Notch signaling regulates CXCR4 expression and the migration of mesenchymal stem cells.


:Mesenchymal stem cells (MSCs) have been used to repair injured tissues through immune-suppression and/or cell replace mechanisms. However, a significant barrier to MSC therapy is insufficient MSC engraftment in injured tissues after systemic administration. Here, we report that cell surface, total protein, and mRNA levels of CXCR4 were significantly increased in MSCs when Notch signaling was interrupted by γ-secretase inhibitor (GSI) or knockout of the transcription factor RBP-J, which mediates signaling from all four mammalian Notch receptors. The GSI-treated or RBP-J deficient MSCs showed stronger migration toward stromal cell-derived factor-1α (SDF-1α) than that of the control. In a mouse hepatic ischemia/reperfusion model, RBP-J deficient MSCs migrated into the injured liver tissues at a significantly higher efficiency than that of the control MSCs. Mice transfused with RBP-J deficient MSCs showed reduced liver damage. Therefore, Notch signaling regulates MSC migration and function, at least partially via the modulation of CXCR4 expression.


Cell Immunol


Cellular immunology


Xie J,Wang W,Si JW,Miao XY,Li JC,Wang YC,Wang ZR,Ma J,Zhao XC,Li Z,Yi H,Han H




Has Abstract


2013-01-01 00:00:00














  • Immune recognition by cytotoxic T lymphocytes of minor histocompatibility antigens expressed on a murine colon carcinoma line.

    abstract::We have characterized in vivo and in vitro responses of mice to the BALB/c-derived carcinoma, C26. BALB/c mice were highly susceptible, in a dose-dependent fashion, to local tumor development following subcutaneous injection of C26. Other strains of mice, including allogeneic strains and major histocompatibility compl...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Mosley RL,Styre D,Klein JR

    更新日期:1989-08-01 00:00:00

  • A revertant TCR gamma delta + cell clone which has lost MHC nonrestricted cytotoxic activity but retains redirected killing upon stimulation of the CD3 receptor.

    abstract::A variant nonkiller (K-) T-cell clone derived from the MHC nonrestricted killer (K+) cell line TALL-103/2 (CD3/TCR gamma delta +) was studied to determine whether its lytic defects were at the tumor-binding or post-binding level. The two TALL-103/2 clones were found to display similar mRNA expression of TCR/CD3 comple...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Visonneau S,Cesano A,Santoli D

    更新日期:1995-10-15 00:00:00

  • Discrimination between receptor- and store-operated Ca(2+) influx in human neutrophils.

    abstract::Ca(2+) and Sr(2+) entry pathways activated by pro-inflammatory agonists FMLP, LTB(4) and PAF have been compared to thapsigargin in human neutrophils. 2-APB (10microM) increased Ca(2+) influx and to a greater extent in agonist than in thapsigargin stimulated neutrophils. This action of 2-APB was specific to Ca(2+) beca...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Salmon MD,Ahluwalia J

    更新日期:2010-01-01 00:00:00

  • Ca(2+)-ATPase inhibitors induce interleukin-2 synthesis and T cell proliferation.

    abstract::In Jurkat cells, the three Ca(2+)-ATPase blockers, thapsigargin, cyclopiazonic acid, and di-tert-butylhydroquinone (DtBuHQ) induced both a release of Ca2+ from intracellular stores and a Ca2+ influx. In contrast to CD3 mAb, the Ca(2+)-ATPase inhibitors did not induce the formation of inositol trisphosphate from the hy...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Breittmayer JP,Ticchioni M,Ferrua B,Bernard A,Aussel C

    更新日期:1993-07-01 00:00:00

  • Involvement of inflammatory cytokines in a delayed-type hypersensitivity reaction.

    abstract::We previously reported the amino acid sequence of the human macrophage chemotactic factor with a molecular weight of 1000 (MCF-1) was WLGREDGSE. In this study we examined the roles of MCF-1 and tumor necrosis factor (TNF) in a guinea pig delayed-type hypersensitivity (DTH) reaction. When macrophage chemotactic activit...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Higashi N,Yoshizuka N,Ohuchi A,Osawa T,Kobayashi Y

    更新日期:1995-04-01 00:00:00

  • Hemorrhage in mice produces alterations in intestinal B cell repertoires.

    abstract::Abnormalities in immune response play a major role in the increased susceptibility to infection after hemorrhage and trauma. Infections occurring after injury often originate in the intestine. In order to determine the effects of hemorrhage on intestinal B cell function, we examined hemorrhage-induced alterations in a...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Abraham E,Chang YH

    更新日期:1990-06-01 00:00:00

  • Cross-linking staphylococcal enterotoxin A bound to major histocompatibility complex class I is required for TNF-alpha secretion.

    abstract::The mechanism of how superantigens function to activate cells has been linked to their ability to bind and cross-link the major histocompatibility complex class II (MHCII) molecule. Cells that lack the MHCII molecule also respond to superantigens, however, with much less efficiency. Therefore, the purpose of this stud...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Wright AD,Chapes SK

    更新日期:1999-11-01 00:00:00

  • The challenges of checkpoint inhibition in the treatment of multiple myeloma.

    abstract::Despite significant improvements in the overall survival of patients with multiple myeloma (MM) over the past 15 years, the disease remains incurable. Treatment options are limited for patients who have relapsed or are refractory to immunomodulatory drugs (IMiDs), proteasome inhibitors, and monoclonal antibodies. In t...

    journal_title:Cellular immunology

    pub_type: 杂志文章,评审


    authors: Paul B,Kang S,Zheng Z,Kang Y

    更新日期:2018-12-01 00:00:00

  • Functional effects of a monoclonal antibody directed against a distinct epitope on 4F2 molecular complex in human peripheral blood mononuclear cell activation.

    abstract::The 4F2 antigenic complex is expressed on most human cell lines in culture, on monocytes and activated lymphocytes, but not on resting T and B lymphocytes. Monoclonal antibody (mAb) CB43 recognizes an epitope of the 4F2 heterodimer either located on the light chain or dependent on the conformation of the molecule. The...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Spagnoli GC,Ausiello C,Palma C,Bellone G,Ippoliti G,Letarte M,Malavasi F

    更新日期:1991-08-01 00:00:00

  • Prolonged allogeneic and xenogeneic microchimerism in unmatched primates without immunosuppression by intrathymic implantation of CD34+ donor marrow cells.

    abstract::Engraftment of stem cell-enriched donor marrow implanted in the thymus of a foreign host might facilitate acceptance of donor-specific organ or tissue grafts. To test this hypothesis, allogeneic and xenogeneic CD34+ marrow cells from unrelated adult male baboons and humans were injected intrathymically in eight infant...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Allen MD,Weyhrich J,Gaur L,Akimoto H,Hall J,Dalesandro J,Sai S,Thomas R,Nelson KA,Andrews RG

    更新日期:1997-11-01 00:00:00

  • Expression of a membrane form of the pregnancy-associated protein TJ6 on lymphocytes.

    abstract::TJ6 is a novel protein which has immunosuppressive activity and may have a functional role in fetal allograft survival during pregnancy. Initial studies indicated that when mice were treated with an anti-TJ6 binding mAb early in pregnancy, the pregnancies were completely ablated and that TJ6 expression is enhanced dra...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Nichols TC,Kang JA,Angkachatchai V,Beer AE,Beaman KD

    更新日期:1994-04-15 00:00:00

  • TGF-beta1 expression in EL4 lymphoma cells overexpressing growth hormone.

    abstract::Our previous studies show that growth hormone overexpression (GHo) upregulates the expression of the IGF-1R and IGF-2R resulting in the protection of the EL4 lymphoma cell line from apoptosis. In this study, we report that GHo also increases TGF-beta1 protein expression measured by luciferase promoter assay, Western a...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Farmer JT,Weigent DA

    更新日期:2006-03-01 00:00:00

  • Inhibition of interleukin 2 production by prostaglandin E2 is not absolute but depends on the strength of the stimulating signal.

    abstract::In view of the eminently important role of interleukin-2 (IL-2) in T-cell responses, and in view of reports about immune stimulatory effects of PGE2, we reinvestigated the question whether PGE2 inhibits IL-2 production. It was found that PGE2 does not inhibit IL-2 production in murine spleen cell cultures after optima...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Wolf M,Falk W,Männel D,Dröge W

    更新日期:1985-01-01 00:00:00

  • Effects of ultraviolet-B irradiation on human LAK and NK cytotoxic activity.

    abstract::In vitro ultraviolet-B (UVB) irradiation of murine and rodent bone marrow cells prevents GVHD without compromising engraftment while inducing tolerance to donor-type allografts. In anticipation of clinical trials of UVB-modified bone marrow grafts, we studied the in vitro effects of UVB irradiation (50-300 J/m2) on hu...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Yaron I,Zakheim AR,Oluwole SF,Hardy MA

    更新日期:1995-10-15 00:00:00

  • Accelerated progression of Hodgkin's-like lymphomas in golli deficient SJL mice.

    abstract::Spontaneously occurring lymphomas in SJL mice have many pathological features similar to Hodgkin's lymphoma in humans. The malignant growth of the tumor cells is dependent on the support of host FoxP3(+)CD4(+) regulatory T cells (Tregs). In this study, we report that the ablation of golli protein, a negative regulator...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Ouyang S,Han G,Wu X,Jiang Z,Feng JM

    更新日期:2016-04-01 00:00:00

  • Alloreactive feature of HLA-DP-specific cytotoxic T-cell clone.

    abstract::The alloreactive feature of CD4+ cytotoxic T-cell clone that could specifically lyse the cells bearing DPB1*0202 sequence was described. The clone was generated from a mixed culture of peripheral blood lymphocytes derived from siblings who were HLA-A, B, C, DR, and DQ identical by serological typing and whose DNA sequ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Nishimura M,Mitsunaga S,Akaza T,Mitomi Y,Tadokoro K,Juji T

    更新日期:1994-01-01 00:00:00

  • Tumor necrosis factor-alpha analyzed within individual macrophages by combined immunocytochemistry and computer-aided image analysis.

    abstract::Immunocytochemical staining procedures were combined with computer-aided image analysis to quantitate the relative intracellular production of tumor necrosis factor-alpha (TNF) within individual macrophages. Optimal conditions for time and methods for the activation of TNF production, fixation of cells for optimal imm...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Brown AR,Fishman M

    更新日期:1990-10-15 00:00:00

  • The choriocarcinoma cell line JEG-3 upregulates regulatory T cell phenotypes and modulates pro-inflammatory cytokines through HLA-G.

    abstract::An understanding of the interactions between immune cells and trophoblast cells, as well as choriocarcinoma cells, are of extreme importance in reproductive immunology and cancer immunology. In this study, we found that the human HLA-G-positive choriocarcinoma cell line JEG-3 upregulates CD4+CD25hiCD127lo T cells, inc...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Melsted WN,Matzen SH,Andersen MH,Hviid TVF

    更新日期:2018-02-01 00:00:00

  • Analysis of expression of lymphocyte homing-related adhesion molecules in ALY mice deficient in lymph nodes and Peyer's patches.

    abstract::The aly, alymphoplasia, is an autosomal recessive mutation in mice of an unknown etiology, which induces total aplasia of lymph nodes and Peyer's patches. We hypothesized that the lack of lymphoid tissue may be due to abnormalities of lymphocyte traffic into these tissues. Therefore, we analyzed the expression of vari...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Koike R,Watanabe T,Satoh H,Hee CS,Kitada K,Kuramoto T,Serikawa T,Miyawaki S,Miyasaka M

    更新日期:1997-08-25 00:00:00

  • Production of lymphokines affecting tumor cells by T-T hybridomas.

    abstract::T-Cell hybridomas were constructed by fusing BW5147, an AKR lymphoma, with concanavalin A-stimulated murine splenic lymphocytes. The hybrids which were formed were studied for their ability to produce a lymphokine which inhibits tumor cell migration (TMIF) as well as macrophage migration (MIF) using in vitro assays. C...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Cohen MC,Lazarus M

    更新日期:1985-07-01 00:00:00

  • Piperine ameliorates oxidative stress, inflammation and histological outcome in collagen induced arthritis.

    abstract:OBJECTIVES:Piperine, a main component of Piper species, is a plant alkaloid with a long history of medical use in a variety of inflammatory disorders like rheumatoid arthritis. Due to side effects in current treatment modalities of rheumatoid arthritis, the interest in alternative, well tolerated anti-inflammatory reme...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Umar S,Golam Sarwar AH,Umar K,Ahmad N,Sajad M,Ahmad S,Katiyar CK,Khan HA

    更新日期:2013-07-01 00:00:00

  • The autoimmune mouse MRL/Mp-lpr/lpr contains cells with spontaneous cytotoxic activity against target cells bearing self-determinants.

    abstract::Spontaneously cytotoxic cells possessing specificity and having a complex pattern of reactivity directed at least partly against self-determinants develop by the age of 10 weeks in the autoimmune mouse strain MRL/Mp-lpr/lpr (MRL-lpr) and by the age of 6 months in C57BL/6-lprl/lpr. Similar effector cells do not develop...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Muraoka S,Miller RG

    更新日期:1988-04-15 00:00:00

  • Thymic hormone modulation of age-induced changes in the induction of graft-versus-host disease by DBA/2J lymphocytes.

    abstract::Aging induces a number of changes in the immune system, including the involution of the thymus which results in the loss of thymic hormone production and alteration in T cell function. One age-dependent change in immune response is the increasing risk of developing acute or chronic form of graft-versus-host disease (G...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Fast LD,Kouttab NM,Badamchian M,Goldstein AL

    更新日期:1990-11-01 00:00:00

  • Increased Zap-70 association with CD3zeta in CD4 T cells from old mice.

    abstract::Aging diminishes the amount of phosphotyrosine in the CD3zeta chains of resting and activated mouse CD4 T cells by about threefold and might therefore be expected to a corresponding decline in Zap-70 association with CD3zeta and in Zap-70 kinase function in CD3zeta complexes. We show here that aging leads, unexpectedl...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Garcia GG,Miller RA

    更新日期:1998-12-15 00:00:00

  • Suppression of interleukin-1 and tumor necrosis factor-alpha production by acanthoic acid, (-)-pimara-9(11),15-dien-19-oic acid, and it antifibrotic effects in vivo.

    abstract::Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) are major proinflammatory cytokines inducing the synthesis and release of many inflammatory mediators. They are involved in immune regulation, autoimmune diseases, and inflammation. Acanthoic acid, (-)-pimara-9(11),15-dien-19-oic acid, is a pimaradiene d...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Kang HS,Kim YH,Lee CS,Lee JJ,Choi I,Pyun KH

    更新日期:1996-06-15 00:00:00

  • The production of immunoregulatory factors by a human macrophage-like cell line. III. The relationship between the lymphoid-specific inhibitor of DNA synthesis and gamma-interferon.

    abstract::Mitogenic stimulation of sublines of the human histiocytic lymphoma, U937, results in the production of an inhibitor of lymphocyte proliferation (IDS-U937). The relationship of IDS-U937 to alpha- and gamma-interferon was examined by several techniques: (1) the antiviral activity of the IDS preparations was determined,...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Wilkins JA,Warrington RJ

    更新日期:1984-07-01 00:00:00

  • Temperature-mediated processes in immunity: differential effects of low temperature on mouse T helper cell responses.

    abstract::A low culture temperature of 27 degrees C inhibited mouse primary in vitro anti-hapten plaque-forming cell responses to a thymus-dependent (TD) antigen (Ag) (trinitrophenyl-keyhole limpet hemocyanin, TNP-KLH). In contrast, the magnitudes of secondary responses to TNP-KLH or primary responses to a thymus-independent (T...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Wang-Yang MC,Buttke TM,Miller NW,Clem LW

    更新日期:1990-04-01 00:00:00

  • Regulation of T-cell activation and T-cell growth factor (TCGF) production by hydrogen peroxide.

    abstract::Activated macrophages are known to release a variety of immunoregulatory substances including the low-molecular-weight substances hydrogen peroxide and lactate. We report here that lactate but not hydrogen peroxide is capable of supporting a substantial production of T-cell growth factor (TCGF) in cultures of accessor...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Roth S,Dröge W

    更新日期:1987-09-01 00:00:00

  • Comparative analysis of the heterogeneity of mononuclear cells present in adult and cord blood by simultaneous examination of multiple phenotypic characteristics.

    abstract::In an attempt to better relate specific membrane characteristics of human adult and cord blood lymphocytes to specific functional activities, the phenotypic differences that exist in these two populations have been examined. Cord blood cells have considerably more spontaneous suppressor cell activity than adult cells....

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Johnson C,Dwyer JM

    更新日期:1983-10-01 00:00:00

  • A single cell tracking system in real-time.

    abstract::We describe here a novel real-time cell tracking system which can measure cell migration routes under cell culture condition. This system includes a mini incubator which controls temperature and CO(2) gas flow and a PDMS (polydimethylsiloxane) chip for chemotaxis measurement. The main differences from previous ones ar...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Kwak YH,Hong SM,Park SS

    更新日期:2010-01-01 00:00:00