Mouse embryonic cells become susceptible to CTL lysis after midgestation.

abstract：:In previous studies, the murine SaI (A/J derived, KkDd) sarcoma was transfected with the allogeneic MHC class I H-2Kb gene, and expressed high levels of H-2Kb antigen. Contrary to expectations, the tumor cells expressing the alloantigen (SKB3.1M tumor cells) were not rejected by autologous A/J mice. Because these resu...

journal_title：Cellular immunology

authors： Cole GA,Ostrand-Rosenberg S

更新日期：1991-05-01 00:00:00

abstract：:There are still questions about whether macrophage differentiation is predetermined or is induced in response to tissue microenvironments. C2D macrophage cells reside early in the macrophage lineage in vitro, but differentiate to a more mature phenotype after adoptive transfer to the peritoneal cavity (PEC-C2D). Since...

journal_title：Cellular immunology

authors： Ortega MT,Xie L,Mora S,Chapes SK

更新日期：2011-01-01 00:00:00

abstract：:The lpr mutation in mice results in premature termination of transcription of the gene encoding the apoptosis-signaling receptor Fas. As a result, lpr mice develop severe lymphoproliferation and lupus-like autoantibodies. Growing evidence suggests that the lpr mutation is "leaky" and that low levels of Fas are express...

journal_title：Cellular immunology

authors： Weintraub JP,Godfrey V,Wolthusen PA,Cheek RL,Eisenberg RA,Cohen PL

更新日期：1998-05-25 00:00:00

abstract：:In the present study, we characterized in monocytes the rise in [Ca(2+)](i) evoked by monoclonal antibodies (mAbs) to aminopeptidase N (APN)/CD13, showing a two-phase calcium increase with a small-belled [Ca(2+)](i) rise due to the release of calcium from intracellular stores and a more sustained plateau due to the in...

journal_title：Cellular immunology

authors： Santos AN,Langner J,Herrmann M,Riemann D

更新日期：2000-04-10 00:00:00

abstract：:Evidence is presented that rat serosal mast cells and cells of the rat basophilic leukemia line, RBL-1, each contain a calcium-activated, phospholipid-dependent protein kinase. The enzymes are very similar in their activation requirements to the calcium-dependent enzymes termed protein kinase Cs in brain. The enzyme i...

journal_title：Cellular immunology

authors： Kurosawa M,Parker CW

更新日期：1986-12-01 00:00:00

abstract：:Interleukin (IL)-1 differs from most other cytokines by the lack of a signal sequence, which results in the retention of the immature proform intracellularly (i.c.). Several cell types have the capacity to produce IL-1, but release has been shown to be restricted predominantly to monocytes/macrophages and associated w...

journal_title：Cellular immunology

authors： Wingren AG,Björkdahl O,Labuda T,Björk L,Andersson U,Gullberg U,Hedlund G,Sjögren HO,Kalland T,Widegren B,Dohlsten M

更新日期：1996-05-01 00:00:00

abstract：:The mechanism of suppression of experimental allergic encephalomyelitis (EAE) induced in Lewis rats by pretreatment with myelin basic protein (MBP) coupled to syngeneic spleen leukocytes (SL) was examined. Studies on the kinetics of the tolerance induction showed that pretreatment with MBP-SL suppressed EAE if given 7...

journal_title：Cellular immunology

authors： McKenna RM,Carter BG,Sehon AH

更新日期：1984-10-15 00:00:00

abstract：:The mechanism by which purinergic agonists modulate murine T-lymphocyte activation and proliferation was investigated. Adenosine and other compounds such as ATP and 2-chloroadenosine (ClAdo) were found to block T-cell mitogenesis induced by concanavalin A (Con A) in a dose-dependent fashion. The nonmetabolizable adeno...

journal_title：Cellular immunology

authors： DosReis GA,Nóbrega AF,de Carvalho RP

更新日期：1986-08-01 00:00:00

abstract：:We have studied the effects of prostaglandin E2 (PGE2) and cholera toxin, two modulators of adenylyl cyclase, and 8-bromo cAMP (8-BrcAMP) on various parameters of lymphocyte activation using the human T cell line Jurkat. Our results show that PGE2 and cholera toxin inhibit, in a dose-related manner, the phytohemagglut...

journal_title：Cellular immunology

authors： Bastin B,Payet MD,Dupuis G

更新日期：1990-07-01 00:00:00

abstract：:That M1/70, a monoclonal anti-murine macrophage antibody, recognizes murine natural killer cells (NK) and that there is an increase in NK following intraperitoneal infection with live Listeria monocytogenes (LM) was previously reported. Here, LM-induced NK cells were further characterized with respect to tumor target ...

journal_title：Cellular immunology

authors： Holmberg LA,Ault KA

更新日期：1984-11-01 00:00:00

abstract：:The interaction between Newcastle disease virus (NDV) and the suppressor cell circuit which regulates the induction phase of contact sensitivity reaction to picryl chloride (Pcl) was investigated. NDV infection impairs the activity of the T suppressor afferent cells (Ts-aff) which inhibit DNA synthesis in the draining...

journal_title：Cellular immunology

authors： Dieli F,Colonna Romano G,Abrignani S,Colizzi V,Salerno A

更新日期：1985-08-01 00:00:00

abstract：:An important subset in regulating antitumor immunity is the maturation and accumulation of intratumor dendritic cells (DCs), inducing potent T cell cytotoxicity. In this study, we explored how the soluble abundant high-mobility group box 1 protein (HMGB1) affected DC activation and retention within lung cancers, and i...

journal_title：Cellular immunology

authors： Gao Q,Li F,Wang S,Shen Z,Cheng S,Ping Y,Qin G,Chen X,Yang L,Cao L,Liu S,Zhang B,Wang L,Sun Y,Zhang Y

更新日期：2019-09-01 00:00:00

abstract：:Tumour necrosis factor (TNF) family ligands and their corresponding receptors play important roles in the immune system and are involved in immune regulation such as lymphoid development, cell proliferation, differentiation, activation and death. Antibodies against these ligands and receptors together with Fc-fusion p...

journal_title：Cellular immunology

authors： Ch'en PF,Xu XG,Liu XS,Liu Y,Song CJ,Screaton GR,Jin BQ,Xu XN

更新日期：2005-07-01 00:00:00

abstract：:To investigate the process of tolerance induction we have developed an in vivo model using TCR beta-chain transgenic mice tolerized with the superantigen staphylococcal enterotoxin B. We have previously demonstrated that tolerized peripheral T cells were anergic when stimulated in vitro with immunogenic peptides, supe...

journal_title：Cellular immunology

authors： Perkins DL,Listman JA,Wang Y,Ho SS,Finn PW,Rimm IJ

更新日期：1994-07-01 00:00:00

abstract：:The effect of the addition of dialyzable leukocyte extract (DLE)(transfer factor) to tuberculostatic drugs in the treatment of superinfected fistulating tuberculosis of bones and joints was evaluated in a controlled study. Eleven patients whose disease had persisted for a mean of 20 +/- 4.8 years and had proved to be ...

journal_title：Cellular immunology

authors： Zielinski CC,Savoini E,Ciotti M,Orani R,Königswieser H,Eibl MM

更新日期：1984-03-01 00:00:00

abstract：:Toll-like receptor (TLR) 2/1 signalling is linked to autophagy through transcriptional actions of the 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-vitamin D receptor (VDR) complex. Population-specific effects have been reported for TLR2/1-VDR signalling. We hypothesized that population effects extend to autophagy and are in...

journal_title：Cellular immunology

authors： Abhimanyu,Meyer V,Jones BR,Bornman L

更新日期：2020-06-01 00:00:00

abstract：:T lymphocytes respond to mitogenic stimulation by expressing the receptor for interleukin 2 (Il-2) and secreting Il-2; once the receptor is expressed, Il-2 induces these cells to proliferation. In the present report using mouse T lymphocytes, thymocytes, and the lymphoma cell line EL4, we studied receptor expression a...

journal_title：Cellular immunology

authors： Truneh A,Simon P,Schmitt-Verhulst AM

更新日期：1986-12-01 00:00:00

abstract：:Previous studies have validated the capacity of classical (HLA-A,B,C) and nonclassical (HLA-G) MHC class I antigens expressed by target cells to influence natural killer (NK) cell-mediated cytolysis. Generally, elevated expression of these HLA class I molecules is correlated with enhanced resistance to lysis by NK cel...

journal_title：Cellular immunology

authors： Storkus WJ,Wei M,Cresswell P,Dawson JR

更新日期：1996-01-10 00:00:00

abstract：:Mygalin is an antibacterial molecule isolated from the hemocytes of the spider Acanthoscurria gomesiana. It was identified as bis-acylpolyamine spermidine. We evaluated the modulator effects of synthetic Mygalin in the innate immune response. We demonstrate that Mygalin induces IFN-γ synthesis by splenocytes increasin...

journal_title：Cellular immunology

authors： Mafra DG,da Silva PI Jr,Galhardo CS,Nassar R,Daffre S,Sato MN,Borges MM

更新日期：2012-01-01 00:00:00

abstract：:The nuclear receptor Small Heterodimer Partner (SHP) is a transcriptional target and inhibitor of Liver Receptor Homolog 1 (LRH-1), the transcriptional regulator of intestinal glucocorticoid (GC) synthesis. The role of SHP in the regulation of intestinal GC synthesis and its impact on T cell-mediated anti-viral immune...

journal_title：Cellular immunology

authors： Huang J,Jia R,Brunner T

更新日期：2018-12-01 00:00:00

abstract：:The quantitative organ distribution and tissue microenvironment positioning of radioisotopically labeled cloned T cells were characterized. Intravenous (iv) injection of 51chromium (51Cr)-labeled, long-term cultured cloned T-helper cells and cells from several cloned cytolytic T-lymphocyte lines (CTLL) resulted in poo...

journal_title：Cellular immunology

authors： Carroll AM,Palladino MA,Oettgen H,De Sousa M

更新日期：1983-02-15 00:00:00

abstract：:Twenty-nine intravenous drug abusers (ivda), with asymptomatic HIV infection at entry, were sequentially studied at 4- to 6-month intervals for variable follow-up periods (mean, 19.6 months). Two of them progressed to AIDS and another one fell into the IV-C2 stage of the CDC classification at the end of the study. CD8...

journal_title：Cellular immunology

authors： Echaniz P,Arrizabalaga J,Iribarren JA,Cuadrado E

更新日期：1993-08-01 00:00:00

abstract：:The clinical outcome of Leishmania pathogenesis ranges from active skin lesions to fatal visceral dissemination and severely impaired T cell immunity. It is well established that a strong Th1 immune response is protective against cutaneous forms of the disease, however a mixed Th1/Th2 response is most commonly observe...

journal_title：Cellular immunology

authors： Banerjee A,Bhattacharya P,Joshi AB,Ismail N,Dey R,Nakhasi HL

更新日期：2016-11-01 00:00:00

abstract：:A variant nonkiller (K-) T-cell clone derived from the MHC nonrestricted killer (K+) cell line TALL-103/2 (CD3/TCR gamma delta +) was studied to determine whether its lytic defects were at the tumor-binding or post-binding level. The two TALL-103/2 clones were found to display similar mRNA expression of TCR/CD3 comple...

journal_title：Cellular immunology

authors： Visonneau S,Cesano A,Santoli D

更新日期：1995-10-15 00:00:00

abstract：:The expression of HLA Class II antigens by resting and phytohemagglutinin (PHA)-activated T cells and their functional properties in autologous mixed-lymphocyte reactions (MLR) were investigated in patients with chronic active hepatitis, with alcoholic cirrhosis, and with primary biliary cirrhosis. In all groups of pa...

journal_title：Cellular immunology

authors： Scudeletti M,Indiveri F,Pierri I,Picciotto A,Ferrone S

更新日期：1986-10-01 00:00:00

abstract：:Macrophages can be divided into two groups as M1 and M2 phenotype. Our results and other groups revealed that IFN-γ can up-regulate the IDO expression and differentiate THP-1 cells to M1 phenotype. Therefore we hypothesized that IDO may play potential roles in macrophage differentiation. Interesting, our results indic...

journal_title：Cellular immunology

authors： Wang XF,Wang HS,Wang H,Zhang F,Wang KF,Guo Q,Zhang G,Cai SH,Du J

更新日期：2014-05-01 00:00:00

abstract：:We showed previously that the expressions of various src family protein tyrosine kinases (PTKs) were induced independently during the monocytic differentiation of HL-60 cells. The role of PTKs was further assessed in the present study by investigating the effects of PTK inhibitors on the differentiation. It was demons...

journal_title：Cellular immunology

authors： Katagiri K,Katagiri T,Kajiyama K,Uehara Y,Yamamoto T,Yoshida T

更新日期：1992-04-01 00:00:00

abstract：:Putative monocytic myeloid-derived suppressor cells (mMDSC; lineage-HLA-DR-/lo) were generated in 7-day cultures from normal rhesus macaque bone marrow (BM) cells in GM-CSF and IL-6. Three subsets were identified based on their differential expression of CD14, CD33, CD34 and CD11b. Following flow sorting, assessment o...

journal_title：Cellular immunology

authors： Zahorchak AF,Perez-Gutierrez A,Ezzelarab MB,Thomson AW

更新日期：2018-07-01 00:00:00

abstract：:Permanent graft acceptance was induced with cyclosporine A in a low responder rat strain combination PVG (RT1(c)) to DA (RT1(av1)) of cardiac transplants. Challenge (alloimmunization) with donor and third-party WF (RT1(u)) cells was performed and followed by the analysis of alloreactive cytotoxicity. The cytotoxic T l...

journal_title：Cellular immunology

authors： Petersson E,Qi Z,Hedlund G,Ekberg H

更新日期：1998-10-10 00:00:00

abstract：:Two signals are required for the in vitro activation of Lyt2+ T suppressor cells (Ts) from mice tolerized with 2,4-dinitrobenzene sulfonate (DNBS) to produce soluble suppressor factors (SSF) which suppress the transfer of contact sensitivity to dinitrofluorobenzene (DNFB). Recognition of DNP/class I MHC (signal one) s...

journal_title：Cellular immunology

authors： Fairchild RL,Moorhead JW

更新日期：1991-03-01 00:00:00