Abstract：
:Mice infected with virulent Mycobacterium tuberculosis exhibit an age-related increase in susceptibility to disease. The basis of this susceptibility has previously been shown to reflect an inability of the aged host to generate protective CD4 T cells during the early course of the infection. The results of the present study, however, indicate that the emergence of interferon-gamma secreting protective CD4 T cells in such mice is not absent, but merely delayed. Furthermore, flow cytometric analysis of such cells accumulating in the spleens of intravenously infected 24-month-old animals revealed that a large percentage of CD4 cells initially had poor or negative expression of the cell surface markers L-selectin and CD11a, molecules that may be important in the movement of T cells across inflamed endothelial blood vessel surfaces. During the course of the tuberculosis infection the numbers of CD4 cells in the spleens of old mice expressing high levels of these molecules rose to levels similar to those observed in young mice, but by that time the numbers of bacilli in target organs had reached close to fatal levels. These data suggest that the capacity of CD4 cells to cross inflamed endothelial surfaces and home into sites of mycobacterial infection may be deficient in old mice, and hence support the hypothesis that the ensuing delay in accumulating such cells within infected lesions contributes to the increased susceptibility of these animals to disease.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Orme IM,Griffin JP,Roberts AD,Ernst DNdoi
10.1006/cimm.1993.1062subject
Has Abstractpub_date
1993-03-01 00:00:00pages
222-9issue
1eissn
0008-8749issn
1090-2163pii
S0008-8749(83)71062-2journal_volume
147pub_type
杂志文章abstract：:Ca(2+) and Sr(2+) entry pathways activated by pro-inflammatory agonists FMLP, LTB(4) and PAF have been compared to thapsigargin in human neutrophils. 2-APB (10microM) increased Ca(2+) influx and to a greater extent in agonist than in thapsigargin stimulated neutrophils. This action of 2-APB was specific to Ca(2+) beca...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2010.07.009
更新日期：2010-01-01 00:00:00
abstract：:Tolerant and nontolerant murine Th1 and Th2 clones, specific for human gamma-globulin (HGG), were compared for their ability to promote cell cycle entry and progression by B cells in vitro. When stimulated with HGG, nontolerant Th1 and Th2 clones induced similar increases in B cell membrane MHC class II levels--a phen...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(92)90264-p
更新日期：1992-06-01 00:00:00
abstract：:The activation by concanavalin A (Con A) of murine lymphocytes derived from aged animals is impaired, as demonstrated by lower IL-2 synthesis, display of fewer IL-2 receptors, and less [3H]thymidine incorporation relative to similarly treated cells from young animals. The ability of the phorbol ester, phorbol 12-myris...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90250-x
更新日期：1988-06-01 00:00:00
abstract：:Peripheral blood leukocytes (PBL), nonadherent lymphocytes, and adherent monocytes separated from freshly isolated blood of 15 dogs were analyzed for their ability to mediate antibody-dependent cell-mediated cytotoxicity (ADCC) in combination with murine anti-tumor monoclonal antibodies (MAbs). Canine monocytes isolat...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90194-3
更新日期：1988-09-01 00:00:00
abstract：:We have systematically studied uncloned human cell lines derived from anti-influenza A virus or anti-Epstein-Barr virus (EBV) bulk cultures, or from cultures highly enriched for CD4+ or CD8+ lymphocytes. The most noteworthy results are the following: (1) Anti-viral bulk cultures consisted of more than 90% of CD8+ cell...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90380-8
更新日期：1989-02-01 00:00:00
abstract：:The knowledge of mechanisms of regulation of IL-10 production by B cells remains still very limited. We show here that highly purified mouse B cells stimulated with LPS produce significant levels of IL-10, but Bregs in our model do not express detectable level of either Foxp3 or GATA-3. Nevertheless, IL-10 production ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2019.103987
更新日期：2020-01-01 00:00:00
abstract：:The impact of BCR:CD21 co-engagement on B cell expression of molecules critical for T cell activation was investigated with receptor-specific mAbs conjugated to high MW dextran as stimulatory ligands. In the absence of IL-4, BCR:CD21 co-ligation augmented BCR-triggered CD86 only under conditions of very low BCR ligand...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/s0008-8749(02)00512-9
更新日期：2002-03-01 00:00:00
abstract：:We investigated the regulation of IL6 biological activity, de novo synthesis, and mRNA levels in adult vascular endothelial cells (EC) by bacterial endotoxin or inflammatory cytokines. Cells incubated without stimulus released scant IL6 activity. IFN gamma, IL2, or PDGF did not augment IL6 release from EC. LPS, lipid ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90095-6
更新日期：1989-09-01 00:00:00
abstract：:TE44, an H-2b-restricted, self-reactive T-cell line, did not produce autocrine-acting growth factors, neither after antigenic nor after mitogenic activation; they remained for their proliferation completely dependent on exogenously added IL-2. Administration of IL-4, which poorly promotes growth by itself, resulted in...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90163-l
更新日期：1990-10-01 00:00:00
abstract：:Recently, it has been reported that IL-4 production by murine Th2 cell lines is insensitive to inhibition by E-type prostaglandins. In the present study, IL-4 production in vitro by freshly isolated concanavalin A (Con A)-stimulated murine spleen cells was readily suppressed by PGE2 with an I50 of 2 nM. Comparable sup...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(95)80039-l
更新日期：1995-02-01 00:00:00
abstract：:Neuroinflammation plays a pivotal role in the incidence and progression of Alzheimer's disease (AD). Cathelicidin-related antimicrobial peptide (CRAMP) is critically involved in the innate neuronal responses of chronic neuroinflammation in AD and thus plays a key role in the disease. Here, we show that Aβ42 induced mi...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2018.05.008
更新日期：2018-09-01 00:00:00
abstract：:We compared the effects of calorie restriction (CR) and cyclophosphamide (CTX) on the progression of lupus nephritis and immunological changes in NZB/NZW F1 mice. Ad libitum (AL)/CTX and CR delayed onset of proteinuria and significantly decreased serum levels of anti-dsDNA, anti-histone, and circulating immune complex...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2004.04.001
更新日期：2004-03-01 00:00:00
abstract：:Cytokines are soluble proteins that mediate immune reactions and are responsible for communication among immune cells. CD4(+) T cells are the principle sources of cytokines of adaptive immunity. Cytokines play critical roles in the differentiation and effector function of CD4(+) T cells. They also play key roles in di...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2012.07.009
更新日期：2012-07-01 00:00:00
abstract：:Immunosuppression is a well-established risk factor for Visceral Leishmaniasis. Post-immunosuppression leishmaniasis is characterized by an increase of parasite burden, hematopoietic disorders and unusual clinical manifestations. Although there are many reports on bone marrow findings in VL, less is known about the re...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2017.10.016
更新日期：2018-04-01 00:00:00
abstract：:Interleukin-4 (IL-4) acts directly on purified human peripheral blood B cells cultured in the presence of Epstein-Barr virus (EBV) to induce IgE secretion and to enhance the secretion of IgG and IgM. Interferon-gamma (IFN-gamma) inhibits IgE secretion in this system, without affecting the secretion of the other Ig iso...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(91)90114-q
更新日期：1991-04-01 00:00:00
abstract：:There are now several murine models of autoimmune cholangitis that have features both similar and distinct from human PBC. One such model, the NOD.c3c4 mouse, manifests portal cell infiltrates, anti-mitochondrial antibodies but also biliary cysts. The biliary cysts are not a component of PBC and not found in the other...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2011.01.005
更新日期：2011-01-01 00:00:00
abstract：:Mature thymocytes are usually defined and separated from other less mature thymocytes on the basis of their mutually exclusive expression of either CD4 or CD8. However, such murine "single positives" include a subpopulation of immature cells with properties resembling CD4- CD8- thymocytes or CD4+ CD8+ cortical blasts....
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90042-1
更新日期：1988-05-01 00:00:00
abstract：:We compared macrophage binding and killing of F5b cells to the binding and killing of P815 mastocytoma cells and to several other nontransformed and transformed cell lines. Formalin fixation of elicited or activated macrophages did not affect binding of F5b or 3T3 cells but did abrogate binding of P815 cells. However,...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(91)90190-m
更新日期：1991-03-01 00:00:00
abstract：:Simultaneous stimulation of human monocytes/macrophages or THP1 cells with LPS and an antibody specific for the activation marker CD69 induces apoptosis. Here we demonstrate the involvement of multiple independent signals that are necessary for apoptosis induction. Thus, inhibitors of phospholipase A2 and lipoxygenase...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0232
更新日期：1996-09-15 00:00:00
abstract：:Neutrophils exhibit intrinsic sinusoidal metabolite concentration oscillations of 3 min in resting cells and an additional approximately 10- or 20-s oscillation in migrating/adhering cells. To better understand immune complex (IC)-mediated leukocyte activation, we have studied neutrophil metabolic oscillations in the ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1999.1481
更新日期：1999-05-25 00:00:00
abstract：:To determine the relative contributions of DC subsets in the development of protective immunity to Listeria monocytogenes we examined the relationship between maturation, bacterial burden, and T cell priming capacity of four well characterized subsets of splenic DC following infection with Lm. CD8α(+), CD4(+), and CD8...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2011.03.001
更新日期：2011-01-01 00:00:00
abstract：:Previous studies have shown that supernatants from concanavalin A-stimulated human peripheral blood mononuclear cells and isolated Leu-2 suppressor/cytotoxic T cells are chemotactic for Leu-3 helper/inducer T cells. The current study shows that lymphocyte chemotactic factor (LCF) is also produced following antigen (te...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(86)90375-8
更新日期：1986-01-01 00:00:00
abstract：:Double immunofluorescence studies for terminal deoxynucleotidyl transferase (TdT) and leucocyte surface membrane antigens have been used to characterize the small subpopulation of TdT-positive cells in human peripheral blood. The predominant antigens demonstrated were those coded for by the major histocompatibility co...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(85)90223-0
更新日期：1985-02-01 00:00:00
abstract：:Al adjuvants are used in vaccines to increase the immune response. NTPDase and AChE play a pivotal role and act in the regulation of the immune system. The effect of Al exposure in vitro and in vivo on NTPDase and AChE activities in the lymphocytes of rats was determined. In vitro, ATP hydrolysis was decreased by 20.4...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2010.08.001
更新日期：2010-01-01 00:00:00
abstract：:Gene products coded for within the HLA complex play an important role in the control of immune responses. Class I antigens, coded for by the HLA-A, B, and C loci, are expressed by virtually all mononuclear blood cells. Class II antigens, coded for by the DR, DQ, and DP loci, have a more limited tissue distribution. Th...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(86)90050-x
更新日期：1986-07-01 00:00:00
abstract：:Essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis share the same acquired genetic lesion, JAK2V617F. It is believed that cytokines participate in the activation of JAK2V617F. In this study, we analyzed the plasma levels of interleukin (IL)-23, IL-10 and IL-22 in patients with PV and ET. In the s...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2012.07.003
更新日期：2012-07-01 00:00:00
abstract：:Aging diminishes the amount of phosphotyrosine in the CD3zeta chains of resting and activated mouse CD4 T cells by about threefold and might therefore be expected to a corresponding decline in Zap-70 association with CD3zeta and in Zap-70 kinase function in CD3zeta complexes. We show here that aging leads, unexpectedl...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1998.1394
更新日期：1998-12-15 00:00:00
abstract：:Non-obese diabetic (NOD) mice develop spontaneous T-cell responses against pancreatic beta-cells, leading to islet cell destruction and diabetes. Despite high genetic similarity, non-obese resistant (NOR) mice do not develop diabetes. We show here that spleen cells of both NOD and NOR mice respond to the islet cell an...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2005.05.003
更新日期：2005-05-01 00:00:00
abstract：:Mesenchymal stromal cells (MSCs) are promising candidates for developing cell therapies for intractable diseases. To assess the feasibility of transplantation with human umbilical cord blood (hUCB)-derived MSCs, we analyzed the ability of these cells to function as alloantigen-presenting cells (APC) in vitro. hUCB-MSC...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2008.04.003
更新日期：2008-02-01 00:00:00
abstract：:In vivo adoptive transfer of T-cell-mediated immunity to the facultative intracellular bacterium Listeria monocytogenes is restricted, not only by the H-2 haplotype of the mice, but also by incompatibilities at non-H-2 loci. Thus, transfer between H-2 identical strains of mice with different background genes was repro...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(83)90373-8
更新日期：1983-03-01 00:00:00
