Colony formation by subpopulations of human T lymphocytes. III. Antigenic phenotype and function of colony-forming cells, colony cells, and their expanded progeny.

abstract：:Estrogen displays potent immunoregulatory properties. In the present study we investigated the in vivo effect of estrogen on natural killer (NK) cell cytotoxic activity in several mouse strains. After castration, 17 beta-estradiol was administered in low or high doses. After 3-6 weeks of hormone administration an in v...

journal_title：Cellular immunology

authors： Nilsson N,Carlsten H

更新日期：1994-10-01 00:00:00

abstract：:Unconventional T cells are gaining center stage as important effector and regulatory cells that orchestrate innate and adaptive immune responses. Human Vγ9/Vδ2 T cells are amongst the best understood unconventional T cells, as they are easily accessible in peripheral blood, can readily be expanded and manipulated in v...

journal_title：Cellular immunology

authors： Tyler CJ,Doherty DG,Moser B,Eberl M

更新日期：2015-07-01 00:00:00

abstract：:The actions of interleukin-4 (IL-4) in vivo are likely to be positively influenced by the expression of membrane IL-4 receptors (mIL-4R) on target cells and negatively by the concentration of soluble IL-4 receptors (sIL-4R) in the extracellular environment. Inasmuch as the two forms of the mouse IL-4R are differential...

journal_title：Cellular immunology

authors： Chilton PM,Fernandez-Botran R

更新日期：1997-09-15 00:00:00

abstract：:CD5 is a 67-kDa antigen that is expressed on the membrane of the majority of human T cells, and on a subset of B cells. Previous studies have demonstrated that anti-CD5 monoclonal antibodies (mAb) can provide a helper signal for T cell activation through the TCR/CD3 complex. We now demonstrate that when CD5 is crossli...

journal_title：Cellular immunology

authors： Verwilghen J,Vandesande R,Vandenberghe P,Ceuppens JL

更新日期：1990-11-01 00:00:00

abstract：:An important subset in regulating antitumor immunity is the maturation and accumulation of intratumor dendritic cells (DCs), inducing potent T cell cytotoxicity. In this study, we explored how the soluble abundant high-mobility group box 1 protein (HMGB1) affected DC activation and retention within lung cancers, and i...

journal_title：Cellular immunology

authors： Gao Q,Li F,Wang S,Shen Z,Cheng S,Ping Y,Qin G,Chen X,Yang L,Cao L,Liu S,Zhang B,Wang L,Sun Y,Zhang Y

更新日期：2019-09-01 00:00:00

abstract：:The concentration of cytosolic-free calcium (Ca2+i) was determined with aequorin in RAW-264 macrophage-like cells activated in vitro for tumor cell killing with lymphokine (LK) and lipopolysaccharide (LPS). Treatments of these cells with optimal doses of stimulants, which evoked the development of cytolytic activity, ...

journal_title：Cellular immunology

authors： Gorecka-Tisera AM,Snowdowne KW,Borle AB

更新日期：1986-07-01 00:00:00

abstract：:Transduction with recombinant, replication-defective adenoviral (rAd) vectors encoding a transgene is an efficient method for gene transfer into human dendritic cells (DCs). Livin is a good candidate for cancer immunotherapy since it is overexpressed in most common human cancers, poorly expressed in most normal adult ...

journal_title：Cellular immunology

authors： Xie J,Guo X,Liu F,Luo J,Duan F,Tao X

更新日期：2015-09-01 00:00:00

abstract：:The activation by concanavalin A (Con A) of murine lymphocytes derived from aged animals is impaired, as demonstrated by lower IL-2 synthesis, display of fewer IL-2 receptors, and less [3H]thymidine incorporation relative to similarly treated cells from young animals. The ability of the phorbol ester, phorbol 12-myris...

journal_title：Cellular immunology

authors： Thoman ML,Weigle WO

更新日期：1988-06-01 00:00:00

abstract：:American cutaneous leishmaniasis (ACL) is a disease where susceptibility or resistance is dependent on T cell response. This is characterized by an increased in CD4⁺ T cells, capable of inducing opposite disease profiles, and CD8⁺ T cells, that are related to immuno protection. We characterized T lymphocytes from pati...

journal_title：Cellular immunology

authors： Brelaz-de-Castro MC,de Almeida AF,de Oliveira AP,de Assis-Souza M,da Rocha LF,Pereira VR

更新日期：2012-10-01 00:00:00

abstract：:C3H/HeJ mice are homozygous for the Lpsd allele and, as a consequence, are hyporesponsive to all of the biological effects of bacterial lipopolysaccharide (LPS) that have been studied. These mice die in the early phase of infection when inoculated with virulent Salmonella. This susceptibility is also regulated by the ...

journal_title：Cellular immunology

authors： Weinstein DL,Lissner CR,Swanson RN,O'Brien AD

更新日期：1986-10-01 00:00:00

abstract：:Several studies have demonstrated that addition of soluble anti-CD6 mAbs to 12-O-tetradecanoylphorbol 13-acetate (TPA)-treated naive T cells can induce cell proliferation. We showed in the present study that cell proliferation in TPA-treated T cell cultures can be enhanced several fold when the anti-CD6 mAbs are eithe...

journal_title：Cellular immunology

authors： Osorio LM,Ordonez C,Garcia CA,Jondal M,Chow SC

更新日期：1995-11-01 00:00:00

abstract：:The bacterial determinants of pulmonary Francisella induced inflammatory responses and their interaction with host components are not clearly defined. In this study, proteomic and immunoblot analyses showed presence of a cytoplasmic protein elongation factor Tu (EF-Tu) in the membrane fractions of virulent Francisella...

journal_title：Cellular immunology

authors： Sharma J,Mishra BB,Li Q,Teale JM

更新日期：2011-01-01 00:00:00

abstract：:Positive selection of T lymphocytes expressing self. MHC-restricted T cell receptors is mediated by MHC molecules expressed on thymic stroma. Among the more controversial aspects of this process is the relative role of MHC molecules on epithelial versus bone marrow-derived stromal elements (BM-APC). For CD4+ T cells, ...

journal_title：Cellular immunology

authors： Fort MM,Pardoll DM

更新日期：1996-07-10 00:00:00

abstract：:G proteins are membrane-bound molecules involved in coupling of surface receptors with signal transduction effector systems in multiple cell types including T lymphocytes. Given that mature T cells which lack antigen receptors (CDl-Ti) are refractory to stimulation through CD2 or other accessory molecules, T cell rece...

journal_title：Cellular immunology

authors： Moingeon P,Jin YJ,Stebbins CC,Lopez PA,Alcover A,Reinherz EL

更新日期：1990-07-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) play a major role in modulating immune response, but only a few reports focused on MDSCs in the liver of sepsis states. Here, we investigated the changes in MDSCs in liver of the cecal ligation and puncture (CLP) mice. The results of flow cytometry showed that MDSCs accumulate ...

journal_title：Cellular immunology

authors： Ren D,Bi Q,Li L,Gao Y,Liang Y,Li Y,Liu J,Peng L,Xiao J

更新日期：2012-09-01 00:00:00

abstract：:Visceral leishmaniasis (VL) is a fatal disease when acute and untreated. The treatment against this disease is long and presents toxicity and/or high costs. Moreover, parasite resistance has been increasing. Therefore, alternative control measures to avoid the spread of disease should be considered. It is accepted tha...

journal_title：Cellular immunology

authors： Ribeiro PAF,Dias DS,Lage DP,Costa LE,Martins VT,Tavares GSV,Mendonça DVC,Lima MP,Oliveira JS,Steiner BT,Machado-de-Ávila RA,Roatt BM,Chávez-Fumagalli MA,Menezes-Souza D,Duarte MC,Teixeira AL,Coelho EAF

更新日期：2018-09-01 00:00:00

abstract：:The first step of Ig heavy chain class switch recombination (CSR) is considered to be DNA double strand break (DSB) formation in the two switch (S) regions (S(mu) and downstream S(H)), although the underlying mechanism is unknown. Recently, it has been demonstrated that at least Spo11, a homolog of the novel type II t...

journal_title：Cellular immunology

authors： Tokuyama H,Tokuyama Y

更新日期：2000-05-25 00:00:00

abstract：:The myelin-associated stress protein alphaB-crystallin triggers strong proliferative responses and IFN-gamma production by human T cells and it is considered a candidate autoantigen in multiple sclerosis. In this study we examined the capacity of alphaB-crystallin or peptides derived thereof to induce experimental aut...

journal_title：Cellular immunology

authors： van Stipdonk MJ,Willems AA,Verbeek R,Boog CJ,van Noort JM

更新日期：2000-09-15 00:00:00

abstract：:Thymic (T) or bursal (B) lymphocytes from chicks sensitized to Mycobacterium tuberculosis produce an avian lymphocyte inhibitory factor (LyIF). The physiochemical properties of both T and B LyIF were established by ultrafiltration which yielded four fractions with molecular weight ranges of greater than 100,000; 50,00...

journal_title：Cellular immunology

authors： Martin DE,Glick B

更新日期：1983-07-15 00:00:00

abstract：:In this study, the major histocompatibility complex-unrestricted cytotoxic effectors elicited in human peripheral blood mononuclear cells (PBMC) by a mannoprotein (MP) component from the cell wall of the human indigenous microorganism Candida albicans have been compared with those obtained by stimulation with interleu...

journal_title：Cellular immunology

authors： Ausiello CM,Palma C,Spagnoli GC,Piazza A,Casciani CU,Cassone A

更新日期：1989-07-01 00:00:00

abstract：:Semaphorins are important regulators of peripheral T and B-cell mediated immune responses in mice and humans. Modulatory roles of semaphorins in T cell development are also being characterized. We carefully analyzed the gene expression and protein levels of semaphorins 4A, 4D, and 7A at various developmental stages of...

journal_title：Cellular immunology

authors： Linder GE,Chuntova PD,McLelland BT,Añó L,Obodo UC,Crider NJ,Matthes DJ,García-Ojeda ME,Manilay JO,Chatterjea D

更新日期：2013-02-01 00:00:00

abstract：:Rat IL-2 produced by spleen cells in culture with concanavalin A was purified using gel filtration, hydrophobic chromatography, and ion-exchange chromatography. At least two forms of rat IL-2 were found to be separable by ion-exchange chromatography. These two forms have been designated form I and form II. Form I of r...

journal_title：Cellular immunology

authors： Thompson LP,Di Sabato G

更新日期：1988-06-01 00:00:00

abstract：:Inhibitors of energy metabolism, 2-deoxyglucose and cyanide were shown to inhibit NKCF-mediated lysis of L929 target cells at the same molar concentrations that effectively inhibited cellular ATP levels and the toxic effects of pseudomonas toxin A. In addition, inhibitors of receptor-mediated endocytosis, cytochalasin...

journal_title：Cellular immunology

authors： Deem RL,Niederlehner A,Targan SR

更新日期：1986-10-01 00:00:00

abstract：:The skin and draining lymph nodes of BALB/c mice were examined for IFN-gamma, IL-2, and IL-4 mRNA expression by in situ hybridization in three successive infestations with nymphal Ixodes ricinus ticks. IFN-gamma and IL-2 mRNA positive cells were readily detected in lymph node sections during primary antigenic stimulat...

journal_title：Cellular immunology

authors： Mbow ML,Rutti B,Brossard M

更新日期：1994-06-01 00:00:00

abstract：:The anti-spirochete T cell immune response to immunization with Borrelia burgdorferi was investigated. The cellular immune response to vaccination of immunocompetent BALB/c mice was characterized initially in vitro by assay of the proliferative response of primary lymph node cells to B. burgdorferi sonicate. Subsequen...

journal_title：Cellular immunology

authors： Rao TD,Frey AB

更新日期：1995-05-01 00:00:00

abstract：:Monolayers of freshly isolated human monocytes are known to ingest particulate activators of the human alternative complement pathway. The ingestion of rabbit erythrocytes, ER, by human monocytes in serum-free medium was studied. The process is Mg2+-dependent and optimum phagocytic activity was obtained at approximate...

journal_title：Cellular immunology

authors： Chakravarti B

更新日期：1988-05-01 00:00:00

abstract：:We have previously described a novel human B cell differentiation factor (BCDF), 446-BCDF, that is distinct biochemically and functionally from other cytokines. Since signal transduction pathways involved in human B cell differentiation have been incompletely studied and are poorly understood, we assessed the effects ...

journal_title：Cellular immunology

authors： Huang R,Cioffi J,Berg K,London R,Cidon M,Maayani S,Mayer L

更新日期：1995-04-15 00:00:00

abstract：:To investigate a role for T lymphocytes in primary demyelination of central nervous system (CNS) tissue, antigen-specific T cell lines sensitized to myelin-associated and myelin-unrelated antigens were developed from SJL mice and tested on myelinated organotypic cultures of syngeneic spinal cord. Demyelination was ass...

journal_title：Cellular immunology

authors： Lyman WD,Roth GA,Chiu FC,Brosnan CF,Bornstein MB,Raine CS

更新日期：1986-10-01 00:00:00

abstract：:Twenty-seven different CD45 monoclonal antibodies (mAb) were assessed for their ability to block cytotoxicity of alloreactive CD4+ MHC class II-specific or CD8+ class I-specific human T cell clones (n = 3 and 5, respectively). Twelve of 27 blocked the former but only 1/27 the latter, although all 27 significantly inhi...

journal_title：Cellular immunology

authors： Pawelec G,Bühring HJ,Müller C

更新日期：1990-05-01 00:00:00

abstract：:Mice infected with virulent Mycobacterium tuberculosis exhibit an age-related increase in susceptibility to disease. The basis of this susceptibility has previously been shown to reflect an inability of the aged host to generate protective CD4 T cells during the early course of the infection. The results of the presen...

journal_title：Cellular immunology

authors： Orme IM,Griffin JP,Roberts AD,Ernst DN

更新日期：1993-03-01 00:00:00