrest. In this study, we analyze developing mechanisms of experimental autoimmune sialadenitis (EAS) i...

journal_title：Cellular immunology

authors： Hayashi Y,Haneji N,Hamano H,Yanagi K,Takahashi M,Ishimaru N

更新日期：1996-08-01 00:00:00

abstract：:The role of lymphostromal complexes in T-cell differentiation is far from elucidated, mainly because a clear association of a particular stromal cell type with a distinct thymocyte subset has never been identified. Using an in vitro system, detecting the adherence of thymocytes to a thymic medullary epithelial cell li...

journal_title：Cellular immunology

authors： Hugo P,Potworowski EF

更新日期：1990-03-01 00:00:00

abstract：:We investigated whether sn-1,2-dioctanoylglycerol (diC8) activates highly purified human T cells. diC8's signaling activity was also compared with that of 12-O-tetradecanoylphorbol-13-acetate (TPA). diC8 and ionomycin were synergistic in promoting T-cell proliferation. The proliferative response was dependent upon an ...

journal_title：Cellular immunology

authors： Subramaniam A,Sehajpal P,Murthi VK,Stenzel KH,Suthanthiran M

更新日期：1988-10-15 00:00:00

abstract：:CD8+ T cell differentiation is controlled by the transcription factors T-bet and Eomesodermin, in concert with the cytokines IL-2, IL-10 and IL-12. Among these pathways, the mechanisms by which T-box proteins and IL-10 interact to promote a memory T cell fate remain poorly understood. Here, we show that Eomes and IL-1...

journal_title：Cellular immunology

authors： Reiser J,Sadashivaiah K,Furusawa A,Banerjee A,Singh N

更新日期：2019-01-01 00:00:00

abstract：:CD48, the murine homolog of human CD58, binds to CD2 in rats and mice. Whereas inhibition of CD2 signaling leads to profound immunosuppression, no information is available on CD48-targeted therapy in the rat. We could show that anti-CD2 treatment (OX34) efficiently inhibited TCR-driven as well as CD2-mediated prolifer...

journal_title：Cellular immunology

authors： Sido B,Otto G,Zimmermann R,Müller P,Meuer SC,Dengler TJ

更新日期：1997-11-25 00:00:00

abstract：:We investigated the influence of Panagen DNA preparations on laboratory animals and IFN-induced human dendritic cells, as well as analyzed the data from a phase II clinical trial in the therapy of breast cancer. It was shown that this treatment resulted in increased number of CD8+/perforin+ T cells in peripheral lymph...

journal_title：Cellular immunology

authors： Alyamkina EA,Leplina OY,Ostanin AA,Chernykh ER,Nikolin VP,Popova NA,Proskurina AS,Gvozdeva TS,Dolgova EV,Orishchenko KE,Rogachev VA,Sidorov SV,Varaksin NA,Ryabicheva TG,Bogachev SS,Shurdov MA

更新日期：2012-03-01 00:00:00

abstract：:With old age (∼2y old), mice show substantial differences in B cell composition within the lymphoid tissues. In particular, a novel subset of IgM+ CD21/35lo/- CD23- mature B cells, the age-associated B cells or ABC, increases numerically and proportionately. This occurs at the expense of other B cell subsets, includin...

journal_title：Cellular immunology

authors： Riley RL,Khomtchouk K,Blomberg BB

更新日期：2017-11-01 00:00:00

abstract：:Activin A is a multifunctional factor of the transforming growth factor-beta (TGF-beta) superfamily and acts as an anti-inflammatory cytokine produced by microglia and macrophages. In this study, we investigated the regulatory effect and possible mechanism of activin A on activation of lipopolysaccharide (LPS)-induced...

journal_title：Cellular immunology

authors： Zhou J,Tai G,Liu H,Ge J,Feng Y,Chen F,Yu F,Liu Z

更新日期：2009-01-01 00:00:00

abstract：:Cytokines are soluble proteins that mediate immune reactions and are responsible for communication among immune cells. CD4(+) T cells are the principle sources of cytokines of adaptive immunity. Cytokines play critical roles in the differentiation and effector function of CD4(+) T cells. They also play key roles in di...

journal_title：Cellular immunology

authors： Guo X,Zhang Y,Wang P,Li T,Fu W,Mo X,Shi T,Zhang Z,Chen Y,Ma D,Han W

更新日期：2012-07-01 00:00:00