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The acute inflammatory process in murine lymphocytic choriomeningitis is dependent on Lyt-2+ immune T cells.

Abstract：

:Virus-immune spleen cells induce fatal immunopathology following adoptive transfer into adult C57B1/6J mice that have been infected with lymphocytic choriomeningitis virus (LCMV) and immunosuppressed with cyclophosphamide. This is accompanied by the development of potent cytotoxic T-lymphocyte (CTL) activity of donor origin in the recipient spleen. Both the capacity to trigger the acute meningitis observed at 72 hr and to generate CTL effectors in lymphoid tissue are completely abrogated by the removal of Lyt-2+ cells from the donor population. However a lower level of inflammatory process in the central nervous system may emerge, in the absence of significant CTL function in recipient spleen, by 5 days after transfer of the Lyt-2-depleted cell population. Treatment of the transferred cells with antibody to the L3T4 marker does not reduce either the severity of inflammation or the level of CTL effector function in the recipient. Thus Lyt-2+ cells are required for the acute, fatal immunopathology characteristic of LCM, but it is not clear that in a more chronic situation, they are the sole effectors capable of triggering inflammatory process in this disease.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Dixon JE,Allan JE,Doherty PC

doi

10.1016/0008-8749(87)90260-7

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

8-14

issue

1

eissn

0008-8749

issn

1090-2163

pii

0008-8749(87)90260-7

journal_volume

107

pub_type

杂志文章

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