Active target cell processes, possibly involving receptor-mediated endocytosis, are critical for expression of cytotoxicity by natural killer cell-derived cytolytic factor.

abstract：:Peripheral blood polymorphonuclear neutrophils (PMN) from mice immunized with Blastomyces dermatitidis and then stimulated locally (intraperitoneally, ip) with B. dermatitidis antigen had enhanced killing of B. dermatitidis in vitro (54.4 +/- 19.49 of inoculum) compared to nonimmune mice (32.7 +/- 8.7%; P less than 0....

journal_title：Cellular immunology

authors： Morrison CJ,Brummer E,Stevens DA

更新日期：1987-11-01 00:00:00

abstract：:The 4F2 antigenic complex is expressed on most human cell lines in culture, on monocytes and activated lymphocytes, but not on resting T and B lymphocytes. Monoclonal antibody (mAb) CB43 recognizes an epitope of the 4F2 heterodimer either located on the light chain or dependent on the conformation of the molecule. The...

journal_title：Cellular immunology

authors： Spagnoli GC,Ausiello C,Palma C,Bellone G,Ippoliti G,Letarte M,Malavasi F

更新日期：1991-08-01 00:00:00

abstract：:Double immunofluorescence studies for terminal deoxynucleotidyl transferase (TdT) and leucocyte surface membrane antigens have been used to characterize the small subpopulation of TdT-positive cells in human peripheral blood. The predominant antigens demonstrated were those coded for by the major histocompatibility co...

journal_title：Cellular immunology

authors： Bradstock KF,Kerr A,Bollum FJ

更新日期：1985-02-01 00:00:00

abstract：:Class II major histocompatibility antigens (Ia) play a major role in regulating T-B cell interactions; therefore, regulation of the amount of Ia on B cells may be an important point of control in the immune response. Mitogens in human and murine systems have been reported to increase Ia expression on B cells, and in t...

journal_title：Cellular immunology

authors： Leitenberg D,Feldbush TL

更新日期：1988-02-01 00:00:00

abstract：:Alveolar macrophages are thought to play an important role in ongoing tissue breakdown and repair processes in the normal lung. The secretion and regulation of cathepsin D (important for the final breakdown of collagen) and fibronectin (involved in the healing process) in human peripheral blood monocytes (PBM) and pul...

journal_title：Cellular immunology

authors： Rossman MD,Maida BT,Douglas SD

更新日期：1990-04-01 00:00:00

abstract：:There are still questions about whether macrophage differentiation is predetermined or is induced in response to tissue microenvironments. C2D macrophage cells reside early in the macrophage lineage in vitro, but differentiate to a more mature phenotype after adoptive transfer to the peritoneal cavity (PEC-C2D). Since...

journal_title：Cellular immunology

authors： Ortega MT,Xie L,Mora S,Chapes SK

更新日期：2011-01-01 00:00:00

abstract：:The "NK-triggering-antigen regulator" (Nktar) gene is a locus identified in the C57BL/6 genome which regulates the ability of unlabeled activated Con A blasts to compete for recognition of labeled syngeneic Con A blasts by BALB/c NK cells. Linkage analysis on Con A blasts from (BALB/c x CByB6F1) N2 backcross progeny f...

journal_title：Cellular immunology

authors： Chou SR,Brownell A,Ko MS,Kaplan J

更新日期：2000-03-15 00:00:00

abstract：:The many signals that control the progress of various immune responses to both foreign and self antigens can be divided into no less than three major groups. The first group is the initial positive stimulus, associated with activation events through antigen receptors and their associated proteins. These signals launch...

journal_title：Cellular immunology

authors： Sinclair NR

更新日期：1990-10-01 00:00:00

abstract：:We have previously demonstrated that natural killer (NK) cells are lysosome-rich and stain more intensely with lysosomotropic agents such as neutral red and quinacrine (Qu) than do non-NK cells. In this study we combined the quantitation of Qu staining with surface marker staining to define subpopulations of NK cells....

journal_title：Cellular immunology

authors： Shau H,Gray D,Mitchell MS

更新日期：1988-08-01 00:00:00

abstract：:This study examines cytotoxic mechanisms used by channel catfish peripheral blood-derived effector cells. Transmission electron microscopy (TEM), coupled with [(3)H]thymidine DNA fragmentation (JAM) and terminal deoxynucleotidyl nick-end labeling (TUNEL) assays, provided the first evidence that catfish peripheral bloo...

journal_title：Cellular immunology

authors： Hogan RJ,Taylor WR,Cuchens MA,Naftel JP,Clem LW,Miller NW,Chinchar VG

更新日期：1999-08-01 00:00:00

abstract：:The proliferative response of peripheral blood mononuclear cells (PBMC) in synthetic serum-free media depends on the presence of sufficient amounts of transferrin (Tf). In the present communication we show that the reduction of Tf concentration in culture media results in a decreased proliferation, whereas lymphokine ...

journal_title：Cellular immunology

authors： Keyna U,Nüsslein I,Rohwer P,Kalden JR,Manger B

更新日期：1991-02-01 00:00:00

abstract：:Effects of pertussis toxin (PT) on sensitized T-cell populations for delayed-type hypersensitivity (DTH) were examined in mice. DTH was induced by sensitizing mice with ovalbumin (OA) and elicited by injecting OA into the footpad. DTH could be conferred on naive recipient mice by injecting sensitized spleen cells eith...

journal_title：Cellular immunology

authors： Tamura SI,Nakanishi Y,Kojima A,Otokawa M,Uchida N,Sato H,Sato Y

更新日期：1984-05-01 00:00:00

abstract：:The effect of low-dose irradiation on the immune system was investigated in mice. When a 0.2 Gy dose of X-ray irradiation was administered every other day for a total of four times, the number of lymphocytes yielded by the liver, spleen and thymus decreased at the initial stage (around day 10). At this stage, NK cells...

journal_title：Cellular immunology

authors： Ren H,Shen J,Tomiyama-Miyaji C,Watanabe M,Kainuma E,Inoue M,Kuwano Y,Abo T

更新日期：2006-11-01 00:00:00

abstract：:Monolayers of freshly isolated human monocytes are known to ingest particulate activators of the human alternative complement pathway. The ingestion of rabbit erythrocytes, ER, by human monocytes in serum-free medium was studied. The process is Mg2+-dependent and optimum phagocytic activity was obtained at approximate...

journal_title：Cellular immunology

authors： Chakravarti B

更新日期：1988-05-01 00:00:00

abstract：:Dipeptidyl peptidase IV (DP IV, CD26), known as an activation marker of T lymphocytes, is a proline-specific protease thought to be involved in the regulation of the immune response. The physiological role of dipeptidyl peptidase IV in the immune system and the molecular events of lymphocyte activation mediated by thi...

journal_title：Cellular immunology

authors： Kähne T,Kröning H,Thiel U,Ulmer AJ,Flad HD,Ansorge S

更新日期：1996-05-25 00:00:00

abstract：:The administration of low-density lipoproteins from chicken egg yolk (EyLDL) to mice induced T-dependent antibodies against bromelain-treated mouse erythrocytes (BrMRBC). The anti-BrMRBC antibodies produced antigen specifically by EyLDL appear to be identical to the antibodies produced polyclonally by lipopolysacchari...

journal_title：Cellular immunology

authors： Kawaguchi S

更新日期：1988-09-01 00:00:00

abstract：:Macrophages can be divided into two groups as M1 and M2 phenotype. Our results and other groups revealed that IFN-γ can up-regulate the IDO expression and differentiate THP-1 cells to M1 phenotype. Therefore we hypothesized that IDO may play potential roles in macrophage differentiation. Interesting, our results indic...

journal_title：Cellular immunology

authors： Wang XF,Wang HS,Wang H,Zhang F,Wang KF,Guo Q,Zhang G,Cai SH,Du J

更新日期：2014-05-01 00:00:00

abstract：:Despite significant improvements in the overall survival of patients with multiple myeloma (MM) over the past 15 years, the disease remains incurable. Treatment options are limited for patients who have relapsed or are refractory to immunomodulatory drugs (IMiDs), proteasome inhibitors, and monoclonal antibodies. In t...

journal_title：Cellular immunology

authors： Paul B,Kang S,Zheng Z,Kang Y

更新日期：2018-12-01 00:00:00

abstract：:Previous studies have shown that supernatants from concanavalin A-stimulated human peripheral blood mononuclear cells and isolated Leu-2 suppressor/cytotoxic T cells are chemotactic for Leu-3 helper/inducer T cells. The current study shows that lymphocyte chemotactic factor (LCF) is also produced following antigen (te...

journal_title：Cellular immunology

authors： Potter JW,Van Epps DE

更新日期：1986-01-01 00:00:00

abstract：:We recently reported that a cloned murine cell line with "natural killer (NK)-like" cytolytic function and prominent cytoplasmic granules also expressed large numbers of plasma membrane receptors (Fc epsilon R) which bound mouse immunoglobulin E (IgE) with high affinity (S.J. Galli et al., 1982, Nature (London) 298, 2...

journal_title：Cellular immunology

authors： Galli SJ,Brooks CG,Dvorak AM,Ishizaka T

更新日期：1985-11-01 00:00:00

abstract：:The utility of multiple antigenic peptides (MAPs) for the induction of antibody and cellular immune responses in animal models has been demonstrated for a variety of peptide epitopes involved in human disease. However, little is known about immune responses to MAPs constructed with antigenic tumor epitopes, nor has pe...

journal_title：Cellular immunology

authors： Schott ME,Wells DT,Schlom J,Abrams SI

更新日期：1996-12-15 00:00:00

abstract：:We have previously described a novel human B cell differentiation factor (BCDF), 446-BCDF, that is distinct biochemically and functionally from other cytokines. Since signal transduction pathways involved in human B cell differentiation have been incompletely studied and are poorly understood, we assessed the effects ...

journal_title：Cellular immunology

authors： Huang R,Cioffi J,Berg K,London R,Cidon M,Maayani S,Mayer L

更新日期：1995-04-15 00:00:00

abstract：:The bursa of Fabricius represents the primary immune organ where immature B cells undergo maturational changes in avian species. Isolation of bursal lymphocytes for analysis in cell culture results in the rapid endogenous activation of apoptosis. After 2 h of incubation, over 45% of the lymphocytes were shown to be un...

journal_title：Cellular immunology

authors： Compton MM,Waldrip HM

更新日期：1998-03-15 00:00:00

abstract：:The antigenic phenotype of individual PHA-induced T lymphocyte colonies was studied with a direct immunofluorescence technique using fluorescein-labeled anti-Leu-2a and anti-Leu-3a antibodies. Of the colonies grown from mononuclear peripheral blood cells 85% were Leu-3a+ (inducer/helper phenotype), 12% were Leu-2a+ (s...

journal_title：Cellular immunology

authors： Claësson MH,Petersen J,Sønderstrup-Hansen G,Röpke C,Sørensen T

更新日期：1983-10-15 00:00:00

abstract：:Estrogen displays potent immunoregulatory properties. In the present study we investigated the in vivo effect of estrogen on natural killer (NK) cell cytotoxic activity in several mouse strains. After castration, 17 beta-estradiol was administered in low or high doses. After 3-6 weeks of hormone administration an in v...

journal_title：Cellular immunology

authors： Nilsson N,Carlsten H

更新日期：1994-10-01 00:00:00

abstract：:T helper cells reactive to myelin basic protein are clearly implicated in the pathogenesis of murine EAE. We have developed a T cell line, BML-1 that (1) is reactive to the encephalitogenic amino terminal nonapeptide (1-9NAC) of MBP, (2) is I-Au restricted, and (3) induces relapsing EAE in B10.PL (H-2u) mice. Measurem...

journal_title：Cellular immunology

authors： Ando DG,Clayton J,Kono D,Urban JL,Sercarz EE

更新日期：1989-11-01 00:00:00

abstract：:The objective of this study was to evaluate the potential of transcutaneous immunization with tumor antigen to induce cell-mediated immunity. For this purpose, hydrophilic recombinant gp100 protein (HR-gp100) was topically applied on human intact skin in vitro, and used as a vaccine in a mouse model. We demonstrate th...

journal_title：Cellular immunology

authors： Eisenberg G,Machlenkin A,Frankenburg S,Mansura A,Pitcovski J,Yefenof E,Peretz T,Lotem M

更新日期：2010-01-01 00:00:00

abstract：:Murine peritoneal macrophages (M phi), activated in vivo or in vitro, remarkably inhibited the uptake of thymidine by a lens epithelial cell line, while resident M phi, or M phi induced by thioglycollate, exhibited much lower or no cytostatic capacity. The target cells were partially protected from the cytostatic acti...

journal_title：Cellular immunology

authors： Mochizuki M,Zigler JS Jr,Russell P,Gery I

更新日期：1984-01-01 00:00:00

abstract：:Two monoclonal antibodies specific for different rat T-cell subpopulations, the anti-helper-T-cell antibody, W3/25, and the OX8 suppressor cell antibody were used to investigate lectin-stimulated T-lymphocyte differentiation of F-344 rat bone marrow cells in culture. Cytofluorometric analysis of freshly isolated lymph...

journal_title：Cellular immunology

authors： Pfeifer RW,Stillman WS,Irons RD

更新日期：1983-12-01 00:00:00

abstract：:This report compares the ability of cyclosporin A and FK-506 to inhibit human T cell activation triggered via cell surface molecules that utilize different intracellular processes. We stimulated highly purified peripheral blood T lymphocytes with mitogens (Con A and PHA), ionomycin + PMA, or monoclonal antibodies spec...

journal_title：Cellular immunology

authors： Lin CS,Boltz RC,Siekierka JJ,Sigal NH

更新日期：1991-04-01 00:00:00