Abstract：
:A mouse IgG1 monoclonal antibody ED12F8C10 (C10) binds a constant percentage of peripheral blood neutrophils in the same individual when studied over time, defining a distinct subset of neutrophils in all normal individuals studied to date. Bone marrow studies confirm that the heterogeneity is present to the same degree at all stages of neutrophil development from the myelocyte to the mature neutrophil. Neither in vivo nor in vitro activation of neutrophils explains or significantly alters the relative percentages of C10-positive and -negative neutrophils in the same individual. With both activation and exudation, however, expression of the C10-defined epitope increases in intensity in the C10 binding subpopulation. Studies of NBT reduction, phagocytosis, adherence, light scattering characteristics, and monoclonal antibody surface binding have failed to demonstrate physical or functional differences between the C10-defined populations. We examined C10 binding in patients with different defects of phagocyte function. In two patients with neutrophil-specific granule deficiency, less than 1% of the neutrophils were found to be C10 positive, while neutrophils from a patient with idiopathic leukemoid reaction and recurrent infections demonstrated greater than 99% C10 binding. Although the present study does not delineate the physiologic significance of C10 binding heterogeneity, it firmly supports the concept of neutrophil heterogeneity at the level of surface antigen expression.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Brown CC,Malech HL,Jacobson RJ,Shrimpton CF,Beverly PC,Segal AW,Gallin JIdoi
10.1016/0008-8749(91)90010-9subject
Has Abstractpub_date
1991-01-01 00:00:00pages
102-14issue
1eissn
0008-8749issn
1090-2163pii
0008-8749(91)90010-9journal_volume
132pub_type
杂志文章abstract：:Prevention of ultraviolet radiation- or chemical carcinogen-induced morphologic transformation and inhibition of tumor-producing transformed cell growth by lymphotoxin and by normal spleen leukocytes were quantitatively compared to define the antineoplastic activity spectra of these natural immune mediators. When Syri...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(83)90372-6
更新日期：1983-03-01 00:00:00
abstract：:Epstein-Barr virus (EBV) readily immortalizes human peripheral blood lymphocytes (PBL) in vitro. However, during the past several years, we found that PBL from two exceptional EBV-seropositive healthy adult individuals were refractory to immortalization by EBV. We report here a study aimed at learning about the immuno...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90090-7
更新日期：1989-09-01 00:00:00
abstract：:Within the lymphoid compartment, CD8 is expressed either as an alphaalpha homodimer or as an alphabeta heterodimer. Prior functional characterization of CD8alpha transfectants has demonstrated that CD8alphaalpha homodimers can reconstitute T cell responses in the absence of the CD8beta subunit. In order to now examine...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1998.1412
更新日期：1999-02-01 00:00:00
abstract：:Peroxynitrite (ONOO(-)) has been vastly implicated in mutagenesis and cancer development. Present study probes the antigenicity of peroxynitrite damaged DNA (ONOO(-)-DNA) in cancer patients. Purified human placental DNA was damaged by the synergistic action of sodium nitroprusside (SNP) and Pyrogallol for 3h at 37 deg...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2008.08.002
更新日期：2009-01-01 00:00:00
abstract：:Activated macrophages are known to release a variety of immunoregulatory substances including the low-molecular-weight substances hydrogen peroxide and lactate. We report here that lactate but not hydrogen peroxide is capable of supporting a substantial production of T-cell growth factor (TCGF) in cultures of accessor...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(87)90224-3
更新日期：1987-09-01 00:00:00
abstract：:The nonspecific suppression of immunological responses that is generated within host popliteal lymph nodes upon exposure to syngeneic normal spleen cells has been examined. The suppression, which had previously been described as being capable of preventing initiation of cytotoxic T lymphocytes (CTLs) to hapten-altered...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(87)90069-4
更新日期：1987-03-01 00:00:00
abstract：:Inherited deficiency of the enzyme adenosine deaminase (ADA) has been found in a significant proportion of patients with severe combined immunodeficiency disease and inherited defect generally characterized by a deficiency of both B and T cells. Two questions are central to understanding the pathophysiology of this di...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(85)90317-x
更新日期：1985-10-15 00:00:00
abstract：:Previous studies with the lymphokine, histamine-releasing activity (HRA), showed that HRA consisted of a heterogeneous group of molecules. The possibility of using thoracic duct lymphocytes (TDL) as a source of large quantities of HRA has been investigated. Antigen-stimulated TDL synthesize and release HRA in quantiti...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90012-1
更新日期：1984-09-01 00:00:00
abstract：BACKGROUND:Interleukin (IL)-23, composed of p19 and p40 subunits, has diverse functions in regulating immune systems, enhancing cell-mediated immunity. In the present study, we investigated whether forced expression of the p19-linked p40 gene in murine mammary cancer cells (MA891) produced antitumor effects in vivo. Tu...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2009.05.002
更新日期：2009-01-01 00:00:00
abstract：:Anti-CD3 mAb can activate T cells to help in B cell activation as detected by late events, such as maturation of B cells into Ig-secreting cells (IgSC), or by early events, such as B cell surface expression of the activation marker CD23. Two different anti-CD2 mAb each inhibited anti-CD3-induced T cell-dependent B cel...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90269-w
更新日期：1990-10-15 00:00:00
abstract：:PHA stimulation of both freshly isolated and IL-2-dependent cultured T cells induced a rapid rise in intracytoplasmic calcium concentration. Chelation of extracellular calcium with EGTA resulted in a failure of PHA to induce a rise in intracytoplasmic calcium, resulting in the fresh T cells in an inhibition of IL-2 pr...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90060-3
更新日期：1988-01-01 00:00:00
abstract：:The mode of action of T-cell-suppressor factor (TsF) induced by ultraviolet B (UVB) preirradiation in terms of interaction with several cytokines was studied. Suppression of murine contact photosensitivity (CPS) to 3,3',4',5-tetrachlorosalicylanilide (TCSA) by preirradiation of the sensitizing site to low doses of UVB...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90239-n
更新日期：1990-11-01 00:00:00
abstract：:Cytokines are soluble proteins that mediate immune reactions and are responsible for communication among immune cells. CD4(+) T cells are the principle sources of cytokines of adaptive immunity. Cytokines play critical roles in the differentiation and effector function of CD4(+) T cells. They also play key roles in di...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2012.07.009
更新日期：2012-07-01 00:00:00
abstract：AIMS:Non-enzymatic reaction of biomolecules leads to the formation of advanced glycation end products (AGEs). AGEs plays significant role in the pathophysiology of type 2 diabetes mellitus. Methylglyoxal (MG) is a highly reactive carbonyl compound which causes formation of early (ketoamines), intermediate (dicarbonyls)...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2020.104062
更新日期：2020-05-01 00:00:00
abstract：:Endogenous retroviral superantigens such as vSAG-7 are highly stimulatory for T cells through interaction with the T cell receptor on the basis of V beta usage. Priming of adult MMTV 7-negative mice with vSAG-7-expressing cells has been shown to result in peripheral V beta 6/CD4+ T cell activation followed by toleranc...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1995.1164
更新日期：1995-09-01 00:00:00
abstract：:In vitro incubation of the erythroleukemic cell line K562 with interferon-gamma (IFN-gamma) renders these cells relatively resistant to natural killer (NK) cell lysis. However, such treatment does not alter their sensitivity to LAK cell lysis. Thus, the lytic susceptibility of interferon-gamma-treated K562 (I-K562) ce...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90376-6
更新日期：1989-02-01 00:00:00
abstract：:The many signals that control the progress of various immune responses to both foreign and self antigens can be divided into no less than three major groups. The first group is the initial positive stimulus, associated with activation events through antigen receptors and their associated proteins. These signals launch...
journal_title：Cellular immunology
pub_type： 杂志文章,评审
doi：10.1016/0008-8749(90)90174-p
更新日期：1990-10-01 00:00:00
abstract：:Development of contact hypersensitivity in mice depends on the migration of Langerhans cells from the epidermis to regional lymph nodes. Since ICAM-1 and LFA-1 play important roles in leukocyte migration, we sought to determine whether in vivo administration of anti-ICAM-1 and anti-LFA-1 antibodies would inhibit conta...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1285
更新日期：1994-10-15 00:00:00
abstract：:The quantitative organ distribution and tissue microenvironment positioning of radioisotopically labeled cloned T cells were characterized. Intravenous (iv) injection of 51chromium (51Cr)-labeled, long-term cultured cloned T-helper cells and cells from several cloned cytolytic T-lymphocyte lines (CTLL) resulted in poo...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(83)90349-0
更新日期：1983-02-15 00:00:00
abstract：:Burn injury induces immune dysfunction and alters numerous physiological parameters. While clinical studies indicate that burn injury size profoundly impacts patient immune status, only limited experimental studies have systematically addressed its impact on immune functional parameters. In the present study, mice wer...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/s0008-8749(03)00024-8
更新日期：2002-11-01 00:00:00
abstract：:TJ6 is a novel protein which has immunosuppressive activity and may have a functional role in fetal allograft survival during pregnancy. Initial studies indicated that when mice were treated with an anti-TJ6 binding mAb early in pregnancy, the pregnancies were completely ablated and that TJ6 expression is enhanced dra...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1114
更新日期：1994-04-15 00:00:00
abstract：:The transfer of B cells from mice immunized with Type III pneumococcal polysaccharide (SSS-III) results in the activation of suppressor and amplifier T cells that control the magnitude of the antibody response in recipient mice, immunized subsequently with SSS-III. Prior treatment of transferred B cells with an excess...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(85)90368-5
更新日期：1985-12-01 00:00:00
abstract：:Human peripheral blood cells enriched for B lymphocytes were stimulated to focal proliferation in semisolid cultures with lymphocyte-conditioned media, Protein A (Prot A), lipopolysaccharide (LPS) and 2-mercaptoethanol (2-ME). After 6-8 days of incubation, two morphologically distinct colony types were observed. Type ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90059-5
更新日期：1984-10-01 00:00:00
abstract：:The impact of BCR:CD21 co-engagement on B cell expression of molecules critical for T cell activation was investigated with receptor-specific mAbs conjugated to high MW dextran as stimulatory ligands. In the absence of IL-4, BCR:CD21 co-ligation augmented BCR-triggered CD86 only under conditions of very low BCR ligand...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/s0008-8749(02)00512-9
更新日期：2002-03-01 00:00:00
abstract：:The objective of the present investigation was to evaluate the requirement for increased ornithine decarboxylase (ODC) activity and polyamine biosynthesis in the induction of cytolytic T lymphocytes (CTL). In this regard, we have utilized alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ODC. DFMO tre...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(87)90060-8
更新日期：1987-03-01 00:00:00
abstract：:The relay hypothesis [R. Nayak, S. Mitra-Kaushik, M.S. Shaila, Perpetuation of immunological memory: a relay hypothesis, Immunology 102 (2001) 387-395] was earlier proposed to explain perpetuation of immunological memory without requiring long lived memory cells or persisting antigen. This hypothesis envisaged cycles ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2007.05.001
更新日期：2007-03-01 00:00:00
abstract：:Lung cancer cells harboring multiple mutations as a consequence of long-term damage by different etiologic factors are responsible for high immunogenicity. Immune checkpoint inhibitors significantly improve treatment results in non-small cell lung cancer (NSCLC). Unfortunately, the role of T-lymphocytes in early NSCLC...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2017.09.007
更新日期：2017-12-01 00:00:00
abstract：:We have studied the antibody-induced effect of cross-linking the major histocompatibility complex class I (MHC-I) in human T leukemic cells (Jurkat) and human B lymphoma cells (Solubo, Burkitts lymphoma) on intracellular [Ca2+]i levels. The increase in [Ca2+]i after MHC-I cross-linking in Jurkat cells and Solubo cells...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0281
更新日期：1996-11-01 00:00:00
abstract：:Chemokine receptors CCR5 and CXCR4 are of major importance in the pathogenesis of HIV-1 infection because they are co-receptors for human immunodeficiency virus (HIV) entry. We examined the frequency of CD3-CD56+CCR5+ and CD3-CD56+CXCR4+ in HIV-infected long-term slow progressors (SPs), HIV typical progressors (TPs) w...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2008.01.010
更新日期：2008-01-01 00:00:00
abstract：:The proliferation of Molt-4 lymphoblasts and phytohemagglutinin-stimulated human T lymphocytes in vitro was inhibited significantly by 10(-12) to 10(-10) M to 10(-13) to 10(-9) M somatostatin, as assessed by the uptake of [3H]thymidine and [3H]leucine, respectively. The inhibitory effect of somatostatin was not attrib...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90117-5
更新日期：1984-04-01 00:00:00
