Abstract:
:Sialoadhesin (Sn) is a surface receptor expressed on macrophages in steady state conditions, but during inflammation, Sn can be upregulated both on macrophages and on circulating monocytes. It was shown for different species that Sn becomes internalized after binding with monoclonal antibodies. These features suggest that Sn is a potential target for immunotherapies. In this study, human and mouse macrophages were treated with anti-Sn monoclonal antibodies or F(ab')2 fragments and the effect of their binding to Sn on phagocytosis was analyzed. Binding of antibodies to Sn resulted in delayed and reduced phagocytosis of fluorescent beads. No effect was observed on Fc-mediated phagocytosis or phagocytosis of bacteria by human macrophages. In contrast, an enhanced phagocytosis of bacteria by mouse macrophages was detected. These results showed that stimulation of Sn could have different effects on macrophage phagocytosis, depending both on the type of phagocytosis and cellular background.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
De Schryver M,Cappoen D,Elewaut D,Nauwynck HJ,Maes L,Caljon G,Cos P,Delputte PLdoi
10.1016/j.cellimm.2016.11.009subject
Has Abstractpub_date
2017-02-01 00:00:00pages
51-60eissn
0008-8749issn
1090-2163pii
S0008-8749(16)30147-2journal_volume
312pub_type
杂志文章abstract::The ability of calcium ionophore and phorbol ester to stimulate entry into S phase was assessed during short-term cultures of murine B cells extensively depleted of T cells. Neither ionomycin alone nor PMA alone stimulated DNA synthesis. However, the combination of ionomycin plus PMA acted in synergy to induce initiat...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(86)90430-2
更新日期:1986-10-15 00:00:00
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journal_title:Cellular immunology
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journal_title:Cellular immunology
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1984-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Cellular immunology
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更新日期:1985-06-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(86)90268-6
更新日期:1986-03-01 00:00:00
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更新日期:1987-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1991-04-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(86)90204-2
更新日期:1986-08-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1230
更新日期:1994-09-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1996.0232
更新日期:1996-09-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2008.03.003
更新日期:2008-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2009.12.002
更新日期:2010-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1097
更新日期:1995-06-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2017.10.005
更新日期:2017-12-01 00:00:00
abstract::Staphylococcal enterotoxin B (SEB) is a potent polyclonal activator of both human and murine T cells. We previously reported data which show that SEB-induced T cells suppress antibody secretion by various mouse plasmacytoma cell lines. This suppression of antibody secretion was found to be both idiotype and isotype no...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90227-i
更新日期:1990-09-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2020.104082
更新日期:2020-06-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(89)90146-9
更新日期:1989-08-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章,随机对照试验
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更新日期:2012-09-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1996.0134
更新日期:1996-05-25 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90240-5
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:We aim to evaluate the effects of atorvastatin on the expression of Toll-like receptor (TLR4) protein and mRNA, and to explore their effects on TLR4-dependent downstream signaling in human monocytic leukemia (THP-1) cells. METHODS:TLR4 protein and mRNA expression, levels of NF-κB protein, and expression of TNF...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2012.09.008
更新日期:2012-09-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2010.04.008
更新日期:2010-01-01 00:00:00
abstract::It is still a matter of debate, whether tolerance toward self-non-MHC antigens is due to intrathymic deletion or to regulatory processes in the periphery. To further pursue this question, responsiveness toward TNP and an anti-TNP monoclonal antibody (Sp6) carrying a recurrent idiotype was evaluated in prenatally trini...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90298-6
更新日期:1990-03-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90059-5
更新日期:1984-10-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(87)90260-7
更新日期:1987-06-01 00:00:00
abstract::The transfer of B cells from mice immunized with Type III pneumococcal polysaccharide (SSS-III) results in the activation of suppressor and amplifier T cells that control the magnitude of the antibody response in recipient mice, immunized subsequently with SSS-III. Prior treatment of transferred B cells with an excess...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90368-5
更新日期:1985-12-01 00:00:00
abstract::In vitro incubations of CD4+ T cells with anti-CD4 monoclonal antibody (Mab) demonstrated saturation binding and inhibited both PPD-stimulated proliferation and delayed-type hypersensitivity (DTH) after passive transfer of these cells into naive rats. In comparison, in vivo administration of anti-CD4 Mab into rats, 2 ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1104
更新日期:1995-06-01 00:00:00