Abstract：
:Because of the massive cytokine response elicited by superantigen exposure, it has been suggested that superantigens may act as adjuvants to boost conventional antigen responses. However, most previous studies have shown that in vivo exposure to superantigen suppressed subsequent T cell responses. Here we analyzed the effect of the superantigen Staphylococcal enterotoxin B (SEB) on a concurrent CD4(+) immune response to a conventional antigen, an I-Ab-restricted epitope derived from the same protein (SEB127-142). Heat-inactivated SEB, which had lost all superantigenic activity, was capable of eliciting a strong CD4(+) proliferative T cell response to SEB127-142. In contrast, native SEB was relatively nonimmunogenic, even when administered in association with complete Freund's adjuvant. High doses of native SEB coadministered with heat-inactivated SEB had no effect on the peptide response. However, low doses of native SEB were able to strongly enhance the ability of inactive SEB to prime CD4(+) T cells to SEB127-142. Thus, SEB is not always immunosuppressive, and low doses may actually enhance a concurrent immune response. Also, the contribution of Vbeta8(+)/CD4(+) T cells to peptide reactivity was not affected by the presence of low doses of native SEB, suggesting that the enhanced reactivity was not a Vbeta-specific effect of SEB, but was cytokine-mediated.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Wen R,Surman S,Blackman MA,Woodland DLdoi
10.1006/cimm.1996.1077subject
Has Abstractpub_date
1997-03-15 00:00:00pages
166-72issue
2eissn
0008-8749issn
1090-2163pii
S0008-8749(96)91077-1journal_volume
176pub_type
杂志文章abstract：:The effects of mAb therapy to CD4 or CD8 on induction of unresponsiveness to Heymann's nephritis by preimmunization with renal tubular antigen in IFA. Anti-CD4 mAbs (MRC Ox35) given for 2 weeks after RTA/IFA completely prevented the induction of resistance to HN, all rats developing proteinuria as well as high titers ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(91)90118-u
更新日期：1991-04-01 00:00:00
abstract：:Bcl-2 proto-oncogene is expressed in normal lymphoid tissues and its role has been suggested to involve the selection of B and T cells. Here we report three-color flow cytometric studies on the expression of bcl-2 protein in the thymus and periphery. Bcl-2 was expressed in the majority of T and B cells and down-regula...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1127
更新日期：1994-05-01 00:00:00
abstract：:Older humans and experimental animals have been repeatedly found to have higher titers of autoantibodies than do younger individuals despite the impaired responses of older individuals to foreign antigens. The studies reported here were designed to examine the relationship between these two age-related changes in anti...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(91)90294-l
更新日期：1991-07-01 00:00:00
abstract：:T helper cells reactive to myelin basic protein are clearly implicated in the pathogenesis of murine EAE. We have developed a T cell line, BML-1 that (1) is reactive to the encephalitogenic amino terminal nonapeptide (1-9NAC) of MBP, (2) is I-Au restricted, and (3) induces relapsing EAE in B10.PL (H-2u) mice. Measurem...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90117-2
更新日期：1989-11-01 00:00:00
abstract：:Nontypeable Haemophilus influenzae (NTHi) is the etiological agent most frequently associated with bacterial exacerbations of chronic obstructive pulmonary disease (COPD). The present work shows that NTHi strains induced in primary normal human bronchial epithelial cells (NHBE) a cytokine/chemokine response in which C...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2009.09.008
更新日期：2010-01-01 00:00:00
abstract：:MicroRNAs (miRNAs) are aberrant in many human tumors which can be transferred to immune cells by tumor-derived exosomes. Dendritic cells (DCs) play an important role in activation of immune response. However, the effect of tumor-derived exosomes on toll-like receptor (TLR) in DCs remains unclear. We investigated the i...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2014.09.004
更新日期：2014-11-01 00:00:00
abstract：:Oral administration of protein antigens, such as ovalbumin, may result in induction of either tolerance or immunization. To avoid oral tolerance, there are new strategies to protect the antigens from degradation within the gastrointestinal tract and to allow them to reach inductive immunological sites. One such strate...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2008.07.001
更新日期：2008-01-01 00:00:00
abstract：:In vitro ultraviolet-B (UVB) irradiation of murine and rodent bone marrow cells prevents GVHD without compromising engraftment while inducing tolerance to donor-type allografts. In anticipation of clinical trials of UVB-modified bone marrow grafts, we studied the in vitro effects of UVB irradiation (50-300 J/m2) on hu...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1995.1202
更新日期：1995-10-15 00:00:00
abstract：:Previous work in our laboratory established that individual complement components can be regulated in vivo by administration of specific antibody or immunocompetent cells to newborns and in vitro by administration of specific antibody to cultured peritoneal macrophages or splenic fragments. Antibody-induced suppressio...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(85)90337-5
更新日期：1985-11-01 00:00:00
abstract：:Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) can be adoptively transferred using myelin basic protein (BP)-specific helper T cell lines, and suppressor cells may be important in recovery from EAE. In order to generate suppressor cells, spleen cells obtained from BP-complete Freund's adjuvant (CFA...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90322-i
更新日期：1990-04-01 00:00:00
abstract：:The 4F2 antigenic complex is expressed on most human cell lines in culture, on monocytes and activated lymphocytes, but not on resting T and B lymphocytes. Monoclonal antibody (mAb) CB43 recognizes an epitope of the 4F2 heterodimer either located on the light chain or dependent on the conformation of the molecule. The...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(91)90395-r
更新日期：1991-08-01 00:00:00
abstract：:Avirulent clones of Leishmania braziliensis were produced by treatment of parental parasite stock with the mutagen N-methyl-N'-methyl-N'-nitro-N-nitrosoguanidine and selection for growth at 19 degrees C. These clones have a clear preference for infection and growth in vitro at 19 degrees C rather than the normal 28 de...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(85)90081-4
更新日期：1985-08-01 00:00:00
abstract：:The cellular requirements for the in vitro induction of antigen-specific suppressor T cells were examined. Previous reports indicated that Ia-bearing macrophages and anti-idiotypic B cells are required as accessory cells to facilitate the generation of suppressor effector (TS3) cells which regulate the response to the...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90242-0
更新日期：1988-10-15 00:00:00
abstract：:We tested the impact of interleukin-12 (IL-12) and of cytotoxic leukocytes (particularly natural killer (NK) cells) from normal and HIV-1-infected subjects on lysis of human monocytes infected with Mycobacterium tuberculosis. Nylon wool nonadherent cells stimulated with interleukin-2 (IL-2) or with IL-12 developed sig...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1196
更新日期：1994-07-01 00:00:00
abstract：:Chitin oligosaccharides (NA-COS) of two different molecular weight ranges (below 1 and 1-3 kDa) were examined for their capabilities against lipopolysaccharide-induced inflammatory responses in BV-2 murine microglia. It was found that NA-COS reduced the level of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) produc...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2012.06.005
更新日期：2012-05-01 00:00:00
abstract：:The Interferon-inducible gene IFI16, a member of the HIN200 family, is activated by oxidative stress and cell density, in addition to Interferons, and it is implicated in the regulation of endothelial cell proliferation and vessel formation in vitro. We have previously shown that IFI16 is required for proinflammatory ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2009.02.007
更新日期：2009-01-01 00:00:00
abstract：:The kinetic and the H-2 requirements for the induction of nucleoside-specific suppression were examined in several strains of mice; specifically, whether adenosine (A)-coupled spleen cells given intravenously suppress the primary response to adenosine-KLH. The adenosine system was chosen because C57Bl/6 mice were orig...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(83)90333-7
更新日期：1983-02-01 00:00:00
abstract：:PHA stimulation of both freshly isolated and IL-2-dependent cultured T cells induced a rapid rise in intracytoplasmic calcium concentration. Chelation of extracellular calcium with EGTA resulted in a failure of PHA to induce a rise in intracytoplasmic calcium, resulting in the fresh T cells in an inhibition of IL-2 pr...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90060-3
更新日期：1988-01-01 00:00:00
abstract：:We investigated the cellular induction mechanism of antigen-nonspecific CD8+ T suppressor cells which suppressed delayed-type hypersensitivity to sheep red blood cells, by treating BALB/c mice with 7,12-dimethylbenz[a]anthracene (DMBA), a tumor initiator, and 12-O-tetradecanoylphorbol 13-acetate (TPA), a tumor promote...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0029
更新日期：1996-02-01 00:00:00
abstract：:Class I antigens are necessary for the recognition of tumor cells by cytotoxic T lymphocytes (CTL). The line 1 lung carcinoma is a spontaneous murine tumor deficient in class I antigen expression. Consistent with this, line 1 cells are highly metastatic in vivo. We investigated whether increasing class I antigen expre...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90134-d
更新日期：1990-05-01 00:00:00
abstract：:The regulation of the migratory capacity of Percoll-purified large granular lymphocytes (LGL) into nitrocellulose filters was studied in a 2-hr assay with the use of modified Boyden chambers. Compounds that stimulate the natural killer cytotoxic function of LGL, such as interferons (natural beta, recombinant alpha A, ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(86)90198-x
更新日期：1986-08-01 00:00:00
abstract：:Lung cancer cells harboring multiple mutations as a consequence of long-term damage by different etiologic factors are responsible for high immunogenicity. Immune checkpoint inhibitors significantly improve treatment results in non-small cell lung cancer (NSCLC). Unfortunately, the role of T-lymphocytes in early NSCLC...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2017.09.007
更新日期：2017-12-01 00:00:00
abstract：:In this study we investigated whether T cells expressing high or low levels of CD62L were differentially susceptible to the T cell chemokine lymphotactin. We found that lymphotactin induced preferential migration of antigen-specific (CD62L(lo)) T cells over the nonspecific (CD62L(hi)) T cells in vitro and in vivo. The...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.2001.1790
更新日期：2001-05-01 00:00:00
abstract：:Stroke is the leading cause of disability in the United States. Sex differences, including smaller infarcts in females and greater involvement of immune-mediated inflammation in males may affect the efficacy of immune-modulating interventions. To address these differences, we sought to identify distinct stroke-modifyi...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2017.06.003
更新日期：2017-08-01 00:00:00
abstract：:Cells from the spleen, lymph nodes, and peritoneum of DBA/2 mice bearing a subcutaneous tumor mediate nonspecific suppression of an in vitro antibody response to sheep red blood cells (SRBC) when cocultured with a normal T-cell subset(s). The spleen cells from the tumor-bearing mouse required for the suppression bear ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(83)90047-3
更新日期：1983-07-01 00:00:00
abstract：:Intravital imaging of cutaneous immune responses has revealed intricate links between the skin's structural properties, the immune cells that reside therein, and the carefully orchestrated migratory dynamics that enable rapid sensing and subsequent elimination of skin pathogens. In particular, the development of 2-pho...
journal_title：Cellular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.cellimm.2019.04.001
更新日期：2020-04-01 00:00:00
abstract：:Severe aplastic anemia (SAA) is a syndrome of severe bone marrow failure with high mortality. Our previous studies have demonstrated that both immature and activated DC1 increased in the bone marrow of SAA patients, and the balance of DC1 subsets shifted the stable form to active one, which might promote Th0 cells to ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2013.09.007
更新日期：2013-09-01 00:00:00
abstract：:In order to track hematopoetic cells of all lineages unambiguously at all stages of development, we have developed C57BL/6 mice that express a transgene coding for green fluorescent protein (GFP) under control of the human ubiquitin C promoter. These mice, called UBI-GFP/BL6, express GFP in all tissues examined, with ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.2001.1895
更新日期：2001-12-15 00:00:00
abstract：:CD40 and its ligand (CD40L) regulate several cellular functions, including T and B-cell activation. The soluble form of CD40 (sCD40) antagonizes CD40/CD40L interaction. Patients undergoing hemodialysis (HD) present elevated sCD40 serum levels, which underlying molecular mechanisms are unknown. We studied sCD40 serum a...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2012.06.007
更新日期：2012-07-01 00:00:00
abstract：:FOXP3+ regulatory T cells (Tregs) constitute a critical barrier that enforces tolerance to both the self-peptidome and the extended-self peptidome to ensure tissue-specific resistance to autoimmune, allergic, and other inflammatory disorders. Here, we review intuitive models regarding how T cell antigen receptor (TCR)...
journal_title：Cellular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.cellimm.2020.104173
更新日期：2020-09-01 00:00:00
