Induction of antibody response to bromelain-treated mouse erythrocytes by low-density lipoproteins from chicken egg yolk.


:The administration of low-density lipoproteins from chicken egg yolk (EyLDL) to mice induced T-dependent antibodies against bromelain-treated mouse erythrocytes (BrMRBC). The anti-BrMRBC antibodies produced antigen specifically by EyLDL appear to be identical to the antibodies produced polyclonally by lipopolysaccharide (LPS); both antibodies reacted with the liposomes of phosphatidylcholine and showed identical idiotypic patterns. It is suggested that the anti-BrMRBC antibodies may be produced antigen specifically by exogenous antigens to be useful to the mouse. The activation of anti-BrMRBC B cells specifically by EyLDL or polyclonally by LPS resulted in neither expansion nor regression of anti-BrMRBC LPS-reactive B cells. This finding indicates that the population size of anti-BrMRBC LPS-reactive B cells is controlled independently by exogenous specific or polyclonal stimuli.


Cell Immunol


Cellular immunology


Kawaguchi S




Has Abstract


1988-09-01 00:00:00














  • Regulation of helper T cell clone proliferation via the CD2 molecule.

    abstract::We have investigated the requirements for CD2-induced proliferation of a CD4+, CD8-, CD3+, CD2+ antigen-specific, class II-restricted proliferating cloned cell line. A combination pair of two monoclonal antibodies (MoAb) recognizing, respectively, TII1 and D66 epitopes on the CD2 molecule was used as a stimulus. The r...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Sterkers G,Huet S,Moachon L,Hu J,Boumsell L,Bernard A

    更新日期:1987-10-01 00:00:00

  • Galectins distinctively regulate central monocyte and macrophage function.

    abstract::Monocytes and macrophages link the innate and adaptive immune systems and protect the host from the outside world. In inflammatory disorders their activation leads to tissue damage. Galectins have emerged as central regulators of the immune system. However, if they regulate monocyte/macrophage physiology is still unkn...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Paclik D,Werner L,Guckelberger O,Wiedenmann B,Sturm A

    更新日期:2011-01-01 00:00:00

  • Regulation of experimental autoimmune neuritis by transforming growth factor-beta 1.

    abstract::Experimental autoimmune neuritis (EAN) is a T-cell-mediated autoimmune disease characterized by demyelination and mononuclear cell infiltration of the peripheral nervous system. It is induced in Lewis rats by administration of myelin P2 protein or a synthetic peptide (SP-26) corresponding to amino acid residues 53-78 ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Gregorian SK,Lee WP,Beck LS,Rostami A,Amento EP

    更新日期:1994-06-01 00:00:00

  • Expression of chemokine receptors on natural killer cells in HIV-infected individuals.

    abstract::Chemokine receptors CCR5 and CXCR4 are of major importance in the pathogenesis of HIV-1 infection because they are co-receptors for human immunodeficiency virus (HIV) entry. We examined the frequency of CD3-CD56+CCR5+ and CD3-CD56+CXCR4+ in HIV-infected long-term slow progressors (SPs), HIV typical progressors (TPs) w...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Jiang Y,Zhang Z,Diao Y,Jin X,Shi W,Geng W,Dai D,Zhang M,Han X,Liu J,Wang Y,Shang H

    更新日期:2008-01-01 00:00:00

  • Age-associated B cells (ABC) inhibit B lymphopoiesis and alter antibody repertoires in old age.

    abstract::With old age (∼2y old), mice show substantial differences in B cell composition within the lymphoid tissues. In particular, a novel subset of IgM+ CD21/35lo/- CD23- mature B cells, the age-associated B cells or ABC, increases numerically and proportionately. This occurs at the expense of other B cell subsets, includin...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Riley RL,Khomtchouk K,Blomberg BB

    更新日期:2017-11-01 00:00:00

  • Effects of modulators of adenylyl cyclase on interleukin-2 production, cytosolic Ca2+ elevation, and K+ channel activity in Jurkat T cells.

    abstract::We have studied the effects of prostaglandin E2 (PGE2) and cholera toxin, two modulators of adenylyl cyclase, and 8-bromo cAMP (8-BrcAMP) on various parameters of lymphocyte activation using the human T cell line Jurkat. Our results show that PGE2 and cholera toxin inhibit, in a dose-related manner, the phytohemagglut...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Bastin B,Payet MD,Dupuis G

    更新日期:1990-07-01 00:00:00

  • On the molecular basis of T-helper-cell function. IV. B-lymphocyte-promotor factors: on their mode of action, biochemical nature and possible relationship to molecules involved in specific T-helper-cell activity.

    abstract::Some further aspects of B-lymphocyte-promotor factor (B-LPF) activity have been studied. This activity was present in the supernatants of certain helper-T-cell lines, and it induced polyclonal activation of Ig+ B cells into Ig-secreting cells. It was found that B-LPF induced polyclonal, terminal B-cell differentiation...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Reininger L,Fueri J,Boned A,Prat M,Landolfo S,Rubin B

    更新日期:1985-04-15 00:00:00

  • CD8+CD38+ and CD8+DR+ peripheral blood lymphoid subsets of HIV-infected intravenous drug abusers correlate with CD4+ cell counts and proliferation to mitogens.

    abstract::Twenty-nine intravenous drug abusers (ivda), with asymptomatic HIV infection at entry, were sequentially studied at 4- to 6-month intervals for variable follow-up periods (mean, 19.6 months). Two of them progressed to AIDS and another one fell into the IV-C2 stage of the CDC classification at the end of the study. CD8...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Echaniz P,Arrizabalaga J,Iribarren JA,Cuadrado E

    更新日期:1993-08-01 00:00:00

  • Sequential analysis of experimental autoimmune thyroiditis induced by neonatal thymectomy in the Buffalo strain rat.

    abstract::We have studied the evolution of thyroiditis induced by neonatal thymectomy in Buffalo strain rats, with particular emphasis on the thyroid lymphocytic infiltrate. The earliest change was increased endothelial Ia expression, and infiltration of the thyroid at 5 weeks by ED1- and ED2-positive macrophages and B and T ce...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Cohen SB,Dijkstra CD,Weetman AP

    更新日期:1988-06-01 00:00:00

  • The spider acylpolyamine Mygalin is a potent modulator of innate immune responses.

    abstract::Mygalin is an antibacterial molecule isolated from the hemocytes of the spider Acanthoscurria gomesiana. It was identified as bis-acylpolyamine spermidine. We evaluated the modulator effects of synthetic Mygalin in the innate immune response. We demonstrate that Mygalin induces IFN-γ synthesis by splenocytes increasin...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Mafra DG,da Silva PI Jr,Galhardo CS,Nassar R,Daffre S,Sato MN,Borges MM

    更新日期:2012-01-01 00:00:00

  • A proliferation-inducing ligand (APRIL) induced hyper-production of IgA from tonsillar mononuclear cells in patients with IgA nephropathy.

    abstract::IgA nephropathy (IgAN) is a tonsil-related disease. We previously showed that oligodeoxynucleotides with CpG (CpG-ODN) and B-cell activation factor (BAFF) are involved in hyperproduction of IgA from tonsillar mononuclear cells of patients with IgAN (IgAN-TMCs). In this study, we focused on a proliferation-inducing lig...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Takahara M,Nagato T,Nozaki Y,Kumai T,Katada A,Hayashi T,Harabuchi Y

    更新日期:2019-07-01 00:00:00

  • Evaluation of peripheral blood T lymphocyte surface activation markers and transcription factors in patients with early stage non-small cell lung cancer.

    abstract::Lung cancer cells harboring multiple mutations as a consequence of long-term damage by different etiologic factors are responsible for high immunogenicity. Immune checkpoint inhibitors significantly improve treatment results in non-small cell lung cancer (NSCLC). Unfortunately, the role of T-lymphocytes in early NSCLC...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Rutkowski J,Cyman M,Ślebioda T,Bemben K,Rutkowska A,Gruchała M,Kmieć Z,Pliszka A,Zaucha R

    更新日期:2017-12-01 00:00:00

  • MHC class I is functionally associated with antigen receptors in human T and B lymphomas.

    abstract::We have studied the antibody-induced effect of cross-linking the major histocompatibility complex class I (MHC-I) in human T leukemic cells (Jurkat) and human B lymphoma cells (Solubo, Burkitts lymphoma) on intracellular [Ca2+]i levels. The increase in [Ca2+]i after MHC-I cross-linking in Jurkat cells and Solubo cells...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Pedersen AE,Jacoby BF,Skov S,Claesson MH

    更新日期:1996-11-01 00:00:00

  • Anti-Fas antibody induces different types of cell death in the human histiocytic cell line, U937, and the human B cell line, B104: the role of single-strand DNA breaks and poly (ADP-ribosyl)ation in cell death.

    abstract::We investigated the anti-Fas antibody-induced cell death in two different types of human cell lines, U937 and B104. IFN-gamma increased the surface expression of Fas antigen and susceptibility to anti-Fas Ab-induced cell death of B104 and U937 cells. Anti-Fas Ab-induced death of U937 and B104 cells required neither a ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Sumimoto S,Ishigami T,Horiguchi Y,Yonehara S,Kanazashi S,Heike T,Katamura K,Mayumi M

    更新日期:1994-01-01 00:00:00

  • The effects of temperature and oleic acid on murine memory and virgin T cell activation: interleukin-2 secretion and interleukin-2 receptor expression.

    abstract::Previous studies established that low in vitro temperatures (27 degrees C, termed nonpermissive) suppressed murine primary thymus-dependent (TD), but not primary thymus-independent (TI) or secondary TD, antibody responses. Suppression was rescued by the addition of oleic acid (18:1), recombinant interleukin (rIL)-2 an...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Wooten RM,Clem LW,Bly JE

    更新日期:1993-11-01 00:00:00

  • Role of heme oxygenase-1 in potentiation of phagocytic activity of macrophages by taurine chloramine: Implications for the resolution of zymosan A-induced murine peritonitis.

    abstract::Phagocytosis of pathogens by macrophages is crucial for the successful resolution of inflammation induced by microbial infection. Taurine chloramine (TauCl), an endogenous anti-inflammatory and antioxidative substance, is produced by reaction between taurine and hypochlorous acid by myeloperoxidase activity in neutrop...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Kim W,Kim SH,Jang JH,Kim C,Kim K,Suh YG,Joe Y,Chung HT,Cha YN,Surh YJ

    更新日期:2018-05-01 00:00:00

  • Emerging glycobiology tools: A renaissance in accessibility.

    abstract::The glycobiology of the immune response is a topic that has garnered increased attention due to a number of key discoveries surrounding IgG function, the specificity of some broadly neutralizing anti-HIV antibodies, cancer immunoregulation by galectin molecules and others. This review is the opening article in a Speci...

    journal_title:Cellular immunology

    pub_type: 杂志文章,评审


    authors: Oswald DM,Cobb BA

    更新日期:2018-11-01 00:00:00

  • Antitumor synthetic lipid A analog DT-5461a upregulates cytokine expression in a murine macrophage cell line through LPS pathway.

    abstract::We previously showed that DT-5461a, a lipid A analog, has antitumor activity and relatively low toxicity in animals. To clarify its immunostimulatory effect we have studied the cytokine inducibility of DT-5461a and the mechanism involved in the cytokine expression in macrophages. While the activity is lower than that ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Akahane K,Someya K,Tsutomi Y,Akimoto T,Tohgo A

    更新日期:1994-04-15 00:00:00

  • Enhancement of antigen-induced interleukin 4 and IgE production by specific IgG1 in murine lymphocytes.

    abstract::Conalbumin (CA)-specific type 2 helper T cell (Th2) clone, D10G4.1 (D10) produces IL4 when stimulated with varying doses of TNP-CA in the presence of mitomycin C-treated C3H spleen cells or purified B cells as antigen-presenting cells (APC). The production of IL4 was assessed by bioassay and by expression of IL4 mRNA....

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Ohmori H,Hase N,Hikida M,Takai T,Endo N

    更新日期:1992-12-01 00:00:00

  • Ability of tolerized Th1 and Th2 clones to stimulate B cell activation and cell cycle progression.

    abstract::Tolerant and nontolerant murine Th1 and Th2 clones, specific for human gamma-globulin (HGG), were compared for their ability to promote cell cycle entry and progression by B cells in vitro. When stimulated with HGG, nontolerant Th1 and Th2 clones induced similar increases in B cell membrane MHC class II levels--a phen...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Gilbert KM,Rothermel AL,Ernst DN,Hobbs MV,Weigle WO

    更新日期:1992-06-01 00:00:00

  • Interleukin-6 is used as a growth factor by virulent Mycobacterium avium: presence of specific receptors.

    abstract::In this paper, we examined the contribution of the lymphokine interleukin-6 (IL-6) to the growth of four virulent strains of Mycobacterium avium and the nature of the binding moieties on the mycobacteria. First, we showed that human or mouse recombinant interleukin-6 are potent growth factors for four strains of virul...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Denis M

    更新日期:1992-04-15 00:00:00

  • Proliferative effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) and calcium ionophores on human large granular lymphocytes (LGL).

    abstract::The proliferative responses of natural killer (NK) cells to 12-O-tetradecanoylphorbol-13-acetate (TPA), which directly activates protein kinase c(PKC), and to the Ca2+ ionophores A23817 and ionomycin, known to enhance the intracellular calcium, have been investigated. Highly purified large granular lymphocytes (LGL) w...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Procopio A,Gismondi A,Paolini R,Morrone S,Testi R,Piccoli M,Frati L,Herberman RB,Santoni A

    更新日期:1988-04-15 00:00:00

  • Characterization of a novel H2A(-)E+ transgenic model susceptible to heterologous but not self thyroglobulin in autoimmune thyroiditis: thyroiditis transfer with Vbeta8+ T cells.

    abstract::Recently we reported on a novel H2E transgenic, IA-negative model of experimental autoimmune thyroiditis (EAT) that excludes reactivity to self in its susceptibility pattern to heterologous thyroglobulin (Tg). In conventional, susceptible mouse strains, EAT is inducible with both homologous and heterologous Tg; e.g., ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Yan Y,Panos JC,McCormick DJ,Wan Q,Giraldo AA,Brusic V,David CS,Kong YC

    更新日期:2001-08-25 00:00:00

  • Modulation of natural killer cell function leading to spontaneous regression of a histiocytoma.

    abstract::AK-5 is a spontaneously regressing rat histiocytoma and the tumor regression is mediated by CD8+ NK cells. We have investigated the functional status of effector cells mediating complete remission of the tumor. The effector-target interaction takes place with the help of antibody to AK-5 and the mechanism of lysis inv...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Bright JJ,Hegde SP,Begum Z,Khar A

    更新日期:1994-03-01 00:00:00

  • NF-κB cellular and molecular regulatory mechanisms and pathways: therapeutic pattern or pseudoregulation?

    abstract::As fascinating a molecule as it can potentially get, nuclear factor-κB (NF-κB), a regulatory transcription factor, is as intriguing. NF-κB is a dimeric complex that controls the transcription of essential genes. NF-κB is involved in a variety of responses that play a pivotal role in regulating the immune response to i...

    journal_title:Cellular immunology

    pub_type: 杂志文章,评审


    authors: Haddad JJ,Abdel-Karim NE

    更新日期:2011-01-01 00:00:00

  • In vitro viability of lymphoid cells from lines of mice genetically selected for high or low responsiveness to phytohemagglutinin.

    abstract::The kinetics of viability of lymph node and spleen cells of mice genetically selected for "high" or "low" in vitro lymphocyte responsiveness to PHA were studied in PHA or PPD-stimulated short-term cultures. Lo/PHA cells were found to be less viable than Hi/PHA cells in unstimulated control cultures. PHA improved the v...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Stiffel C,Liacopoulos-Briot M,Decreusefond C,Lambert F

    更新日期:1983-04-01 00:00:00

  • Comparative analysis of the heterogeneity of mononuclear cells present in adult and cord blood by simultaneous examination of multiple phenotypic characteristics.

    abstract::In an attempt to better relate specific membrane characteristics of human adult and cord blood lymphocytes to specific functional activities, the phenotypic differences that exist in these two populations have been examined. Cord blood cells have considerably more spontaneous suppressor cell activity than adult cells....

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Johnson C,Dwyer JM

    更新日期:1983-10-01 00:00:00

  • Analysis of B-cell subpopulations. I. Relationships among splenic xid, Ly 1+, and Lyb 5+ B cells.

    abstract::The phenotypic and functional relationships among the various B-cell subsets is of importance for better understanding studies of the immune system. In this report, the realm of B cells encompassed by Lyb 5, Ly 1, and xid has been examined through the use of the alloantiserum anti-Lyb 5, the unique functional properti...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Smith HR,Yaffe LJ,Chused TM,Raveche ES,Klinman DM,Steinberg AD

    更新日期:1985-04-15 00:00:00

  • Suppression of interleukin-1 and tumor necrosis factor-alpha production by acanthoic acid, (-)-pimara-9(11),15-dien-19-oic acid, and it antifibrotic effects in vivo.

    abstract::Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) are major proinflammatory cytokines inducing the synthesis and release of many inflammatory mediators. They are involved in immune regulation, autoimmune diseases, and inflammation. Acanthoic acid, (-)-pimara-9(11),15-dien-19-oic acid, is a pimaradiene d...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Kang HS,Kim YH,Lee CS,Lee JJ,Choi I,Pyun KH

    更新日期:1996-06-15 00:00:00

  • In vivo mechanisms of acquired thymic tolerance.

    abstract::Injection of antigen into the thymus of adult animals induces specific systemic tolerance, but the mechanisms of acquired thymic tolerance are not well understood. To investigate these mechanisms we used a model of intrathymic injection of ovalbumin (OVA) in BALB/c mice. We show an antigen-specific decrease in prolife...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Chen W,Issazadeh S,Sayegh MH,Khoury SJ

    更新日期:1997-08-01 00:00:00