Thymocyte maturation following interaction with thymus-derived macrophages.

Abstract:

:Murine C57BL/6 thymocytes were cultivated together with syngeneic thymus-derived macrophages (TDM phi) for up to 96 hr to determine whether TDM phi participate in thymocyte maturation. The expression level of H-2b and Thy-1.2 antigens served as thymocyte differentiation surface markers as analyzed by flow cytometry. Indirect immunofluorescent staining profiles of the thymocytes demonstrate a dramatic increase in H-2b expression and a profound decrease in Thy-1.2 expression during cultivation with TDM phi. A similar phenomenon was observed when enriched populations of immature thymocytes were cocultivated with TDM phi. These changes were not observed when thymocytes were cultivated alone or with trypsin-treated TDM phi; neither were they observed when cortisone-resistant thymocytes manifesting mature characteristics were cultivated together with TDM phi. These findings suggest that interaction of thymocytes with TDM phi, involving binding and engulfment, results in the appearance of mature thymocyte subsets.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Zeira M,Gallily R,Stein I,Giloh H

doi

10.1016/0008-8749(91)90310-8

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

370-7

issue

2

eissn

0008-8749

issn

1090-2163

pii

0008-8749(91)90310-8

journal_volume

134

pub_type

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