Immobilized staphylococcal enterotoxin A is sufficient to induce T cell proliferation.

abstract：:The allogeneic mixed lymphocyte reaction (MLR) is regarded as an effective model for examining the events which occur during an allospecific immune response. Numerous studies have delineated the role of adherence molecule interactions during the MLR response. In the present study we have identified VCAM-1 as having a ...

journal_title：Cellular immunology

authors： Lukacs NW,Strieter RM,Evanoff HL,Burdick MD,Kunkel SL

更新日期：1994-03-01 00:00:00

abstract：:Although TGF-β and IL-6 would turn CD8(+) T cells to differentiate into non-cytotoxic state, these treated cells were converted to cytolytic phenotypes after re-exposure to their antigenic epitope in vitro. Here, using spleen cells from TCR transgenic mice expressing TCRαβ genes of clone RT1 recognizing an epitope pep...

journal_title：Cellular immunology

authors： Takaku S,Nakagawa Y,Owaki A,Shimizu M,Takahashi M,Takahashi H

更新日期：2012-12-01 00:00:00

abstract：:Mice that differ at Igh loci and the reagents that permit resolution of such distinctions are powerful genetic tools for studying B cell heterogeneity. In this report, IgM-allotype-specific ELISA revealed that two of three sources of mice designated as BALB.nude express the Igh-6b (IgMb) allotype characteristic of C57...

journal_title：Cellular immunology

authors： Riggs JE

更新日期：1993-05-01 00:00:00

abstract：:We have established a long-lasting heart allograft tolerance in H-2-incompatible combinations by intravenous injection of 10(8) allogeneic spleen cells followed by the administration of 200 mg/kg of cyclophosphamide (CP). When C57BL/10 mice (B10, H-2b) were primed iv with 1 x 10(8) viable spleen cells from naive BALB/...

journal_title：Cellular immunology

authors： Matsuura A,Katsuno M,Suzuki Y,Ito T,Yasuura K,Abe T,Yoshikai Y

更新日期：1994-05-01 00:00:00

abstract：:A fibroblastoid cell line TSt-4 was established from fetal thymus tissue of C57BL/6 mice. When fetal thymus (FT) cells or CD4-8- (DN) cells of adult thymuses were cultured on the monolayer of TSt-4, a considerable proportion of lymphocytes expressed CD4 or both CD4 and CD8 within 1 day, and the CD4+CD8- cells were mai...

journal_title：Cellular immunology

authors： Watanabe Y,Mazda O,Aiba Y,Iwai K,Gyotoku J,Ideyama S,Miyazaki J,Katsura Y

更新日期：1992-07-01 00:00:00

abstract：:Peripheral blood leukocytes (PBL), nonadherent lymphocytes, and adherent monocytes separated from freshly isolated blood of 15 dogs were analyzed for their ability to mediate antibody-dependent cell-mediated cytotoxicity (ADCC) in combination with murine anti-tumor monoclonal antibodies (MAbs). Canine monocytes isolat...

journal_title：Cellular immunology

authors： Rosales C,Jeglum KA,Obrocka M,Steplewski Z

更新日期：1988-09-01 00:00:00

abstract：:Mice were infected with Plasmodium (P.) yoelii blood-stage parasites. Both the liver and spleen were the sites of inflammation during malarial infection at the beginning of day 7. The major expanding cells were found to be NK1.1(-) intermediate alphabetaTCR (alphabetaTCR(int)) in the liver and spleen, although the pop...

journal_title：Cellular immunology

authors： Weerasinghe A,Sekikawa H,Watanabe H,Mannoor K,Morshed SR,Halder RC,Kawamura T,Kosaka T,Miyaji C,Kawamura H,Seki S,Abo T

更新日期：2001-01-10 00:00:00

abstract：:Soluble suppressor factors in the sera of cancer patients inhibit lectin-stimulated lymphocyte proliferation. These factors, derived from human material, preclude easy corroboration by other investigators. To gain a general understanding of soluble suppressor factors and to avoid the necessary restrictions of human ex...

journal_title：Cellular immunology

authors： Wile AG,Hensen D,Nahabedian M,Ibsen KH,Granger GA

更新日期：1984-07-01 00:00:00

abstract：:Unique dysregulated expression patterns of microRNAs (miRNAs) have been reported in many disease conditions including autoimmune diseases such as systemic lupus erythematosus (SLE). We have recently reported that miRNAs are differentially expressed not only between autoimmune and control mice, but also between male an...

journal_title：Cellular immunology

authors： Khan D,Dai R,Ansar Ahmed S

更新日期：2015-04-01 00:00:00

abstract：:The mechanisms of glucocorticoid-induced immunosuppression of human monocytes for the defense of Candida albicans were examined in this in vitro study. Dexamethasone at pharmacological concentrations (10(-7)-10(-5) M) dose-dependently attenuated growth inhibition of C. albicans by resident monocytes. In interferon-gam...

journal_title：Cellular immunology

authors： Heidenreich S,Kubis T,Schmidt M,Fegeler W

更新日期：1994-09-01 00:00:00

abstract：:Overexpression of TNF-alpha in the body is critically involved in many diseases. A strategy to construct TNF-alpha autovaccine by introducing a T cell helper epitope to the protein has been developed and may be an alternative because it is cheaper and highly efficient. However, the induction of high level anti-TNF-alp...

journal_title：Cellular immunology

authors： Wan Y,Xue X,Li M,Zhang X,Qin X,Zhang C,You Y,Wang W,Jiang C,Wu S,Liu Y,Zhu W,Ran Y,Zhang Z,Han W,Zhang Y

更新日期：2007-04-01 00:00:00

abstract：:Investigation into the mechanism of action of vaccine adjuvants provides opportunities to define basic immune principles underlying the induction of strong immune responses and insights useful for the rational development of subunit vaccines. A novel HIV vaccine composed of plasmid DNA-encoding p55 gag formulated with...

journal_title：Cellular immunology

authors： Denis-Mize KS,Dupuis M,Singh M,Woo C,Ugozzoli M,O'Hagan DT,Donnelly JJ 3rd,Ott G,McDonald DM

更新日期：2003-09-01 00:00:00

abstract：:The proliferation of Molt-4 lymphoblasts and phytohemagglutinin-stimulated human T lymphocytes in vitro was inhibited significantly by 10(-12) to 10(-10) M to 10(-13) to 10(-9) M somatostatin, as assessed by the uptake of [3H]thymidine and [3H]leucine, respectively. The inhibitory effect of somatostatin was not attrib...

journal_title：Cellular immunology

authors： Payan DG,Hess CA,Goetzl EJ

更新日期：1984-04-01 00:00:00

abstract：:Accessory cell (A-cell) function in a Con A response was analyzed. Irradiated P388D1 cells efficiently induced a proliferative response to Con A of T cells purified from spleen cells, whereas paraformaldehyde-fixed P388D1 cells failed to serve as A cells. Although IL-1 containing culture supernatant (SN) of a macropha...

journal_title：Cellular immunology

authors： Kohno K,Kakiuchi T,Takeuchi M,Taira S,Nariuchi H

更新日期：1987-05-01 00:00:00

abstract：:Interleukin-1 is a potent stimulator of arachidonic acid (AA) metabolism and this activity could be attributed to the activation of the prostaglandin-forming enzyme cyclooxygenase or of the arachidonic-releasing enzyme phospholipase A2 or both. Prostaglandin E2 (PGE2), a cyclooxygenase product, and LTB4 (5-(S),12-(R)-...

journal_title：Cellular immunology

authors： Conti P,Panara MR,Barbacane RC,Placido FC,Bongrazio M,Reale M,Dempsey RA,Fiore S

更新日期：1992-11-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS), and is induced by immunization with disease-causative self-antigens such as myelin oligodendrocyte glycoprotein (MOG). We have previously reported that transplantation of MOG expressing thymic epithelial progenitors (TEPs) ...

journal_title：Cellular immunology

authors： Su M,Lin Y,Cui C,Tian X,Lu X,He Z,Lai L

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:Piperine, a main component of Piper species, is a plant alkaloid with a long history of medical use in a variety of inflammatory disorders like rheumatoid arthritis. Due to side effects in current treatment modalities of rheumatoid arthritis, the interest in alternative, well tolerated anti-inflammatory reme...

journal_title：Cellular immunology

authors： Umar S,Golam Sarwar AH,Umar K,Ahmad N,Sajad M,Ahmad S,Katiyar CK,Khan HA

更新日期：2013-07-01 00:00:00

abstract：:Our group has shown in a randomized clinical trial that psychological intervention to reduce stress in patients with stages II and III breast cancer led to enhanced immune function, fewer recurrences and improved overall survival. We hypothesized that patients with high levels of stress would have alterations in myelo...

journal_title：Cellular immunology

authors： Mundy-Bosse BL,Thornton LM,Yang HC,Andersen BL,Carson WE

更新日期：2011-01-01 00:00:00

abstract：:PICOT (PKC-interacting cousin of thioredoxin) consists of one thioredoxin homology domain in the N-terminal and two tandem PICOT homology domains in the C-terminal. PICOT specifically interacts with protein kinase C theta (PKC-theta) via its thioredoxin homology domain and acts as an important modulator of T cell rece...

journal_title：Cellular immunology

authors： Kato N,Motohashi S,Okada T,Ozawa T,Mashima K

更新日期：2008-01-01 00:00:00

abstract：:Induction of specific antitumor cytotoxic T cell responses was studied in BALB/c mice bearing tumors transfected with a mutant human p53 minigene. We observed that mice were resistant to the induction of peptide-specific CTL as early as 5 days after challenge with a minimal lethal dose of tumor cells, and the cell typ...

journal_title：Cellular immunology

authors： Gabrilovich DI,Ciernik IF,Carbone DP

更新日期：1996-05-25 00:00:00

abstract：:The pre-B cell stage of B lymphocyte development is characterized by the presence of immunoglobulin heavy chains of the IgM isotype in the cytoplasm and no other heavy or light chains in the cytoplasm or on the surface. We established several cell lines that were identical in their serologically defined pre-B cell phe...

journal_title：Cellular immunology

authors： Griffin JA,Spalding DM

更新日期：1989-04-01 00:00:00

abstract：:Latent Mycobacterium tuberculosis (Mtb) infection (LTBI) is the main clinical manifestation after Mtb exposure. During the latent phase, Mtb retards the attempts of eradication by the host immune system. The dormancy survival regulator (DosR) is held as essential for Mtb persistence. Rv1737c is predominantly expressed...

journal_title：Cellular immunology

authors： Gao X,Wu C,He W,Wang X,Li Y,Wang Y,Jia Y,Yuan R,Li H,Zhang B

更新日期：2019-10-01 00:00:00

abstract：:Macrophage-mediated cytostasis was measured in a mouse syngeneic system where EL4 thymoma cells were found to be inhibited by C57B1/6 mouse macrophages. When tumor cells were pretreated with TPA, they became resistant to macrophage-mediated stasis. Nonelutriated as well as elutriated cells enriched in G1/early S and l...

journal_title：Cellular immunology

authors： Nycum LM,Fishman M

更新日期：1989-01-01 00:00:00

abstract：:The delayed-type hypersensitivity (DTH) reaction, a peripheral expression of cell-mediated immunity is still a crucial in vivo immunological test. Nevertheless, the biological significance of its time course remains unclear. Thus, an exhaustive study of DTH was undertaken in mice immunized with increasing doses of she...

journal_title：Cellular immunology

authors： Hurtrel B,Maire MA,Hurtrel M,Lagrange PH

更新日期：1992-07-01 00:00:00

abstract：:Mucus production by goblet cells in the gastrointestinal tract following Salmonella typhimurium infection using a ligated ileal loop model in mice was investigated. Assessment of the morphology of the loop tissue after Salmonella challenge revealed generalized tissue inflammation, characterized by edema and an inflamm...

journal_title：Cellular immunology

authors： Arnold JW,Klimpel GR,Niesel DW

更新日期：1993-10-15 00:00:00

abstract：:The cellular requirements for stimulating primed alloreactive T cells have been investigated. In vitro-primed secondary alloreactive cells, long-term lines, and Ly 1+2- noncytolytic clones which reacted with allo-H-2K, D, or Mls (M locus) antigens were tested. The data indicated that a specialized antigen-presenting c...

journal_title：Cellular immunology

authors： Sunshine GH,Mitchell TJ,Czitrom AA,Edwards S,Glasebrook AL,Kelso A,MacDonald HR

更新日期：1985-03-01 00:00:00

abstract：:Attempts have been made to induce cytolytic T cells to kill target cells that do not express the appropriate target molecules by crosslinking the T cells and the target cells in various ways. One successful strategy has been to use heteroconjugates or bispecific monoclonal antibodies reacting with T cell molecules wit...

journal_title：Cellular immunology

authors： Hedlund G,Dohlsten M,Lando PA,Kalland T

更新日期：1990-09-01 00:00:00

abstract：:Injection of antigen into the thymus of adult animals induces specific systemic tolerance, but the mechanisms of acquired thymic tolerance are not well understood. To investigate these mechanisms we used a model of intrathymic injection of ovalbumin (OVA) in BALB/c mice. We show an antigen-specific decrease in prolife...

journal_title：Cellular immunology

authors： Chen W,Issazadeh S,Sayegh MH,Khoury SJ

更新日期：1997-08-01 00:00:00

abstract：:We investigated the role of IL-12 in regulating IL-2 and IFN-gamma production in primary culture of human T cells. Addition of neutralizing antiserum against the 40-kDa subunit of IL-12 to PHA-stimulated PBMC markedly reduced both IFN-gamma protein production and mRNA accumulation and stability. Moreover, concurrent t...

journal_title：Cellular immunology

authors： Nagy E,Buhlmann JE,Henics T,Waugh M,Rigby WF

更新日期：1994-12-01 00:00:00

abstract：:A variety of thymus hormone preparations, as well as drugs known to perturb cell differentiation, were tested for their ability to induce nonfunctional cortical thymocytes to become functional precursor cells. Murine cortical thymocytes, defined as the high peanut agglutinin (PNA) binding or as the low H-2K, major [86...

journal_title：Cellular immunology

authors： Andrews P,Shortman K,Scollay R,Potworowski EF,Kruisbeek AM,Goldstein G,Trainin N,Bach JF

更新日期：1985-04-01 00:00:00