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Viral-restricted cytolytic T lymphocyte recognition of hybrid human-murine class I histocompatibility antigens.

Abstract：

:Hybrid human-murine major histocompatibility antigens have been constructed and expressed on the surface of both human RD and murine L cell lines after DNA mediated gene transfer. These antigens linked the polymorphic domains (alpha 1 and alpha 2) of H-2Kb and the carboxy-terminal domains (alpha 3, transmembrane, and intracellular) of HLA-A2. Previously we demonstrated that these antigens were serologically intact and were recognized by allospecific cytolytic T lymphocytes. However, the cell lines expressing the hybrid antigen were less well lysed than the native H-2Kb expressing cell lines. In this study, we extend these observations and demonstrate that virally restricted cytolytic T lymphocytes specific for vesicular stomatitis virus and for Sendai virus can recognize cell lines expressing the hybrid antigen, whether expressed on murine (L cell) or human (RD cell) lines. Furthermore, the data show a profound influence by the carboxy-terminal domains upon the polymorphic T-cell restricting epitopes.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Maziarz RT,Burakoff SJ,Reiss CS

doi

10.1016/0008-8749(86)90235-2

subject

Has Abstract

pub_date

1986-04-15 00:00:00

pages

279-86

issue

1

eissn

0008-8749

issn

1090-2163

pii

0008-8749(86)90235-2

journal_volume

99

pub_type

杂志文章

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