Abstract：
:Mesenchymal stem cells (MSCs) have been used to repair injured tissues through immune-suppression and/or cell replace mechanisms. However, a significant barrier to MSC therapy is insufficient MSC engraftment in injured tissues after systemic administration. Here, we report that cell surface, total protein, and mRNA levels of CXCR4 were significantly increased in MSCs when Notch signaling was interrupted by γ-secretase inhibitor (GSI) or knockout of the transcription factor RBP-J, which mediates signaling from all four mammalian Notch receptors. The GSI-treated or RBP-J deficient MSCs showed stronger migration toward stromal cell-derived factor-1α (SDF-1α) than that of the control. In a mouse hepatic ischemia/reperfusion model, RBP-J deficient MSCs migrated into the injured liver tissues at a significantly higher efficiency than that of the control MSCs. Mice transfused with RBP-J deficient MSCs showed reduced liver damage. Therefore, Notch signaling regulates MSC migration and function, at least partially via the modulation of CXCR4 expression.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Xie J,Wang W,Si JW,Miao XY,Li JC,Wang YC,Wang ZR,Ma J,Zhao XC,Li Z,Yi H,Han Hdoi
10.1016/j.cellimm.2013.02.001subject
Has Abstractpub_date
2013-01-01 00:00:00pages
68-75issue
1eissn
0008-8749issn
1090-2163pii
S0008-8749(13)00024-5journal_volume
281pub_type
杂志文章abstract：:Intravital imaging of cutaneous immune responses has revealed intricate links between the skin's structural properties, the immune cells that reside therein, and the carefully orchestrated migratory dynamics that enable rapid sensing and subsequent elimination of skin pathogens. In particular, the development of 2-pho...
journal_title：Cellular immunology
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abstract：:Experimental autoimmune neuritis (EAN) is a T-cell-mediated autoimmune disease characterized by demyelination and mononuclear cell infiltration of the peripheral nervous system. It is induced in Lewis rats by administration of myelin P2 protein or a synthetic peptide (SP-26) corresponding to amino acid residues 53-78 ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1156
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abstract：:This investigation shows that Epstein-Barr virus (EBV)-activated human B cells from marrow transplant recipients can produce in vitro IgG anti-tetanus toxoid antibody (anti-TT) without booster immunizations with tetanus toxoid (TT). Purified B cells (E-rosette negative) from 8 normal subjects, 6 healthy long-term marr...
journal_title：Cellular immunology
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journal_title：Cellular immunology
pub_type： 杂志文章
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journal_title：Cellular immunology
pub_type： 杂志文章
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更新日期：1988-12-01 00:00:00
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journal_title：Cellular immunology
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doi：10.1016/j.cellimm.2006.06.009
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2010.12.002
更新日期：2011-01-01 00:00:00
abstract：:We previously reported the amino acid sequence of the human macrophage chemotactic factor with a molecular weight of 1000 (MCF-1) was WLGREDGSE. In this study we examined the roles of MCF-1 and tumor necrosis factor (TNF) in a guinea pig delayed-type hypersensitivity (DTH) reaction. When macrophage chemotactic activit...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1995.1038
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journal_title：Cellular immunology
pub_type： 杂志文章
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journal_title：Cellular immunology
pub_type： 杂志文章
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2007.10.002
更新日期：2007-08-01 00:00:00
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journal_title：Cellular immunology
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journal_title：Cellular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.cellimm.2018.04.010
更新日期：2018-11-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
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更新日期：2007-08-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(85)90005-x
更新日期：1985-05-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(91)90048-g
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1993.1116
更新日期：1993-05-01 00:00:00
abstract：:Various anti-Fc gamma RIII (CD16) monoclonal antibodies (mAbs) are shown here to have positive or negative modulatory effects on human NK cells. Thus, 3G8 mAb (IgG1) triggered a dose-dependent augmentation of NK activity in 67% (23/34) of individuals tested, who were designated as responders. All four IgG1 anti-CD16 m...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1995.1113
更新日期：1995-07-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2006.06.003
更新日期：2006-03-01 00:00:00
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journal_title：Cellular immunology
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journal_title：Cellular immunology
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更新日期：2014-08-01 00:00:00
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journal_title：Cellular immunology
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doi：10.1016/j.cellimm.2010.06.002
更新日期：2010-01-01 00:00:00
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journal_title：Cellular immunology
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2011.03.023
更新日期：2011-01-01 00:00:00
abstract：:The activation by concanavalin A (Con A) of murine lymphocytes derived from aged animals is impaired, as demonstrated by lower IL-2 synthesis, display of fewer IL-2 receptors, and less [3H]thymidine incorporation relative to similarly treated cells from young animals. The ability of the phorbol ester, phorbol 12-myris...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90250-x
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journal_title：Cellular immunology
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更新日期：2020-01-01 00:00:00
abstract：:It has been reported that the three-dimensional structure of thymic epithelial cells (TECs) is responsible for thymic positive selection but that this ability disappears when TECs are cultured in monolayer. These results have supported the hypothesis that certain TEC-specific molecules are extinguished during monolaye...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.2001.1823
更新日期：2001-07-10 00:00:00
abstract：:The frequency of obesity is enormously growing worldwide. Obesity results when energy intake exceeds, energy expenditure. Excess adiposity is a major risk factor in the progress of various metabolic disorders accounting insulin resistance, hypertension, Type 2 diabetes, nonalcoholic fatty liver disease, polycystic ova...
journal_title：Cellular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.cellimm.2017.03.001
更新日期：2017-05-01 00:00:00
abstract：:The role of the cytokines IL-1 alpha, IL-1 beta, and IL-6 and the cell adhesion molecules ICAM-1, LFA-1 (alpha and beta), and Mac-1 as accessory molecules for stimulation of T cells by the superantigen staphylococcal enterotoxin B (SEB) was examined. Both blood monocytes and alveolar macrophages were used as accessory...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(92)90164-k
更新日期：1992-05-01 00:00:00
