Abstract：
:A single nucleotide A49G polymorphism (SNP) of CTLA-4 has been linked and associated with the autoimmune thyroid diseases (AITD) and thyroid autoantibody secretion. We have explored the functional mechanisms of CTLA-4 by means of recombinant human CTLA-4 expressed on transfected Jurkat T cells. Analysis of CTLA-4 transcripts with quantitative real-time PCR demonstrated similar baseline and PHA-stimulated levels for both the A49 and G49 alleles, which were markedly enhanced by anti-CTLA-4 engagement. Both alleles also coded for proteins which were expressed on the cell membrane, as measured by FACS analysis using anti-CTLA-4 (G: 34.4+/-11.9% cells, A: 27.6+/-8.6% cells) (p=ns). Baseline and PHA-stimulated IL-2 production were also similar among control and CTLA-4 clones expressing both alleles. After anti-CTLA-4 engagement, IL-2 production was markedly inhibited in a dose- and time-dependent manner but this also appeared to be similar in the A and G allele expressing cells (95.7+/-1.2% inhibition and 94.9+/-1.1% inhibition, respectively). In conclusion, both the extrinsic and intrinsic actions of human CTLA-4 were not affected by the signal peptide A49G polymorphism. Therefore, the linkage of the CTLA-4 A49G SNP to AITD is most likely secondary to linkage disequilibrium.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Xu Y,Graves PN,Tomer Y,Davies TFdoi
10.1016/s0008-8749(02)00018-7subject
Has Abstractpub_date
2002-02-01 00:00:00pages
133-40issue
2eissn
0008-8749issn
1090-2163pii
S0008874902000187journal_volume
215pub_type
杂志文章abstract：:We examined the effects of a rare sugar, D-allose, which is 6-carbon monosaccharide, on endocytosis and T cell stimulation by dendritic cells (DCs). The endocytosis of BCG-anti-BCG immune complexes by DCs markedly decreased in D-allose-containing medium. Co-culture with T cells (mixed leukocyte reaction, MLR) of DCs, ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2011.06.015
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abstract：:Experimental autoimmune encephalomyelitis was induced in a Lewis rat by sensitization with synthetic peptide GP68-86, representing the 68-86 sequence of guinea pig myelin basic protein (GPMBP). To delineate T cell determinants of GP68-86, lymph node cells from this rat were activated in culture with GP68-86 and were f...
journal_title：Cellular immunology
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doi：10.1016/0008-8749(89)90099-3
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journal_title：Cellular immunology
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2018.04.013
更新日期：2018-07-01 00:00:00
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journal_title：Cellular immunology
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更新日期：2011-01-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0289
更新日期：1996-11-25 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2009.10.013
更新日期：2010-01-01 00:00:00
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journal_title：Cellular immunology
pub_type： 历史文章,杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
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更新日期：1984-06-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2006.01.001
更新日期：2005-11-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2018.11.008
更新日期：2019-01-01 00:00:00
abstract：:American cutaneous leishmaniasis (ACL) is a disease where susceptibility or resistance is dependent on T cell response. This is characterized by an increased in CD4⁺ T cells, capable of inducing opposite disease profiles, and CD8⁺ T cells, that are related to immuno protection. We characterized T lymphocytes from pati...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2012.11.006
更新日期：2012-10-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2017.10.016
更新日期：2018-04-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90354-x
更新日期：1984-06-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1998.1353
更新日期：1998-10-10 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(87)90295-4
更新日期：1987-10-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1993.1230
更新日期：1993-10-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1986-06-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/0008-8749(84)90342-3
更新日期：1984-12-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
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更新日期：1985-11-01 00:00:00
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pub_type： 杂志文章
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journal_title：Cellular immunology
pub_type： 杂志文章
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更新日期：1996-11-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0020
更新日期：1996-01-10 00:00:00
abstract：:Experimental autoimmune thyroiditis is induced in mice by immunization with thyroglobulin emulsified in Freund's complete adjuvant. The disease is characterized both by thyroid infiltration with mononuclear cells and by circulating thyroglobulin antibodies. The magnitude of the thyroid infiltration and the titer of th...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(87)90302-9
更新日期：1987-10-01 00:00:00
abstract：:Atherosclerosis involves immune mechanisms: T lymphocytes are found in atherosclerotic plaques, suggesting their activation during atherogenesis. The predominant voltage-gated potassium channel of T cells, Kv1.3 is a key regulator of the Ca(2+)-dependent activation pathway. In the present experiments we studied the pr...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2013.01.004
更新日期：2013-01-01 00:00:00
