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Immunological properties of umbilical cord blood-derived mesenchymal stromal cells.

Abstract：

:Mesenchymal stromal cells (MSCs) are promising candidates for developing cell therapies for intractable diseases. To assess the feasibility of transplantation with human umbilical cord blood (hUCB)-derived MSCs, we analyzed the ability of these cells to function as alloantigen-presenting cells (APC) in vitro. hUCB-MSCs were strongly positive for MSC-related antigens and stained positively for human leukocyte antigen (HLA)-AB and negatively for HLA-DR. When treated with interferon (IFN)-gamma, the expression of HLA-AB and HLA-DR, but not the co-stimulatory molecules CD80 and CD86, was increased. hUCB-MSCs did not provoke allogeneic PBMC (peripheral blood mononuclear cell) proliferation, even when their HLA-molecule expression was up-regulated by IFN-gamma pretreatment. When added to a mixed lymphocyte reaction (MLR), hUCB-MSCs actively suppressed the allogeneic proliferation of the responder lymphocytes. This suppressive effect was mediated by soluble factors. We conclude that hUCB-MSCs can suppress the allogeneic response of lymphocytes and may thus be useful in allogeneic cell therapies.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Oh W,Kim DS,Yang YS,Lee JK

doi

10.1016/j.cellimm.2008.04.003

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

116-23

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(08)00073-7

journal_volume

251

pub_type

杂志文章

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