A distinct subset of natural killer T cells produces IL-17, contributing to airway infiltration of neutrophils but not to airway hyperreactivity.

abstract：:PHA stimulation of both freshly isolated and IL-2-dependent cultured T cells induced a rapid rise in intracytoplasmic calcium concentration. Chelation of extracellular calcium with EGTA resulted in a failure of PHA to induce a rise in intracytoplasmic calcium, resulting in the fresh T cells in an inhibition of IL-2 pr...

journal_title：Cellular immunology

authors： Watman NP,Crespo L,Davis B,Poiesz BJ,Zamkoff KW

更新日期：1988-01-01 00:00:00

abstract：:Purine nucleoside phosphorylase (PNP) is a purine salvage pathway enzyme which we have found to be 8-10 times more active (per cell) in human peripheral blood null lymphocytes than in T lymphocytes. To test the hypothesis that null cells are, in part, pre-T lymphocytes we have defined an in vitro system for null cell ...

journal_title：Cellular immunology

authors： Cowan MJ,Fraga M,Ammann AJ

更新日期：1983-06-01 00:00:00

abstract：:Positive selection of T lymphocytes expressing self. MHC-restricted T cell receptors is mediated by MHC molecules expressed on thymic stroma. Among the more controversial aspects of this process is the relative role of MHC molecules on epithelial versus bone marrow-derived stromal elements (BM-APC). For CD4+ T cells, ...

journal_title：Cellular immunology

authors： Fort MM,Pardoll DM

更新日期：1996-07-10 00:00:00

abstract：:We have investigated the ability of interleukin-10 (IL-10) to modulate murine intrathymic T cell differentiation using a fetal thymic organ culture (FTOC) model. Addition of as little as 11 ng of recombinant murine IL-10 (mIL-10) per day produced a significant increase in the proportion and number of gamma delta-TCR+ ...

journal_title：Cellular immunology

authors： Fine JS,Macosko HD,Grace MJ,Narula SK

更新日期：1994-04-15 00:00:00

abstract：:The incubation of murine splenocytes in recombinant interleukin 2 (IL-2) gives rise to both lymphokine-activated killer (LAK) cells capable of lysing fresh tumor cells and cells capable of mediating antibody-dependent cellular cytotoxicity (ADCC) in the presence of anti-H2 allosera. A similarity between these two IL-2...

journal_title：Cellular immunology

authors： Eisenthal A,Shiloni E,Rosenberg SA

更新日期：1988-09-01 00:00:00

abstract：:Latex microspheres-based artificial antigen-presenting cell constructs (aAPCs) are proved to be valuable tools to expand T cells ex vivo for adoptive cell therapy, but little is known about their potential for active immunization. In this report, HLA-A2/peptide tetramers were generated and co-coated with anti-mouse CD...

journal_title：Cellular immunology

authors： Shen C,Zhang J,Xia L,Meng F,Xie W

更新日期：2007-05-01 00:00:00

abstract：:We examined the effects of a rare sugar, D-allose, which is 6-carbon monosaccharide, on endocytosis and T cell stimulation by dendritic cells (DCs). The endocytosis of BCG-anti-BCG immune complexes by DCs markedly decreased in D-allose-containing medium. Co-culture with T cells (mixed leukocyte reaction, MLR) of DCs, ...

journal_title：Cellular immunology

authors： Tanaka S,Sakamoto H

更新日期：2011-01-01 00:00:00

abstract：:Peripheral blood leukocytes (PBL), nonadherent lymphocytes, and adherent monocytes separated from freshly isolated blood of 15 dogs were analyzed for their ability to mediate antibody-dependent cell-mediated cytotoxicity (ADCC) in combination with murine anti-tumor monoclonal antibodies (MAbs). Canine monocytes isolat...

journal_title：Cellular immunology

authors： Rosales C,Jeglum KA,Obrocka M,Steplewski Z

更新日期：1988-09-01 00:00:00

abstract：:This paper investigates the presence of HLA class I-restricted and tumor-specific cytotoxic T lymphocytes (CTL) in tumor sites of esophageal cancers. Five CTL lines were established from the metastatic lymph nodes or pleural effusion by incubation with interleukin-2 of tumor-infiltrating lymphocytes: cases 1 and 5, HL...

journal_title：Cellular immunology

authors： Toh U,Yamana H,Nakao M,Imai Y,Seki N,Takasu H,Kaneshige T,Fujita H,Shirouzu K,Itoh K

更新日期：1997-05-01 00:00:00

abstract：:The skin and draining lymph nodes of BALB/c mice were examined for IFN-gamma, IL-2, and IL-4 mRNA expression by in situ hybridization in three successive infestations with nymphal Ixodes ricinus ticks. IFN-gamma and IL-2 mRNA positive cells were readily detected in lymph node sections during primary antigenic stimulat...

journal_title：Cellular immunology

authors： Mbow ML,Rutti B,Brossard M

更新日期：1994-06-01 00:00:00

abstract：:We have reported that Burkitt lymphomas (BL) that arise in HLA-A11 positive individuals are resistant to lysis by HLA-A11-specific and HLA-A11-restricted CTLs(10,11). Here we show that this phenomenon can be explained by a selective loss of the HLA-A11 polypeptide. The HLA-A11 negative phenotype is due to a regulatory...

journal_title：Cellular immunology

authors： Masucci MG,Stam NJ,Torsteinsdottir S,Neefjes JJ,Klein G,Ploegh HL

更新日期：1989-05-01 00:00:00

abstract：:Olopatadine hydrochloride is an H1-receptor-blocker but has other anti-allergic pharmacological potencies. We investigated whether olopatadine inhibits murine contact hypersensitivity, focussing on its modulatory action on epidermal Langerhans cells serving as antigen-presenting cells. While BALB/c mice were sensitize...

journal_title：Cellular immunology

authors： Tokura Y,Kobayashi M,Ito T,Takahashi H,Matsubara A,Takigawa M

更新日期：2003-07-01 00:00:00

abstract：:This study addresses the nature of the pathogenic effector T cell in experimental autoimmune uveoretinitis and the effect of different cytokines on these cells in vitro. Lymph node cells of B10.RIII mice immunized with the uveitogenic peptide 161-180 of interphotoreceptor retinoid binding protein were cultured with th...

journal_title：Cellular immunology

authors： Xu H,Rizzo LV,Silver PB,Caspi RR

更新日期：1997-05-25 00:00:00

abstract：:Transcriptional regulation of gene expression is a key component of orchestrating proper immune cell development and function. One strategy for maintaining these transcriptional programs has been the evolution of transcription factor families with members possessing overlapping functions. Using the germ line deletion ...

journal_title：Cellular immunology

authors： Pioli PD,Chen X,Weis JJ,Weis JH

更新日期：2015-05-01 00:00:00

abstract：:The effects of IL-10 on in vitro antigen-driven murine antibody responses and helper cell IL-4 and IFN-gamma secretory capacity were investigated. Low antigen concentrations stimulated high responses in all antibody isotypes examined; IgD was not assayed. Under these conditions, exogenous IL-10 minimally potentiated s...

journal_title：Cellular immunology

authors： Marcelletti JF,Katz DH

更新日期：1996-01-10 00:00:00

abstract：:The proapoptotic caspase adaptor protein (PACAP) is involved in cell-cycle regulation and promotes apoptosis. Both MGC29506 and PACAP are isoforms of the MGC29506 gene and are generated by differential splicing of the alternative splice-acceptor. In studying PACAP, we inadvertently constructed the eukaryotic expressio...

journal_title：Cellular immunology

authors： Xia L,Shen C,Fu Y,Tian L,Chen M

更新日期：2013-01-01 00:00:00

abstract：:We describe here a novel real-time cell tracking system which can measure cell migration routes under cell culture condition. This system includes a mini incubator which controls temperature and CO(2) gas flow and a PDMS (polydimethylsiloxane) chip for chemotaxis measurement. The main differences from previous ones ar...

journal_title：Cellular immunology

authors： Kwak YH,Hong SM,Park SS

更新日期：2010-01-01 00:00:00

abstract：:Toll-like receptors are a family of pattern-recognition receptors that contribute to the innate immune response. Toll-like receptor 3 (TLR3) signals in response to foreign, endogenous and synthetic ligands including viral dsRNA, bacterial RNA, mitochondrial RNA, endogenous necrotic cell mRNA and the synthetic dsRNA an...

journal_title：Cellular immunology

authors： Duffy KE,Lamb RJ,San Mateo LR,Jordan JL,Canziani G,Brigham-Burke M,Korteweg J,Cunningham M,Beck HS,Carton J,Giles-Komar J,Duchala C,Sarisky RT,Mbow ML

更新日期：2007-08-01 00:00:00

abstract：:The bursa of Fabricius represents the primary immune organ where immature B cells undergo maturational changes in avian species. Isolation of bursal lymphocytes for analysis in cell culture results in the rapid endogenous activation of apoptosis. After 2 h of incubation, over 45% of the lymphocytes were shown to be un...

journal_title：Cellular immunology

authors： Compton MM,Waldrip HM

更新日期：1998-03-15 00:00:00

abstract：:Upregulation of immunoglobulin D-specific receptors (IgD-R) on CD4+ T cells may facilitate their interaction with specific carbohydrate moieties uniquely associated with membrane IgD on B cells. Previous studies have shown that upregulation of IgD-R facilitates cognate T-B cell interactions by mediating bidirectional ...

journal_title：Cellular immunology

authors： Lakshmi Tamma SM,Wu Y,Toporovsky I,Lima V,Coico RF

更新日期：2001-02-01 00:00:00

abstract：:Staphylococcal enterotoxin B (SEB) is a member of a family of gram-positive bacterial exotoxins which act as superantigens in both mouse and man. The administration of this toxin has been shown to inhibit antibody responses in vivo. We have previously shown that SEB is a potent inducer in vitro of multiple T suppresso...

journal_title：Cellular immunology

authors： Lin YS,Hu SC,Jan MS,Rogers TJ

更新日期：1991-02-01 00:00:00

abstract：:To determine the relative contributions of DC subsets in the development of protective immunity to Listeria monocytogenes we examined the relationship between maturation, bacterial burden, and T cell priming capacity of four well characterized subsets of splenic DC following infection with Lm. CD8α(+), CD4(+), and CD8...

journal_title：Cellular immunology

authors： Mitchell LM,Brzoza-Lewis KL,Henry CJ,Grayson JM,Westcott MM,Hiltbold EM

更新日期：2011-01-01 00:00:00

abstract：:Rotavirus infection of permissive cells is a multi-step process that requires interaction with several cell surface receptors. Integrins alpha2beta1, alpha4beta1, alphaXbeta2, and alphavbeta3 are involved in the attachment and entry into permissive cells for many rotavirus strains. However, possible roles of known par...

journal_title：Cellular immunology

authors： Halasz P,Fleming FE,Coulson BS

更新日期：2005-07-01 00:00:00

abstract：:The Lyt phenotype of cytotoxic T cells generated in the primary H-2 response was investigated kinetically. The cytotoxicity generated in the early stage of culture was abolished by treatment with alpha Lyt-1,2,3, and complement (C), whereas that generated in the late stage was only partially eliminated by alpha Lyt-1,...

journal_title：Cellular immunology

authors： Nakayama E,Uenaka A

更新日期：1984-08-01 00:00:00

abstract：:Normal spleen cells cultured in high or low concentrations of interleukin (IL) 2 for 3 days contain Thy-1+ CD4- CD8+ cells that powerfully suppress primary but not ongoing or active lymphocyte responses. The precursors of these cells are Thy-1+ AGM-1- and are absent or present in greatly diminished numbers in athymic ...

journal_title：Cellular immunology

authors： Torre-Amione G,Tuetken R,Rowley DA

更新日期：1989-11-01 00:00:00

abstract：:Functional helper and suppressor hybridomas were constructed from fractionated Type II NFR/nude mouse splenocytes which resemble precursors of T cells. After carrier priming with rabbit erythrocytes (RE), splenocytes from Type II NFR/nude mice were fractionated on nylon wool columns. Cells from two distinct fractions ...

journal_title：Cellular immunology

authors： Webb GC,Misfeldt ML,Hanna EE

更新日期：1984-12-01 00:00:00

abstract：:Inherited deficiency of the enzyme adenosine deaminase (ADA) has been found in a significant proportion of patients with severe combined immunodeficiency disease and inherited defect generally characterized by a deficiency of both B and T cells. Two questions are central to understanding the pathophysiology of this di...

journal_title：Cellular immunology

authors： Barton RW

更新日期：1985-10-15 00:00:00

abstract：:TE44, an H-2b-restricted, self-reactive T-cell line, did not produce autocrine-acting growth factors, neither after antigenic nor after mitogenic activation; they remained for their proliferation completely dependent on exogenously added IL-2. Administration of IL-4, which poorly promotes growth by itself, resulted in...

journal_title：Cellular immunology

authors： Vandenabeele P,Grooten J,Fiers W

更新日期：1990-10-01 00:00:00

abstract：:In this study we have examined the cellular and molecular specificity of lymphocyte interaction with fibroblasts. Using mitogen-activated T-cells, we found that attachment to fibroblasts was highly sensitive to protease treatment, and to an antibody raised against the purified lymphocyte plasma membrane, but it was no...

journal_title：Cellular immunology

authors： Abraham D,Bou-Gharios G,Muir H,Olsen I

更新日期：1989-08-01 00:00:00

abstract：:The adoptive transfer of tumor-reactive T lymphocytes has recently been demonstrated to be an effective means for mediating the regression of experimental intracranial fibrosarcomas. In this study, mice bearing syngeneic intracranial GL261 gliomas were cured by the combination of sublethal whole body irradiation follo...

journal_title：Cellular immunology

authors： Plautz GE,Touhalisky JE,Shu S

更新日期：1997-06-15 00:00:00