Thymocyte maturation following interaction with thymus-derived macrophages.


:Murine C57BL/6 thymocytes were cultivated together with syngeneic thymus-derived macrophages (TDM phi) for up to 96 hr to determine whether TDM phi participate in thymocyte maturation. The expression level of H-2b and Thy-1.2 antigens served as thymocyte differentiation surface markers as analyzed by flow cytometry. Indirect immunofluorescent staining profiles of the thymocytes demonstrate a dramatic increase in H-2b expression and a profound decrease in Thy-1.2 expression during cultivation with TDM phi. A similar phenomenon was observed when enriched populations of immature thymocytes were cocultivated with TDM phi. These changes were not observed when thymocytes were cultivated alone or with trypsin-treated TDM phi; neither were they observed when cortisone-resistant thymocytes manifesting mature characteristics were cultivated together with TDM phi. These findings suggest that interaction of thymocytes with TDM phi, involving binding and engulfment, results in the appearance of mature thymocyte subsets.


Cell Immunol


Cellular immunology


Zeira M,Gallily R,Stein I,Giloh H




Has Abstract


1991-05-01 00:00:00














  • Anti-tumor effects of fusion vaccine prepared by renal cell carcinoma 786-O cell line and peripheral blood dendritic cells of healthy volunteers in vitro and in human immune reconstituted SCID mice.

    abstract::Dendritic cells (DC), as professional antigen presenting cells, play the central role in the process of body initiating the anti-tumor immunity, and the study on DC anti-tumor vaccine has become heated in recent years. In this study, we used polyethylene glycol (PEG) to induce renal cell carcinoma (RCC) 786-O cell lin...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Hu Z,Liu S,Mai X,Hu Z,Liu C

    更新日期:2010-01-01 00:00:00

  • Cytostatic and cytolytic activities of macrophages regulation by prostaglandins.

    abstract::Murine peritoneal macrophages (M phi), activated in vivo or in vitro, remarkably inhibited the uptake of thymidine by a lens epithelial cell line, while resident M phi, or M phi induced by thioglycollate, exhibited much lower or no cytostatic capacity. The target cells were partially protected from the cytostatic acti...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Mochizuki M,Zigler JS Jr,Russell P,Gery I

    更新日期:1984-01-01 00:00:00

  • Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3.

    abstract::Transcriptional regulation of gene expression is a key component of orchestrating proper immune cell development and function. One strategy for maintaining these transcriptional programs has been the evolution of transcription factor families with members possessing overlapping functions. Using the germ line deletion ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Pioli PD,Chen X,Weis JJ,Weis JH

    更新日期:2015-05-01 00:00:00

  • Interleukin-4 enhances anti-IgM stimulation of B cells by improving cell viability and by increasing the sensitivity of B cells to the anti-IgM signal.

    abstract::The lymphokine IL-4 is a potent enhancer of anti-IgM-induced B cell proliferation. Although the mechanism of this enhancement is not known, a commonly held view suggests that IL-4 acts together with anti-IgM as a costimulating factor for the activation of a subpopulation of B cells. To evaluate this hypothesis we exam...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Hodgkin PD,Go NF,Cupp JE,Howard M

    更新日期:1991-04-15 00:00:00

  • Microarray analysis of the gene expression profile of HMC-1 mast cells following Schizonepeta tenuifolia Briquet treatment.

    abstract::It has long been believed that mast cells play a crucial role in the development of many physiological changes during immediate allergic responses. This study was conducted to evaluate the anti-inflammation mechanism of Schizonepeta tenuifolia (ST) extract and ST purified chemicals on the PMA plus A23187-induced stimu...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Sohn SH,Cho S,Ji ES,Kim SH,Shin M,Hong M,Bae H

    更新日期:2012-05-01 00:00:00

  • Prostaglandin E2 inhibits TNF production in murine bone marrow-derived dendritic cells.

    abstract::Exposure to pathogens induces dendritic cells to release inflammatory cytokines and chemokines. The inflammatory response is controlled by endogenous agents such as anti-inflammatory cytokines, glucocorticoids, anti-inflammatory neuropeptides, and lipid mediators. This study is the first report on the inhibition by pr...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Vassiliou E,Jing H,Ganea D

    更新日期:2003-06-01 00:00:00

  • Eomesodermin driven IL-10 production in effector CD8+ T cells promotes a memory phenotype.

    abstract::CD8+ T cell differentiation is controlled by the transcription factors T-bet and Eomesodermin, in concert with the cytokines IL-2, IL-10 and IL-12. Among these pathways, the mechanisms by which T-box proteins and IL-10 interact to promote a memory T cell fate remain poorly understood. Here, we show that Eomes and IL-1...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Reiser J,Sadashivaiah K,Furusawa A,Banerjee A,Singh N

    更新日期:2019-01-01 00:00:00

  • Aminopeptidase N/CD13 is directly linked to signal transduction pathways in monocytes.

    abstract::In the present study, we characterized in monocytes the rise in [Ca(2+)](i) evoked by monoclonal antibodies (mAbs) to aminopeptidase N (APN)/CD13, showing a two-phase calcium increase with a small-belled [Ca(2+)](i) rise due to the release of calcium from intracellular stores and a more sustained plateau due to the in...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Santos AN,Langner J,Herrmann M,Riemann D

    更新日期:2000-04-10 00:00:00

  • AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.

    abstract::7 anterior gradient homolog 2 (AGR2)-inhibited different molecular mutual positive correlation network was constructed in lung adenocarcinoma compared with human normal adjacent tissues by 17 overlapping molecules of 358 GRNInfer and 19 Pearson (AGR2 CC⩽-0.25). Based on GO, KEGG, GenMAPP, BioCarta and disease database...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Huang J,Wang L,Jiang M,Chen Q,Jiang Z,Feng H

    更新日期:2014-07-01 00:00:00

  • Runx-dependent regulation of G-protein gamma3 expression in T-cells.

    abstract::Heterotrimeric G-proteins control diverse biological processes by conveying signals from seven-transmembrane receptors to intracellular effectors. Although their signaling roles were originally ascribed to their GTP-bound alpha-subunits, more recent evidence points to the equally active roles played by their betagamma...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Dubeykovskiy A,McWhinney C,Robishaw JD

    更新日期:2006-04-01 00:00:00

  • Age-associated B cells (ABC) inhibit B lymphopoiesis and alter antibody repertoires in old age.

    abstract::With old age (∼2y old), mice show substantial differences in B cell composition within the lymphoid tissues. In particular, a novel subset of IgM+ CD21/35lo/- CD23- mature B cells, the age-associated B cells or ABC, increases numerically and proportionately. This occurs at the expense of other B cell subsets, includin...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Riley RL,Khomtchouk K,Blomberg BB

    更新日期:2017-11-01 00:00:00

  • Induction of CD8+ suppressor T cells by treatment with DMBA and TPA in vitro.

    abstract::Antigen-nonspecific CD8+ T suppressor cells, which suppressed delayed-type hypersensitivity (DTH) against sheep red blood cells in BALB/c mice, were induced by incubating spleen cells from mice treated with 7,12-dimethylbenz[a]anthracene (DMBA), a tumor initiator, with 12-O-tetradecanoylphorbol 13-acetate (TPA), a tum...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Negoro T,Iinuma F,Watanabe M

    更新日期:1991-12-01 00:00:00

  • Activation of vascular endothelial cells by IL-1alpha released by epithelial cells infected with respiratory syncytial virus.

    abstract::Although pulmonary inflammation is a serious, sometimes life-threatening, consequence of respiratory syncytial virus (RSV) infection, the mechanisms involved are not well understood. Since the process of inflammation is initiated by a complex series of events including the activation of specific adhesion molecules on ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Chang CH,Huang Y,Anderson R

    更新日期:2003-01-01 00:00:00

  • Activation of human T cell clones through the UM4D4/CDw60 surface antigen.

    abstract::UM4D4 is a recently defined antigen that is expressed on approximately 25% of peripheral blood T cells, but on the majority of T cells in inflammatory synovial fluid. Anti-UM4D4 activates peripheral blood T cells in the presence of accessory cells and/or phorbol ester. UM4D4 has been assigned to a new antigen cluster ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Fox DA,Davis W,Zeldes W,Kan L,Higgs J,Duby AD,Holoshitz J

    更新日期:1990-07-01 00:00:00

  • Crosslinking of the CD5 antigen on human T cells induces functional IL2 receptors.

    abstract::CD5 is a 67-kDa antigen that is expressed on the membrane of the majority of human T cells, and on a subset of B cells. Previous studies have demonstrated that anti-CD5 monoclonal antibodies (mAb) can provide a helper signal for T cell activation through the TCR/CD3 complex. We now demonstrate that when CD5 is crossli...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Verwilghen J,Vandesande R,Vandenberghe P,Ceuppens JL

    更新日期:1990-11-01 00:00:00

  • LAIR-1 activation inhibits inflammatory macrophage phenotype in vitro.

    abstract::Macrophages are key cell types of innate immunity and play a central role in inflammation and host defense. Leukocyte-associated Ig-like receptor-1 (LAIR-1) is highly expressed on macrophages and regulates macrophage functions in several conditions. However, whether LAIR-1 is involved in governing macrophage polarizat...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Jin J,Wang Y,Ma Q,Wang N,Guo W,Jin B,Fang L,Chen L

    更新日期:2018-09-01 00:00:00

  • Antitumor effects and immunoregulation mechanisms of IL-23 gene in mouse mammary cancer mediated by retrovirus.

    abstract:BACKGROUND:Interleukin (IL)-23, composed of p19 and p40 subunits, has diverse functions in regulating immune systems, enhancing cell-mediated immunity. In the present study, we investigated whether forced expression of the p19-linked p40 gene in murine mammary cancer cells (MA891) produced antitumor effects in vivo. Tu...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Liu L,Shan B,Feng Y

    更新日期:2009-01-01 00:00:00

  • The 2H4 molecule but not the T3-receptor complex is involved in suppressor inducer signals in the AMLR system.

    abstract::It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cel...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Takeuchi T,Schlossman SF,Morimoto C

    更新日期:1987-06-01 00:00:00

  • Local synthesis of immunosuppressive glucocorticoids in the intestinal epithelium regulates anti-viral immune responses.

    abstract::The nuclear receptor Small Heterodimer Partner (SHP) is a transcriptional target and inhibitor of Liver Receptor Homolog 1 (LRH-1), the transcriptional regulator of intestinal glucocorticoid (GC) synthesis. The role of SHP in the regulation of intestinal GC synthesis and its impact on T cell-mediated anti-viral immune...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Huang J,Jia R,Brunner T

    更新日期:2018-12-01 00:00:00

  • Key genes and proteins involved in CTCM-reducing microvascular endothelial cell permeability induced by SLT-IIv using gene chips and DIGE.

    abstract::An Affymetrix mouse genome array and differential in-gel electrophoresis (DIGE) techniques were used to investigate the pharmacological mechanisms of a mixture of herbs, designated CTCM, a compound of traditional Chinese medicine, for the treatment of increased permeability in mouse intestinal microvascular endothelia...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Yi P,Guo Y,Wang X,Mu X,Wei X

    更新日期:2010-01-01 00:00:00

  • Degradation signals in ErbB-2 dictate proteasomal processing and immunogenicity and resist protection by cis glycine-alanine repeat.

    abstract::ErbB-2 is ubiquitinated and degraded when dissociated from its membrane chaperone or bound by specific antibody. Reagents which induce such degradation have demonstrated antitumor activity and may impact ErbB-2 immunogenicity. To further understand ErbB-2 degradation and immunogenicity, a glycine-alanine repeat (GAr) ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Piechocki MP,Pilon SA,Kelly C,Wei WZ

    更新日期:2001-09-15 00:00:00

  • Prolonged allogeneic and xenogeneic microchimerism in unmatched primates without immunosuppression by intrathymic implantation of CD34+ donor marrow cells.

    abstract::Engraftment of stem cell-enriched donor marrow implanted in the thymus of a foreign host might facilitate acceptance of donor-specific organ or tissue grafts. To test this hypothesis, allogeneic and xenogeneic CD34+ marrow cells from unrelated adult male baboons and humans were injected intrathymically in eight infant...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Allen MD,Weyhrich J,Gaur L,Akimoto H,Hall J,Dalesandro J,Sai S,Thomas R,Nelson KA,Andrews RG

    更新日期:1997-11-01 00:00:00

  • DosR antigen Rv1737c induces activation of macrophages dependent on the TLR2 pathway.

    abstract::Latent Mycobacterium tuberculosis (Mtb) infection (LTBI) is the main clinical manifestation after Mtb exposure. During the latent phase, Mtb retards the attempts of eradication by the host immune system. The dormancy survival regulator (DosR) is held as essential for Mtb persistence. Rv1737c is predominantly expressed...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Gao X,Wu C,He W,Wang X,Li Y,Wang Y,Jia Y,Yuan R,Li H,Zhang B

    更新日期:2019-10-01 00:00:00

  • Human anti-pneumococcal polysaccharide antibodies are secreted by the CD5- B cell lineage.

    abstract::To determine whether human antibody responses to T cell-independent pneumococcal polysaccharide antigens are derived from CD5+ or CD5- B cells, we utilized an ELISPOT assay to detect individual anti-polysaccharide antibody-secreting cells. Human anti-type IV pneumococcal polysaccharide antibody-secreting cells were fo...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Barrett DJ,Sleasman JW,Schatz DA,Steinitz M

    更新日期:1992-08-01 00:00:00

  • Induction of endogenous mammary tumor virus in lymphocytes infected with murine acquired immunodeficiency syndrome virus.

    abstract::Mice infected with murine acquired immunodeficiency syndrome (MAIDS) virus developed lymphoadenopathy and profound immunodeficiency. Concomitantly the expression of endogenous mammary tumor virus (MTV) mRNA increased significantly, especially for the 1.7-kb 3' open reading frame (ORF) mRNA encoding MTV superantigen. B...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Gayama S,Doyon L,Vaupel B,Sekaly RP,Kanagawa O

    更新日期:1998-08-01 00:00:00

  • Interleukin-2 induces apoptosis in mouse thymocytes.

    abstract::Interleukins play a role in the process of T-cell development and, like other cytokines, seem able to modulate apoptosis. Interleukin-2 has been reported to inhibit apoptotic cell death of thymocytes induced in vitro by either activation of CD3/TCR complex or treatment with glucocorticoid hormone. We demonstrate here ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Migliorati G,Nicoletti I,Pagliacci MC,D'Adamio L,Riccardi C

    更新日期:1993-01-01 00:00:00

  • Comparison of the capacity of murine and human class I MHC molecules to stimulate T cell activation.

    abstract::The mechanism underlying the apparent differences in the capacity of murine and human class I MHC molecules to function as signal transducing structures in T cells was examined. Cross-linking murine class I MHC molecules on splenic T cells did not stimulate an increase in intracellular calcium ([Ca2+]i) and failed to ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Gur H,Wacholtz MC,Lie WR,Lipsky PE,Geppert TD

    更新日期:1992-10-15 00:00:00

  • Expression of CD45 isoforms in fresh and IL-2-cultured tumor-infiltrating lymphocytes from basal cell carcinoma.

    abstract::Immunohistochemistry and flow cytometry analyses were performed to characterize the specific T cell subpopulations infiltrating basal cell carcinomas (BCC) and to determine their phenotypic response to in vitro expansion with IL-2. Tumor-infiltrating lymphocytes (TIL) within BCC predominantly expressed the CD45RO (act...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Nguyen QH,Moy RL,Roth MD,Yamamoto R,Tomono S,Dubinett SM

    更新日期:1993-02-01 00:00:00

  • Immunosuppression and induction of anergy by CTLA4Ig in vitro: effects on cellular and antibody responses of lymphocytes from rats with experimental autoimmune myasthenia gravis.

    abstract::The pathogenic antibody response to acetylcholine receptor (AChR) in experimental autoimmune myasthenia gravis (EAMG) is T cell dependent. Therefore, it should be possible to design specific immunotherapeutic approaches to treat EAMG (and human MG) by interfering with AChR-specific helper T cells. Productive T cell ac...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: McIntosh KR,Linsley PS,Drachman DB

    更新日期:1995-11-01 00:00:00

  • Cytokine production by NZB, C58, and NZB X C58 recombinant inbred mice.

    abstract::Humans with autoimmune disease and autoimmune mouse strains such as NZB have been shown to produce reduced levels of the cytokines interleukin 1 and interleukin 2. The NZB X C58 recombinant inbred (N X 8 RI) strains exhibit certain of the autoimmune characteristics of the NZB strain. Their abilities to produce interle...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Bocchieri MH,Knittweis L,Seaton DS

    更新日期:1984-10-15 00:00:00