Post-transcriptional down-regulation of Toll-like receptor signaling pathway in umbilical cord blood plasmacytoid dendritic cells.

abstract：:Mesenchymal stem cells (MSCs) have been used to repair injured tissues through immune-suppression and/or cell replace mechanisms. However, a significant barrier to MSC therapy is insufficient MSC engraftment in injured tissues after systemic administration. Here, we report that cell surface, total protein, and mRNA le...

journal_title：Cellular immunology

authors： Xie J,Wang W,Si JW,Miao XY,Li JC,Wang YC,Wang ZR,Ma J,Zhao XC,Li Z,Yi H,Han H

更新日期：2013-01-01 00:00:00

abstract：:The in vivo and in vitro accessory cell requirements of class I major histocompatability complex (MHC) antigen-restricted cytotoxic T-lymphocyte (CTL) responses were determined using cell-depletion experiments coupled with active immunizations using ovalbumin (OVA) as the immunogen and saponin adjuvant (QS-21). To par...

journal_title：Cellular immunology

authors： Wu JY,Gardner BH,Kushner NN,Pozzi LA,Kensil CR,Cloutier PA,Coughlin RT,Newman MJ

更新日期：1994-04-01 00:00:00

abstract：:The actions of interleukin-4 (IL-4) in vivo are likely to be positively influenced by the expression of membrane IL-4 receptors (mIL-4R) on target cells and negatively by the concentration of soluble IL-4 receptors (sIL-4R) in the extracellular environment. Inasmuch as the two forms of the mouse IL-4R are differential...

journal_title：Cellular immunology

authors： Chilton PM,Fernandez-Botran R

更新日期：1997-09-15 00:00:00

abstract：:Blood and tissue eosinophilia is obtained when mice pretreated with cyclophosphamide (CY) and sensitized with picryl chloride are challenged on each ear lobe on day 13. To gain important insights into the cellular mechanisms involved in CY-induced eosinophilia in the contact-sensitivity reaction, we examined the cytok...

journal_title：Cellular immunology

authors： Sasaki G,Satoh T,Yokozeki H,Katayama I,Nishioka K

更新日期：2000-08-01 00:00:00

abstract：:Due to their immunomodulatory properties, adipose tissue (AT) and Wharton's Jelly (WJ) constitute valuable alternatives to BM as sources of MSCs for managing graft-versus-host disease. To ensure the efficiency of AT- and WJ-MSCs implies the characterization of their immunomodulatory functions in comparison to those of...

journal_title：Cellular immunology

authors： Najar M,Raicevic G,Boufker HI,Fayyad Kazan H,De Bruyn C,Meuleman N,Bron D,Toungouz M,Lagneaux L

更新日期：2010-01-01 00:00:00

abstract：:During ultrastructural studies of the early kinetics of anaphylactic degranulation and early and late recovery intervals from these release reactions induced in isolated, partially purified, cultured human lung mast cells stimulated to release histamine and granules by exposure to anti-IgE, we noted the ability of mas...

journal_title：Cellular immunology

authors： Dvorak AM,Schleimer RP,Lichtenstein LM

更新日期：1987-03-01 00:00:00

abstract：:Although it is well established that the processes of cellular proliferation and apoptosis are linked, the role of cell cycle regulators in T cell responses in vivo is not well understood. In recent years, tumor suppressor molecule p19(ARF) has emerged as a key cell cycle regulator important in cellular apoptosis agai...

journal_title：Cellular immunology

authors： Gao X,Svaren J,Suresh M

更新日期：2002-10-01 00:00:00

abstract：:CD20 is expressed strictly by B-cells and is ubiquitously expressed at high surface densities of malignant human B-cells. This suggests that CD20 may be a tumor target for immunotherapy of B-cell lymphomas. Rituximab, a chimeric monoclonal antibody directed against CD20, has been demonstrated to be an effective treatm...

journal_title：Cellular immunology

authors： Li M,Yan Z,Han W,Zhang Y

更新日期：2006-02-01 00:00:00

abstract：:The role of macrophages (M phi) in the in vitro primary antibody response of murine lymphocytes to sheep erythrocytes was investigated. Peritoneal M phi were activated to express Ia antigens either in vitro or in vivo. Nonactivated Ia- M phi were also examined. We observed that only Ia- M phi but also Ia+ M phi failed...

journal_title：Cellular immunology

authors： Komatsubara S,Hirayama Y,Inaba K,Naito K,Yoshida K,Kawai J,Muramatsu S

更新日期：1985-10-15 00:00:00

abstract：:The cellular requirements for stimulating primed alloreactive T cells have been investigated. In vitro-primed secondary alloreactive cells, long-term lines, and Ly 1+2- noncytolytic clones which reacted with allo-H-2K, D, or Mls (M locus) antigens were tested. The data indicated that a specialized antigen-presenting c...

journal_title：Cellular immunology

authors： Sunshine GH,Mitchell TJ,Czitrom AA,Edwards S,Glasebrook AL,Kelso A,MacDonald HR

更新日期：1985-03-01 00:00:00

abstract：:The knowledge of mechanisms of regulation of IL-10 production by B cells remains still very limited. We show here that highly purified mouse B cells stimulated with LPS produce significant levels of IL-10, but Bregs in our model do not express detectable level of either Foxp3 or GATA-3. Nevertheless, IL-10 production ...

journal_title：Cellular immunology

authors： Bohacova P,Kossl J,Hajkova M,Hermankova B,Javorkova E,Zajicova A,Krulova M,Holan V

更新日期：2020-01-01 00:00:00

abstract：:Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronically intestinal autoimmune disease, the pathological mechanisms of which are not very clear. Wild type p-53 induced phosphatase 1 (Wip1), a serine/threonine protein phosphatase, has been reported to negatively reg...

journal_title：Cellular immunology

authors： Zhang Q,Zhang C,Chang F,Liang K,Yin X,Li X,Zhao K,Niu Q,Tian Z

更新日期：2016-12-01 00:00:00

abstract：:An IgG1 monoclonal antibody, termed ACM-1, has been shown to react with rabbit T cells, but not Ig+ cells or macrophages. This antibody appears to recognize the same epitope as the previously described 9AE10 antibody and, together with 9AE10, has been used to obtain highly pure and fully functional T- and B-cell popul...

journal_title：Cellular immunology

authors： Chen Z,Metzger DW,Adler FL

更新日期：1984-05-01 00:00:00

abstract：:The voltage gated potassium channel (Kv1.3) has been shown to play a role in immune responsiveness. Blockade of the channel led to diminution of T cell activation and delayed type hypersensitivity. Previous in vitro studies of the blockade were focused on T cell activation and proliferation. In this study we examined ...

journal_title：Cellular immunology

authors： Shah K,Tom Blake J,Huang C,Fischer P,Koo GC

更新日期：2003-02-01 00:00:00

abstract：:The phenotype, T-cell antigen receptor (TCR) usage and specificity of intestinal intraepithelial lymphocytes (IEL), and hybridomas derived from IEL have been examined. In young conventionally reared mice, approximately 50% of the IEL express TCR alpha beta and 50% express TCR gamma delta, although there is considerabl...

journal_title：Cellular immunology

authors： Sydora BC,Mixter PF,Houlden B,Hershberg R,Levy R,Comay M,Bluestone J,Kronenberg M

更新日期：1993-12-01 00:00:00

abstract：:Basic Immunology has had only two significant public priority disputes. The first began in the late 1650s and concerned the recognition of the peripheral network of vessels which collects lymph throughout the body. The publication of this major anatomical discovery prompted a priority feud discussed in a previous pape...

journal_title：Cellular immunology

authors： Ambrose CT

更新日期：2007-01-01 00:00:00

abstract：:Previous work in our laboratory established that individual complement components can be regulated in vivo by administration of specific antibody or immunocompetent cells to newborns and in vitro by administration of specific antibody to cultured peritoneal macrophages or splenic fragments. Antibody-induced suppressio...

journal_title：Cellular immunology

authors： Goldman JN,O'Rourke KS,Goldman MB

更新日期：1985-11-01 00:00:00

abstract：:Injection of antigen into the thymus of adult animals induces specific systemic tolerance, but the mechanisms of acquired thymic tolerance are not well understood. To investigate these mechanisms we used a model of intrathymic injection of ovalbumin (OVA) in BALB/c mice. We show an antigen-specific decrease in prolife...

journal_title：Cellular immunology

authors： Chen W,Issazadeh S,Sayegh MH,Khoury SJ

更新日期：1997-08-01 00:00:00

abstract：:Micromolar amounts of SV-IV, one of the major proteins secreted from the rat seminal vesicle epithelium, induce in vitro a marked release of a variety of cytokines (interferon-gamma, tumor necrosis factor-alpha, interleukin 6, and granulocyte-monocyte colony-stimulating factor) from human resting peripheral blood mono...

journal_title：Cellular immunology

authors： Tufano MA,Porta R,Farzati B,Di Pierro P,Rossano F,Catalanotti P,Baroni A,Metafora S

更新日期：1996-03-15 00:00:00

abstract：:A single nucleotide A49G polymorphism (SNP) of CTLA-4 has been linked and associated with the autoimmune thyroid diseases (AITD) and thyroid autoantibody secretion. We have explored the functional mechanisms of CTLA-4 by means of recombinant human CTLA-4 expressed on transfected Jurkat T cells. Analysis of CTLA-4 tran...

journal_title：Cellular immunology

authors： Xu Y,Graves PN,Tomer Y,Davies TF

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Piper nigrum L. (Piperaceae) is commonly used as a spice and traditional medicine in many countries. It has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. However, the protective role of P. nigrum on epithelial function of uppe...

journal_title：Cellular immunology

authors： Bui TT,Fan Y,Piao CH,Nguyen TV,Shin DU,Jung SY,Hyeon E,Song CH,Lee SY,Shin HS,Chai OH

更新日期：2020-05-01 00:00:00

abstract：:Inhibition of DPP IV has been shown to abrogate the stress-related increase in murine abortions and a concomitant increase in gamma-interferon. The aim of the present study was to investigate a potential impact of the DPP IV inhibitor Isoleucine Cyanopyrrolidide on the expression of surface antigens involved in T-cell...

journal_title：Cellular immunology

authors： Rüter J,Hoffmann T,Heiser U,Demuth HU,Arck PC,Klapp BF,Hildebrandt M

更新日期：2002-12-01 00:00:00

abstract：:PICOT (PKC-interacting cousin of thioredoxin) consists of one thioredoxin homology domain in the N-terminal and two tandem PICOT homology domains in the C-terminal. PICOT specifically interacts with protein kinase C theta (PKC-theta) via its thioredoxin homology domain and acts as an important modulator of T cell rece...

journal_title：Cellular immunology

authors： Kato N,Motohashi S,Okada T,Ozawa T,Mashima K

更新日期：2008-01-01 00:00:00

abstract：:In this report, we present experimental evidence that antigen-presenting cell lines take up peptide antigens in a manner consistent with fluid-phase endocytosis. Using the fluid phase endocytic marker inulin and a mathematical model for fluid phase uptake, we have found a basal uptake rate constant of approximately 0....

journal_title：Cellular immunology

authors： Selby DM,Singer DF,Anderson RW,Coligan JE,Linderman JJ,Nairn R

更新日期：1995-06-01 00:00:00

abstract：:Fibroblast activation protein α (FAPα) is expressed in cancer-associated fibroblasts (CAFs), which are the main type of cells in the tumor microenvironment. CAFs exert immunosuppressive activity, which can weaken the effects of cancer immunotherapy and mainly account for poor outcomes with therapeutic vaccines. To bet...

journal_title：Cellular immunology

authors： Xia Q,Zhang FF,Geng F,Liu CL,Wang YQ,Xu P,Lu ZZ,Xie Y,Wu H,Chen Y,Zhang Y,Kong W,Yu XH,Zhang HH

更新日期：2016-12-01 00:00:00

abstract：:The effect of prior maternal immunization on the murine offspring response to subsequent immunization with hen egg-white lysozyme was examined. Adult female A/J mice were immunized with 100 micrograms HEL-CFA intraperitoneally 10-27 weeks before conception. The offspring of these experimental female mice were then imm...

journal_title：Cellular immunology

authors： Jelonek MT,Brust JL,Song CH,Calandra GB,Miller A,Sercarz EE,Keller MA

更新日期：1993-05-01 00:00:00

abstract：:A low culture temperature of 27 degrees C inhibited mouse primary in vitro anti-hapten plaque-forming cell responses to a thymus-dependent (TD) antigen (Ag) (trinitrophenyl-keyhole limpet hemocyanin, TNP-KLH). In contrast, the magnitudes of secondary responses to TNP-KLH or primary responses to a thymus-independent (T...

journal_title：Cellular immunology

authors： Wang-Yang MC,Buttke TM,Miller NW,Clem LW

更新日期：1990-04-01 00:00:00

abstract：:Enriched human B lymphocytes cocultivated with mouse L cells produced human leukocyte interferon (IFN-alpha) and shortly thereafter transferred antiviral activity to the recipient cells (99% inhibition of expected virus yield). In contrast, cocultivation of enriched T-cell populations with mouse L cells resulted in no...

journal_title：Cellular immunology

authors： Weigent DA,Langford MP,Stanton GJ,Blalock JE

更新日期：1984-09-01 00:00:00

abstract：:A monoclonal anti-actin antibody, 2C9, was used to study the distribution of an actin-like cell-surface antigen (hereafter termed actin) on a lymphoblastoid cell line LA350 and on human peripheral blood lymphocytes. It was determined that 8-40% of LA350 cells and 3-15% of peripheral blood lymphocytes from healthy dono...

journal_title：Cellular immunology

authors： Bach MA,Lewis DE,McClure JE,Parikh N,Rosenblatt HM,Shearer WT

更新日期：1986-04-01 00:00:00

abstract：:In an attempt to better relate specific membrane characteristics of human adult and cord blood lymphocytes to specific functional activities, the phenotypic differences that exist in these two populations have been examined. Cord blood cells have considerably more spontaneous suppressor cell activity than adult cells....

journal_title：Cellular immunology

authors： Johnson C,Dwyer JM

更新日期：1983-10-01 00:00:00