Effects of human exogenous DNA on production of perforin-containing CD8+ cytotoxic lymphocytes in laboratory setting and clinical practice.

abstract：:The cell-averaged microviscosity of intact murine peritoneal mononuclear phagocytes in various stages of activation was assessed by quantifying fluorescent depolarization of 1,6-diphenyl-1,3,5-hexatriene. Macrophages activated in vivo with Mycobacterium bovis, strain BCG, were significantly more fluid than resident pe...

journal_title：Cellular immunology

authors： Somers SD,Yuli I,Snyderman R,Adams DO

更新日期：1987-02-01 00:00:00

abstract：:Idiotope-specific immunoenhancement or suppression was induced in C57BL/6 mice by the injection of physiological amounts (100 ng-10 micrograms) of monoclonal anti-idiotope antibody. As previously described, nanogram doses enhanced idiotope expression while a 10-micrograms dose of anti-idiotope antibody induced the act...

journal_title：Cellular immunology

authors： Kelsoe G

更新日期：1986-03-01 00:00:00

abstract：:Seeking common abnormalities in mice genetically predisposed to lupus-like autoimmune disease, we investigated (1) the ontogeny of Ia antigens (I-A/I-E) on the surfaces of resident peritoneal macrophages (rpM phi) of lupus and normal mice, (2) spontaneous and lectin-induced in vitro production of M phi-stimulating fac...

journal_title：Cellular immunology

authors： Kofler R,Schreiber RD,Dixon FJ,Theofilopoulos AN

更新日期：1984-08-01 00:00:00

abstract：:Oxidants, heavy metals, and heat shock, collectively known as stress stimuli, induce the synthesis of a variety of proteins, termed stress proteins, and enhance glucose uptake. In this study, we have demonstrated that stress stimuli enhance protein tyrosine phosphorylation (PTyr-P), modulate protein tyrosine phosphata...

journal_title：Cellular immunology

authors： Lander HM,Levine DM,Novogrodsky A

更新日期：1992-11-01 00:00:00

abstract：:Autoimmune regulator (Aire) is a transcriptional activator that regulates the ectopic expression of many tissue-restricted antigens in medullary thymic epithelial cells, and that has an important role in the negative selection of autoreactive T cells. However, the roles of Aire expression in peripheral lymphoid tissue...

journal_title：Cellular immunology

authors： Zhu W,Yang W,He Z,Liao X,Wu J,Sun J,Yang Y,Li Y

更新日期：2011-01-01 00:00:00

abstract：:Toll-like receptor (TLR) 2/1 signalling is linked to autophagy through transcriptional actions of the 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-vitamin D receptor (VDR) complex. Population-specific effects have been reported for TLR2/1-VDR signalling. We hypothesized that population effects extend to autophagy and are in...

journal_title：Cellular immunology

authors： Abhimanyu,Meyer V,Jones BR,Bornman L

更新日期：2020-06-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are promising candidates for developing cell therapies for intractable diseases. To assess the feasibility of transplantation with human umbilical cord blood (hUCB)-derived MSCs, we analyzed the ability of these cells to function as alloantigen-presenting cells (APC) in vitro. hUCB-MSC...

journal_title：Cellular immunology

authors： Oh W,Kim DS,Yang YS,Lee JK

更新日期：2008-02-01 00:00:00

abstract：:Many studies have shown that tumor necrosis factor (TNF) is a potent soluble mediator of immunoregulation and inflammation. Neuropeptide substance P (SP) has been known to exert significant influence on production of certain inflammatory cytokine by immune cells. Immunopathogenic mechanism underlying the effect of neu...

journal_title：Cellular immunology

authors： Nair MP,Schwartz SA

更新日期：1995-12-01 00:00:00

abstract：:Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide induced diabetic r...

journal_title：Cellular immunology

authors： Mojani MS,Sarmadi VH,Vellasamy S,Sandrasaigaran P,Rahmat A,Peng LS,Ramasamy R

更新日期：2014-05-01 00:00:00

abstract：:As an atypical guanine nucleotide exchange factor (GEF), Dock5 has been extensively studied in cellular functions. However, the role of Dock5 on B-cell immunity still remain elusive. In this study, we generated a Dock5 knockout mouse model to study the effect of Dock5 deficiency on B cell development, differentiation ...

journal_title：Cellular immunology

authors： Chen A,Yang D,Xuan X,Miller H,Luo X,Yu J,Yang G,Wang H,Liu C

更新日期：2019-03-01 00:00:00

abstract：:The pre-B cell stage of B lymphocyte development is characterized by the presence of immunoglobulin heavy chains of the IgM isotype in the cytoplasm and no other heavy or light chains in the cytoplasm or on the surface. We established several cell lines that were identical in their serologically defined pre-B cell phe...

journal_title：Cellular immunology

authors： Griffin JA,Spalding DM

更新日期：1989-04-01 00:00:00

abstract：:OVA-specific T cells were immortalized by infection with radiation leukemia virus (RadLV). Some clones derived from such population were shown to exhibit helper activity. We then tested clones without such function and found among them some that secreted macrophage migration inhibition factor (MIF) and leukocyte migra...

journal_title：Cellular immunology

authors： Szigeti R,Kagan-Haion K,Klein E,Ben-Sasson SZ

更新日期：1986-10-01 00:00:00

abstract：:An Affymetrix mouse genome array and differential in-gel electrophoresis (DIGE) techniques were used to investigate the pharmacological mechanisms of a mixture of herbs, designated CTCM, a compound of traditional Chinese medicine, for the treatment of increased permeability in mouse intestinal microvascular endothelia...

journal_title：Cellular immunology

authors： Yi P,Guo Y,Wang X,Mu X,Wei X

更新日期：2010-01-01 00:00:00

abstract：:The recombinant retrovirus J2, which contains the v-raf/mil and v-myc oncogenes, was used to immortalize mouse splenic macrophages that had been cloned in soft agar. When added to freshly harvested colonies, J2 failed to yield cell lines but it immortalized up to 30% of the clones if they had been maintained for at le...

journal_title：Cellular immunology

authors： Roberson SM,Walker WS

更新日期：1988-10-15 00:00:00

abstract：:Poxviruses are a large, complex group of highly successful pathogens that cause disease in humans and other animals. They encode several proteins postulated to be involved in the evasion of host immunity and therefore serve as excellent models for understanding virus-host interaction during the early stages of viral i...

journal_title：Cellular immunology

authors： Miller CG,Justus DE,Jayaraman S,Kotwal GJ

更新日期：1995-05-01 00:00:00

abstract：:One of the auto-antigens aberrantly targeted in Multiple sclerosis is myelin basic protein (MBP). In this study, chronic progressive multiple sclerosis (CPMS) patients receiving the experimental drug MBP8298, on a compassionate care trial, were examined before and after high dose peptide treatment for their circulatin...

journal_title：Cellular immunology

authors： Loo EW,Krantz MJ,Agrawal B

更新日期：2012-11-01 00:00:00

abstract：:Development of contact hypersensitivity in mice depends on the migration of Langerhans cells from the epidermis to regional lymph nodes. Since ICAM-1 and LFA-1 play important roles in leukocyte migration, we sought to determine whether in vivo administration of anti-ICAM-1 and anti-LFA-1 antibodies would inhibit conta...

journal_title：Cellular immunology

authors： Ma J,Wang JH,Guo YJ,Sy MS,Bigby M

更新日期：1994-10-15 00:00:00

abstract：:The mechanism underlying the apparent differences in the capacity of murine and human class I MHC molecules to function as signal transducing structures in T cells was examined. Cross-linking murine class I MHC molecules on splenic T cells did not stimulate an increase in intracellular calcium ([Ca2+]i) and failed to ...

journal_title：Cellular immunology

authors： Gur H,Wacholtz MC,Lie WR,Lipsky PE,Geppert TD

更新日期：1992-10-15 00:00:00

abstract：:We have investigated the ability of interleukin-10 (IL-10) to modulate murine intrathymic T cell differentiation using a fetal thymic organ culture (FTOC) model. Addition of as little as 11 ng of recombinant murine IL-10 (mIL-10) per day produced a significant increase in the proportion and number of gamma delta-TCR+ ...

journal_title：Cellular immunology

authors： Fine JS,Macosko HD,Grace MJ,Narula SK

更新日期：1994-04-15 00:00:00

abstract：:CCR5 is a chemokine receptor expressed by T cells and macrophages, which also functions as the principal coreceptor for macrophage (M)-tropic HIV-1 strains to enter the host cells. In this study, we aim to better understand the ligand-binding profiles of CCR5 and the chemokine-receptor usage on leukocyte cells. We fou...

journal_title：Cellular immunology

authors： Ruffing N,Sullivan N,Sharmeen L,Sodroski J,Wu L

更新日期：1998-11-01 00:00:00

abstract：:We have established a long-lasting heart allograft tolerance in H-2-incompatible combinations by intravenous injection of 10(8) allogeneic spleen cells followed by the administration of 200 mg/kg of cyclophosphamide (CP). When C57BL/10 mice (B10, H-2b) were primed iv with 1 x 10(8) viable spleen cells from naive BALB/...

journal_title：Cellular immunology

authors： Matsuura A,Katsuno M,Suzuki Y,Ito T,Yasuura K,Abe T,Yoshikai Y

更新日期：1994-05-01 00:00:00

abstract：:Staphylococcal enterotoxin B (SEB) is a potent polyclonal activator of both human and murine T cells. We previously reported data which show that SEB-induced T cells suppress antibody secretion by various mouse plasmacytoma cell lines. This suppression of antibody secretion was found to be both idiotype and isotype no...

journal_title：Cellular immunology

authors： Newcomb JR,Lin YS,Rogers TJ

更新日期：1990-09-01 00:00:00

abstract：:Dexamethasone is a potent anti-inflammatory and immunosupressive agent that has complex, yet incompletely defined, effects on the immune response. Here, we explored the effect of dexamethasone on the expression of TCR zeta chain and TCR/CD3-induced early signaling events in human T lymphocytes. Immunoblotting studies ...

journal_title：Cellular immunology

authors： Nambiar MP,Enyedy EJ,Fisher CU,Warke VG,Juang YT,Tsokos GC

更新日期：2001-02-25 00:00:00

abstract：:Thirty-two cord blood samples taken after caesarean section or vaginal delivery and concurrent venous blood samples obtained from normal adult controls were evaluated using monoclonal antibodies. The percentage of circulating pan-T-cell+ lymphocytes was significantly lower in cord blood (46%) compared with adult contr...

journal_title：Cellular immunology

authors： Solinger AM

更新日期：1985-04-15 00:00:00

abstract：:Vibrio vulnificus, a pathogenic bacterium causing primary septicemia, exhibited cytotoxicity towards Jurkat cells of T-lymphocytes through intracellular reactive oxygen species (ROS) production. Pretreatment of Jurkat T-cells with diphenyleneiodonium chloride (DPI) abolished V. vulnificus-induced ROS generation and ba...

journal_title：Cellular immunology

authors： Kim WH,Goo SY,Shin MH,Chun SJ,Lee H,Lee KH,Park SJ

更新日期：2008-05-01 00:00:00

abstract：:It has been reported that granulocyte/macrophage colony-stimulating factor (GM-CSF), one of the hemopoietic growth factors which regulates the function of phagocytic cells, is a potent activator of cultured macrophages and induces antimicrobial activities as well as differentiation of precursor cells. In this study, w...

journal_title：Cellular immunology

authors： Yamamoto Y,Klein TW,Tomioka M,Friedman H

更新日期：1997-02-25 00:00:00

abstract：:The primary objective of this study was to determine whether the n-3 PUFA-mediated changes in host response to a Listeria monocytogenes infection (e.g., cytokine production and bacterial clearance) were dependent upon neutrophils. Balb/c mice were fed one of two semi-purified diets that contained either 0 or 41 g of n...

journal_title：Cellular immunology

authors： Fritsche K,Irons R,Pompos L,Janes J,Zheng Z,Brown C

更新日期：2005-05-01 00:00:00

abstract：:IL-5 is a pleiotropic cytokine that promotes eosinophil differentiation and survival. While naïve bronchial epithelial cells (BEC) produce low levels of IL-5, the role of BEC-derived IL-5 in allergic airway inflammation is unknown. We now show that BEC, isolated from mice with OVA-induced allergic airway disease (AAD)...

journal_title：Cellular immunology

authors： Wu CA,Peluso JJ,Zhu L,Lingenheld EG,Walker ST,Puddington L

更新日期：2010-01-01 00:00:00

abstract：:Intercellular adhesion molecule (ICAM)-1, or CD54, is a member of the immunoglobulin superfamily that binds to lymphocyte function-associated antigen-1 and macrophage-1 antigen. ICAM-1:LFA-1/Mac-1 interaction may be involved in both activation and extravasation of leukocytes. To determine the roles of ICAM-1 in the de...

journal_title：Cellular immunology

authors： Samoilova EB,Horton JL,Chen Y

更新日期：1998-11-25 00:00:00

abstract：:Our earlier studies revealed that a rapid and progressive loss of splenic NK activity in mice during the development of a number of transplanted tumors as well as of spontaneous tumors was due to an inactivation of natural killer (NK) lineage cells rather than to their disappearance. The mechanism of this inactivation...

journal_title：Cellular immunology

authors： Parhar RS,Lala PK

更新日期：1985-07-01 00:00:00