Abstract：
:Aging leads to an increase in the proportion of cells that have the surface phenotype (CD45RBlo, CD44hi) characteristic of memory T lymphocytes and also to a decline in both the production of IL-2 and the response to this lymphokine. Several groups have reported an increase, with age, in the secretion of IL-4 in short-term T cell cultures and have suggested that this increase could reflect the age-dependent accumulation of memory T cells, which are thought to be principally responsible for IL-4 production in young mice. Because the response to IL-2 declines with age, we hypothesized that IL-4 production would also decline with age if tested under conditions that promoted IL-2-driven expansion and maturation of IL-4-secreting effectors. Using a culture system in which T cells are first activated by immobilized anti-CD3 antibody for 2 days, and then cultured with anti-CD3 plus IL-2 for an additional 9-11 days, we found a 3-fold decline with age in IL-4 production by murine splenic CD4 T cells. Under these conditions memory (CD45RBlo) CD4 T cells from young mice produced 22-fold more IL-4 than the reciprocal naive (CD44lo) subset. Production of IL-4 by old T cells was also largely attributable to memory T cells, but memory cells from these old donors generated 6-fold less IL-4 in extended cultures than memory cells from young donors. Cultured memory (but not naive) T cells increase in number over a 9-day interval, but the amount of expansion by young memory cells is 4-fold higher than that for old cells. We conclude that the production of IL-4 by memory T cells declines with age under conditions that promote IL-2-driven proliferation and differentiation.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Li SP,Miller RAdoi
10.1006/cimm.1993.1230subject
Has Abstractpub_date
1993-10-01 00:00:00pages
187-95issue
1eissn
0008-8749issn
1090-2163pii
S0008-8749(83)71230-Xjournal_volume
151pub_type
杂志文章abstract：:Sequential immunization with a carrier molecule and a new epitope (hapten) conjugated to the carrier (carrier/hapten-carrier immunization) induces specific suppression for IgG antibody production to the new epitope (hapten) on the carrier. Once induced, this "epitope-specific" suppression persists and specifically sup...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90387-3
更新日期：1984-07-01 00:00:00
abstract：:CD40--CD40L interactions between resting B cells and activated T cells are essential for germinal center formation. It has been shown that CD40L can induce both Fas expression and susceptibility to Fas-mediated killing in B cells, while anti-Ig can partially rescue B cells from Fas-mediated killing. However, the intra...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0260
更新日期：1996-10-10 00:00:00
abstract：:In view of the critical role played by bacillus Calmette-Guérin (BCG) in the development and functional activation of protective T cells against tuberculosis, it has become important to understand the mechanisms by which cytokines regulate BCG-mediated immune responses. There is evidence that cytokine-mediated suppres...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.2000.1662
更新日期：2000-06-15 00:00:00
abstract：:Microglia are important immunoregulatory cells within the central nervous system (CNS). Viral infection of primary microglia and splenic macrophage clones revealed that both exhibited a heterogeneous, but relatively low, sensitivity to cytolysis mediated by CD8(+) cytotoxic T lymphocytes (CTL). The majority of clones ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1999.1581
更新日期：1999-11-25 00:00:00
abstract：:Basic Immunology has had only two significant public priority disputes. The first began in the late 1650s and concerned the recognition of the peripheral network of vessels which collects lymph throughout the body. The publication of this major anatomical discovery prompted a priority feud discussed in a previous pape...
journal_title：Cellular immunology
pub_type： 历史文章,杂志文章
doi：10.1016/j.cellimm.2007.02.015
更新日期：2007-01-01 00:00:00
abstract：:Study of primary immune responses in leprosy has been limited, since disease becomes manifest long after infection or is not detectable. To study primary immune responses, we immunized in vitro human peripheral blood mononuclear cells from unexposed individuals using phenolic glycolipid 1 (PGL-1), an important water-i...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(91)90058-j
更新日期：1991-10-01 00:00:00
abstract：:A thymic epithelial cell line (tsTNC-1) that maintains the ability to selectively bind and internalize immature alpha beta TCRloCD4+CD8+ thymocytes in vitro was used in the development of a monoclonal antibody that is specific to the cell surface of thymic nurse cells (TNCs) in the thymus. The rat monoclonal antibody ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1998.1279
更新日期：1998-05-01 00:00:00
abstract：:Respiratory immunization is an attractive way to generate systemic and mucosal protective memory responses that are required for preventing mucosally transmitted infections. However, the molecular and cellular mechanisms for controlling memory T cell responses remain incompletely understood. In this study, we investig...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2016.07.006
更新日期：2016-12-01 00:00:00
abstract：:One of the auto-antigens aberrantly targeted in Multiple sclerosis is myelin basic protein (MBP). In this study, chronic progressive multiple sclerosis (CPMS) patients receiving the experimental drug MBP8298, on a compassionate care trial, were examined before and after high dose peptide treatment for their circulatin...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2012.11.004
更新日期：2012-11-01 00:00:00
abstract：:Neuroendocrine hormones such as growth hormone (GH) and prolactin (PRL) have been demonstrated to accelerate the recovery of the immune response after chemotherapy and bone marrow transplantation and to enhance the restoration of immunity in individuals infected with HIV and in normal individuals with compromised immu...
journal_title：Cellular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.cellimm.2007.12.003
更新日期：2008-03-01 00:00:00
abstract：:Human melanoma tumor cells were genetically modified in vitro by transferring the interleukin-2 (IL-2) gene via a retroviral vector into established or fresh tumor cells. In addition, human melanoma cells were transduced in vivo by the direct injection of the IL-2/retroviral vector into melanoma xenografts in nude mic...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1292
更新日期：1994-11-01 00:00:00
abstract：:This study was designed to investigate the regulatory role of soluble interleukin-6 receptor (sIL-6R) and interleukin-6 (IL-6) fusion protein (Hyper-IL-6) in the differentiation of human myeloid and erythroid progenitors by a serum-free liquid suspension culture system, using the human cord blood-derived CD34(+)CD38(-...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2006.07.008
更新日期：2006-05-01 00:00:00
abstract：:Previous studies have validated the capacity of classical (HLA-A,B,C) and nonclassical (HLA-G) MHC class I antigens expressed by target cells to influence natural killer (NK) cell-mediated cytolysis. Generally, elevated expression of these HLA class I molecules is correlated with enhanced resistance to lysis by NK cel...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0020
更新日期：1996-01-10 00:00:00
abstract：:Several lines of evidence suggest that nitric oxide (NO), generated through nitric oxide synthase (NOS) by cleavage of terminal guanidino nitrogen from L-arginine, mediates tumor cell killing by mononuclear phagocytes. Natural killer (NK) cells are cytotoxic effector cells that lyse a variety of tumor and virus-infect...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1215
更新日期：1994-08-01 00:00:00
abstract：:Testis-specific gene antigen 10 (TSGA10) encodes an 82-kDa protein expressed during development, and in testis and brain tissues. We report its expression in human monocyte-derived dendritic cells (DC) and macrophages in vitro and in murine spleen CD11c(+) cells ex vivo. An interaction between DC/macrophage-derived TS...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2010.07.012
更新日期：2010-01-01 00:00:00
abstract：:Murine peritoneal macrophages (M phi), activated in vivo or in vitro, remarkably inhibited the uptake of thymidine by a lens epithelial cell line, while resident M phi, or M phi induced by thioglycollate, exhibited much lower or no cytostatic capacity. The target cells were partially protected from the cytostatic acti...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90222-3
更新日期：1984-01-01 00:00:00
abstract：:It has been documented that interleukin-6 (IL-6) supports the proliferation of purified, anti-CD3-stimulated murine T cells. We found that stimulation of human peripheral blood mononuclear cells (PBMCs) with anti-CD3 induced a significant accumulation of IL-6 mRNA, indicating that antigen-mediated T-cell activation ma...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(91)90322-3
更新日期：1991-05-01 00:00:00
abstract：:The regulation of the migratory capacity of Percoll-purified large granular lymphocytes (LGL) into nitrocellulose filters was studied in a 2-hr assay with the use of modified Boyden chambers. Compounds that stimulate the natural killer cytotoxic function of LGL, such as interferons (natural beta, recombinant alpha A, ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(86)90198-x
更新日期：1986-08-01 00:00:00
abstract：:Neoplastic thymocytes from rat thymic lymphoma-leukemias induced by the rat-adapted Gross leukemia virus (RAGV) were analyzed for a variety of differentiation markers. The neoplasms from individual rats all expressed the antigenic phenotype MP+, W3/13+, Thy-1+, RT-1+, RT-7+, W3/25-. However, approximately two-thirds o...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(85)90089-9
更新日期：1985-08-01 00:00:00
abstract：:IgA nephropathy (IgAN) is a tonsil-related disease. We previously showed that oligodeoxynucleotides with CpG (CpG-ODN) and B-cell activation factor (BAFF) are involved in hyperproduction of IgA from tonsillar mononuclear cells of patients with IgAN (IgAN-TMCs). In this study, we focused on a proliferation-inducing lig...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2019.103925
更新日期：2019-07-01 00:00:00
abstract：:The mechanism of how superantigens function to activate cells has been linked to their ability to bind and cross-link the major histocompatibility complex class II (MHCII) molecule. Cells that lack the MHCII molecule also respond to superantigens, however, with much less efficiency. Therefore, the purpose of this stud...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1999.1571
更新日期：1999-11-01 00:00:00
abstract：:We have studied the evolution of thyroiditis induced by neonatal thymectomy in Buffalo strain rats, with particular emphasis on the thyroid lymphocytic infiltrate. The earliest change was increased endothelial Ia expression, and infiltration of the thyroid at 5 weeks by ED1- and ED2-positive macrophages and B and T ce...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90260-2
更新日期：1988-06-01 00:00:00
abstract：:Peripheral blood large granular lymphocytes (LGL) expressing Leu 11 (CD16) antigen with potent natural killer cytotoxicity inhibited soluble antigen-induced T-cell production of interleukin 2 (IL-2). Depletion of Leu 11-reactive cells from T-cells doubled IL-2 activity (P less than 0.05). Leu 11-enriched cells did not...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90389-4
更新日期：1989-02-01 00:00:00
abstract：:Subcutaneous Ehrlich tumor-bearing mice were treated with in situ inoculation of a beta-glucan-rich extract of Agaricus brasiliensis (ATF), which reduced tumor growth. Histopathological analysis showed that the tumor masses of control mice (Ehr) presented giant tumor cells and many mitotic figures whereas the tumor ti...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2009.01.002
更新日期：2009-01-01 00:00:00
abstract：:Arriving at an understanding of the role of suppressor T-cells (regulatory T-cells, CD4(+)CD25+) depends on whether their functional repertoire is somatically selected to be anti-Self or anti-Nonself. Immunologists are ambivalent; often publications espousing opposite views share an author. Here the arguments are deta...
journal_title：Cellular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.cellimm.2004.02.004
更新日期：2004-02-01 00:00:00
abstract：:Upregulation of immunoglobulin D-specific receptors (IgD-R) on CD4+ T cells may facilitate their interaction with specific carbohydrate moieties uniquely associated with membrane IgD on B cells. Previous studies have shown that upregulation of IgD-R facilitates cognate T-B cell interactions by mediating bidirectional ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.2000.1747
更新日期：2001-02-01 00:00:00
abstract：:Altered neutrophil function may contribute to the development of AIDS during the course of HIV infection. It has been described that Nef, a regulatory protein from HIV, can modulate superoxide production in other cells, therefore altered superoxide production in neutrophils from HIV infected patients, could be seconda...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2010.03.012
更新日期：2010-01-01 00:00:00
abstract：:The role of the cytokines IL-1 alpha, IL-1 beta, and IL-6 and the cell adhesion molecules ICAM-1, LFA-1 (alpha and beta), and Mac-1 as accessory molecules for stimulation of T cells by the superantigen staphylococcal enterotoxin B (SEB) was examined. Both blood monocytes and alveolar macrophages were used as accessory...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(92)90164-k
更新日期：1992-05-01 00:00:00
abstract：:Cytokines are soluble proteins that mediate immune reactions and are responsible for communication among immune cells. CD4(+) T cells are the principle sources of cytokines of adaptive immunity. Cytokines play critical roles in the differentiation and effector function of CD4(+) T cells. They also play key roles in di...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2012.07.009
更新日期：2012-07-01 00:00:00
abstract：:Many studies have shown that tumor necrosis factor (TNF) is a potent soluble mediator of immunoregulation and inflammation. Neuropeptide substance P (SP) has been known to exert significant influence on production of certain inflammatory cytokine by immune cells. Immunopathogenic mechanism underlying the effect of neu...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1995.9969
更新日期：1995-12-01 00:00:00
