当前位置： SCI文献检索 > CELLULAR IMMUNOLOGY期刊下所有文献 > Can bone marrow-derived thymic stromal cells mediate the positive selection of class I-restricted T cells?

Can bone marrow-derived thymic stromal cells mediate the positive selection of class I-restricted T cells?

Abstract：

:Positive selection of T lymphocytes expressing self. MHC-restricted T cell receptors is mediated by MHC molecules expressed on thymic stroma. Among the more controversial aspects of this process is the relative role of MHC molecules on epithelial versus bone marrow-derived stromal elements (BM-APC). For CD4+ T cells, the weight of evidence suggests that positive selection is driven solely by MHC class II molecules expressed on thymic epithelial cells. In contrast, recent experiments have been interpreted to show that CD8+ T cell development can be driven by MHC class I molecules expressed on BM-APCs as well as epithelial cells. To directly address this issue, we have examined the development of T cells expressing a transgenic, MHC class I-restricted TCR in mice deficient in the rearrangement of endogenous TCR genes. Since the transgenic TCR is the only TCR expressed, this system is extremely sensitive and specific for detecting even inefficient events in T cell development. Our experiments demonstrate that MHC class I expression exclusively on BM-APC is incapable of driving positive selection of CD8+ T cells. This finding, together with earlier experiments for MHC class II, suggests a qualitatively unique function of thymic epithelial cells in mediating positive selection.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Fort MM,Pardoll DM

doi

10.1006/cimm.1996.0175

subject

Has Abstract

pub_date

1996-07-10 00:00:00

pages

74-9

issue

1

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(96)90175-6

journal_volume

171

pub_type

杂志文章

相关文献

CELLULAR IMMUNOLOGY文献大全
  • Characterization and mechanisms of thymic atrophy in protein-malnourished mice: role of corticosterone.

    abstract：:The purpose of this project was to characterize changes in murine T lymphocyte subpopulations during thymic atrophy induced by protein malnutrition and to determine the role of elevated serum corticosterone in this process. A suitable animal model was generated by placing mice on protein-sufficient (PS) and protein-de...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1105

    authors： Barone KS,O'Brien PC,Stevenson JR

    更新日期：1993-04-15 00:00:00

  • "Cross-wiring" of the immune response in old mice: increased autoantibody response despite reduced antibody response to nominal antigen.

    abstract：:Older humans and experimental animals have been repeatedly found to have higher titers of autoantibodies than do younger individuals despite the impaired responses of older individuals to foreign antigens. The studies reported here were designed to examine the relationship between these two age-related changes in anti...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90294-l

    authors： Bovbjerg DH,Kim YT,Schwab R,Schmitt K,DeBlasio T,Weksler ME

    更新日期：1991-07-01 00:00:00

  • A monoclonal antibody to human B lymphoblastoid cells activates human and murine T lymphocytes.

    abstract：:A B lymphoblastoid cell line can provide a comitogenic, accessory signal for mitogen-treated T cells. In a study evaluating the antigenic determinant of such cells that mediate this effect, a monoclonal antibody (I57) was raised against the Daudi cell line. This antibody was found to interact with a 30-kDa protein on ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90354-7

    authors： Hardy B,Dotan D,Novogrodsky A

    更新日期：1989-01-01 00:00:00

  • Ultraviolet-induced suppressor T cells and factor(s) in murine contact photosensitivity. III. Mode of action of T-cell-suppressor factor(s) and interaction with cytokines.

    abstract：:The mode of action of T-cell-suppressor factor (TsF) induced by ultraviolet B (UVB) preirradiation in terms of interaction with several cytokines was studied. Suppression of murine contact photosensitivity (CPS) to 3,3',4',5-tetrachlorosalicylanilide (TCSA) by preirradiation of the sensitizing site to low doses of UVB...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90239-n

    authors： Satoh T,Tokura Y,Satoh Y,Takigawa M

    更新日期：1990-11-01 00:00:00

  • Sex differences in regulatory cells in experimental stroke.

    abstract：:Stroke is the leading cause of disability in the United States. Sex differences, including smaller infarcts in females and greater involvement of immune-mediated inflammation in males may affect the efficacy of immune-modulating interventions. To address these differences, we sought to identify distinct stroke-modifyi...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2017.06.003

    authors： Seifert HA,Benedek G,Liang J,Nguyen H,Kent G,Vandenbark AA,Saugstad JA,Offner H

    更新日期：2017-08-01 00:00:00

  • Anti-inflammatory properties of estrogen. I. In vivo suppression of leukocyte production in bone marrow and redistribution of peripheral blood neutrophils.

    abstract：:We have recently demonstrated that estrogen has differential immunomodulatory properties in mice because it stimulates antibody responses but inhibits T cell-mediated inflammation. In the present study we have examined the influence of estrogen on T cell-independent inflammatory responses. A local inflammation was ind...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90269-u

    authors： Josefsson E,Tarkowski A,Carlsten H

    更新日期：1992-06-01 00:00:00

  • Eomesodermin driven IL-10 production in effector CD8+ T cells promotes a memory phenotype.

    abstract：:CD8+ T cell differentiation is controlled by the transcription factors T-bet and Eomesodermin, in concert with the cytokines IL-2, IL-10 and IL-12. Among these pathways, the mechanisms by which T-box proteins and IL-10 interact to promote a memory T cell fate remain poorly understood. Here, we show that Eomes and IL-1...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2018.11.008

    authors： Reiser J,Sadashivaiah K,Furusawa A,Banerjee A,Singh N

    更新日期：2019-01-01 00:00:00

  • Colony formation by subpopulations of human T lymphocytes. III. Antigenic phenotype and function of colony-forming cells, colony cells, and their expanded progeny.

    abstract：:The antigenic phenotype of individual PHA-induced T lymphocyte colonies was studied with a direct immunofluorescence technique using fluorescein-labeled anti-Leu-2a and anti-Leu-3a antibodies. Of the colonies grown from mononuclear peripheral blood cells 85% were Leu-3a+ (inducer/helper phenotype), 12% were Leu-2a+ (s...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(83)90235-6

    authors： Claësson MH,Petersen J,Sønderstrup-Hansen G,Röpke C,Sørensen T

    更新日期：1983-10-15 00:00:00

  • The effects of an induced adenosine deaminase deficiency on T-cell differentiation in the rat.

    abstract：:Inherited deficiency of the enzyme adenosine deaminase (ADA) has been found in a significant proportion of patients with severe combined immunodeficiency disease and inherited defect generally characterized by a deficiency of both B and T cells. Two questions are central to understanding the pathophysiology of this di...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90317-x

    authors： Barton RW

    更新日期：1985-10-15 00:00:00

  • Lymphocyte subsets involved in tumor-activated nonspecific feedback suppression.

    abstract：:Cells from the spleen, lymph nodes, and peritoneum of DBA/2 mice bearing a subcutaneous tumor mediate nonspecific suppression of an in vitro antibody response to sheep red blood cells (SRBC) when cocultured with a normal T-cell subset(s). The spleen cells from the tumor-bearing mouse required for the suppression bear ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(83)90047-3

    authors： Ingenito GG,Calkins CE

    更新日期：1983-07-01 00:00:00

  • Maternal HEL immunization has no lasting effects on the immune response of offspring to immunization with hen egg-white lysozyme.

    abstract：:The effect of prior maternal immunization on the murine offspring response to subsequent immunization with hen egg-white lysozyme was examined. Adult female A/J mice were immunized with 100 micrograms HEL-CFA intraperitoneally 10-27 weeks before conception. The offspring of these experimental female mice were then imm...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1123

    authors： Jelonek MT,Brust JL,Song CH,Calandra GB,Miller A,Sercarz EE,Keller MA

    更新日期：1993-05-01 00:00:00

  • Autologous stromal vascular fraction cells: a tool for facilitating tolerance in rheumatic disease.

    abstract：:Since the days of Medawar, the goal of therapeutic tolerogenesis has been a "Holy Grail" for immunologists. While knowledge of cellular and molecular mechanisms of this process has been increasing at an exponential rate, clinical progress has been minimal. To provide a mechanistic background of tolerogenesis, we overv...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2010.04.002

    authors： Ichim TE,Harman RJ,Min WP,Minev B,Solano F,Rodriguez JP,Alexandrescu DT,De Necochea-Campion R,Hu X,Marleau AM,Riordan NH

    更新日期：2010-01-01 00:00:00

  • Migration of lymphocytes through endothelial cell monolayers: augmentation by interferon-gamma.

    abstract：:During normal lymphocyte recirculation and in chronic inflammation, lymphocytes emigrate from blood into the perivascular tissue. The mechanism of lymphocyte migration through the endothelial cell (EC) layer of blood vessels is poorly understood. To identify factors that control lymphocyte emigration, a method has bee...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90324-3

    authors： Oppenheimer-Marks N,Ziff M

    更新日期：1988-07-01 00:00:00

  • Modulation of granulomatous inflammation in murine schistosomiasis mansoni by enteric exposure to schistosome ova: in vitro characterization of a regulatory mechanism within the granuloma.

    abstract：:Enteric immunization with schistosome ova results in a diminished granulomatous response. This study explored a mechanism by which enteric immunization may decrease granuloma size. Granulomas from livers of acutely infected mice were dissociated and the dispersed cells were depleted of macrophages. As defined by a dir...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(87)90227-9

    authors： Weinstock JV,Blum AM

    更新日期：1987-09-01 00:00:00

  • Adhesion of lymphoid cells to fibroblasts in tissue culture.

    abstract：:In this study we have examined the cellular and molecular specificity of lymphocyte interaction with fibroblasts. Using mitogen-activated T-cells, we found that attachment to fibroblasts was highly sensitive to protease treatment, and to an antibody raised against the purified lymphocyte plasma membrane, but it was no...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90146-9

    authors： Abraham D,Bou-Gharios G,Muir H,Olsen I

    更新日期：1989-08-01 00:00:00

  • Semaphorin 4A is dynamically regulated during thymocyte development in mice.

    abstract：:Semaphorins are important regulators of peripheral T and B-cell mediated immune responses in mice and humans. Modulatory roles of semaphorins in T cell development are also being characterized. We carefully analyzed the gene expression and protein levels of semaphorins 4A, 4D, and 7A at various developmental stages of...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2013.03.006

    authors： Linder GE,Chuntova PD,McLelland BT,Añó L,Obodo UC,Crider NJ,Matthes DJ,García-Ojeda ME,Manilay JO,Chatterjea D

    更新日期：2013-02-01 00:00:00

  • Role of immune cells in obesity induced low grade inflammation and insulin resistance.

    abstract：:The frequency of obesity is enormously growing worldwide. Obesity results when energy intake exceeds, energy expenditure. Excess adiposity is a major risk factor in the progress of various metabolic disorders accounting insulin resistance, hypertension, Type 2 diabetes, nonalcoholic fatty liver disease, polycystic ova...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2017.03.001

    authors： Asghar A,Sheikh N

    更新日期：2017-05-01 00:00:00

  • Characterization of a long-term T-helper-cell line which produces IL-2 and induces immunoglobulin secretion.

    abstract：:Six OKT4+ human T-cell lines that require continuing PHA stimulation and TCGF for continuous growth were established. The cells from all six of these T-cell lines became smaller in size and lost the cell surface Ia antigen when they were grown in phytohemagglutinin (PHA)-depleted growth factor. These cells were unable...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90275-2

    authors： Tsui F,Underdown BJ,Klein M,Zimmerman B

    更新日期：1984-04-15 00:00:00

  • Monoclonal anti-actin antibody recognizes a surface molecule on normal and transformed human B lymphocytes: expression varies with phase of cell cycle.

    abstract：:A monoclonal anti-actin antibody, 2C9, was used to study the distribution of an actin-like cell-surface antigen (hereafter termed actin) on a lymphoblastoid cell line LA350 and on human peripheral blood lymphocytes. It was determined that 8-40% of LA350 cells and 3-15% of peripheral blood lymphocytes from healthy dono...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(86)90296-0

    authors： Bach MA,Lewis DE,McClure JE,Parikh N,Rosenblatt HM,Shearer WT

    更新日期：1986-04-01 00:00:00

  • Anti-Fas antibody induces different types of cell death in the human histiocytic cell line, U937, and the human B cell line, B104: the role of single-strand DNA breaks and poly (ADP-ribosyl)ation in cell death.

    abstract：:We investigated the anti-Fas antibody-induced cell death in two different types of human cell lines, U937 and B104. IFN-gamma increased the surface expression of Fas antigen and susceptibility to anti-Fas Ab-induced cell death of B104 and U937 cells. Anti-Fas Ab-induced death of U937 and B104 cells required neither a ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1994.1016

    authors： Sumimoto S,Ishigami T,Horiguchi Y,Yonehara S,Kanazashi S,Heike T,Katamura K,Mayumi M

    更新日期：1994-01-01 00:00:00

  • Suppressor cell regulation of encephalitogenic T cell lines: generation of suppressor macrophages with cyclosporin A and myelin basic protein.

    abstract：:Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) can be adoptively transferred using myelin basic protein (BP)-specific helper T cell lines, and suppressor cells may be important in recovery from EAE. In order to generate suppressor cells, spleen cells obtained from BP-complete Freund's adjuvant (CFA...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90322-i

    authors： Whitham RH,Vandenbark AA,Bourdette DN,Chou YK,Offner H

    更新日期：1990-04-01 00:00:00

  • Beta2-integrin, LFA-1, and TCR/CD3 synergistically induce tyrosine phosphorylation of focal adhesion kinase (pp125(FAK)) in PHA-activated T cells.

    abstract：:Complete T cell activation requires not only a first signal via TCR/CD3 engagement but also a costimulatory signal through accessory receptors such as CD2, CD28, or integrins. Focal adhesion kinase, pp125(FAK) (FAK), was previously shown to be localized in focal adhesions in fibroblasts and to be involved in integrin-...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1999.1472

    authors： Tabassam FH,Umehara H,Huang JY,Gouda S,Kono T,Okazaki T,van Seventer JM,Domae N

    更新日期：1999-05-01 00:00:00

  • Partial restoration of Con A-induced proliferation, IL-2 receptor expression, and IL-2 synthesis in aged murine lymphocytes by phorbol myristate acetate and ionomycin.

    abstract：:The activation by concanavalin A (Con A) of murine lymphocytes derived from aged animals is impaired, as demonstrated by lower IL-2 synthesis, display of fewer IL-2 receptors, and less [3H]thymidine incorporation relative to similarly treated cells from young animals. The ability of the phorbol ester, phorbol 12-myris...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90250-x

    authors： Thoman ML,Weigle WO

    更新日期：1988-06-01 00:00:00

  • Altered cell-averaged microviscosity of murine peritoneal macrophages undergoing activation in vivo or in vitro.

    abstract：:The cell-averaged microviscosity of intact murine peritoneal mononuclear phagocytes in various stages of activation was assessed by quantifying fluorescent depolarization of 1,6-diphenyl-1,3,5-hexatriene. Macrophages activated in vivo with Mycobacterium bovis, strain BCG, were significantly more fluid than resident pe...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(87)90026-8

    authors： Somers SD,Yuli I,Snyderman R,Adams DO

    更新日期：1987-02-01 00:00:00

  • CTLA-4 and autoimmune thyroid disease: lack of influence of the A49G signal peptide polymorphism on functional recombinant human CTLA-4.

    abstract：:A single nucleotide A49G polymorphism (SNP) of CTLA-4 has been linked and associated with the autoimmune thyroid diseases (AITD) and thyroid autoantibody secretion. We have explored the functional mechanisms of CTLA-4 by means of recombinant human CTLA-4 expressed on transfected Jurkat T cells. Analysis of CTLA-4 tran...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/s0008-8749(02)00018-7

    authors： Xu Y,Graves PN,Tomer Y,Davies TF

    更新日期：2002-02-01 00:00:00

  • Preferential recognition of peroxynitrite modified human DNA by circulating autoantibodies in cancer patients.

    abstract：:Peroxynitrite (ONOO(-)) has been vastly implicated in mutagenesis and cancer development. Present study probes the antigenicity of peroxynitrite damaged DNA (ONOO(-)-DNA) in cancer patients. Purified human placental DNA was damaged by the synergistic action of sodium nitroprusside (SNP) and Pyrogallol for 3h at 37 deg...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2008.08.002

    authors： Habib S,Moinuddin,Ali A,Ali R

    更新日期：2009-01-01 00:00:00

  • Analysis of CD3-antibody-mediated inhibition of T-cell activation.

    abstract：:In this study the influence of a non-mitogenic anti-CD3 antibody on accessory cell-dependent antigen and mitogen-induced T-lymphocyte proliferation has been investigated. The antibody was found to completely inhibit PHA, Con A, PWM, and tetanus toxoid stimulation, with no effect on the proliferation induced by the cal...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(86)90014-6

    authors： Holter W,Majdic O,Stockinger H,Liszka K,Fischer G,Knapp W

    更新日期：1986-06-01 00:00:00

  • Cross-linking staphylococcal enterotoxin A bound to major histocompatibility complex class I is required for TNF-alpha secretion.

    abstract：:The mechanism of how superantigens function to activate cells has been linked to their ability to bind and cross-link the major histocompatibility complex class II (MHCII) molecule. Cells that lack the MHCII molecule also respond to superantigens, however, with much less efficiency. Therefore, the purpose of this stud...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1999.1571

    authors： Wright AD,Chapes SK

    更新日期：1999-11-01 00:00:00

  • Identification of a T cell membrane protein possibly involved in IL-4-induced B cell immunoglobulin class switching to IgE.

    abstract：:The murine T cell hybridoma line, MBI-1.15, secretes a 17-kDa protein which decreases binding activity of the CD23 molecule for its natural ligand, IgE. This protein, denoted epsilon receptor-modulating protein (epsilon RMP), was previously characterized and shown to be a novel serine protease. The present studies sho...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1994.1036

    authors： Matsushita S,Katz DH

    更新日期：1994-02-01 00:00:00

  • TLR7, IFNγ, and T-bet: their roles in the development of ABCs in female-biased autoimmunity.

    abstract：:The majority of autoimmune diseases have a strong gender bias, affecting mostly females. Gender-specific factors like sex-hormones, the presence or absence of a second X chromosome, and gender-specific gut microbiota may contribute to this bias. In this review we will discuss the role of the X chromosome encoded toll-...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2014.12.002

    authors： Rubtsova K,Marrack P,Rubtsov AV

    更新日期：2015-04-01 00:00:00