Deletion of the C6orf120 gene with unknown function ameliorates autoimmune hepatitis induced by concanavalin A.

abstract：:Antigen-specific signal transduction leading to IL2 induction and secretion in the T cell line 171 is augmented by association of p56lck with CD4. Although no change in cytoplasmic calcium level ([Ca2+]i) was detectable during antigen-specific signal transduction of 171-CD4+ cells, IL2 induction was inhibited by FK506...

journal_title：Cellular immunology

authors： Metcalfe S,Alexander D,Turner J

更新日期：1994-10-01 00:00:00

abstract：:Recombinant IL-4 inhibits IL-2-induced lymphokine-activated killer (LAK) cell development of PBMC. We evaluated the effect of various cytokines in reversing IL-4-mediated LAK inhibition. PBMC were cultured in IL-2 (10-1000 u/ml) with or without IL-4 (2-100 u/ml) and tested for cytotoxicity against the NK-sensitive K56...

journal_title：Cellular immunology

authors： Swisher SG,Economou JS,Holmes EC,Golub SH

更新日期：1990-07-01 00:00:00

abstract：:Mice carrying a rearranged TCR Vbeta 8.2 transgene express the Vbeta protein on the vast majority of peripheral T-cells. The bone marrow and peripheral blood, as well as other lymphoid organs of both untreated animals and animals depleted of T-cells by neonatal thymectomy and/or injection from birth of monoclonal anti...

journal_title：Cellular immunology

authors： Lincoln GC,Sheng B,Odebralski J,Lucchetta R,Smith RT

更新日期：1997-10-10 00:00:00

abstract：:When guinea pigs were treated by complete Freund's adjuvant (CFA), eosinophil-directed chemotactic inhibitory factor (ECIF) appeared in the serum of the treated animals. The inhibition of the response of eosinophils by ECIF was selective for the T cell-derived chemotactic factor, which has been isolated from DNP-ascar...

journal_title：Cellular immunology

authors： Hirashima M,Tashiro K,Hayashi H

更新日期：1984-11-01 00:00:00

abstract：:Previous studies established that low in vitro temperatures (27 degrees C, termed nonpermissive) suppressed murine primary thymus-dependent (TD), but not primary thymus-independent (TI) or secondary TD, antibody responses. Suppression was rescued by the addition of oleic acid (18:1), recombinant interleukin (rIL)-2 an...

journal_title：Cellular immunology

authors： Wooten RM,Clem LW,Bly JE

更新日期：1993-11-01 00:00:00

abstract：:Despite significant improvements in the overall survival of patients with multiple myeloma (MM) over the past 15 years, the disease remains incurable. Treatment options are limited for patients who have relapsed or are refractory to immunomodulatory drugs (IMiDs), proteasome inhibitors, and monoclonal antibodies. In t...

journal_title：Cellular immunology

authors： Paul B,Kang S,Zheng Z,Kang Y

更新日期：2018-12-01 00:00:00

abstract：:This investigation shows that Epstein-Barr virus (EBV)-activated human B cells from marrow transplant recipients can produce in vitro IgG anti-tetanus toxoid antibody (anti-TT) without booster immunizations with tetanus toxoid (TT). Purified B cells (E-rosette negative) from 8 normal subjects, 6 healthy long-term marr...

journal_title：Cellular immunology

authors： Jin NR,Lum LG

更新日期：1986-08-01 00:00:00

abstract：:Incubation of C57BL/6 thymus-derived macrophages (TDM phi) with syngeneic thymocytes resulted in binding of thymocytes to macrophages and rosette formation. Up to 60% of the TDM phi formed rosettes with thymocytes after 6 hr of interaction at 4 degrees C. Rosette formation of the immature PNA+ thymocyte fraction was u...

journal_title：Cellular immunology

authors： Zeira M,Gallily R

更新日期：1988-12-01 00:00:00

abstract：:We have established murine T-cell clones which respond to allotypic and species-specific determinants found on chicken erythrocytes (cRBC). Their relative antigen specificities were determined by assessing lymphokine production and proliferation in response to syngeneic spleen cells and cRBC obtained from chickens hom...

journal_title：Cellular immunology

authors： Giedlin MA,Longenecker BM,Mosmann TR

更新日期：1986-02-01 00:00:00

abstract：:Tiazofurin treatment of K562 leukemia cells in vitro depletes the metabolites of the guanylate biosynthetic pathway, inducing erythroid differentiation, that, in turn, alters the phenotypic profile. As a consequence, K562 cells possibly modify their interaction with immune cells. Here we describe the binding and killi...

journal_title：Cellular immunology

authors： Zamai L,Zauli G,Bavelloni A,Marmiroli S,Cataldi A,Weber G,Vitale M

更新日期：1995-08-01 00:00:00

abstract：:PIM kinases are a family of three serine/threonine kinases expressed following T cell activation. Using potent selective small molecule antagonists of PIM-1/3 kinases, we demonstrate a potential role for these enzymes in naïve and effector CD4+ T cell activation. PIM-1/3 inhibition prevented CD4+ T cell proliferation ...

journal_title：Cellular immunology

authors： Jackson LJ,Pheneger JA,Pheneger TJ,Davis G,Wright AD,Robinson JE,Allen S,Munson MC,Carter LL

更新日期：2012-01-01 00:00:00

abstract：:Lenalidomide, a daughter molecule of Thalidomide, and IMIDs are immunomodulatory drugs that have been described as having immunomodulatory properties and anti-tumor activity. The effect of Lenalidomide towards Peripheral Blood Mononuclear Cells (PBMC) has been studied and direct effects towards T cells have been descr...

journal_title：Cellular immunology

authors： Dauguet N,Fournié JJ,Poupot R,Poupot M

更新日期：2010-01-01 00:00:00

abstract：:A monoclonal mouse antibody (HNC-1A3) which defines a subset of human lymphocytes with natural cytotoxic activity was produced and studied. HNC-1A3+ cells represent 12 +/- 3% of peripheral blood mononuclear leukocytes. When sorted out using a fluorescence-activated cell sorter, they consist of 60% small lymphocytes, 3...

journal_title：Cellular immunology

authors： Rola-Pleszczynski M,Lieu H

更新日期：1983-12-01 00:00:00

abstract：:Due to their immunomodulatory properties, adipose tissue (AT) and Wharton's Jelly (WJ) constitute valuable alternatives to BM as sources of MSCs for managing graft-versus-host disease. To ensure the efficiency of AT- and WJ-MSCs implies the characterization of their immunomodulatory functions in comparison to those of...

journal_title：Cellular immunology

authors： Najar M,Raicevic G,Boufker HI,Fayyad Kazan H,De Bruyn C,Meuleman N,Bron D,Toungouz M,Lagneaux L

更新日期：2010-01-01 00:00:00

abstract：:The proliferative responses of human peripheral blood mononuclear cells (PBL) and thymocytes to OKT3 monoclonal antibody have been investigated. The PBL response to OKT3 was maximal after 72 hr while that of thymocytes was inappreciable at all times measured. Unlike phytohemagglutinin, OKT3 was unable to elicit the mi...

journal_title：Cellular immunology

authors： Musiani P,Maggiano N,Aiello FB,Lauriola L,Ranelletti FO,Piantelli M

更新日期：1984-04-01 00:00:00

abstract：:The hematopoietically restricted member of the NF-kappaB/Rel family, c-Rel, is essential for B cell survival and proliferation. Here we demonstrate that the production of the interleukins 6, 10, and 15 (IL-6, IL-10, and IL-15) are diminished in c-Rel(-/-) B lymphocytes. In a manner similar to that seen in IL-6(-/-) B ...

journal_title：Cellular immunology

authors： Tumang JR,Hsia CY,Tian W,Bromberg JF,Liou HC

更新日期：2002-05-01 00:00:00

abstract：:Like the thymus, the bursa of Fabricius is a site of massive lymphopoiesis accompanied by cell death in vivo. In the present study we have, therefore, examined whether chicken bursa and thymus cells exhibit apoptosis. Bursa and thymus cells from SC chickens, 4-10 weeks of age, were incubated for 8-24 hr with various r...

journal_title：Cellular immunology

authors： Asakawa J,Tsiagbe VK,Thorbecke GJ

更新日期：1993-03-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are promising candidates for developing cell therapies for intractable diseases. To assess the feasibility of transplantation with human umbilical cord blood (hUCB)-derived MSCs, we analyzed the ability of these cells to function as alloantigen-presenting cells (APC) in vitro. hUCB-MSC...

journal_title：Cellular immunology

authors： Oh W,Kim DS,Yang YS,Lee JK

更新日期：2008-02-01 00:00:00

abstract：:Antigen-nonspecific CD8+ T suppressor cells, which suppressed delayed-type hypersensitivity (DTH) against sheep red blood cells in BALB/c mice, were induced by incubating spleen cells from mice treated with 7,12-dimethylbenz[a]anthracene (DMBA), a tumor initiator, with 12-O-tetradecanoylphorbol 13-acetate (TPA), a tum...

journal_title：Cellular immunology

authors： Negoro T,Iinuma F,Watanabe M

更新日期：1991-12-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) play a major role in modulating immune response, but only a few reports focused on MDSCs in the liver of sepsis states. Here, we investigated the changes in MDSCs in liver of the cecal ligation and puncture (CLP) mice. The results of flow cytometry showed that MDSCs accumulate ...

journal_title：Cellular immunology

authors： Ren D,Bi Q,Li L,Gao Y,Liang Y,Li Y,Liu J,Peng L,Xiao J

更新日期：2012-09-01 00:00:00

abstract：:Caused mainly by Candida albicans, oropharyngeal candidiasis is the most common oral complication associated with HIV disease worldwide. Host defenses against C. albicans essentially fall into two categories: specific immune mechanisms and local oral mucosal epithelial cell defenses. Since oral mucosa is the first lin...

journal_title：Cellular immunology

authors： Rouabhia M,Semlali A,Audoy J,Chmielewski W

更新日期：2012-11-01 00:00:00

abstract：:Our previous studies show that growth hormone overexpression (GHo) upregulates the expression of the IGF-1R and IGF-2R resulting in the protection of the EL4 lymphoma cell line from apoptosis. In this study, we report that GHo also increases TGF-beta1 protein expression measured by luciferase promoter assay, Western a...

journal_title：Cellular immunology

authors： Farmer JT,Weigent DA

更新日期：2006-03-01 00:00:00

abstract：:Injection of antigen into the thymus of adult animals induces specific systemic tolerance, but the mechanisms of acquired thymic tolerance are not well understood. To investigate these mechanisms we used a model of intrathymic injection of ovalbumin (OVA) in BALB/c mice. We show an antigen-specific decrease in prolife...

journal_title：Cellular immunology

authors： Chen W,Issazadeh S,Sayegh MH,Khoury SJ

更新日期：1997-08-01 00:00:00

abstract：:The concentration of cytosolic-free calcium (Ca2+i) was determined with aequorin in RAW-264 macrophage-like cells activated in vitro for tumor cell killing with lymphokine (LK) and lipopolysaccharide (LPS). Treatments of these cells with optimal doses of stimulants, which evoked the development of cytolytic activity, ...

journal_title：Cellular immunology

authors： Gorecka-Tisera AM,Snowdowne KW,Borle AB

更新日期：1986-07-01 00:00:00

abstract：:Large suppressive macrophages (LSM) were induced by restimulating spleen cells from rats with experimental autoimmune myasthenia gravis (EAMG) in vitro, with the autoantigen acetylcholine receptor (AChR) in the presence of cyclosporine A. LSM, purified from these cultures, are extremely potent suppressors of AChR-stim...

journal_title：Cellular immunology

authors： McIntosh KR,Drachman DB

更新日期：1999-04-10 00:00:00

abstract：:Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is caused by mutations in the AIRE gene. Murine studies suggest that AIRE controls thymic expression of tissue-restricted antigens, its absence allowing nonselected autoreactive cells to escape. We tested this in humans using the TCRβ CDR3 length ...

journal_title：Cellular immunology

authors： Niemi HJ,Laakso S,Salminen JT,Arstila TP,Tuulasvaara A

更新日期：2015-06-01 00:00:00

abstract：:This paper investigates the presence of HLA class I-restricted and tumor-specific cytotoxic T lymphocytes (CTL) in tumor sites of esophageal cancers. Five CTL lines were established from the metastatic lymph nodes or pleural effusion by incubation with interleukin-2 of tumor-infiltrating lymphocytes: cases 1 and 5, HL...

journal_title：Cellular immunology

authors： Toh U,Yamana H,Nakao M,Imai Y,Seki N,Takasu H,Kaneshige T,Fujita H,Shirouzu K,Itoh K

更新日期：1997-05-01 00:00:00

abstract：:In vivo treatment with anti-IA antibodies has been shown to induce a haplotype-specific inhibition of EAE when the disease was following passive transfer of MBP-sensitized T cells. In order to determine the mechanism by which anti-IA antibody prevents passively transferred EAE, the homing of radiolabeled cells to the ...

journal_title：Cellular immunology

authors： Sriram S,Carroll L

更新日期：1991-06-01 00:00:00

abstract：:In vitro incubation of the erythroleukemic cell line K562 with interferon-gamma (IFN-gamma) renders these cells relatively resistant to natural killer (NK) cell lysis. However, such treatment does not alter their sensitivity to LAK cell lysis. Thus, the lytic susceptibility of interferon-gamma-treated K562 (I-K562) ce...

journal_title：Cellular immunology

authors： Powell J,Stone J,Chan WC,Yang ZD,Leatherbury A,Sell KW,Wiktor-Jedrzejczak W,Ahmed-Ansari A

更新日期：1989-02-01 00:00:00

abstract：:Mygalin is an antibacterial molecule isolated from the hemocytes of the spider Acanthoscurria gomesiana. It was identified as bis-acylpolyamine spermidine. We evaluated the modulator effects of synthetic Mygalin in the innate immune response. We demonstrate that Mygalin induces IFN-γ synthesis by splenocytes increasin...

journal_title：Cellular immunology

authors： Mafra DG,da Silva PI Jr,Galhardo CS,Nassar R,Daffre S,Sato MN,Borges MM

更新日期：2012-01-01 00:00:00