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Regulation of human T-cell production of interleukin 2 by Leu 11 (CD16) positive large granular lymphocytes.

Abstract：

:Peripheral blood large granular lymphocytes (LGL) expressing Leu 11 (CD16) antigen with potent natural killer cytotoxicity inhibited soluble antigen-induced T-cell production of interleukin 2 (IL-2). Depletion of Leu 11-reactive cells from T-cells doubled IL-2 activity (P less than 0.05). Leu 11-enriched cells did not express high affinity IL-2 receptors nor did they deplete IL-2 activity from culture media. Upon addition in low ratios to Leu 11-depleted cells, Leu 11-enriched fractions increased antigen-induced IL-2 production three-fold (P less than 0.05), whereas at higher ratios IL-2 production was suppressed P less than 0.01. Additionally, adherent monocytes were increasingly accessory when added in graded numbers to Leu 11-depleted but not T-cell cultures. In the presence of small numbers (5%) of Leu 11-enriched cells, however, monocytes down-regulated IL-2 production of Leu 11-depleted cell cultures. Thus Leu 11-reactive lymphocytes have noncytotoxic functions and may play a major role in immunoregulation.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Toossi Z,Paris MR,Purvis SF,Ellner JJ

doi

10.1016/0008-8749(89)90389-4

subject

Has Abstract

pub_date

1989-02-01 00:00:00

pages

413-24

issue

2

eissn

0008-8749

issn

1090-2163

pii

0008-8749(89)90389-4

journal_volume

118

pub_type

杂志文章

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