Accelerated progression of Hodgkin's-like lymphomas in golli deficient SJL mice.

Abstract:

:Spontaneously occurring lymphomas in SJL mice have many pathological features similar to Hodgkin's lymphoma in humans. The malignant growth of the tumor cells is dependent on the support of host FoxP3(+)CD4(+) regulatory T cells (Tregs). In this study, we report that the ablation of golli protein, a negative regulator of CRAC (calcium release activated calcium) channel, in SJL mice results in an accelerated progression of Hodgkin's-like lymphoma which is accompanied by a facilitated conversion of FoxP3(+) Treg cells. Our results suggest that golli protein might affect the progression of Hodgkin's-like lymphomas through regulating the induction of Treg cells.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Ouyang S,Han G,Wu X,Jiang Z,Feng JM

doi

10.1016/j.cellimm.2016.01.006

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

41-49

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(16)30006-5

journal_volume

302

pub_type

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