Selective modulation of IFN-gamma mRNA stability by IL-12/NKSF.

Abstract:

:We investigated the role of IL-12 in regulating IL-2 and IFN-gamma production in primary culture of human T cells. Addition of neutralizing antiserum against the 40-kDa subunit of IL-12 to PHA-stimulated PBMC markedly reduced both IFN-gamma protein production and mRNA accumulation and stability. Moreover, concurrent treatment of partially purified T cells (> 90% CD3+) with PHA and rIL-12 selectively enhanced IFN-gamma mRNA stability and protein production, while IL-2 protein and mRNA levels were unaffected. These studies also show that IFN-gamma and IL-2 mRNA stability are temporally dissociated during the course of T cell activation, and we propose that this dissociation may be mediated through the production of IL-12. The effect of IL-12 on modulation of IFN-gamma mRNA turnover is not associated with detectable changes in either the levels or affinity of cytoplasmic RNA-binding proteins capable of recognizing AU-rich sequences in the 3'UTR of IFN-gamma mRNA.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Nagy E,Buhlmann JE,Henics T,Waugh M,Rigby WF

doi

10.1006/cimm.1994.1303

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

140-51

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(84)71303-7

journal_volume

159

pub_type

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