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Adhesion of lymphoid cells to fibroblasts in tissue culture.

Abstract：

:In this study we have examined the cellular and molecular specificity of lymphocyte interaction with fibroblasts. Using mitogen-activated T-cells, we found that attachment to fibroblasts was highly sensitive to protease treatment, and to an antibody raised against the purified lymphocyte plasma membrane, but it was not mediated by the MEL-14 surface antigen or phosphomannosyl receptors. Lymphocyte interaction with fibroblasts was also unaffected by monoclonal antibodies against the LFA-1, Mac-1, and Class II MHC antigen complexes. In contrast, adhesion of both T- and B-lymphocytes was strongly inhibited by fucoidan, a polymer of sulphated fucose, whereas fucose, mannan, and mannose 6-phosphate had no effect. Both B- and T-lymphoid cell lines were able to recognise and adhere to fibroblasts, although the marked differences between the attachment of the different types of cell did not appear to be related to their immunological function. The attachment of most of the cell lines was prevented by the presence of fucoidan, whereas the inhibition of binding of each of the lymphoid lines in the presence of the anti-T-lymphocyte plasma membrane antibody varied widely. These findings suggest that lymphocyte attachment to fibroblasts involves multiple cell surface receptors, and that these are expressed at different levels on specific T- and B-cells.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Abraham D,Bou-Gharios G,Muir H,Olsen I

doi

10.1016/0008-8749(89)90146-9

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

33-47

issue

1

eissn

0008-8749

issn

1090-2163

pii

0008-8749(89)90146-9

journal_volume

122

pub_type

杂志文章

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