Abstract:
:Prior studies have shown that intraperitoneal (ip) injection of 25 IU of human rIL-2 can effectively modulate in vivo immune reactivity to thymus-dependent and thymus-independent type 2 immunogens in Xenopus laevis, the South African clawed toad, but is less successful at affecting toad cells in vitro. Here we compare the capacities of human rIL-2 and autologous TCGF to modulate Xenopus splenocytes in vitro and find that autologous TCGF (1) is more effective at stimulating mitogenesis, (2) can serve as a ligand for inducible receptors that will also bind rIL-2 and an F1*-mouse anti-human p55 antibody, and (3) will regulate the expression these receptors.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Ruben LN,Rak JC,Johnson RO,Shiigi S,Clothier RHdoi
10.1006/cimm.1994.1224subject
Has Abstractpub_date
1994-08-01 00:00:00pages
300-5issue
1eissn
0008-8749issn
1090-2163pii
S000887498471224Xjournal_volume
157pub_type
杂志文章abstract::Heterotrimeric G-proteins control diverse biological processes by conveying signals from seven-transmembrane receptors to intracellular effectors. Although their signaling roles were originally ascribed to their GTP-bound alpha-subunits, more recent evidence points to the equally active roles played by their betagamma...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2006.06.008
更新日期:2006-04-01 00:00:00
abstract::The proliferative response of peripheral blood mononuclear cells (PBMC) in synthetic serum-free media depends on the presence of sufficient amounts of transferrin (Tf). In the present communication we show that the reduction of Tf concentration in culture media results in a decreased proliferation, whereas lymphokine ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(91)90038-d
更新日期:1991-02-01 00:00:00
abstract::Mice repeatedly immunized with the methanol extraction residue fraction of tubercle bacilli (MER) in incomplete Freund's adjuvant produced high titers of circulating antibodies against MER, as assessed by the enzyme-linked immunosorbent assay (ELISA) method. Spleen cells derived from these animals failed to respond to...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90021-8
更新日期:1985-05-01 00:00:00
abstract::To investigate a role for T lymphocytes in primary demyelination of central nervous system (CNS) tissue, antigen-specific T cell lines sensitized to myelin-associated and myelin-unrelated antigens were developed from SJL mice and tested on myelinated organotypic cultures of syngeneic spinal cord. Demyelination was ass...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(86)90340-0
更新日期:1986-10-01 00:00:00
abstract::To characterize the binding properties of the Fc receptors on human macrophages, the binding of radiolabeled human IgG1 to peritoneal macrophages was assessed. Cells were obtained at the time of diagnostic laparoscopy from women undergoing evaluation of infertility. Macrophages bound on the average more IgG1 monomer t...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90403-9
更新日期:1984-07-01 00:00:00
abstract::An understanding of the interactions between immune cells and trophoblast cells, as well as choriocarcinoma cells, are of extreme importance in reproductive immunology and cancer immunology. In this study, we found that the human HLA-G-positive choriocarcinoma cell line JEG-3 upregulates CD4+CD25hiCD127lo T cells, inc...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2017.11.008
更新日期:2018-02-01 00:00:00
abstract::Adenomatous polyposis coli (APC) functions are involved in the heterotypic interactions occurring between intestinal epithelial cells (IECs) and intra-epithelial lymphocytes (IELs). These interactions may be of interest in cancer prevention, since recent data provide evidence for lymphocyte mediated immunosurveillance...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/s0008-8749(03)00149-7
更新日期:2003-05-01 00:00:00
abstract::The role of class II antigens for B-cell activation was analyzed using purified human B cells and anti-class II monoclonal antibodies. The stimulation of purified B cells with Staphylococcus aureus Cowan I induced proliferation and differentiation into immunoglobulin-producing cells in the presence of interleukin-1 an...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(88)90295-x
更新日期:1988-04-01 00:00:00
abstract::The induction of ornithine decarboxylase (ODC) activity in lymphocytes is associated with activation and the initiation of cellular proliferation. ODC is also an essential component in tumor promotion. Phorbol myristic acetate (PMA) is a mitogen for lymphocytes, but can also promote tumor formation. Tumor promotion is...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(88)90015-9
更新日期:1988-04-15 00:00:00
abstract::Estrogen displays potent immunoregulatory properties. In the present study we investigated the in vivo effect of estrogen on natural killer (NK) cell cytotoxic activity in several mouse strains. After castration, 17 beta-estradiol was administered in low or high doses. After 3-6 weeks of hormone administration an in v...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1262
更新日期:1994-10-01 00:00:00
abstract::We have established a long-lasting heart allograft tolerance in H-2-incompatible combinations by intravenous injection of 10(8) allogeneic spleen cells followed by the administration of 200 mg/kg of cyclophosphamide (CP). When C57BL/10 mice (B10, H-2b) were primed iv with 1 x 10(8) viable spleen cells from naive BALB/...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1142
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Interleukin (IL)-23, composed of p19 and p40 subunits, has diverse functions in regulating immune systems, enhancing cell-mediated immunity. In the present study, we investigated whether forced expression of the p19-linked p40 gene in murine mammary cancer cells (MA891) produced antitumor effects in vivo. Tu...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2009.05.002
更新日期:2009-01-01 00:00:00
abstract::NK and extrathymic T cells are abundant in the decidua of the pregnant uterus. To determine how this unique pattern is induced, overall populations of leukocytes were examined in the blood and other tissues in pregnant women. Time-kinetic studies showed that a basal change of leukocytes during pregnancy was granulocyt...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1999.1541
更新日期:1999-08-25 00:00:00
abstract::In this study, we demonstrate that HIV-1 Tat protein is able to induce IL-10 and TNF-alpha in human macrophages. We show that N-terminal Tat 1-45 fragment initiates the PKC pathway by acting at the membrane. Inhibition of PKC pathway, by chemical inhibitors or after PMA treatment, abolishes both IL-10 and TNF-alpha pr...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2008.06.011
更新日期:2008-01-01 00:00:00
abstract::Monocytes and macrophages link the innate and adaptive immune systems and protect the host from the outside world. In inflammatory disorders their activation leads to tissue damage. Galectins have emerged as central regulators of the immune system. However, if they regulate monocyte/macrophage physiology is still unkn...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2011.06.003
更新日期:2011-01-01 00:00:00
abstract::Veto cells suppress generation of CD8(+) T cell immune responses in an antigen-specific manner, with specificity dictated by antigens on the veto cell surface. Activated bone marrow (ABM) veto cells belong to the NK cell type lineage and veto by clonally deleting antigen-specific precursor cytotoxic T cell lymphocyte ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.2001.1771
更新日期:2001-03-15 00:00:00
abstract::Polyunsaturated fatty acid [omega-3 polyunsaturated fatty acids (omega-3PUFAs)] incorporation into cell membranes has been shown to have potent anti-inflammatory activity, though the mechanisms involved are only partially characterized. Here, we show that PUFA enrichment of T cell membranes decreased the overall expre...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2004.04.004
更新日期:2004-04-01 00:00:00
abstract::BST2 is a type II transmembrane protein that had been initially identified as a surface molecule expressed on terminally differentiated B cells. Here, we characterize the expression of BST2 in human endothelial cells, HUVECs. IFN-γ, among various inflammatory stimuli, dramatically upregulates BST2 expression in HUVECs...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2010.10.011
更新日期:2011-01-01 00:00:00
abstract::In this report, we present experimental evidence that antigen-presenting cell lines take up peptide antigens in a manner consistent with fluid-phase endocytosis. Using the fluid phase endocytic marker inulin and a mathematical model for fluid phase uptake, we have found a basal uptake rate constant of approximately 0....
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1097
更新日期:1995-06-01 00:00:00
abstract::The adoptive transfer of tumor-reactive T lymphocytes has recently been demonstrated to be an effective means for mediating the regression of experimental intracranial fibrosarcomas. In this study, mice bearing syngeneic intracranial GL261 gliomas were cured by the combination of sublethal whole body irradiation follo...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1997.1140
更新日期:1997-06-15 00:00:00
abstract::TH1 cytokines have recently been detected in rheumatoid arthritis (RA) and osteoarthritis (OA). For this reason we studied the TH-1-promoting cytokine IL-12 in synovial membranes from patients with RA and OA. IL-12 transcripts and protein were analyzed by reverse transcriptase-polymerase chain reaction (PCR) and immun...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1998.1363
更新日期:1998-09-15 00:00:00
abstract::The lpr mutation in mice results in premature termination of transcription of the gene encoding the apoptosis-signaling receptor Fas. As a result, lpr mice develop severe lymphoproliferation and lupus-like autoantibodies. Growing evidence suggests that the lpr mutation is "leaky" and that low levels of Fas are express...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1998.1290
更新日期:1998-05-25 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curable strategy for the treatment of hematological malignancies and nonmalignant diseases. However, graft-versus-host disease (GVHD) and relapse are still two major causes of morbidity and mortality after allo-HSCT, and both restrict the improvement ...
journal_title:Cellular immunology
pub_type: 杂志文章,评审
doi:10.1016/j.cellimm.2019.103991
更新日期:2019-12-01 00:00:00
abstract::In the present study, we have examined the ability of phagocytes from different anatomical districts to discriminate between the two morphogenetic forms of Candida albicans. We have demonstrated that resident peritoneal macrophages (RP-M phi) and thioglycollate-elicited peritoneal macrophages (TP-M phi) were able to d...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1021
更新日期:1994-01-01 00:00:00
abstract::MHC class II-restricted antigen presentation requires trafficking of newly synthesized class II-invariant chain complexes from the trans-Golgi network to endosomal, peptide-loading compartments. This transport is mediated by dileucine-like motifs within the cytosolic tail of the invariant chain. Although these signals...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.2001.1817
更新日期:2001-06-15 00:00:00
abstract::This report describes a model for investigating the role of the thymus in regulating natural killer (NK) cell activity in vivo. Evidence is presented that the thymus can regulate NK cells, and that at least some NK cells can develop without thymic help. Marrow from thymectomized rats depleted of circulating T cells by...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90201-1
更新日期:1985-02-01 00:00:00
abstract::Injection of the 708-amino-acid (aa) viral protein "large tumor antigen" (T-Ag) of simian virus 40 (SV40) or its N-terminal 272-aa fragment into C57BL/6 (B6) mice (H-2b) primed CD8+ cytotoxic T lymphocytes (CTL) in vivo. Surprisingly, injection of this nonstructural viral protein (or its N-terminal fragment) in solubl...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1993.1169
更新日期:1993-07-01 00:00:00
abstract::A spontaneously arising murine plasmacytoma, HPC-202, derived from a BALB/c.H-2b congenic mouse that lacks any detectable H-2 determinants on its cell surface is described. However, the expression of H-2 determinants is inducible by interferon-gamma. The H-2 negative cell surface phenotype permits the HPC-202 tumor to...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90114-7
更新日期:1990-04-15 00:00:00
abstract::The mechanisms of glucocorticoid-induced immunosuppression of human monocytes for the defense of Candida albicans were examined in this in vitro study. Dexamethasone at pharmacological concentrations (10(-7)-10(-5) M) dose-dependently attenuated growth inhibition of C. albicans by resident monocytes. In interferon-gam...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1230
更新日期:1994-09-01 00:00:00
abstract::Apolipoprotein E (apoE), a lipid transport protein important in cholesterol homeostasis, inhibits the proliferation of interleukin-dependent lymphocytes. Growth factor-responsive cells are blocked in the G1A phase of the cell cycle. Suppression by apoE is independent of growth factor, as evidenced by the fact that int...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(95)80004-3
更新日期:1995-01-01 00:00:00