当前位置： SCI文献检索 > CELLULAR IMMUNOLOGY期刊下所有文献 > The choriocarcinoma cell line JEG-3 upregulates regulatory T cell phenotypes and modulates pro-inflammatory cytokines through HLA-G.

The choriocarcinoma cell line JEG-3 upregulates regulatory T cell phenotypes and modulates pro-inflammatory cytokines through HLA-G.

Abstract：

:An understanding of the interactions between immune cells and trophoblast cells, as well as choriocarcinoma cells, are of extreme importance in reproductive immunology and cancer immunology. In this study, we found that the human HLA-G-positive choriocarcinoma cell line JEG-3 upregulates CD4+CD25hiCD127lo T cells, increases the expression of HLA-G+CD4+ and CD8+ T cells, and decreases the expression of ILT2+ on CD4+ T cells in resting PBMCs after six days of co-culture. Expression of HLA-G on JEG-3 cells did not affect regulatory T cell phenotypes, but promoted modulation of pro-inflammatory cytokines IFN-γ, TNF-α and IL-17A. When JEG-3 cells were stimulated with rhIFN-γ prior to co-culture, CD4+HLA-G+ T cells were significantly increased, and IFN-γ and TNF-α elevated. Taken together, the results indicate that JEG-3 cells upregulate regulatory T cell phenotypes and modulate the level of pro-inflammatory cytokines, which might be important mechanisms in the tumor microenvironment and at the feto-maternal interface during pregnancy.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Melsted WN,Matzen SH,Andersen MH,Hviid TVF

doi

10.1016/j.cellimm.2017.11.008

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

14-23

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(17)30217-4

journal_volume

324

pub_type

杂志文章

相关文献

CELLULAR IMMUNOLOGY文献大全
  • VSTM1-v2, a novel soluble glycoprotein, promotes the differentiation and activation of Th17 cells.

    abstract：:Cytokines are soluble proteins that mediate immune reactions and are responsible for communication among immune cells. CD4(+) T cells are the principle sources of cytokines of adaptive immunity. Cytokines play critical roles in the differentiation and effector function of CD4(+) T cells. They also play key roles in di...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2012.07.009

    authors： Guo X,Zhang Y,Wang P,Li T,Fu W,Mo X,Shi T,Zhang Z,Chen Y,Ma D,Han W

    更新日期：2012-07-01 00:00:00

  • Regulation of human natural killer cell migration and proliferation by the exodus subfamily of CC chemokines.

    abstract：:Natural killer (NK) cells play an important role in innate and adaptive immune responses to obligate intracellular pathogens. Nevertheless, the regulation of NK cell trafficking and migration to inflammatory sites is poorly understood. Exodus-1/MIP-3alpha/LARC, Exodus-2/6Ckine/SLC, and Exodus-3/MIP-3beta/ELC/CKbeta-11...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1999.1601

    authors： Robertson MJ,Williams BT,Christopherson K 2nd,Brahmi Z,Hromas R

    更新日期：2000-01-10 00:00:00

  • Interleukin-4 enhances anti-IgM stimulation of B cells by improving cell viability and by increasing the sensitivity of B cells to the anti-IgM signal.

    abstract：:The lymphokine IL-4 is a potent enhancer of anti-IgM-induced B cell proliferation. Although the mechanism of this enhancement is not known, a commonly held view suggests that IL-4 acts together with anti-IgM as a costimulating factor for the activation of a subpopulation of B cells. To evaluate this hypothesis we exam...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90327-8

    authors： Hodgkin PD,Go NF,Cupp JE,Howard M

    更新日期：1991-04-15 00:00:00

  • Some news from the unknown soldier, the Peyer's patch macrophage.

    abstract：:In mammals, macrophages (MF) are present in virtually all tissues where they serve many different functions linked primarily to the maintenance of homeostasis, innate defense against pathogens, tissue repair and metabolism. Although some of these functions appear common to all tissues, others are specific to the homin...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2018.01.012

    authors： Wagner C,Bonnardel J,Da Silva C,Martens L,Gorvel JP,Lelouard H

    更新日期：2018-08-01 00:00:00

  • Macrophage I-A/I-E expression and macrophage-stimulating lymphokines in murine lupus.

    abstract：:Seeking common abnormalities in mice genetically predisposed to lupus-like autoimmune disease, we investigated (1) the ontogeny of Ia antigens (I-A/I-E) on the surfaces of resident peritoneal macrophages (rpM phi) of lupus and normal mice, (2) spontaneous and lectin-induced in vitro production of M phi-stimulating fac...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90133-3

    authors： Kofler R,Schreiber RD,Dixon FJ,Theofilopoulos AN

    更新日期：1984-08-01 00:00:00

  • Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways.

    abstract：:IL-5 is a pleiotropic cytokine that promotes eosinophil differentiation and survival. While naïve bronchial epithelial cells (BEC) produce low levels of IL-5, the role of BEC-derived IL-5 in allergic airway inflammation is unknown. We now show that BEC, isolated from mice with OVA-induced allergic airway disease (AAD)...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2010.04.008

    authors： Wu CA,Peluso JJ,Zhu L,Lingenheld EG,Walker ST,Puddington L

    更新日期：2010-01-01 00:00:00

  • The role of antigen in the activation of regulatory T cells by immune B cells.

    abstract：:The transfer of B cells from mice immunized with Type III pneumococcal polysaccharide (SSS-III) results in the activation of suppressor and amplifier T cells that control the magnitude of the antibody response in recipient mice, immunized subsequently with SSS-III. Prior treatment of transferred B cells with an excess...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90368-5

    authors： Baker PJ,Taylor C,Fauntleroy MB,Stashak PW,Prescott B

    更新日期：1985-12-01 00:00:00

  • Igh-6b expression in BALB.nude mice.

    abstract：:Mice that differ at Igh loci and the reagents that permit resolution of such distinctions are powerful genetic tools for studying B cell heterogeneity. In this report, IgM-allotype-specific ELISA revealed that two of three sources of mice designated as BALB.nude express the Igh-6b (IgMb) allotype characteristic of C57...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1125

    authors： Riggs JE

    更新日期：1993-05-01 00:00:00

  • VCAM-1 influences lymphocyte proliferation and cytokine production during mixed lymphocyte responses.

    abstract：:The allogeneic mixed lymphocyte reaction (MLR) is regarded as an effective model for examining the events which occur during an allospecific immune response. Numerous studies have delineated the role of adherence molecule interactions during the MLR response. In the present study we have identified VCAM-1 as having a ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1994.1059

    authors： Lukacs NW,Strieter RM,Evanoff HL,Burdick MD,Kunkel SL

    更新日期：1994-03-01 00:00:00

  • Phenotypic and functional changes of GM-CSF differentiated human macrophages following exposure to apoptotic neutrophils.

    abstract：:The engulfment of apoptotic cells by monocytes and unprimed macrophages results in M2 polarization. In the current study, we investigated whether apoptotic cells influence the phenotypic and functional characteristics of GM-CSF-differentiated human macrophages (GM-Mφ). Our results demonstrate that GM-Mφ preincubated w...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2018.06.002

    authors： Chernykh ER,Sakhno LV,Shevela EY,Tikhonova MA,Khonina NA,Ostanin AA

    更新日期：2018-09-01 00:00:00

  • Mouse embryonic cells become susceptible to CTL lysis after midgestation.

    abstract：:The susceptibility of murine embryonic cells to CTL lysis has been assessed. Zona-free blastocysts were not lysed during 6 hr incubation with CTL sensitized against the embryonic genotype and remained capable of implantation and normal development in vivo as well as outgrowth in vitro. Freshly dissociated cells from p...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(87)90037-2

    authors： Croy BA,Rossant J

    更新日期：1987-02-01 00:00:00

  • Internalization of iscom-borne antigens and presentation under MHC class I or class II restriction.

    abstract：:Exogenous nonreplicating antigens (Ag) incorporated into immunostimulating complexes (iscoms) induce CTL responses under MHC class I restriction. A requirement for inducing CTL responses is that the Ag is delivered to the cytosol of antigen-presenting cells (APC), a route restricted to endogenously produced Ag. To inv...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1998.1278

    authors： Villacres MC,Behboudi S,Nikkila T,Lovgren-Bengtsson K,Morein B

    更新日期：1998-04-10 00:00:00

  • Triggering HLA-DR molecules on human peripheral monocytes induces their death.

    abstract：:Although engagement of MHC class II molecules on human monocytes triggers various cellular events, their possible role in monocyte death is yet unknown. We demonstrate that ligation of MHC class II on primary monocytes induces a rapid cell death that has all the characteristics of monocyte apoptosis, does not require ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1998.1428

    authors： Thibeault A,Zekki H,Mourad W,Charron D,Al-Daccak R

    更新日期：1999-02-25 00:00:00

  • Age-associated decline in IL-4 production by murine T lymphocytes in extended culture.

    abstract：:Aging leads to an increase in the proportion of cells that have the surface phenotype (CD45RBlo, CD44hi) characteristic of memory T lymphocytes and also to a decline in both the production of IL-2 and the response to this lymphokine. Several groups have reported an increase, with age, in the secretion of IL-4 in short...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1230

    authors： Li SP,Miller RA

    更新日期：1993-10-01 00:00:00

  • Macrophage binding of cells resistant and sensitive to contact-dependent cytotoxicity.

    abstract：:We compared macrophage binding and killing of F5b cells to the binding and killing of P815 mastocytoma cells and to several other nontransformed and transformed cell lines. Formalin fixation of elicited or activated macrophages did not affect binding of F5b or 3T3 cells but did abrogate binding of P815 cells. However,...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90190-m

    authors： Rosenkrans CF Jr,Chapes SK

    更新日期：1991-03-01 00:00:00

  • Inflammatory cells implicated in neoplasia development in idiopathic inflammatory bowel disease.

    abstract：:The inflammatory mechanisms that lead to the clinical symptoms that are grouped under the term inflammatory bowel disease have not been fully characterized. Although a specific mechanism has not been identified, inflammatory bowel disease is believed to be related to an inability by the immune system to shut active in...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2017.11.004

    authors： Hashash JG,Hartman DJ

    更新日期：2019-09-01 00:00:00

  • Lymphokine regulation of surface Ia expression on rat B cells.

    abstract：:Class II major histocompatibility antigens (Ia) play a major role in regulating T-B cell interactions; therefore, regulation of the amount of Ia on B cells may be an important point of control in the immune response. Mitogens in human and murine systems have been reported to increase Ia expression on B cells, and in t...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90108-6

    authors： Leitenberg D,Feldbush TL

    更新日期：1988-02-01 00:00:00

  • The regulation of resistance to Schistosoma mansoni by a soluble alpha/beta TCR analog, produced by a cloned T cell hybridoma.

    abstract：:Immunity to Schistosoma mansoni is regulated by an auto-anti-idiotypic network. The T cells in this network interact through soluble regulatory factors. These studies describe a soluble suppressor-inducer factor (TsiF) derived from TCR+ suppressor-inducer clone Q37. Q37 is the fusion product of CD4+ T cells derived fr...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1144

    authors： Perrin PJ,Phillips SM

    更新日期：1993-06-01 00:00:00

  • Effector and precursor phenotypes of lymphokine-activated killer cells in mice with severe combined immunodeficiency (scid) and athymic (nude) mice.

    abstract：:The lineage of lymphokine-activated killer (LAK) cells is poorly understood. To examine the relationship between LAK and natural killer (NK) cells we utilized two congenitally immunodeficient mice, namely severe combined immunodeficient (scid) and athymic (nude) mice that lack T cells but have normal NK cells. LAK act...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90190-1

    authors： Hasui M,Saikawa Y,Miura M,Takano N,Ueno Y,Yachie A,Miyawaki T,Taniguchi N

    更新日期：1989-04-15 00:00:00

  • Regulation of immune responses by E3 ubiquitin ligase Cbl-b.

    abstract：:Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. Intriguingly, recent studies indicate...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2018.11.002

    authors： Tang R,Langdon WY,Zhang J

    更新日期：2019-06-01 00:00:00

  • Thymic alterations in Plasmodium berghei-infected mice.

    abstract：:The primary function of the thymus is to develop immature T-cells into cells that further in the periphery will be able to carry out immune functions. The Literature has shown that thymus can be a target for many pathogens and severe structural alterations take place in this organ during infectious diseases. Here, we ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2008.06.001

    authors： Andrade CF,Gameiro J,Nagib PR,Carvalho BO,Talaisys RL,Costa FT,Verinaud L

    更新日期：2008-05-01 00:00:00

  • Activation of human peripheral blood-derived monocytes by OK-432 (Streptococcus pyogenes): augmented cytotoxicity and secretion of TNF and synergy with rIFN-gamma.

    abstract：:The biological response modifier OK-432 has been shown both to exert the enhancement of several immunological activities and to have a direct anti-tumor effect. The present study examines the immunopotentiating effect of OK-432 on peripheral blood monocytes (PBM) derived from normal humans. Monocyte activation was ass...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90297-9

    authors： Bonavida B,Jewett A

    更新日期：1989-10-15 00:00:00

  • Mechanisms in opposite modulation of spleen cell and lymph node cell responses to mitogens following muramyl dipeptide treatment in vivo.

    abstract：:It has been reported that a muramyl dipeptide (MDP) treatment regimen (200 micrograms MDP per mouse, Days -4, -3, -2, and -1) that, given prophylactically, affords protection against several infectious agents also induces lymph node hyperplasia, lymph node cell (LNC) hyperresponsiveness to mitogens, and spleen cell hy...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90248-5

    authors： Brummer E,Stevens DA

    更新日期：1985-04-01 00:00:00

  • Constitutive expression of ligand for natural killer cell NKp44 receptor (NKp44L) by normal human articular chondrocytes.

    abstract：:Normal chondrocytes display susceptibility to lysis by natural killer (NK) cells and this phenomenon may play a role in some inflammatory cartilage disorders. The mechanisms of chondrocyte recognition and killing by NK cells remain unclear. Using flow cytometry and immunohistochemical staining we found that normal hum...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2013.08.005

    authors： Białoszewska A,Baychelier F,Niderla-Bielińska J,Czop A,Debré P,Vieillard V,Kieda C,Malejczyk J

    更新日期：2013-09-01 00:00:00

  • Neuroendocrine hormones such as growth hormone and prolactin are integral members of the immunological cytokine network.

    abstract：:Neuroendocrine hormones such as growth hormone (GH) and prolactin (PRL) have been demonstrated to accelerate the recovery of the immune response after chemotherapy and bone marrow transplantation and to enhance the restoration of immunity in individuals infected with HIV and in normal individuals with compromised immu...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2007.12.003

    authors： Redelman D,Welniak LA,Taub D,Murphy WJ

    更新日期：2008-03-01 00:00:00

  • Impact of polyunsaturated fatty acids on cytoskeletal linkage of L-selectin.

    abstract：:Polyunsaturated fatty acid [omega-3 polyunsaturated fatty acids (omega-3PUFAs)] incorporation into cell membranes has been shown to have potent anti-inflammatory activity, though the mechanisms involved are only partially characterized. Here, we show that PUFA enrichment of T cell membranes decreased the overall expre...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2004.04.004

    authors： Leid JG,Jutila MA

    更新日期：2004-04-01 00:00:00

  • Immobilized staphylococcal enterotoxin A is sufficient to induce T cell proliferation.

    abstract：:We investigated the role of HLA-DR molecules in T cell stimulation by staphylococcal enterotoxin A (SEA). Previous results with immobilized purified HLA-DR preincubated with peptide showed that peptide-specific T cell clones were able to bind to and proliferate in response to purified HLA-DR/peptide complexes in the a...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1255

    authors： Rust CJ,Koning F,van Schooten WC

    更新日期：1993-10-15 00:00:00

  • Dock5 controls the peripheral B cell differentiation via regulating BCR signaling and actin reorganization.

    abstract：:As an atypical guanine nucleotide exchange factor (GEF), Dock5 has been extensively studied in cellular functions. However, the role of Dock5 on B-cell immunity still remain elusive. In this study, we generated a Dock5 knockout mouse model to study the effect of Dock5 deficiency on B cell development, differentiation ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2019.01.001

    authors： Chen A,Yang D,Xuan X,Miller H,Luo X,Yu J,Yang G,Wang H,Liu C

    更新日期：2019-03-01 00:00:00

  • Induction of linked suppression in addition to the donor H-2 class I-specific unresponsiveness in recipient T cells by transfusing class I plus class II-disparate, but not class I alone-disparate, bone marrow cells.

    abstract：:This study was undertaken to determine whether bone marrow (BM) cells contain a cell population with the capacity to induce an unresponsiveness of T cells specific to the BM self-H-2 class I antigens in vivo, i.e., veto cell population. Recombinant or congenic mice were infused intravenously with H-2-incompatible BM c...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90024-l

    authors： Muraoka S

    更新日期：1990-06-01 00:00:00

  • MHC class I is functionally associated with antigen receptors in human T and B lymphomas.

    abstract：:We have studied the antibody-induced effect of cross-linking the major histocompatibility complex class I (MHC-I) in human T leukemic cells (Jurkat) and human B lymphoma cells (Solubo, Burkitts lymphoma) on intracellular [Ca2+]i levels. The increase in [Ca2+]i after MHC-I cross-linking in Jurkat cells and Solubo cells...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1996.0281

    authors： Pedersen AE,Jacoby BF,Skov S,Claesson MH

    更新日期：1996-11-01 00:00:00