Semaphorin 4A is dynamically regulated during thymocyte development in mice.

abstract：:Peripheral blood polymorphonuclear neutrophils (PMN) from mice immunized with Blastomyces dermatitidis and then stimulated locally (intraperitoneally, ip) with B. dermatitidis antigen had enhanced killing of B. dermatitidis in vitro (54.4 +/- 19.49 of inoculum) compared to nonimmune mice (32.7 +/- 8.7%; P less than 0....

journal_title：Cellular immunology

authors： Morrison CJ,Brummer E,Stevens DA

更新日期：1987-11-01 00:00:00

abstract：:Recombinant IL-4 inhibits IL-2-induced lymphokine-activated killer (LAK) cell development of PBMC. We evaluated the effect of various cytokines in reversing IL-4-mediated LAK inhibition. PBMC were cultured in IL-2 (10-1000 u/ml) with or without IL-4 (2-100 u/ml) and tested for cytotoxicity against the NK-sensitive K56...

journal_title：Cellular immunology

authors： Swisher SG,Economou JS,Holmes EC,Golub SH

更新日期：1990-07-01 00:00:00

abstract：:Interleukin-4 (IL-4) acts directly on purified human peripheral blood B cells cultured in the presence of Epstein-Barr virus (EBV) to induce IgE secretion and to enhance the secretion of IgG and IgM. Interferon-gamma (IFN-gamma) inhibits IgE secretion in this system, without affecting the secretion of the other Ig iso...

journal_title：Cellular immunology

authors： Thyphronitis G,Banchereau J,Heusser C,Tsokos GC,Levine AD,Finkelman FD

更新日期：1991-04-01 00:00:00

abstract：:The complement receptor 2 (CR2; CD21), a 145,000 MW glycoprotein, has been useful as a marker of B lymphocyte maturation. It is expressed on the 1:13 monoclonal, EBV-transformed, B cell line which produces TNP-specific IgM-kappa and displays an in vitro capacity for differentiation. The line expresses the CD20+CD21+ p...

journal_title：Cellular immunology

authors： Pillemer SR,Tsokos GC,Barbieri SA,Balow JE,Golding B

更新日期：1990-02-01 00:00:00

abstract：:Mice infected with virulent Mycobacterium tuberculosis exhibit an age-related increase in susceptibility to disease. The basis of this susceptibility has previously been shown to reflect an inability of the aged host to generate protective CD4 T cells during the early course of the infection. The results of the presen...

journal_title：Cellular immunology

authors： Orme IM,Griffin JP,Roberts AD,Ernst DN

更新日期：1993-03-01 00:00:00

abstract：:The mechanism of suppression of experimental allergic encephalomyelitis (EAE) induced in Lewis rats by pretreatment with myelin basic protein (MBP) coupled to syngeneic spleen leukocytes (SL) was examined. Studies on the kinetics of the tolerance induction showed that pretreatment with MBP-SL suppressed EAE if given 7...

journal_title：Cellular immunology

authors： McKenna RM,Carter BG,Sehon AH

更新日期：1984-10-15 00:00:00

abstract：:We investigated the influence of Panagen DNA preparations on laboratory animals and IFN-induced human dendritic cells, as well as analyzed the data from a phase II clinical trial in the therapy of breast cancer. It was shown that this treatment resulted in increased number of CD8+/perforin+ T cells in peripheral lymph...

journal_title：Cellular immunology

authors： Alyamkina EA,Leplina OY,Ostanin AA,Chernykh ER,Nikolin VP,Popova NA,Proskurina AS,Gvozdeva TS,Dolgova EV,Orishchenko KE,Rogachev VA,Sidorov SV,Varaksin NA,Ryabicheva TG,Bogachev SS,Shurdov MA

更新日期：2012-03-01 00:00:00

abstract：:Recently we have shown that the generation of IFN-gamma-producing cells (IFN-gamma pc) were severely suppressed in cultures of Con A-stimulated splenocytes obtained from HgCl2-exposed BN but not Lewis rats. Since BN rats develop a TH2-biased polyclonal autoimmune syndrome upon exposure to HgCl2, whereas Lewis rats exh...

journal_title：Cellular immunology

authors： van der Meide PH,de Labie MC,Botman CA,Aten J,Weening JJ

更新日期：1995-04-01 00:00:00

abstract：:Inherited deficiency of the enzyme adenosine deaminase (ADA) has been found in a significant proportion of patients with severe combined immunodeficiency disease and inherited defect generally characterized by a deficiency of both B and T cells. Two questions are central to understanding the pathophysiology of this di...

journal_title：Cellular immunology

authors： Barton RW

更新日期：1985-10-15 00:00:00

abstract：:One of the auto-antigens aberrantly targeted in Multiple sclerosis is myelin basic protein (MBP). In this study, chronic progressive multiple sclerosis (CPMS) patients receiving the experimental drug MBP8298, on a compassionate care trial, were examined before and after high dose peptide treatment for their circulatin...

journal_title：Cellular immunology

authors： Loo EW,Krantz MJ,Agrawal B

更新日期：2012-11-01 00:00:00

abstract：:Like the thymus, the bursa of Fabricius is a site of massive lymphopoiesis accompanied by cell death in vivo. In the present study we have, therefore, examined whether chicken bursa and thymus cells exhibit apoptosis. Bursa and thymus cells from SC chickens, 4-10 weeks of age, were incubated for 8-24 hr with various r...

journal_title：Cellular immunology

authors： Asakawa J,Tsiagbe VK,Thorbecke GJ

更新日期：1993-03-01 00:00:00

abstract：:Because of the massive cytokine response elicited by superantigen exposure, it has been suggested that superantigens may act as adjuvants to boost conventional antigen responses. However, most previous studies have shown that in vivo exposure to superantigen suppressed subsequent T cell responses. Here we analyzed the...

journal_title：Cellular immunology

authors： Wen R,Surman S,Blackman MA,Woodland DL

更新日期：1997-03-15 00:00:00

abstract：:The systemic adoptive transfer of activated T cells, derived from tumor-draining lymph nodes (LNs), mediates the regression of established tumors. In this study, the requirement of cell adhesion molecules, CD11a/CD18 (LFA-1), CD54 (ICAM-1), CD49d/CD29 (VLA-4), and CD106 (VCAM-1), for T cell infiltration into tumors an...

journal_title：Cellular immunology

authors： Mukai S,Kagamu H,Shu S,Plautz GE

更新日期：1999-03-15 00:00:00

abstract：:Optical imaging is a valuable tool to visualise biological processes in the context of the tissue. Each imaging modality provides the biologist with different types of information - cell dynamics and migration over time can be tracked with time-lapse imaging (e.g. intra-vital imaging); an overview of whole tissues can...

journal_title：Cellular immunology

authors： Husna N,Gascoigne NRJ,Tey HL,Ng LG,Tan Y

更新日期：2019-10-01 00:00:00

abstract：:The aim of this study was to clarify the role of IL-4, IL-10, IL-13 and interferon (IFN) -γ levels in atopic asthma patients by studying the relation between their serum levels and severity of the disease. The effect of IL-10 -1082G/A and IFN-γ +874T/A SNPs was also studied. The study included 200 atopic children with...

journal_title：Cellular immunology

authors： Hussein YM,Alzahrani SS,Alharthi AA,Ghonaim MM,Alhazmi AS,Eed EM,Shalaby SM

更新日期：2014-05-01 00:00:00

abstract：:To characterize the binding properties of the Fc receptors on human macrophages, the binding of radiolabeled human IgG1 to peritoneal macrophages was assessed. Cells were obtained at the time of diagnostic laparoscopy from women undergoing evaluation of infertility. Macrophages bound on the average more IgG1 monomer t...

journal_title：Cellular immunology

authors： Kurlander RJ,Haney AF,Gartrell J

更新日期：1984-07-01 00:00:00

abstract：:Unconventional T cells are gaining center stage as important effector and regulatory cells that orchestrate innate and adaptive immune responses. Human Vγ9/Vδ2 T cells are amongst the best understood unconventional T cells, as they are easily accessible in peripheral blood, can readily be expanded and manipulated in v...

journal_title：Cellular immunology

authors： Tyler CJ,Doherty DG,Moser B,Eberl M

更新日期：2015-07-01 00:00:00

abstract：:In the present study we show that the opioid peptide beta-endorphin (beta-End) enhances Ia expression on murine B cells in cultures of unseparated spleen cells, mediated by low concentrations of IL-4 in the absence of antigenic or mitogenic stimulation. Since this effect was not found with purified B cells and no enha...

journal_title：Cellular immunology

authors： van den Bergh P,Rozing J,Nagelkerken L

更新日期：1993-06-01 00:00:00

abstract：:The interaction between Newcastle disease virus (NDV) and the suppressor cell circuit which regulates the induction phase of contact sensitivity reaction to picryl chloride (Pcl) was investigated. NDV infection impairs the activity of the T suppressor afferent cells (Ts-aff) which inhibit DNA synthesis in the draining...

journal_title：Cellular immunology

authors： Dieli F,Colonna Romano G,Abrignani S,Colizzi V,Salerno A

更新日期：1985-08-01 00:00:00

abstract：:Mammals and microorganisms have evolved a complex and tightly controlled mutual relationship. This interaction grants protection and energy source for the microorganisms, and on the other hand, provides several immunologic, metabolic and physiological advantages for the host. The gastrointestinal tract (GI) harbors th...

journal_title：Cellular immunology

authors： Nakagaki BN,Vieira AT,Rezende RM,David BA,Menezes GB

更新日期：2018-08-01 00:00:00

abstract：:The regulation of the migratory capacity of Percoll-purified large granular lymphocytes (LGL) into nitrocellulose filters was studied in a 2-hr assay with the use of modified Boyden chambers. Compounds that stimulate the natural killer cytotoxic function of LGL, such as interferons (natural beta, recombinant alpha A, ...

journal_title：Cellular immunology

authors： Polentarutti N,Bottazzi B,Balotta C,Erroi A,Mantovani A

更新日期：1986-08-01 00:00:00

abstract：:Intercellular adhesion molecule (ICAM)-1, or CD54, is a member of the immunoglobulin superfamily that binds to lymphocyte function-associated antigen-1 and macrophage-1 antigen. ICAM-1:LFA-1/Mac-1 interaction may be involved in both activation and extravasation of leukocytes. To determine the roles of ICAM-1 in the de...

journal_title：Cellular immunology

authors： Samoilova EB,Horton JL,Chen Y

更新日期：1998-11-25 00:00:00

abstract：:Eighty-seven murine monoclonal antibodies (MAb) produced against human tumors of various origins and representing six different immunoglobulin classes were tested for antitumor reactivity in antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) assays. Mouse splenocytes, thio...

journal_title：Cellular immunology

authors： Herlyn D,Herlyn M,Steplewski Z,Koprowski H

更新日期：1985-04-15 00:00:00

abstract：:Hybrid human-murine major histocompatibility antigens have been constructed and expressed on the surface of both human RD and murine L cell lines after DNA mediated gene transfer. These antigens linked the polymorphic domains (alpha 1 and alpha 2) of H-2Kb and the carboxy-terminal domains (alpha 3, transmembrane, and ...

journal_title：Cellular immunology

authors： Maziarz RT,Burakoff SJ,Reiss CS

更新日期：1986-04-15 00:00:00

abstract：:Human K cells are able to lyse human lymphoblastoid B cells in the presence of specific anti-human immunoglobulin isotype antibodies. The human lymphoblastoid B-cell line DAUDI (surface mu- and kappa-chains positive) was lysed in the presence of anti-mu and anti-kappa antisera, or IgG fraction of these antisera, and B...

journal_title：Cellular immunology

authors： Caraux J,Weigle WO

更新日期：1983-03-01 00:00:00

abstract：:Mutations in the X-linked inhibitor of apoptosis (XIAP) have recently been identified in patients with the rare genetic disease, X-linked lymphoproliferative syndrome (XLP), which was previously thought to be solely attributable to mutations in a distinct gene, SAP. To further understand the roles of these two factors...

journal_title：Cellular immunology

authors： Rumble JM,Oetjen KA,Stein PL,Schwartzberg PL,Moore BB,Duckett CS

更新日期：2009-01-01 00:00:00

abstract：:Acting through CD14 and TLR4/MD-2, lipopolysaccharide (LPS) triggers strong pro-inflammatory activation of macrophages, which, if not appropriately controlled, may lead to lethal septic shock. Therefore, numerous mechanisms of negative regulation of responses to LPS exist, but whether they include down-regulation of L...

journal_title：Cellular immunology

authors： Józefowski S,Śróttek M

更新日期：2017-02-01 00:00:00

abstract：:Although TGF-β and IL-6 would turn CD8(+) T cells to differentiate into non-cytotoxic state, these treated cells were converted to cytolytic phenotypes after re-exposure to their antigenic epitope in vitro. Here, using spleen cells from TCR transgenic mice expressing TCRαβ genes of clone RT1 recognizing an epitope pep...

journal_title：Cellular immunology

authors： Takaku S,Nakagawa Y,Owaki A,Shimizu M,Takahashi M,Takahashi H

更新日期：2012-12-01 00:00:00

abstract：:A majority (42/62) of TCR2+ interleukin 2-dependent human T lymphocyte clones was found concordantly to express not only the CD28 co-receptor structure at the cell surface but also its ligand B7. Interactions between CD28 and B7 can have important consequences for T cell activation, particularly in providing "signal 2...

journal_title：Cellular immunology

authors： Friccius H,Siegels-Hübenthal P,Rehbein A,Schlotz E,Pawelec G

更新日期：1993-10-15 00:00:00

abstract：:Earlier work from this laboratory revealed an increase in the level of null (Thy-1-, IgM-) lymphocytes in the maternal lymphoid organs during the first pregnancy in the mouse that was more pronounced during allogeneic pregnancy than during syngeneic pregnancy. In view of the suggestive evidence for the bone marrow ori...

journal_title：Cellular immunology

authors： Chatterjee-Hasrouni S,Parhar R,Lala PK

更新日期：1984-04-01 00:00:00