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Association of intermediate T cell receptor cells, mainly their NK1.1(-) subset, with protection from malaria.

Abstract：

:Mice were infected with Plasmodium (P.) yoelii blood-stage parasites. Both the liver and spleen were the sites of inflammation during malarial infection at the beginning of day 7. The major expanding cells were found to be NK1.1(-) intermediate alphabetaTCR (alphabetaTCR(int)) in the liver and spleen, although the population of NK1.1(+) alphabetaTCR(int) cells remained constant or slightly increased. These TCR(int) cells are of extrathymic origin or are generated by an alternative intrathymic pathway and are distinguished from conventional T cells of thymic origin. During malarial infection, the population of conventional T cells did not increase at all. TCR(int) cells purified from the liver of mice which had recovered from P. yoelii infection protected mice from malaria when they were transferred into 6.5-Gy-irradiated mice. Interestingly, the immunity against malaria seemed to disappear as a function of time after recovery, namely, mice which had recovered from malaria 1 year previously again became susceptible to malarial infection. The present results suggest that TCR(int) cells are intimately associated with protection against malarial infection and, therefore, that mice which had recovered from malaria 1 year previously lost such immunity.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Weerasinghe A,Sekikawa H,Watanabe H,Mannoor K,Morshed SR,Halder RC,Kawamura T,Kosaka T,Miyaji C,Kawamura H,Seki S,Abo T

doi

10.1006/cimm.2000.1737

subject

Has Abstract

pub_date

2001-01-10 00:00:00

pages

28-35

issue

1

eissn

0008-8749

issn

1090-2163

pii

S0008874900917374

journal_volume

207

pub_type

杂志文章

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